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| Number | Title | Issue Date |
| 8110393 | Method and apparatus for separating and harvesting cells from a whole blood sample The present specification discloses an automated method and apparatus useful for separating and harvesting cells of interest, e.g., mononuclear cells, in a whole blood sample. The method of the invention uses the aspirating/dispensing probe of an automated sample pr... | 02/07/2012 |
| 8105819 | Plasmon fluorescence augmentation for chemical and biological testing apparatus The sensitivity and durability of fluorescent assays may be increased through structures and methods using plasmon fluorescence augmentation and sealing of the structure against degradation by reagents used in the assay. The resulting structures make practical extre... | 01/31/2012 |
| 8084246 | Method and apparatus for in vivo surveillance of circulating biological components The invention relates generally to in vivo collection of circulating molecules, tumor cells and other biological markers using a collecting probe. The probe is configured for placement within a living organism for an extended period of time to provide sufficient yie... | 12/27/2011 |
| 8080407 | Calibration procedures and devices for investigation biological systems Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems. ... | 12/20/2011 |
| 8071362 | Sterilization indicator The disclosed technology relates to a sterilization indicator and a process to concentrate signal generated by constraining it to a minimal surface, in a minimal volume and minimal pH and growth buffering or mediating influences. The sterilization indicator may comp... | 12/06/2011 |
| 8053225 | Flow cell array and the utilization thereof for multianalyte determination A one- or two-dimensional arrangement of flow cells is provided, as part of an array of sample compartments, with at least one inlet and outlet for each sample compartment, formed by a base plate and a body, with an arrangement of spatial recesses corresponding to t... | 11/08/2011 |
| 8039247 | Method of forming planar lipid double membrane for membrane protein analysis and apparatus therefor To provide a method of forming a planar lipid-bilayer membrane for membrane protein analysis, by which downsizing, simplifying, and multichanneling of a device therefore are achieved. A planar lipid-bilayer membrane 24 is formed by filling a microchannel 1... | 10/18/2011 |
| 8039248 | Modified flavin adenine dinucleotide dependent glucose dehydrogenase The invention provides a modified flavin adenine dinucleotide dependent glucose dehydrogenase (FADGDH), as well as a glucose sensor comprising the modified FADGDH and a method for measuring glucose comprising using the glucose sensor to measure glucose of a sample. | 10/18/2011 |
| 8034303 | Sample arraying/assembling device, its method, and apparatus using sample assembly The present invention relates to a sample arraying/assembling device, its method, and an apparatus using a sample assembly, and has an object of providing a sample arraying/assembling device which is adapted to various microplates of International Standards, and is ... | 10/11/2011 |
| 8034609 | Ablation based laser machining of biomolecule patterns on substrates A method for patterning a one or more biomolecules on a substrate that includes coating the substrate with a coating of the one or more biomolecules, applying a laser to the coating, and ablating a portion of the one or more biomolecules with the laser in a predeter... | 10/11/2011 |
| 8030059 | Apparatus for measuring extracellular potential A sensing element for measuring extracellular potential including a substrate, a well provided in a substrate, a guide section provided on the wall of the well, and a detective electrode formed at a lower surface of the substrate. The guide section is for guiding dr... | 10/04/2011 |
| 8017380 | Real-time PCR system A real-time PCR system for detecting gene expression levels includes plural reaction regions, a like plural number of heating portions arranged corresponding to the reaction regions and having heat sources, respectively, an optical unit capable of irradiating exciti... | 09/13/2011 |
| 8012742 | Buffy coat tube and float system and method A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells a... | 09/06/2011 |
| 8008065 | Disposable bioreactor vessel port A port for use with a bioreactor vessel comprising: i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vessel ii) a hollow, generally tubular bushin... | 08/30/2011 |
| 8008064 | Calibration procedure for investigating biological systems Use of calibrant in extraction phase is described for quantification of components of interest in samples in laboratory application as well as in on-site monitoring. This approach is particularly useful for in-vivo investigation of living systems. ... | 08/30/2011 |
| 8003373 | Optical detector for enzyme activation Activation of an enzyme in a bodily fluid is detected based on the amount of cleavage of a substrate for the enzyme. The substrate is tagged with two fluorescent dyes—a donor and an acceptor. The tagged substrate is presented to the bodily fluid. A device emits en... | 08/23/2011 |
| 7993906 | Closed-loop electrical stimulation system for cell cultures The present invention provides a sensitive system for measuring the physiological response of an in-vitro cell culture to an environmental parameter. An electrical property of the cell culture is measured as a control signal, and a parameter of a stimulus is adjuste... | 08/09/2011 |
| 7981662 | Analyzer A sample analyzer for analyzing a biological sample is disclosed that comprising: a measurement specimen preparation section for preparing a measurement specimen by using a reagent and the biological sample; a irradiator for irradiating the measurement specimen with... | 07/19/2011 |
| 7981663 | Group of reagent carriers that is combined to form a composite The invention concerns a group of reagent carriers that is combined to form a composite, each one of said carriers having at least one test region located in a shallow trough-like depression, where the reagent carriers in the composite are held together exclusively ... | 07/19/2011 |
| 7964388 | Chemical reaction device, chemical reaction system, and chemical reaction method A device is provided for a chemical reaction between molecules immobilized on a solid phase and molecules in a solution. A chemical analysis device is also provided to capture molecules in the solution and subsequently measure the captured molecules. Reaction effici... | 06/21/2011 |
| 7960168 | Biologically active substance transfer sheet, cell culture kit constituted of cell culture plate and biologically active substance transfer sheet, producing method thereof and method for screening cell culture conditions utilizing the same The invention provides a biologically active substance transfer sheet which can be formed with simple steps, a cell culture kit which comprises a cell culture plate and a biologically active substance transfer sheet, a producing method therefor, and a method for scr... | 06/14/2011 |
| 7951581 | Method and reagent system with non-regenerable enzyme-coenzyme complex The present invention is generally directed towards a reagent system for detecting an analyte in a sample. The reagent system has a detection reagent comprising an enzyme-coenzyme complex in a form such that no regeneration of the coenzyme takes place, whereby the e... | 05/31/2011 |
| 7951582 | Systems and methods for analyzing and manipulating biological samples A system for qualifying cells of a cell sample labeled with a magnetic or magnetizable moiety is provided. The system includes a cell sample holder for holding a cell of the cells and a first cell analyzer which includes a magnetic field source for applying a magnet... | 05/31/2011 |
| 7947490 | Recording assay device The invention herein described relates to an assessment device comprising an assay part and a detachable recording part. The assessment device facilitates the rapid assaying and processing of tissue/fluid samples by healthcare workers. Also, advantageously, the resu... | 05/24/2011 |
| 7935518 | Smart hydrogel particles for biomarker harvesting Capture particles for harvesting analytes from solution and methods for using them are described. The capture particles are made up of a polymeric matrix having pore size that allows for the analytes to enter the capture particles. The pore size of the capture parti... | 05/03/2011 |
| 7932080 | Double brilliance beta-arrestin: a biosensor for monitoring the activity of receptors and signalling molecules, and method of using same An intramolecular bioluminescence resonance energy transfer (BRET), biosensor for monitoring receptor activity and signalling cascades is disclosed. The “double-brilliance” biosensor sandwiches β-arrestin (β-arr) between Renilla luciferase (Luc) and the... | 04/26/2011 |
| 7927864 | Methods, kits, and compositions for detecting enzyme activity The inventive subject matter relates to methods, kits, and compositions for detecting enzyme activity in a biological sample. In particular, the inventive subject matter relates to methods, kits, and compositions for detecting von Willebrand factor degrading enzyme ... | 04/19/2011 |
| 7923239 | Guided mode resonant filter biosensor using a linear grating surface structure Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 04/12/2011 |
| 7915029 | Buffy coat tube and float system and method A tube and float system for use in separation and axial expansion of the buffy coat is provided. The system includes a transparent, or semi-transparent, flexible sample tube and a rigid separator float having a specific gravity intermediate that of red blood cells a... | 03/29/2011 |
| 7910352 | Method for assaying a target analyte while reducing interference in an immunosensor system An electrochemical immunosensor system with reduced interference, comprising: a first immunosensor that generates an electrochemical signal based on the formation of a sandwich between an immobilized antibody, a target analyte and a labeled antibody, wherein a porti... | 03/22/2011 |
| 7906317 | Apparatus for thin-layer cell smear preparation and in-situ hybridization The present invention discloses an apparatus for thin-layer cell smear preparation and in-situ hybridization, comprising at least one positioning device and a sealing device. The positioning device comprises at least one first opening. When the positioning device is... | 03/15/2011 |
| 7901931 | Cell for measuring biological activities and/or physiological parameters of micro-organisms Device for the measurement of biological activities and/or physiological magnitudes, includes a measuring cell, equipped with a chamber suitable to receive micro-organisms to be analyzed, and one or more probes opening into the chamber. The probes are connected to m... | 03/08/2011 |
| 7892815 | Device and method for conditioning biological cells A conditioning device (100) for biological cells includes a support (10), adapted to support at least one biological cell (1) in a supporting zone (11), and a contact device (20), adapted to support at least one conditioning sample... | 02/22/2011 |
| 7888106 | Microarrays and method for running hybridization reaction for multiple samples on a single microarray The present invention provides a microarray for multiple sample analysis that does not require an alignment of well walls with corresponding probe sets. Methods for building and using such a microarray are also within the scope of the present invention. ... | 02/15/2011 |
| 7875447 | Cell incubator for single cell operation supporting robot To provide an inexpensive cell incubator for a single cell operation supporting robot having the markers (first and second feature points) required to transform the position of a cell detected on a table coordinate system into a position on the intrinsic coordinate ... | 01/25/2011 |
| 7867753 | Method and device for the characterization of interactions between different species A device detects interactions between species in liquid and species on a solid support. It includes a solid support (11), a mechanism (16) for temporarily reducing the amount of a liquid to which the support is exposed, a detector (12) capable o... | 01/11/2011 |
| 7867754 | Microarrays for analyte detection Method and device for detection of analytes, particularly biohazards. A microarray containing immobilized sensing molecules captures complementary analytes on a redundant patterned substrate. Pattern analysis is performed using a computer algorithm. ... | 01/11/2011 |
| 7863035 | Fluidics devices The invention relates to fluidics as used in medical and diagnostic equipment and relates further to means for purifying, abstracting, filtering, detecting and/or measuring analytes in liquid samples. ... | 01/04/2011 |
| 7851201 | Method and device for measuring multiple physiological properties of cells A method of analyzing cells disposed in media within a vessel includes the steps of providing a vessel having an original volume of media about the cells, reducing the original volume of media about at least a portion of the cells to define a reduced volume of media... | 12/14/2010 |
| 7838284 | Measurement of concentrations and binding energetics Free-standing microfluidic channels are used to both transport and analyze molecules of interest. In a biochemical context, such molecules may be polypeptides, nucleic acids, or other biomolecules. The free-standing channels provide a real-time readout of concentrat... | 11/23/2010 |
