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| Number | Title | Issue Date |
| 8105821 | Silane mixtures Silanation compositions containing a mixture of two or more silanation reagents, where at least one silanation reagent includes a functional group capable of supporting polymer synthesis and at least one silanation reagent includes no functional group capable of sup... | 01/31/2012 |
| 8105820 | Assay chip, and uses of said assay chip to determine molecular structures and functions An assay chip for investigation the functionality of membrane proteins and their interactions with molecules includes a nanopore array having a plurality of nanopores in a suitable support layer deposited on the nanopore substrate and being a substantially planar su... | 01/31/2012 |
| 8101402 | Medical device for analyte monitoring and drug delivery The invention relates to an ingestible, implantable or wearable medical device comprising a microarray which comprises a bioactive agent capable of interacting with a disease marker biological analyte; a reservoir which comprises at least one therapeutic agent and i... | 01/24/2012 |
| 8101403 | Method and device for rapid parallel microfluidic molecular affinity assays Disclosed are methods and devices for rapid parallel molecular affinity assays performed in a microfluidic environment. The invention exploits hydrodynamic addressing to provide simultaneous performance of multiple assays in parallel using a minimal sample volume fl... | 01/24/2012 |
| 8088616 | Heater unit for microfluidic diagnostic system The present technology provides for a heater substrate that contains networks of heater elements configured to controllably and selectively deliver heat to one or more PCR reaction chambers in a microfluidic substrate with which the heater substrate makes contact. I... | 01/03/2012 |
| 8088615 | Optical component for observing a nanometric sample, system comprising same, analysis method using same, and uses thereof The invention concerns an optical component for observing a sample, which includes a substrate and at least one complex index layer of predetermined thickness, designed to show a high intensity or color contrast for optical path variations, reliefs, nanometric thick... | 01/03/2012 |
| 8084203 | Methods for the determination of telomere length in a semi-automatic manner of every single cell in a immobilized cell population The invention relates to methods and reagents for the determination of telomere length in tissue sections by the single cell telomeric mapping technique based on a fluorescent in situ hybridization step using a telomere-specific probe and an interpolation step using... | 12/27/2011 |
| 8080409 | Sample processing device compression systems and methods Sample processing systems and methods of using those systems for processing sample materials located in sample processing devices are disclosed. The sample processing systems include a rotating base plate on which the sample processing devices are located during ope... | 12/20/2011 |
| 8080381 | Infectious etiologic agent detection probe and probe set, carrier, and genetic screening method An infectious etiologic agent detection probe set which detects an infectious etiologic agent gene, includes a plurality of kinds of probes including oligonucleotide having base sequences selected from each of a plurality of groups selected from a first group includ... | 12/20/2011 |
| 8080408 | Bioassay substrate and bioassay method A bioassay substrate and method thereof is provide. In the bioassay substrate, a sample solution is dripped onto a spot area to which a plurality of detection substances is fixed and an interaction between the detection substance and a target substance in the sample... | 12/20/2011 |
| 8076079 | Single molecule detection using molecular motors The present invention provides methods and compositions for highly sensitive nucleic acid detection, down to the single nucleic acid molecule level. In one aspect, the present invention provides methods for detecting a target nucleic acid comprising: (a) providing f... | 12/13/2011 |
| 8076126 | Single column immunological test elements A plurality of individual single column test elements are provided for use in a clinical testing apparatus. Each test element is defined by a single test column that includes a quantity of a test material, such as gel material or a bead matrix, including a cover str... | 12/13/2011 |
| 8071363 | Chip for cell electrophysiological sensor, cell electrophysiological sensor using the same, and manufacturing method of chip for cell electrophysiological sensor A chip for a cell electrophysiological sensor has a substrate. The substrate has a through-hole formed from the upside to the downside, and the opening of the through-hole is formed in a curved surface curved from the upside and downside of the substrate toward the ... | 12/06/2011 |
| 8067226 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more of a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurali... | 11/29/2011 |
| 8067169 | Detection of macromolecular complexes on ultraflat surfaces with harmonic cantilevers Method and apparatus which uses harmonic cantilevers, such as used in atomic force microscopy, to detect variations in the attractive and repulsive forces on a solid surface as a result of macromolecular binding, for example, hybridization of a single stranded DNA m... | 11/29/2011 |
| 8062883 | Device and method for multiple analyte detection The invention is directed to a method and device for simultaneously testing a sample for the presence, absence, and/or amounts of one or more a plurality of selected analytes. The invention includes, in one aspect, a device for detecting or quantitating a plurality ... | 11/22/2011 |
| 8058055 | High resolution chromosomal mapping The present invention generally relates to spatial and structural genomic analysis compositions, which can be used for the mapping of chromosomes and structural analyses of chromosomal rearrangements, including the entire chromosome, as well as specific portions or ... | 11/15/2011 |
| 8053227 | Biosensor A biosensor provided herein includes a semiconductor laser device having an optical resonator with at least one reflective surface and a light output surface, and a surface plasmon resonance (SPR) unit disposed on the reflective surface of the optical resonator. The... | 11/08/2011 |
| 8053226 | Device and method for simultaneously identifying blood group antigens The invention relates to a device for simultaneously, qualitatively or quantitatively identifying a number of analytes in a liquid sample. The device comprises a membrane with: a charging zone for applying the liquid sample; at least two indicator zones, which can i... | 11/08/2011 |
| 8039249 | Compact disk based platform for separating and detecting immunomagnetic bead labeled cells Disclosed is a disk based platform for separating and detecting cells that are labeled with immunomagnetic beads. A disk-like carrier board forms therein at least one flow channel structure, which includes an inner reservoir for receiving a sample fluid, an outer re... | 10/18/2011 |
| 8039250 | Piezoelectric-based nanopore device for the active control of the motion of polymers through the same Apparatus, system, and methods are provided for utilizing piezoelectric material for controlling a polymer through a nanopore. A reservoir is formed filled with conductive fluid. A membrane is formed that separates the reservoir. A nanopore is formed through the mem... | 10/18/2011 |
| 8030060 | Gene signature for diagnosis and prognosis of breast cancer and ovarian cancer A first embodiment is a breast cancer prognosticator comprising a detection mechanism consisting a 15-gene signature. In addition there are embodiments comprised of 23-gene signatures and 28-gene signatures. The 28-gene signature may also be used for the prognosis o... | 10/04/2011 |
| 8026094 | Microarray synthesis instrument and method During the light illumination period of a monomer addition cycle in synthesizing an DNA microarray, undesirable reflections of illumination light from various interfaces that the illumination light passes through near the synthesis surface of the substrate may reduc... | 09/27/2011 |
| 8017381 | Composite electroporation plate with interchangeable well inserts Electroporation on a plurality of samples of membranous structures is performed in an electroporation well plate that includes a frame that can hold a plurality of well strips to form a two-dimensional array of wells, and a set of well strips, the set containing str... | 09/13/2011 |
| 8012743 | Detection of target analytes using particles and electrodes The invention relates to the use of particles comprising binding ligands and electron transfer moieties (ETMs). Upon binding of a target analyte, a particle and a reporter composition are associated and transported to an electrode surface. The ETMs are then detected... | 09/06/2011 |
| 8003374 | Reagentless, reusable, bioelectronic detectors A reagentless, reusable bioelectronic DNA, or other oligonucleotide sequence sensor is disclosed. The sensor includes an oligonucleotide (aptamer) probe tagged with a electroactive, redoxable moiety, self-assembled on or near an electrode. This surface-confined olig... | 08/23/2011 |
| 8003375 | Qualitative differential screening The invention concerns a method for identifying and/or cloning nucleic acid regions representing qualitative differences associated with alternative splicing events and/or with insertions, deletions located in RNA transcribed genome regions, between two physiologica... | 08/23/2011 |
| 7998726 | Method for fixing a protein on a pyrrole-based polymer and use thereof for making a sensor The aim of the present invention is to provide a method for attaching a protein to a conductive polymer, that can be used in particular for producing a sensor or a multisensor, for example a biochip. This aim, and also others, are achieved, in accordance with... | 08/16/2011 |
| 7998727 | DNA-based electronic diodes and their applications A semiconductor device provides a metal contact, a DNA layer, wherein the metal layer and the DNA layer are adapted to form a Schottky barrier junction there between, and a conductive contact with the DNA layer. ... | 08/16/2011 |
| 7993908 | Microstructure for particle and cell separation, identification, sorting, and manipulation The invention relates to microscale cell separating apparatus which are able to separate cells on the basis of size of the cells, interaction of the cells with surfaces of the apparatus, or both. The apparatus comprises a stepped or sloped separation element (16 | 08/09/2011 |
| 7993909 | Method and apparatus for in vivo collection of circulating biological components The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yie... | 08/09/2011 |
| 7993907 | Biochips and method of screening using drug induced gene and protein expression profiling The present invention provides a biochip microarray, with multiple properties for use in identification of gene- and protein-induction or repression by drugs, the evaluation of efficacy and toxicity of any drug of choice, prediction of efficacy and toxicity of newly... | 08/09/2011 |
| 7993910 | Methods and apparatus for amplification of DNA using sonic energy Apparatus and methods for amplification of DNA are provided that use sonic energy in place of conventional thermocyclers. In one embodiment, sonic energy is applied to a PCR cocktail to effect dissociation of double stranded DNA into single strands of DNA. A quiesce... | 08/09/2011 |
| 7989197 | Microfluidic device including a microchannel with a hydrophobic porous polymer bonded to walls thereof and to a magnetic bead, and methods of making and using the device This invention provides a microfluidic device comprising an inlet and an outlet which are connected with each other through a microchannel, wherein a polymerized hydrophobic porous polymer is bonded to magnetic beads and to the walls of the microchannel. The inventi... | 08/02/2011 |
| 7989198 | Active NEMS arrays for biochemical analyses A biofunctionalized nanoelectromechanical device (BioNEMS) for sensing single-molecules in solution by measuring the variation in the mechanical displacement of the BioNEMS device during a binding event is provided. The biofunctionalized nanoelectromechanical device... | 08/02/2011 |
| 7981665 | Supports for assaying analytes and methods of making and using thereof Described herein are supports for assaying an analyte and methods of making and using thereof. ... | 07/19/2011 |
| 7981664 | Apparatus and method for performing ligand binding assays on microarrays in multiwell plates Each well of a multiwell plate adapted to accept a plurality of biological samples for testing for the presence of analytes in the sample is further adapted herein for immobilizing on the side walls of a well a 3D arrangement of ligand arrays. A well is formed with ... | 07/19/2011 |
| 7981666 | Sensing switch and detecting method using the same Provided are a sensing switch and a sensing method using the same. The sensing switch includes: a substrate; a supporter on the substrate; a sensing plate that is connected to a side of the supporter and is in parallel with the substrate by a predetermined distance;... | 07/19/2011 |
| 7977086 | Platform A platform for a devise for wetting objects, especially for an incubation/hybridization chamber is defined by an object support. The platform is arranged at a distance to the object support. The platform comprises a base provided with a least one spacer and a frame ... | 07/12/2011 |
| 7977087 | Detection instrument with the use of polynucleotides mapped on barley chromosome As the results of mass sequencing of cDNA clones originating in barley varieties “H. spontaneum”, “Haruna Nijo” and “Akashinriki”, a large number of sites showing single nucleotide polymorphisms (SNPs) among the varieties are found out. Because of... | 07/12/2011 |
