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| Number | Title | Issue Date |
| 8058058 | Submerged membrane supported bioreactor for conversion of syngas components to liquid products A submerged membrane supported bioreactor for anaerobic conversion of gas into liquid products including a plurality of membrane modules having a plurality of hollow fibers, each of the plurality of hollow fibers having a gas permeable hollow fiber wall defining a h... | 11/15/2011 |
| 8017384 | Modular membrane supported bioreactor for conversion of syngas components to liquid products A modular membrane supported bioreactor for anaerobic conversion of gas into liquid products including membrane module(s) having a plurality of hollow fibers packed across a cross sectional area of the membrane module in a direction transverse to the axis of the mem... | 09/13/2011 |
| 7943371 | System and testing biological and chemical agents using two or more cartridges simulating systems in the body and methods The present invention relates to joining two or more cartridges containing cell or tissue cultures from different organs found in the human body in fluid connection. It includes a vitro method and system for testing chemicals and agents as they pass through organs o... | 05/17/2011 |
| 7695958 | Cell-filled hollow fiber membranes having modified cross-section To provide a cell-filled device that is suitable for use in, for example, an implantable or circulation type hybrid artificial organ. In a cell-filled device including hollow fiber membranes whose hollow portions are filled with cells, the hollow fiber membranes hav... | 04/13/2010 |
| 7531351 | Liquid-gas-phase exposure reactor for cell culturing Initiation of growth and cultivation of cells can be performed by introducing the cells into culture compartments of a liquid-gas-phase exposure bioreactor containing a supply chamber in which there are disposed hollow-filament membranes having an inside diameter of... | 05/12/2009 |
| 7371567 | Bioreactor, particularly for bioartificial organs A bioreactor for bioartificial organs, comprising a closed and substantially tubular body inside which there is a containment cavity; an animal and/or human cell culture and support structure, accommodated in the cavity and suitable to be crossed by a fluid to be pr... | 05/13/2008 |
| 7367550 | Peristaltic mixing and oxygenation system The present invention provides devices and methods for achieving mixing and gas exchange in chambers having a small volume. According to the invention a chamber includes one or more walls that are made of a gas-permeable material and that include multiple portions t... | 05/06/2008 |
| 7329539 | Bioreactor for sewage and wastewater treatment The present invention relates to a bioreactor for sewage and wastewater treatment, which is capable of agitating and supplying oxygen simultaneously. A bioreactor of the present invention, comprises a culture drum in which microorganisms are cultured; a supplier for... | 02/12/2008 |
| 7270996 | Automated bioculture and bioculture experiments system The present invention provides a feedback controlled bioculture platform for use as a precision cell biology research tool and for clinical cell growth and maintenance applications. The system provides individual closed-loop flowpath cartridges, with integrated, ase... | 09/18/2007 |
| 7186549 | Container for shipping items in aircraft A container for shipping items in an aircraft includes a shipping compartment and an expandable chamber for receiving gas from the shipping compartment. At least one conduit connects the expandable chamber to the shipping department so as to permit the flow of gas t... | 03/06/2007 |
| 7160719 | Bioartificial liver system A bioartificial liver system is described that incorporates a cell reservoir and hepatocyte spheroids to both increase the number of and longevity of cells in the system. Additional methods are also described for forming spheroid aggregates from isolated hepatocytes... | 01/09/2007 |
| 7101519 | Zirconium basic carbonate and methods of making the same Methods of making zirconium basic carbonate are further described which involve titrating an aqueous slurry of sodium zirconium carbonate to a pH of from about 3.5 to about 4.0 with an acidic agent wherein the sodium zirconium carbonate has a moisture content of fro... | 09/05/2006 |
| 7067307 | Bioartificial device for the storage, cultivation and/or multiplication of cells The bioartificial reactor has a reactor vessel. A cell culture chamber in the reactor, in particular for liver cells, is divided off from a flow chamber for a nutritive medium and from a flow chamber for plasma and blood by semipermeable walls. At least one flow cha... | 06/27/2006 |
| 7033498 | Cartridges useful in cleaning dialysis solutions Cartridges useful in regenerating or purifying dialysis solutions are described as well as methods to regenerate or purify spent dialysis solutions. Dialysis systems using the sorbent cartridges of the present invention are further described. ... | 04/25/2006 |
| 7022518 | Apparatus and method for co-culturing of cells A co-culture apparatus and method for, among other things, converting a progenitor cell line into a target cell line. The apparatus comprises an exterior receptacle, a removable cartridge that fits into the exterior receptacle, and a closure member to seal the appar... | 04/04/2006 |
| 6979308 | Bioreactor design and process for engineering tissue from cells A scaled-up multi-coaxial fiber bioreactor, and variations of this bioreactor. The device is characterized by a hollow housing and an array of from about 20 to about 400 modules of hollow fibers, where each module includes at least three coaxial semipermeable hollow... | 12/27/2005 |
| 6933144 | Apparatus for growing cells A cell-culture apparatus forms an extra-capillary space between at least one hollow fiber and an enclosed chamber. Cells are placed in the extra-capillary space to grow. A media reservoir holds a cell-culture medium. The cell-culture medium is allowed to pass throug... | 08/23/2005 |
| 6921662 | Cell/tissue culture apparatus The invention provides a cell/tissue culture apparatus for applying a physical stimulation necessary for the proliferation and growth of a cell or tissue to a material to be cultivated serving as a cell or tissue to be cultivated, thereby realizing the culture as de... | 07/26/2005 |
| 6821762 | Reactor module with capillary membranes The present invention relates to a reactor module constructed of hollow fibers and cells as well as to reactors comprising this reactor module. ... | 11/23/2004 |
| 6667172 | Cell and tissue culture modeling device and apparatus and method of using same A cell and tissue culture modeling device comprising a housing having an interior chamber, an inlet port in fluid communication with the internal chamber, an outlet port in fluid communication with the internal chamber, a plurality of hollow fibers dispos... | 12/23/2003 |
| 6582955 | Bioreactor with application as blood therapy device A bioreactor having an outer shell compartment containing many coaxial pairs of hollow microporous fibers. An annular compartment exists between an outer surface of the inner hollow microporous fiver and the inner surface of the outer hollow microporous f... | 06/24/2003 |
| 6566126 | Apparatus and method for growing cells A cell-culture apparatus forms an extra-capillary space between at least one hollow fiber and an enclosed chamber. Cells are placed in the extra-capillary space to grow. A media reservoir holds a cell-culture medium. The cell-culture medium is allowed to ... | 05/20/2003 |
| 6518058 | Method of preparing polypeptides in cell-free system and device for its realization The present invention provides a method for synthesis polypeptides in a cell-free system by which products of synthesis are branched in a low molecular weight fraction and a fraction which contains high molecular weight components with the target polypept... | 02/11/2003 |
| 6410307 | Membrane module for testing active substances at cells Membrane module for testing active substances in cells with an interior chamber (2) which is limited by a lid (3), a bottom (4), and a side wall (5) and a system of first capillary membranes (6) and a system of second capillary membranes (11) located ther... | 06/25/2002 |
| 6319706 | Process and apparatus for remedying polluted media A process to remedy a polluted medium includes contacting a first medium containing a pollutant with a second medium containing a microorganism which is capable of decomposing the pollutant. A membrane permeable to the pollutant and impermeable to the mic... | 11/20/2001 |
| 6306644 | Device for cultivating different mammal cells at the same time A process and device are disclosed for simultaneously cultivating different mammal cells, for separately obtaining different mammal cell products and for simulating organic interactions on the humoral plane. Essentially, the invention consists of arrangin... | 10/23/2001 |
| 6271023 | Module made of at least two-type hollow fibres, and production of same Membrane module and process for its manufacture, wherein the membrane module contains at least two groups of hollow-fiber membranes, the groups arranged in layers and capable of being fed independently by fluids. The membrane module has a housing shell co... | 08/07/2001 |
| 6242248 | Bioreactor and related method A bioreactor (10) has arranged within its internal chamber (14) a bundle of liquid-impermeable hollow tubes (16), which are used to freeze or vitrify a biologically active material seeded within the internal chamber. When the bioreactor is ready for use, ... | 06/05/2001 |
| 6228607 | Bioreactor The invention relates to a bioreactor for a cell treatment of a medium. Said bioreactor comprises an element defining a chamber in which cells for treating the medium are located, a liquid permeable membrane separating the said chamber from a first channe... | 05/08/2001 |
| 6214574 | Cross-flow filtration and culture method A culturing system and method particularly useful for producing cellular products such as viral pathogens of cells. It includes a mass transfer culture segment, stacked filter plates to adjust the medium composition, and a product removal and concentratio... | 04/10/2001 |
| 6207448 | Bioreactor and related method A bioreactor (10) comprises an elastic housing (12) and a plurality of hollow, porous fibers (14) disposed within the housing. The lumens of the fibers define an intrafiber compartment, and the outer surfaces of the fibers and the housing define an extraf... | 03/27/2001 |
| 6136593 | Astrocyte apparatus for bioprocessing a circulating fluid The invention relates to a container having astrocytes for use in removing toxins from a biological fluid. The container includes a first port for receiving the biological fluid and a second port through which the biological fluid exits the container. The... | 10/24/2000 |
| 6127141 | Culture device and method A culturing system and method particularly useful for producing cellular products such as viral pathogens of cells. It includes a mass transfer culture segment, stacked filter plates to adjust the medium composition, and a product removal and concentratio... | 10/03/2000 |
| 6068775 | Removal of agent from cell suspension The invention relates to a method of removing an agent from a suspension of cells using a semi-permeable membrane. In one aspect of the invention, the cells are used to bioprocess a biological fluid after removal of the agent.... | 05/30/2000 |
| 6048727 | Apparatus and method for mass transfer involving biological/pharmaceutical media A mass transfer apparatus and method is based upon use of a mass transfer chamber, such as a hollow fiber membrane bioreactor, with a control to change the directional flow therethrough for enhancement of the mass transfer operation. The invention has par... | 04/11/2000 |
| 6022742 | Culture device and method A culturing system and method particularly useful for producing cellular products such as viral pathogens of cells. It includes a mass transfer culture segment, stacked filter plates to adjust the medium composition, and a product removal and concentratio... | 02/08/2000 |
| 6022733 | Simulated biological dissolution and absorption system The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a cell culture chamb... | 02/08/2000 |
| 6001585 | Micro hollow fiber bioreactor A "micro" hollow fiber bioreactor and method of use are provided for use in screening different cell lines and process conditions. The bioreactor includes the use of an oxygen permeable (e.g., silicone rubber) tube sealably containing a hollow fiber bundl... | 12/14/1999 |
| 5998184 | Basket-type bioreactor Improved hollow fiber bioreactor systems and cell culture methods are described. The improvement includes means which may be a novel basket bioreactor for extending the extracapillary space of a conventional hollow fiber bioreactor.... | 12/07/1999 |
| 5981211 | Maintaining cells for an extended time by entrapment in a contracted matrix Methods of maintaining animal cells for product production, for supporting hepatocyte function and viability to treat a patient suffering from hepatic failure and for preserving tissue-specific function of mammalian cells are carried out with a bioreactor... | 11/09/1999 |
