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| Number | Title | Issue Date |
| 8105817 | Methods and systems for toxin delivery to the nasal cavity Methods and systems for delivering toxin and toxin fragments to a patient's nasal cavity provide for both release of the toxin and delivery of energy which selectively porates target cells to enhance uptake of the toxin. The use of energy-mediated delivery is partic... | 01/31/2012 |
| 8093039 | Surfaces differentially adhesive to eukaryotic cells and non-eukaryotic cells A surface coating comprises a primer coat that permits adhesion of eukaryotic cells thereto, and a plurality of macromolecular structures attached to the primer coat. At least some of the macromolecular structures have a cell-resistant character, meaning that cells ... | 01/10/2012 |
| 8093038 | Apparatus and method for encapsulating pancreatic cells An apparatus and method for coating micron-sized or sub-micron-sized particles such as living cells. The coating apparatus includes an encapsulation chamber enclosing a two-layer water-oil system for coating each islet cell with an aqueous polymeric coat. Islets tog... | 01/10/2012 |
| 8084245 | Apparatus and method for polymer synthesis using arrays A polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base assembly (25) hav... | 12/27/2011 |
| 8080405 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 12/20/2011 |
| 8071359 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 12/06/2011 |
| 8071361 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 12/06/2011 |
| 8071360 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 12/06/2011 |
| 8062881 | Method for making a polymer blend for reducing protein binding to surfaces Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2 are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying... | 11/22/2011 |
| 8058054 | Systems and methods for real-time PCR In one aspect, the present invention provides a systems and methods for the real-time amplification and analysis of a sample of DNA. ... | 11/15/2011 |
| 8039245 | Method and devices for improved disinfection process A method which enhances a disinfection process by using a catalyst which increases in effective surface area during the process. Also disclosed are contact lens disinfecting systems which are designed to maintain a high concentration of hydrogen peroxide solution fo... | 10/18/2011 |
| 8030056 | Substrate patterning using a digital optical chemistry micromirror imager An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redir... | 10/04/2011 |
| 8017379 | Nucleic acid purification instrument According to this invention, a nucleic acid purification instrument whereby it is possible to prevent dispersion of a mist thai causes contamination upon discharge of a solution is realized. A pressurizing nozzle is allowed to come into contact with a nucleic acid c... | 09/13/2011 |
| 8003370 | Thermal cycling apparatus This invention provides an apparatus for providing heating and cooling of samples in sample vessels having uniform temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity. The system employs a ... | 08/23/2011 |
| 7993905 | Device containing cytophilic islands that adhere cells separated by cytophobic regions The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells... | 08/09/2011 |
| 7964386 | Process of immobilizing biomolecules in porous supports by using an electronic beam A process of immobilizing biomolecules on a support of porous silicon locally activated by using an electronic beam, activated supports of porous silicon produced in this way, and their use for sensorics applications in biological, medical fields. ... | 06/21/2011 |
| 7951580 | Automated, programmable, high throughput, multiplexed assay system for cellular and biological assays Systems and methods are providing for performing high-throughput, programmable, multiplexed assays of biological, chemical or biochemical systems. Preferably, a micro-pallet includes a small flat surface designed for single adherent cells to plate, a cell plating re... | 05/31/2011 |
| 7947486 | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics A method for analyzing nucleic acid obtained from a cell sample on a platform is described. A platform having a cell selector, a nucleic acid selector, and an array of microlocations, wherein at least one microlocation has an associated capture sequence, is provided... | 05/24/2011 |
| 7947487 | Multifunctional encoded particles for high-throughput analysis Method for making multifunctional particles. The method includes flowing a first monomer stream loaded with a fluorescent entity along a microfluidic channel and flowing a second monomer stream loaded with a probe adjacent to the first monomer stream along the micro... | 05/24/2011 |
| 7947485 | Method and apparatus for molecular analysis using nanoelectronic circuits Devices and methods for detecting the constituent parts of biological polymers are disclosed. A molecular analysis device comprises a molecule sensor and a molecule guide. The molecule sensor comprises a single electron transistor including a first terminal, a secon... | 05/24/2011 |
| 7939310 | Systems and methods for analyzing nucleic acid sequences The invention relates to systems and methods for analyzing clinically relevant nucleic acid sequences. ... | 05/10/2011 |
| 7923237 | Method and apparatus for combined electrochemical synthesis and detection of analytes Described are devices and methods for detecting binding on an electrode surface. In addition, devices and methods for electrochemically synthesizing polymers and devices and methods for synthesizing and detecting binding to the polymer on a common integrated device ... | 04/12/2011 |
| 7906316 | Apparatus for detecting molecules A molecular sensor includes a membrane layer having parallel pores extending through the membrane layer and incorporating therein probe molecules that bind with corresponding target molecules when present in the pores, electrodes, and an ionic solution in contact wi... | 03/15/2011 |
| 7871811 | Method for eliminating crosstalk between waveguide grating-based biosensors located in a microplate and the resulting microplate The present invention includes several methods for modifying the current processes of manufacturing optical sensing microplates that use continuous waveguide films to reduce/eliminate crosstalk between the biosensors that are incorporated within wells. The methods i... | 01/18/2011 |
| 7871810 | Multiaxis focusing mechanism for microarray analysis Systems and methods for positioning a multi-featured biological array relative to a signal acquisition device. Detection of the array's positional deviation may be achieved by a calibration beam reflected from the array surface and detected by a position sensitive d... | 01/18/2011 |
| 7867751 | Plasmid DNA isolation The invention provides apparatus, reagents, and methods for rapidly isolating plasmid DNA from a bacterial alkaline lysate. ... | 01/11/2011 |
| 7858363 | Plasmid DNA isolation Apparatus, reagents, and methods for isolating plasmid DNA from bacteria by alkaline lysis using a solid or immobilized P2 and/or P3 reagent in combination with a DNA-binding matrix. ... | 12/28/2010 |
| 7858364 | Apparatus and method for polymer synthesis using arrays The invention concerns a polymer synthesis apparatus (20) for building a polymer chain including a head assembly (21) having an array of nozzles (22) with each nozzle coupled to a reservoir (23) of liquid reagent (24), and a base a... | 12/28/2010 |
| 7846713 | Calibrating microarrays An assay for measuring the amount of a first analyte in a sample, comprises the steps of: (i) contacting the sample with a device that comprises one or more first reaction sites which comprise a first ligand having affinity for the first analyte, and a series of sec... | 12/07/2010 |
| 7846715 | Sample chamber volume reducer An apparatus includes a chamber insert capable of being received by a sample chamber of a conditioning system. The received chamber insert reduces the volume of the sample chamber and defines a cavity that substantially surrounds a sample holder located in the sampl... | 12/07/2010 |
| 7846714 | Synthesis of chemical tags A method for forming a biological chemical tag. At least one double stranded DNA molecule is provided. At least a portion of the at least one double stranded DNA molecule is denatured. At least one chemical moiety that prohibits recrystallization of the at least one... | 12/07/2010 |
| 7838280 | Device for squeezing of biological mass of cultures A device for wringing a biological mass of cultures has a substantially vertical container having a bottom provided with a discharge opening, a rotor means located under the discharge opening and including at least two rotors which are rotatable toward one another t... | 11/23/2010 |
| 7799553 | Microfabricated integrated DNA analysis system Methods and apparatus for genome analysis are provided. A microfabricated structure including a microfluidic distribution channel is configured to distribute microreactor elements having copies of a sequencing template into a plurality of microfabricated thermal cyc... | 09/21/2010 |
| 7799554 | Lateral flow devices An analytical test for an analyte comprises (a) a base, having a reaction area and a visualization area, (b) a capture species, on the base in the visualization area, comprising nucleic acid, and (c) analysis chemistry reagents, on the base in the reaction area. The... | 09/21/2010 |
| 7785863 | Digital optical chemistry micromirror imager An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redir... | 08/31/2010 |
| 7785862 | Thin film coated microwell arrays The invention relates to a thin film coated array and the process of fabricating and using the array including methods of etching, depositing a thin film coating, preparing and using the thin film coated array. ... | 08/31/2010 |
| 7759112 | Apparatus, system, and method for purifying nucleic acids Methods and devices for isolating nucleic acids from a mixture containing such nucleic acids and extraneous matter are provided. In one embodiment, the method of the invention comprises passing the mixture through a glass frit under conditions effective to separate ... | 07/20/2010 |
| 7759111 | Cell encapsulation microfluidic device Devices and methods for the encapsulation of cells on microfluidic platforms are disclosed. The microfluidic device generally includes a plurality of functional regions to shear, focus, and encapsulate a desired cell or group of cells into a droplet. The microfluidi... | 07/20/2010 |
| 7754472 | Device and method for detecting analytes by visualization and separation of agglutination The invention relates to a device for detecting one or several analytes in a sample, characterized in that it comprises one or more reaction chambers and/or one or more reagent application channels, and one or more capillary systems and one or more negative vessels.... | 07/13/2010 |
| 7745203 | Base sequence detection apparatus and base sequence automatic analyzing apparatus A base sequence detection apparatus is provided with a channel formed on a base sequence detection chip. Working electrodes are formed along the channel and include a probe immobilized thereon, counter electrodes are formed on the inner surface of the channel and, r... | 06/29/2010 |
