Class 435/285.3 - Including projectile means

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Apparatus wherein a projectile means is utilized to incorporate
No. of patents: 29
Last issue date: 05/03/2011

Number	Title	Issue Date
7935517	Nanospearing for molecular transportation into cells A nanostructured molecular delivery vehicle comprising magnetic materials and configured to receive passenger biomolecules. The application of a an appropriate magnetic field having a gradient orients and drives the vehicle into a biological target, which may compri...	05/03/2011
7332339	Transferring materials into cells using porous silicon Porous and/or polycrystalline silicon are used in the delivery of substances into cells. The porous and/or polycrystalline silicon can be formed into micropiercers, microneedles and biolistic bullets for penetration of the cell. The control of the pore size and poro...	02/19/2008
7279322	Electrospraying apparatus and method for coating particles An electrospraying apparatus and/or method is used to coat particles. For example, a flow including at least one liquid suspension may be provided through at least one opening at a spray dispenser end. The flow includes at least particles and a coating material. A s...	10/09/2007
7132242	Method and device for targeted delivery of materials to selected single cells A method and device for delivering a quantity of at least one material to a selected single cell in a manner that permits impingement of material with the cell. The material travels at a suitable trajectory and velocity and is ejected from an electronically controll...	11/07/2006
7025120	Rapid thermal cycling device A lid for a well plate is provided. Pins penetrate the lid and project downwardly into the wells of the well plate. Thermal energy is applied to the upper end of the pin to regulate the temperature of liquid samples in the well plate. Ultrasonic energy is applied to...	04/11/2006
6929950	Microprojectile delivery system and particulate product The invention relates to a particulate product comprising at least one microprojectile; characterized in that the or at least one of the microprojectiles comprises silicon. The invention also relates to devices and components used in the microprojectile implantation...	08/16/2005
6770480	Transferring materials into cells using porous silicon The present invention relates to the use of porous silicon in the delivery of substances into cells. The porous silicon can be formed into micropiercers, microneedles and biolistic bullets for peenetration of the cell. The control of the pore size and porosity of th...	08/03/2004
6767743	Method and an apparatus for generating shockwave, a method and an apparatus for accelerating particles, an apparatus for delivering drugs, and a method and an apparatus for delivering DNA Method and apparatus for accelerating micro particles for use in delivering DNA or a solid drug in which a shockwave is generated by applying a short pulse energy to a surface of a metal foil to be absorbed and cause vaporization and plasmatization of the metal foil...	07/27/2004
6617153	Portable magneto-mechanical delivery device and method for delivery of reactive substances A method of delivery of reactive substances that are attached to magnetizable needle-like particles using a magneto-mechanical delivery device. The subject method and device can be utilized for the delivery of reactive or other substances, such as DNA via...	09/09/2003
6436709	Low pressure-accelerated particle gene gun A gene gun is described wherein the contour design of the spray nozzle of the gene gun modifies the operation of the gene gun. A low pressure gas is used to accelerate the micro-particles that are coated with nucleic acid of a foreign gene into cytoplasma...	08/20/2002
6399362	Electrospraying apparatus and method for introducing material into cells A method of introducing biological material into cells includes providing one or more target cells and establishing a spray of substantially dispersed particles including biological material. The substantially dispersed particles have an electrical charge...	06/04/2002
6361991	Targeting gene expression to living tissue using jet injection The present invention provides a method of targeting transient gene expression and stable gene expression from the exogenous administration of a DNA sequence, which sequence is less than a complete genome, wherein said DNA sequence encodes RNA and protein...	03/26/2002
6287850	Bioarray chip reaction apparatus and its manufacture Agitation systems for reversibly directing fluid samples flow back and forth across a nucleic acid array, thereby promoting hybridization between targets in the fluid sample and probes on the nucleic acid array....	09/11/2001
6232113	Particle bombardment device An improved particle bombardment device for transporting biological substances such as DNA into living cells. The device has a flexible barrel (40) that facilitates endoscopic particle bombardment of in vivo cells without a significant concomitant blast e...	05/15/2001
6221666	Method and apparatus for cytoplasmic loading using an impact-mediated procedure The present invention is directed to the method and apparatus for the cytoplasmic loading of macromolecules into living cells by an impact-mediated procedure that impacts the cells with a predetermined number of solid particles in a blast of propellant ga...	04/24/2001
6013863	Fertile transgenic corn plants A process of preparing fertile Zea mays plants is provided wherein said plants are resistant to the herbicide glyphosate, as well as processes for preparing seed, human food or animal feed therefrom....	01/11/2000
5853663	Pressure distributor and multi-macrocarrier assembly for ballistic transfer transfection apparatus The ballistic transfer transfection technology employs a cold gas shock wave to accelerate microprojectiles that carry matter into cells by mechanical force. The present invention relates to a device that splits the cold gas shock wave into several indivi...	12/29/1998
5753496	Apparatus for introducing biological substances or biologically active substances An apparatus for injecting biological substances or biologically active substances into biological materials without contaminating or damaging the biological materials, which includes a sealed cylinder at one end of which is connected a source of compress...	05/19/1998
5525510	Coanda effect gene delivery instrument An apparatus is disclosed for the genetic transformation of organisms by accelerated particle mediated transformation. Foreign genes are introduced into cells by coating on carrier particles which are physically accelerated into the cells by positioning t...	06/11/1996
5506125	Gene delivery instrument with replaceable cartridges An apparatus for acceleration of carrier particles into a target organism which may be used for rapid, sequential particle acceleration procedures comprises a holder for removable mounting cartridges. A first removable mounting cartridge detachably holds ...	04/09/1996
5478744	Method for transporting substances into living cells and tissues and apparatus therefor Inert or biologically active particles are propelled at cell at a speed whereby the particles penetrate the surface of the cells and become incorporated into the interior of the cells. The process can be used to mark cells or tissue or to biochemically af...	12/26/1995
5405779	Apparatus for genetic transformation An apparatus for the particle mediated genetic transformation of organisms in vivo has two parts, a support unit and a hand unit. The hand unit is of a convenient hand manipulable size so that it can be placed readily against the organism the cells of whi...	04/11/1995
5371015	Apparatus for transporting substances into living cells and tissues Inert or biologically active particles are propelled at cell at a speed whereby the particles penetrate the surface of the cells and become incorporated into the interior of the cells. The process can be used to mark cells or tissue or to biochemically af...	12/06/1994
5240855	Particle gun An improved particle gun for transporting biological substances such as nucleic acid into the cytoplasm of living cells. The gun has a barrel which is rifled to allow effective sealing on an acetal plastic macroprojectile within the barrel such that there...	08/31/1993
5204253	Method and apparatus for introducing biological substances into living cells A process is described which uses a "cold" gas shock to accelerate microprojectiles wherein particles are presented to the gas shock on a planar surface perpendicular to the plane of expansion of the gas shock wave. Several different apparatus capable of ...	04/20/1993
5179022	Biolistic apparatus for delivering substances into cells and tissues in a non-lethal manner An apparatus for delivering substances into living cells and tissues includes an impeller of the type adapted to use an explosive charge for sending a macroprojectile through an accelerator passage into a vacuum chamber. The vacuum chamber is divided into...	01/12/1993
5149655	Apparatus for genetic transformation An apparatus for the particle mediated genetic transformation of organisms in vivo has two parts, a support unit and a hand unit. The hand unit is of a convenient hand manipulable size so that it can be placed readily against the organism the cells of whi...	09/22/1992
5120657	Apparatus for genetic transformation An apparatus is disclosed for the genetic transformation of organisms by accelerated particle mediated transformation. Foreign genes are introduced into cells by coating on carrier particles which are physically accelerated into the cells by positioning t...	06/09/1992
5066587	Gas driven microprojectile accelerator and method of use A foreign substance, such as DNA, is injected into plant cells or tissue by a biological ballistical insertion technique. High pressure propellant gas is employed to accelerate the macroprojectile containing microprojectiles coated with the foreign substa...	11/19/1991

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Class 435/285.3 - Including projectile means