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| Number | Title | Issue Date |
| 7678565 | Flow cell array and the utilization thereof for multianalyte determination A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to t... | 03/16/2010 |
| 7674616 | Device and method for measuring properties of a sample Test strips designed to prevent or reduce false results when measuring the condition of a sample are provided. The test strips can be used for analysis of samples by methods including electrical and optical measurements. The reagent test strips and methods are parti... | 03/09/2010 |
| 7666661 | Substrates, devices, and methods for quantitative liquid crystal assays The present invention relates to the field of molecular diagnostics, and in particular to diagnostics based on a liquid crystal assay format. In particular, the present invention provided improved substrates and methods of using liquid crystal assays for quantitatin... | 02/23/2010 |
| 7666663 | Correction method for the distribution of quantity of light and biochip-reader The present invention is characterized by the following points: In a biochip reader used for reading a measurement sample image by light beam irradiation, a correction method for the distribution of quantity of light which is devised to remove the influence o... | 02/23/2010 |
| 7666662 | Chemical reaction device, chemical reaction system and chemical reaction method A chemical reaction device is provided for a chemical reaction between molecules immobilized on a solid phase and molecules in a solution, and a chemical analysis device is also provided to capture molecules in the solution by molecules immobilized on the solid phas... | 02/23/2010 |
| 7655456 | Analytical device having temperature detection unit The present invention relates to an analytical device (X1) including a mounting portion (10) for mounting an analytical tool (2) capable of outputting information for computation, a computation unit for conducting computation for analyzing a sam... | 02/02/2010 |
| 7651851 | Handheld Raman body fluid analyzer Methods and apparatus for in vitro detection of an analyte in a body fluid sample using low resolution Raman spectroscopy are disclosed. The body fluid analyzer includes a disposable strip for receiving a sample of body fluid on a target region, the target region in... | 01/26/2010 |
| 7648834 | Plasmon fluorescence augmentation for chemical and biological testing apparatus The sensitivity and durability of fluorescent assays may be increased through structures and methods using plasmon fluorescence augmentation and sealing of the structure against degradation by reagents used in the assay. The resulting structures make practical extre... | 01/19/2010 |
| 7638321 | Method and device for measuring multiple physiological properties of cells A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media... | 12/29/2009 |
| 7632671 | Molecular detection and assay by electrobiochip micro-array The presence of a nucleic acid target, molecule or ligand can be detected by hybridization, antigen-antibody reaction or receptor-ligand binding. This is reported by the strategic positioning of a first probe and a second probe attached to a small particle of electr... | 12/15/2009 |
| 7632672 | Composite membrane containing a cross-linked enzyme matrix for a biosensor An electrochemical sensor system and membrane and method thereof for increased accuracy and effective life of electrochemical and enzyme sensors. ... | 12/15/2009 |
| 7632673 | Reactor device The invention relates to a reactor device. In order to keep the equipment costs low and to make it possible to handle a plurality of cultivations during a short time period, the device includes a channel and mechanism for delivering fluid to a monitor; reactor vesse... | 12/15/2009 |
| 7632670 | Fet sensor with specially configured gate electrode for the highly sensitive detection of analytes Disclosed is a sensor comprising a substrate, a source contact region, a drain contact region, and the gate oxide of a transistor. A gate electrode is disposed between the gate oxide and a detection electrode made of a nonconducting material. The contact area A... | 12/15/2009 |
| 7622294 | Methods for detecting target analytes and enzymatic reactions A microsphere-based analytic chemistry system and method for making the same is disclosed in which microspheres or particles carrying bioactive agents may be combined randomly or in ordered fashion and dispersed on a substrate to form an array while maintaining the ... | 11/24/2009 |
| 7615369 | Reconfigurable protein patterning using electrowetting microelectrodes A protein patterning electrode device consisting of capacitor microelectrode arrays coated with a protein non-adherent layer is provided. Operation of the electrode is based on a phenomenon called “electrowetting,” where surface wettability can dynamically be co... | 11/10/2009 |
| 7595189 | Integrated optics fiber array The device for detecting the binding of two chemical species includes a first plate having a base, multiple optical fibers and a second plate. The base has multiple grooves formed therein. The multiple optical fibers are each disposed within a corresponding one of t... | 09/29/2009 |
| 7582470 | Device for amplifying and detecting a target nucleic acid Compositions, methods and devices for detecting nucleic acids. The invention particularly regards composite arrays of immobilized amplification primers and hybridization probes. Also disclosed are compositions and methods for covalently immobilizing oligonucleotides... | 09/01/2009 |
| 7582471 | Biosensor for the detection of protein kinase A, and kit comprising the same The present invention relates to a biosensor specifically detecting a protein kinase A (PKA), and a diagnosis kit comprising the biosensor. In particular, the present invention relates to a biosensor for detecting a PKA comprising a cantilever, and a protein kinase ... | 09/01/2009 |
| 7566564 | Signal amplification using a synthetic zymogen Described herein are zymogens, methods of use for zymogens, and devices that incorporate zymogens. The zymogens include a substrate and an enzyme. The substrate can inhibit the enzyme and is a target for a protein produced by a microorganism. When the substrate is m... | 07/28/2009 |
| 7563615 | Apparatus and method for automated monitoring of airborne bacterial spores An apparatus and method for automated monitoring of airborne bacterial spores. The apparatus is provided with an air sampler, a surface for capturing airborne spores, a thermal lysis unit to release DPA from bacterial spores, a source of lanthanide ions, and a spect... | 07/21/2009 |
| 7544503 | Apparatus for the pH determination of blood and method therefor The present invention relates to a spectroscopic apparatus for non-invasive in vivo analysis of blood and to a corresponding analysis method, in particular for direct determination of the pH value of the blood. From a Raman signal detected from an excited target reg... | 06/09/2009 |
| 7524670 | Protocol and apparatus for determining heparin-induced thrombocytopenia A hemostasis analyzer, such as the Thrombelastograph® (TEG®) hemostasis analyzer is utilized to measure continuously in real time, the hemostasis process from the initial fibrin formation, through platelet-fibrin interaction and lysis to generate blood hemostasis ... | 04/28/2009 |
| 7524671 | Handheld raman blood analyzer Methods and apparatus for in vitro detection of an analyte in a blood sample using low resolution Raman spectroscopy are disclosed. The blood analyzer includes a disposable strip for receiving a sample of blood on a target region, the target region including gold so... | 04/28/2009 |
| 7521226 | One-step enzymatic and amine detection technique A technique for detecting the presence or quantity of an enzyme (or enzyme inhibitor) and/or an amine within a test sample is provided. For example, in one embodiment, a diagnostic test kit is employed that utilizes reactive complexes that each includes a substrate ... | 04/21/2009 |
| 7521225 | Nanotube structures having a surfactant bilayer inner wall coating Nanotubes and nanotube array structures comprise (a) a nanotube having an inner wall portion; and (b) a bilayer coating formed on the inner wall portions, with the bilayer coating comprised of surfactants. A secondary compound such as a protein, peptide or nucleic a... | 04/21/2009 |
| 7514255 | Methods and devices for detecting pancreatic lipase A method and device for determining pancreatic lipase in an animal blood sample. In one aspect, the device includes a compartmentalized container for storing and reacting the reagents for use in the assay. In another aspect, the device include a multilayer device ha... | 04/07/2009 |
| 7485453 | Diffraction-based diagnostic devices A biosensor includes a substrate with areas of active receptive material disposed thereon. The receptive material is specific for an analyte of interest. A pattern of the active areas is defined on the substrate by an oxidizing photo-masking process. ... | 02/03/2009 |
| 7473548 | Optical detector for enzyme activation Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits en... | 01/06/2009 |
| 7473547 | Test piece, method of and apparatus for manufacturing the test piece and method of and system for reading the same A test piece for use in biological analysis of a sample is formed of a strip-like substrate and numbers of known specific binding agents which are different from each other and are arranged in a line at predetermined intervals in the longitudinal direction of the st... | 01/06/2009 |
| 7459303 | Impedance based apparatuses and methods for analyzing cells and particles A device for monitoring the migration or invasion of a biological particle such as a cell is disclosed. The device includes an upper chamber adapted to receive and retain a cell sample, a lower chamber having at least two electrodes, and a biocompatible porous membr... | 12/02/2008 |
| 7442823 | Silanyl-n-alkanal compounds, method for production and use thereof The invention relates to ω-silanyl n-alkanal compounds, method for production and use thereof in the fuctionalization of solid supports, solid supports functionalized by the compounds and the use of solid supports thus functionalized for the immobilization and/or s... | 10/28/2008 |
| 7438856 | Microfluidic devices and methods Embodiments of the invention are directed to microfluidic devices. In one embodiment, a microanalysis chip comprises a body having at least one transfer-separation channel with a channel bottom that has a bottom opening. The transfer-separation channel terminates in... | 10/21/2008 |
| 7439079 | Assay devices having detection capabilities within the hook effect region A lateral flow assay device for detecting the presence or quantity of an analyte within a test sample is provided. The device utilizes multiple zones, one of which serves as an indicator of whether or not the analyte in the test sample is within the “hook effect... | 10/21/2008 |
| 7435569 | Method of forming a molded protein matrix for use in a sensor A method for formulating and immobilizing a protein and a protein matrix formed by the method. The protein matrix preparation method results in a physically and chemically stable protein matrix that has low swelling, non-leaching, high activity, and high mechanical ... | 10/14/2008 |
| 7435579 | Biosensor and related method A microscale biosensor for use in the detection of target biological substances includes a detection chamber disposed on the substrate and defining a volume between 1 pico-liter and 1 micro-liter. The detection chamber is adapted to confine a composition containing ... | 10/14/2008 |
| 7432113 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7432111 | Non-continuous immunoassay device and immunoassay method using the same A non-continuous immunoassay device which includes two or more separated pads for immunoassay analysis, and is capable of controlling the migration speed of a mobile phase between the separated pads, and an immunoassay method using the same are disclosed. The immuno... | 10/07/2008 |
| 7432112 | Surface modification of metals for biomolecule detection using surface enhanced Raman scattering (SERS) The present invention is based on the discovery that the methods described herein for the production of metallic colloids result in colloids exhibiting increased signal enhancement and reproducibility for the SERS detection of biomolecules. Thus, using the methods o... | 10/07/2008 |
| 7430039 | Sensor Sensors are provided which enable detection with a high sensitivity in microchemistry and biochemical analysis by using devices integrated into a compact configuration and can be freely disposed on desired positions of a channel to perform detection. A measur... | 09/30/2008 |
| 7429479 | Inverted orientation for a microplate A method of conducting amplification comprising loading a liquid polynucleotide sample into a well of a microplate and covering the well of the microplate with a cover, such that the cover fluidly seals the liquid polynucleotide sample within the well. The method th... | 09/30/2008 |