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| Number | Title | Issue Date |
| 8440403 | Apparatus and method An apparatus for investigating a molecule comprising a channel provided in a substrate, a metallic moiety capable of plasmon resonance which is associated with the channel in a position suitable for the electromagnetic field produced by the metallic moiety to intera... | 05/14/2013 |
| 8431337 | Apparatus for detecting nucleic acids using bead and nanopore There are provided a method and apparatus for detecting nucleic acid using bead and nanopore, and more specifically, a method and apparatus capable of detecting nucleic acid fragments of 70 bps to 300 bps in length by a nanopore detection unit with nanopores of 20 t... | 04/30/2013 |
| 8431339 | Integrated microfluidic component for purifying analyte molecules and purification method The present invention relates to a method for purifying analyte molecules and in particular to a component of this type in which a separation section is used for separating analyte molecules and other constituents of a sample, and in which provision is made of at le... | 04/30/2013 |
| 8431384 | Stable protein storage and stable nucleic acid storage in recoverable form The invention provides compositions and methods for storage of biomolecules. The biomolecules are stored via absorption to a substrate. Absorbed biomolecules can be eluted or recovered from the substrate at a future time, and optionally be subjected to a subsequent ... | 04/30/2013 |
| 8420379 | Material for capturing microbes, device for capturing microbes, method of capturing microbes, and method of producing material for capturing microbes The invention relates to a material for capturing microbes or the like, a device for capturing microbes or the like, a method of capturing microbes or the like, and a method of producing a material for capturing microbes or the like, and has an object of using a pul... | 04/16/2013 |
| 8420313 | Multiplexed electrochemical detection system and method Multiplexed analysis of molecular structures of samples. A plurality of sample wells is arranged on a substrate. A plurality of electrodes is fabricated on a first side of the substrate. The electrodes are disposed on the side of the substrate exposed to the sample ... | 04/16/2013 |
| 8415139 | Method for packaging cells in culture in a low-pressure environment, and corresponding device Method for packaging cells in culture in a low-pressure environment, and corresponding device. The invention relates to a method for packaging live cells in culture for the purpose of transporting them, wherein said cells are in a culture medium contained in at leas... | 04/09/2013 |
| 8415101 | Digital optical chemistry micromirror imager An apparatus and method for catalyzing a reaction on a substrate (24) comprising, a light source (12), a micromirror (16) positioned to redirect light (14) from the light source (12) toward a substrate (24) wherein the redir... | 04/09/2013 |
| 8415138 | Apparatuses and methods for oligonucleotide preparation Provided are improved processes and apparatuses for solid phase oligonucleotide synthesis, the improvements comprising carrying out detritylation of the nascent oligonucleotide using a composition of an organic solvent, a protic solvent and a selected concentration,... | 04/09/2013 |
| 8404440 | Device for carrying out cell lysis and nucleic acid extraction The present invention provides an integrated lab-on-a-chip device for carrying out a nucleic acid extraction process on a fluid sample containing cells and/or particles, the device comprising: (a) a sample inlet (1) for loading of a fluid sample, (b) a lysis ... | 03/26/2013 |
| 8394625 | Lab-on-a-pipette This invention generally relates to an integrated ‘lab-on-a-Pipette’™ which will provide sample-to-answer single cell genetic diagnosis for preimplantation genetic diagnosis (PGD) and other forms of single cell analysis (SCA). SCA is a quickly growing field wi... | 03/12/2013 |
| 8389212 | Method for the electronic analysis of a sample oligonucleotide sequence A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antig... | 03/05/2013 |
| 8383393 | Titer plate, reading device therefor and method for detecting an analyte, and use thereof A titer plate and a method for detecting an analyte, and the use thereof are disclosed. According to at least one embodiment of the invention, it is proposed that a plurality of depressions and a biochip of the titer plate sposed adjacent thereto be surrounded by a ... | 02/26/2013 |
| 8383342 | Compositions, products, methods and systems to monitor water and other ecosystems Disclosed are compositions, products, methods and systems for monitoring ecosystems, such as bodies of water, for a parameter of the ecosystems, such as the presence or absence of mercury. In one embodiment, the product may include a plurality of oligonucleotides im... | 02/26/2013 |
| 8367397 | Active biochip for nucleic acid analysis Embodiments of the invention relate to an active biochip for nucleic acid analysis. The biochip comprises an inlet for introducing a nucleic acid sample, fluid channels, valves in contact with the fluid channels and pumps in contact with the fluid channels and adapt... | 02/05/2013 |
| 8361717 | Magnetic particles for nucleic acid sequencing and method of sequencing nucleic acid using the same Provided are magnetic particles for nucleic acid sequencing and a method of sequencing nucleic acid using the same. The nucleotide sequence of a target nucleic acid may be efficiently determined using the magnetic particles and the method of sequencing nucleic acid ... | 01/29/2013 |
| 8361720 | Real time cleavage assay A cleavage-based real-time PCR assay method is provided. In general terms, the assay method includes subjecting a reaction mixture comprising a) PCR reagents for amplifying a nucleic acid target, and b) flap cleavage reagents for performing a flap cleavage assay on ... | 01/29/2013 |
| 8361781 | Cell aggregation and encapsulation device and method The invention is a cell aggregation device comprising a hydrogel substrate having at least one, preferably a plurality, of cell-repellant compartments recessed into the uppermost surface. Each compartment is composed of an upper cell suspension seeding chamber havin... | 01/29/2013 |
| 8343754 | Annealing curve analysis in PCR The present invention is directed to devices for performing PCR and monitoring the reaction of a sample comprising a nucleic acid and a fluorescent dye. Illustrative devices comprise a heat exchange component for heating and cooling the sample, a control device for ... | 01/01/2013 |
| 8338164 | Systems and methods for delivery of a therapeutic agent Methods and apparatus are provided for applying an fragment of a neurotoxin such as the active light chain (LC) of the botulinum toxin (BoNT), such as one of the serotype A, B, C, D, E, F or G botulinum toxins, via permeabilization of targeted cell membranes to enab... | 12/25/2012 |
| 8329401 | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest The invention is directed to enhanced methods for detecting an analyte of interest in situ, by immunoassay, or by hybridization comprising binding an enzyme-labeled conjugate molecule to an analyte of interest in the presence of a redox-inactive reductive species an... | 12/11/2012 |
| 8323953 | Detection device for detecting biological microparticles such as bacteria, viruses, spores, pollen or biological toxins, and detection method A device for the detection of micro particles that can be marked by probes or antibodies capable of being detected by radiation has a filter, a supply system, and a detection system. Fluid to be examined is passed over a filter to filter out the micro particles and ... | 12/04/2012 |
| 8313940 | Self-addressable self-assembling microelectronic systems and devices for molecular biological analysis and diagnostics A self-addressable, self-assembling microelectronic device is designed and fabricated to actively carry out and control multi-step and multiplex molecular biological reactions in microscopic formats. These reactions include nucleic acid hybridization, antibody/antig... | 11/20/2012 |
| 8313906 | Methods and systems for microfluidic DNA sample preparation The present invention relates to methods and systems for microfluidic DNA sample preparation. More specifically, embodiments of the present invention relate to methods and systems for the isolation of DNA from patient samples on a microfluidic device and use of the ... | 11/20/2012 |
| 8304186 | Reactor for performing biochemical processes A reactor (1) for performing biochemical processes, particularly for extraction, purification, enrichment, sedimentation, comprising a container which is provided with at least one mouth (2) which is associated with closure means (3) of the remo... | 11/06/2012 |
| 8304185 | Methods and systems for DNA isolation on a microfluidic device The present invention relates to methods and systems for the isolation of DNA on a microfluidic device and the subsequent analysis of the DNA on the microfluidic device. More specifically, embodiments of the present invention relate to methods and systems for the is... | 11/06/2012 |
| 8298763 | Automated high-throughput flow-through real-time diagnostic system An automated real-time flow-through system capable of processing multiple samples in an asynchronous, simultaneous, and parallel fashion for nucleic acid extraction and purification, followed by assay assembly, genetic amplification, multiplex detection, analysis, a... | 10/30/2012 |
| 8293519 | Microarray devices having controllable reaction volume This invention relates generally to the field of microarray chips and uses thereof. In particular, the invention provides a microarray reaction device that can be used in assaying the interaction between various moieties, e.g., nucleic acids, immunoreactions involvi... | 10/23/2012 |
| 8288152 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 10/16/2012 |
| 8288151 | Biochemical reaction cassette A biochemical reaction cassette is designed to uniformize the flow of liquid in the reaction chamber by using a simple additional arrangement. A member for reducing the cross sectional area of the flow channel that includes an injection port, a reaction chamber and ... | 10/16/2012 |
| 8288153 | Semiconductor nanocrystal probes for biological applications and process for making and using such probes A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a s... | 10/16/2012 |
| 8273532 | Capture, recapture, and trapping of molecules with a nanopore In a molecular analysis system, there is provided a structure including a nanopore and first and second fluidic reservoirs. The two reservoirs are fluidically connected via the nanopore. A detector is connected to detect molecular species translocation of the nanopo... | 09/25/2012 |
| 8268552 | Biomolecule detector and detection method using the same Disclosed is a biomolecule detector and a detection method using the same. The biomolecule detector includes a biomolecule chip having a substrate and a slit formed therein. Biomolecules are immobilized on at least a portion of the edges of the slit. A light source ... | 09/18/2012 |
| 8268611 | Microtiter plate and use thereof The invention relates to a microtiter plate and use thereof for conducting fermentation under fed-batch conditions. In order to produce a microtiter plate which permits screening under fed-batch conditions, the invention proposes that the cavities (2) of the ... | 09/18/2012 |
| 8263387 | Sheath flow devices and methods The invention relates generally to fluid processing and, in particular aspects, processing fluids for detection, selection, trapping and/or sorting of particulate moieties. Sheath flow devices described allow isolation of target species from fluid samples while avoi... | 09/11/2012 |
| 8263331 | Device and method for the detection of an analyte A device and a method are disclosed for the detection and/or for the quantification of an analyte. In at least one embodiment, the device includes a basic matrix and magnetized nanoparticles, which are arranged in moveable fashion in or at the basic matrix and to wh... | 09/11/2012 |
| 8263336 | Methods and apparatus for measuring analytes Methods and apparatus relating to FET arrays including large FET arrays for monitoring chemical and/or biological reactions such as nucleic acid sequencing-by-synthesis reactions. Some methods provided herein relate to improving signal (and also signal to noise rati... | 09/11/2012 |
| 8263386 | Digital bio disc (DBD), DBD driver apparatus, and assay method using the same An aspect of embodiment relates to a digital bio disc (DBD) including new valve control means and fluid movement system, a digital bio disc (DBD) driver apparatus, and an assay method using the same. More particularly, an aspect of embodiment relates to a DBD with a... | 09/11/2012 |
| 8263388 | Method and apparatus for detecting specific DNA sequences An apparatus for detecting the presence of a microorganism in a sample includes a housing that includes a base fixed with a first DNA primer having a nucleotide sequence that is complementary to a DNA sequence of the microorganism of interest, a fibrinogen-splitting... | 09/11/2012 |
| 8257961 | Oxygen-assisted fermentation process A fermentation process uses substantially pure oxygen. The oxygen is the only reactive gas which is injected into a fermentation vessel. The oxygen is moved through the vessel solely by its own pressure. The process can be used with both mechanically-agitated and ai... | 09/04/2012 |
