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| Number | Title | Issue Date |
| 8183035 | Single container manufacturing of biological product A method of manufacturing biological products in a single container from the growth of cells to purification of the product is performed in a flexible disposable bioreactor that uses only a compressed gas for mixing and gasification. A porous septum is used to creat... | 05/22/2012 |
| 7435576 | Filter snapper A device for applying an axial compressive force to a fluid contamination detection system comprising a cup joined by a frangible connection to a filter ring, the force being sufficient to break the frangible connection and collapse a portion of the ring into the cu... | 10/14/2008 |
| 7390653 | Culture chamber for biologicals The culture chamber of the present invention has a fluid-filled culture compartment in which cells, tissues and other biologicals are cultured. The culture compartment is transversed by one or more molecular weight cut-off membranes attached to a membrane carrier as... | 06/24/2008 |
| 7329539 | Bioreactor for sewage and wastewater treatment The present invention relates to a bioreactor for sewage and wastewater treatment, which is capable of agitating and supplying oxygen simultaneously. A bioreactor of the present invention, comprises a culture drum in which microorganisms are cultured; a supplier for... | 02/12/2008 |
| 7067307 | Bioartificial device for the storage, cultivation and/or multiplication of cells The bioartificial reactor has a reactor vessel. A cell culture chamber in the reactor, in particular for liver cells, is divided off from a flow chamber for a nutritive medium and from a flow chamber for plasma and blood by semipermeable walls. At least one flow cha... | 06/27/2006 |
| 6867040 | Bioreactor and methods for producing synchronous cells Apparatus and methods are directed to a perfusion culture system in which a rotating bioreactor is used to grow cells in a liquid culture medium, while these cells are attached to an adhesive-treated porous surface. As a result of this arrangement and its rotation, ... | 03/15/2005 |
| 6673598 | Disposable culture bag A cell culture bag for culturing cells, cellular aggregates, particles, tissues and organoids is disclosed. The cell culture bag is a flexible and disposable culture bag that fits within a bag support chamber of a bioreactor. The cell culture bag has an i... | 01/06/2004 |
| 6187053 | Process for producing a natural implant In a process for producing a natural implant for tissue of a human or animal body, the body's own cells are multiplied and/or differentiated on a cell base using a culture medium to form the implant.... | 02/13/2001 |
| 6099730 | Apparatus for treating whole blood comprising concentric cylinders defining an annulus therebetween Apparatus for removing substances from blood is disclosed. The apparatus includes concentric cylinders defining an annulus therebetween with the inner cylinder adapted for rotation with respect to the outer cylinder. At least one of the cylinders includes... | 08/08/2000 |
| 6071727 | Production of microbial cellulose A microbial cellulose with high water content and process for making the microbial cellulose utilizes a rotary disk or linear conveyor bioreactor containing a biological medium and a cellulose producing microorganism are provided.... | 06/06/2000 |
| 6022733 | Simulated biological dissolution and absorption system The invention relates to a system and method for assessing simulated biological dissolution of a pharmaceutical formulation and absorption of a pharmaceutically active compound therefrom. The system comprises a dissolution chamber and a cell culture chamb... | 02/08/2000 |
| 6001642 | Bioreactor and cell culturing processes using the bioreactor A bioreactor and cell culturing method using the bioreactor have been developed to enhance cell production and growth and decrease the shear forces on the cells and multicellular aggregates. The bioreactor contains a dome-shaped culture vessel having wall... | 12/14/1999 |
| 5955326 | Production of microbial cellulose using a rotating disk film bioreactor A new microbial cellulose with high water content and process for making the new microbial cellulose utilizes a trough containing a biological medium and a cellose producing micro organism. A plurality of disks are partly submerged in the medium and moved... | 09/21/1999 |
| 5846817 | Bioreactor, in particular for microgravity A bioreactor, in particular for a microgravity, comprising at least one cell culture chamber, an oxygen supply and an agitator for a cell culture. In particular, the chamber includes two housing elements (1, 2) having a first (1', 9) and a second (2', 9')... | 12/08/1998 |
| 5795750 | Process for the continuous enzymatic extraction of hydrophobic products and device suitable therefor In a process for the continuous enzyme-catalyticzed enzymatic production of hydrophobic products in an aqueous solution of a reaction mixture, the product is extracted from the product containing reaction mixture by way of a product-permeable microporous ... | 08/18/1998 |
| 5728577 | Stirred tank bioreactor A bioreactor includes a treatment tank for receiving liquid to be treated, at least one carrier member having a carrier body formed of porous materials and immobilized with nonagglutinative microorganisms for treating the liquid, and a drive unit for movi... | 03/17/1998 |
| 5705390 | Bioreactor A radial flow bioreactor comprising a reaction vessel having an inlet and an outlet respectively for adding and withdrawing a culture medium and at least one cell basket within the reaction vessel for accommodating a plurality of cell carriers and having ... | 01/06/1998 |
| 5482854 | Growth environment assembly and method of use thereof A method and assembly for treating living and non-living biological environments with varying doses of fluids in vitro. The assembly comprises a vessel, a closure and a tubular membrane extending from the closure and suspended into the vessel to provide r... | 01/09/1996 |
| 5437998 | Gas permeable bioreactor and method of use A new rotating cell vessel and method of use have been developed. The vessel is constructed of materials which are permeable to oxygen and carbon dioxide, and when rotated horizontally suspend the contents, cells and particle substrates, in a liquid mediu... | 08/01/1995 |
| 5316945 | Cell carrier arrangement A cell carrier arrangement for cultivating adhering cells having at least two blanks connected with one another. The blanks are separated by a gap and are made of flat material, wherein at least one of the blanks is produced from a material which is perme... | 05/31/1994 |
| 5254472 | Organic digesting system An organic digesting system incorporating a pair of digester units each of which includes an elongated, horizontally disposed frusto-conical, stationary outer drum with each outer drum including a correspondingly frusto-conical inner drum that is rotatabl... | 10/19/1993 |
| 5126269 | Spin filter perfusion bioreactor (SFPB) cell culture apparatus An apparatus is disclosed that separates and removes to an external source, spent cell culture media from a cell culture media and cell culture mixture. The apparatus generally comprises a culture vessel, a filter member, wherein the filter member is posi... | 06/30/1992 |
| 5032524 | Apparatus and process for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures The invention relates to an apparatus and a process for the bubble-free gassing of liquids, especially of culture media for propagating tissue cultures by means of a porous membrane filament system, whereby liquid media and gas are introduced into the cul... | 07/16/1991 |
| 5019512 | Spin filter for removing substantially cell-free culture medium from suspension cell culture system A spin filter for removing substantially cell-free medium from a stirred suspension culture vessel, wherein a stationary baffle is arranged in the interior space of the spin filter to disrupt liquid flow therein and minimize the tendency of cells to colle... | 05/28/1991 |
| 5008197 | Process and a device for improved oxygenation of biological cultures The present invention provides an improved method and apparatus for cultivating mammalian cells. The invention relates to reaction vessels having a mechanical stirrer therein. The improvement comprises supplying oxygen to the culture media in the vessel t... | 04/16/1991 |
| 5002890 | Spiral vane bioreactor A spiral vane bioreactor of a perfusion type in which a vertical chamber (10), intended for use in a microgravity condition, has a central rotating filter assembly (30) and has flexible membranes (56) disposed to rotate annularly about the filter assembly... | 03/26/1991 |
| 4999302 | Biological contact gas scrubber for waste gas purification Process and apparatus is disclosed for removing pollutants from a waste gas stream comprising culturing in a rotary biocontactor a biomass capable of assimilating the pollutants and producing harmless metabolites. The waste gas stream is brought into cont... | 03/12/1991 |
| 4988623 | Rotating bio-reactor cell culture apparatus A bio-reactor system wherein a tubular housing contains an internal circularly disposed set of blade members and a central tubular filter all mounted for rotation about a common horizontal axis and each having independent rotational support and rotational... | 01/29/1991 |
| 4888294 | Apparatus and method for the continuous cultivation of microorganisms in a culture liquid Cultivation tank (1) for continuous cultivation of cells or micro-organisms, containing a rotating separating device (11,12) for separating suspended cells from cultivation liquid (10) supplied continuously through a supply (4) and passed through the sepa... | 12/19/1989 |
| 4649118 | Cell culturing apparatus with improved stirring and filter means A cell culturing apparatus having a unitary filter and stirring head suspended within a culture vessel by a flexible conduit which permits movement of the head in a predetermined nonrotary path for stirring the culture medium within the vessel while at th... | 03/10/1987 |
| 4639422 | Cell culture filter apparatus and method Cell culture filter apparatus and method is disclosed for the large scale cultivation of mammalian cells. This system is adapted for convenient manual assembly - disassembly of internal parts and interchangeability of filtration units.... | 01/27/1987 |
| 4596779 | Culture vessel with agitator A culture vessel has an agitator arranged to orbit about an upright axis while being hollow at least at one end. A filter is provided on said one end and a conduit communicates with the hollow portion of the agitator for withdrawing filtered fluid from th... | 06/24/1986 |
| 4535062 | Apparatus for growing microorganisms Growing of microorganisms takes place in a fermenter in which simultaneously products of metabolism are separated and withdrawn by microfiltration with the aid of a diaphragm filter, and a suspension of microorganisms is stirred in the fermenter in the re... | 08/13/1985 |
| 4242450 | Method of hydrolyzing sugar, protein or the like and apparatus therefor This method of hydrolyzing sugar, protein or the like and apparatus are advantageous especially in achieving the effective exhibition of the activity of immobilized enzymes, which method comprises jet-dispersing a constant-temperature aqueous solution con... | 12/30/1980 |
| 4184916 | Continuous cell culture system A cell culture system and apparatus is provided for the suspension culturing of mammalian cells in which fresh media can be added and spent medium filtered and withdrawn on a continuous or semi-continuous basis without cell disruption. The apparatus compr... | 01/22/1980 |
| 4166768 | Continuous cell culture system A cell culture system and apparatus is provided for the suspension culturing of mammalian cells in which fresh media can be added and spent medium filtered and withdrawn on a continuous or semi-continuous basis without cell disruption. The apparatus compr... | 09/04/1979 |
| 4156630 | Process and apparatus for carrying out a fermentation operation upon recycling of microorganisms In a fermentation employing microorganisms or enzymes the nutrient medium is mixed in the fermenter with a filter aid and the inoculum. After completion of the fermentation the fermentation broth is passed into a filter where it is directed through filtra... | 05/29/1979 |
