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| Number | Title | Issue Date |
| 8158406 | Method for the enantioselective enzymatic reduction of keto compounds using R-specific oxidoreductase The present invention relates to a process for the enantioselective enzymatic reduction of keto compounds, in particular of 4-halo-3-oxobutyric acid esters, to the corresponding R-alcohols or S-4-halo-3-hydroxybutyric acid esters, respectively, using an R-specific o... | 04/17/2012 |
| 8153416 | Process for manufacture of optically active 2-(acyloxymethyl)-1,3-oxathiolanes using enzymatic resolution There is provided a process for manufacture of optically-active, 2-(acyloxymethyl)-1,3-oxathiolanes of Formula I comprising a preparation of a racemic compound and an enzyme-catalyzed kinetic resolution of the enantiomers. The invention may further provide for the e... | 04/10/2012 |
| 8143052 | Process for preparing optically active (S or R)-α amino acid and (R or S)-α amino acid ester in one phase organic reaction medium The present invention discloses a process for preparing an optically active (S or R)-α-amino acid represented by the formula (II): wherein R represents an alkyl group, alkenyl group, alkynyl group,... | 03/27/2012 |
| 8133717 | Stereoinversion of amino acids in a single reactor A process is described to prepare a single enantiomer of an amino acid from its opposite enantiomer or from a racemic mixture, using an oxidase biocatalyst and a supported metal catalyst in separate, sequential reactions in water. The process can be operated in batc... | 03/13/2012 |
| 8129173 | Selective enzymatic esterification and solvolysis of epimeric vitamin D analog and separation of the epimers Provided is a method of selectively enzymatically esterifying or selectively enzymatically solvolyzing epimers of analogs of vitamin D having a stereogenic center at C-24 that has a free or esterified OH group. The metod can be used, for example, for separating mixe... | 03/06/2012 |
| 8017378 | Method for production of optically active biphenylalanine compound or salt or ester thereof Disclosed is a method for production of an optically active biphenylalanine compound represented by the formula (2): (wherein, R2 is a protective group of an amino group, and R3 and R4 are e... | 09/13/2011 |
| 8008062 | Production of (R)- and (S)-4-(1-aminoethyl) benzoic acid methyl ester sulfate by lipase acylation of racemic 4-(1-aminoethyl) benzoic acid methyl ester and sulfuric acid precipitation A method for preparing optically active methyl 4-(1-ammoniumethyl)benzoate sulfate by reacting racemic methyl 4-(1-aminoethyl)benzoate with an acylating agent in the presence of a lipase to give methyl 4-(1-aminoethyl)benzoate and subsequently precipitating methyl 4... | 08/30/2011 |
| 7993904 | Process for the preparation of optically active 5-substituted 2-oxazolidinones from racemic epoxides and cyanate employing a halohydrin dehalogenase A process for the production of an optically enriched oxazolidinone of the formula (2a) or (2b), by reacting an epoxide of the formula (1) with cyanate in the presence of halo-hydrin dehalogenase. ... | 08/09/2011 |
| 7972836 | Method of enzymatic optical resolution of racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of: treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formul... | 07/05/2011 |
| 7968328 | Method for producing optically active aminoalkylphenols The invention relates to a method for the enantioselective N-acylation of aminoalkylphenols, and to a method for producing enantiomer-pure compounds of formulae (I-S) and/or (I-R). ... | 06/28/2011 |
| 7955835 | Stereoselective process for the production of dioxolane nucleoside analogues The present invention relates to a process for producing compounds of formula (I) and (VII); said process comprising the steps of: a) subjecting a compound of formula (II) to an enzymatic diastereomeric resolution in the presence of a suitable amount of enzyme chose... | 06/07/2011 |
| 7888105 | Enzymatic process for stereo-selective preparation of chemical compounds in hydrofluorocarbon solvents A process for preparing a second compound stereo-selectively is described. The process comprises reacting a substrate comprising at least one first compound with a reagent in the presence of a biological catalyst and a solvent comprising at least one (hydro)fluoroca... | 02/15/2011 |
| 7829324 | Method for the microbiological isomerisation of alpha-hydroxy carboxylic acids The present invention relates to a method for the microbiological isomerization of alpha-hydroxycarboxylic acids using an alpha-hydroxycarboxylic acid racemase, the enzymes used for this method and microorganisms which express a suitable racemase activity, a screeni... | 11/09/2010 |
| 7824899 | Preparation of enantiomerically enriched amines and amides by enzymatic resolution using a sulfonylacetic acid ester as acyl donor A process for the preparation of an enantiomerically enriched amine, is performed by a) cleaving a racemic mixture of a reaction product of i) a chiral amine and ii) an acyl donor, in the presence of a hydrolase, to obtain a mixture of an enantiomerically enriched a... | 11/02/2010 |
| 7816119 | Chemoenzymatic process for the stereoselective preparation of (R)-γ-amino-β-hydroxybutyric acid or (R)-carnitine from 3,4-dihydroxybutanenitrile The present invention provides a chemoenzymatic process for the preparation of (R)-GABOB and (R)-carnitine employing lipase-mediated resolution of 3-hydroxy-4-tosyloxybutanenitrile as the key step. The drawing accompanying this specification represents the preparati... | 10/19/2010 |
| 7803606 | Method for the production of flavor-active terpenes Disclosed is a method for producing flavor-active terpenes from terpene hydrocarbons. According to said method, a lyophilized mycel which is first rehydrated and is then mixed with the substrate is used preferably in a submerged culture in the framework of selective... | 09/28/2010 |
| 7795004 | Process for the racemization of optically active secondary alcohols with the use of two alcohol dehydrogenases A method for racemizing optically active secondary alcohols by incubating these alcohols with at least one alcohol dehydrogenase of the E.C. 1.1.1. class. ... | 09/14/2010 |
| 7790436 | Method for production of (1S)-3-chloro-1-(2-thienyl)-propan-1-ol using alcohol dehydrogenase from thermoanaerobacter A process for preparing optically active (1S)-3-chloro-1-(2-thienyl)propan-1-ol of the formula I by, in a medium comprising 3-chloro-1-(2-thienyl)propan-1-one of the formula II re... | 09/07/2010 |
| 7776582 | Optically enhanced chiral ionic liquids The invention relates to the use of optically enhanced chiral ionic liquids, particularly for gas chromatography and as a reaction solvent. Specific optically enhanced chiral cationic liquids are described as is a class of optically enhanced chiral anionic liquids. | 08/17/2010 |
| 7759110 | Process for the production of ()-5-chloro-2-isopropylpent-4-enoic acid esters A process for preparing a compound of formula (1) in enantiomerically enriched form, which comprises selective hydrolysis of the corresponding racemic compound (2) catalysed by an enzyme derived from a non-mammalian source and having esterase or lipase activity, whe... | 07/20/2010 |
| 7674614 | Method of optically resolving racemic alcohols with a bicyclooxaoctane or a bicycooxaoctene resolving reagents An optical resolving reagent comprising at least one of compounds represented by the following formulae (1) and (2) (1) (2) (wherein R1 to R8 each represents hydrogen or C1-20 alkyl; R9 represents optionally substituted C | 03/09/2010 |
| 7666658 | Antibody catalysis of enantio- and diastereo-selective aldol reactions Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol reaction. Ch... | 02/23/2010 |
| 7666659 | Process for producing optically active 3-hydroxypropionic ester derivative The present invention is to provide a process for simply producing an optically active 3-hydroxypropionic ester derivative useful as a medicament intermediate from an inexpensive material. More specifically, the present invention is directed to a process for produci... | 02/23/2010 |
| 7662610 | Synthesis of intermediates for the preparation of pramipexol A process for the preparation of an acid of formula (I), as the individual (R) enantiomer or (S), or a salt thereof wherein R is a protected amino group; and the asterisk * denotes the stereogenic carbon atom, comprising co... | 02/16/2010 |
| 7659106 | Non-homogeneous systems for the resolution of enantiomeric mixtures The present invention relates to a process for the biocatalyst-mediated enantioselective conversion of enantiomeric mixtures of hydrophobic esters using a biphasic solvent system. More particularly, the present invention relates to the enzyme-mediated enantioselecti... | 02/09/2010 |
| 7645607 | Method for producing optically active N-protected-propargylglycine A method for producing (S)—N-protected-propargylglycine of the following formula (2), wherein the method comprises asymmetrically hydrolyzing an N-protected-propargylglycine ester of the following formula (1) by using an asymmetric hydrolysis enzyme or a cultured ... | 01/12/2010 |
| 7611886 | Enzymatic transformation of a prostaglandin (bimatoprost) intermediate A method for the selective enzymatic acetylation of a bimatoprost intermediate is provided. ... | 11/03/2009 |
| 7582468 | Process for preparing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane and intermediates thereof The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4... | 09/01/2009 |
| 7582469 | Method for enantioselectively opening oxetan-2-ones A method for preparing substantially enantiopure 3-hydroxy carboxylic acids or esters of the general formula (III) by reacting racemic oxetan-2-ones of the general formula (I) with compounds R3-OH of the general formula (II) in the presence of a lipase from Candi... | 09/01/2009 |
| 7485452 | Method of making optically active ester derivatives and their acids from racemic esters The present invention relates to process for the preparing of optically active ester derivatives and their acid derivatives which are used intensively as important chiral intermediates from racemic β-hydroxybutyl ester derivatives. In more detail, this invention re... | 02/03/2009 |
| 7459301 | Stereoisomerically enriched N-protected β-lactams using candida antarctica The present disclosure provides enzymatic methods for generating stereoisomerically pure products by resolving a racemic mixture of N-protected β-lactams with a lipase from Candida antarctica with high stereospecificity. The presence of a carbamate protectin... | 12/02/2008 |
| 7449325 | Process for enzymatically producing either optically active N-substituted β-amino acids or esters thereof or optically active N-substituted 2-homopipecolic acids or esters thereof The present invention discloses a process which comprises selectively hydrolyzing one enantiomer of racemic mixtures of an N-substituted β-amino acid alkyl ester or N-substituted 2-homopipecolic acid ester represented by the formula (I): | 11/11/2008 |
| 7413883 | Enantioselective immobilized lipase Immobilization of Candida rugosa lipase on a carrier selected from the group consisting of macroporous adsorbent resin of the acrylic type, synthetic epoxy activated resin and Mg—Al-hydrotalcite enhances its enantioselectivity by six to seven folds. The imm... | 08/19/2008 |
| 7405070 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is select... | 07/29/2008 |
| 7390647 | Method for producing chiral α-hydroxycarboxylic crystalline acids The invention relates to a method for producing chiral α-hydroxycarboxylic crystalline acids consisting in transforming cyanhydrins (R) or (S) into α-hydroxycarboxylic acids (R) or (S), respectively by enzymatic hydrolysis in the presence of Rhodococcus erythro... | 06/24/2008 |
| 7378269 | Process for the production of amino acids The present invention relates to the processes of racemization and deprotection of special N-protected amino acids in the acylase/racemase system for the total conversion of special N-protected racemic amino acids into optically pure amino acids. ... | 05/27/2008 |
| 7374926 | Enantioconvergent chemoenzymatic synthesis of ()-γ-amino-β-hydroxybutyric acid (()-GABOB) The present invention particularly relates to a chemoenzymatic process for the stereoselective preparation of both enantiomers of 3-hydroxy-4-trityloxy butanenitrile key intermediates for the preparation of (R)-GABOB by lipase mediated kinetic resolution of its race... | 05/20/2008 |
| 7358396 | Preparation of optically active amines A process for preparing optically active amines, a process for preparing racemic amines which can be resolved using optically active carboxylic acids or enzymes, and racemic and optically active amines and optically active amides are described. ... | 04/15/2008 |
| 7354771 | Method of determining absolute configuration of chiral compound The absolute configuration of a chiral compound is determined by (i) coordinating the chiral compound to a metalloporphyrin having a carbon chain-crosslinked porphyrin dimer structure in which one of the two porphyrin rings has at least one ethyl or substituent bulk... | 04/08/2008 |
| 7351567 | Enzymatic resolution of selective estrogen receptor modulators The present invention relates to a process for preparing 5-substitued-6-cyclic-5,6,7,8-tetrahydronaphthalen-2-ol compounds useful as an estrogen agonist. ... | 04/01/2008 |
