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| Number | Title | Issue Date |
| 8129136 | Kit for performing an assay The present invention relates to a kit for performing an assay. The kit comprises luminol, an oxidant, an electron mediator and a hypernucleophilic acylation catalyst. ... | 03/06/2012 |
| 7892781 | Detecting a target using a composite probe comprising a directing agent, a metal nanoparticle and an enzyme A test agent includes a composite probe having at least one nanoparticle having multiple metal atoms, a directing agent, and an enzyme. The directing agent attaches the probe to a target in a test sample. The test sample and bound probe are then treated with an enzy... | 02/22/2011 |
| 7803573 | Method for increasing light emission from a chemiluminescent reaction Method for increasing the emission of light from a chemiluminescent reaction including luminol, a peroxidase enzyme, an oxidant and a mediator of electrons through the use of a hypernucleophilic acylation catalyst belonging to the class of 4-aminopyridines. It is al... | 09/28/2010 |
| 7776563 | Methods for identifying agents for treating cardiovascular disease using inhibition of myeloperoxidase binding The present invention provides methods and agents for treating subjects who have or are at risk of developing or having cardiovascular disease. Such agents inhibit binding of myeloperoxidase (MPO) to a molecule comprising the MPO binding site of apolipoprotein A-1 (... | 08/17/2010 |
| 7687244 | Chromogenic composition for detecting spilled blood and associated methods A chromogenic composition for detecting spilled blood includes a mixture of an acidified aqueous solution containing reduced FD&C Blue #1 and hydrogen peroxide. The chromogenic composition has a relatively long shelf life and will produce a bright blue visible color... | 03/30/2010 |
| 7459286 | Assessing the risk of a major adverse cardiac event in patients with chest pain Methods for characterizing the near term risk of experiencing a major adverse cardiac event in a patient presenting with chest pain are provided. In one embodiment the method comprises determining the level of myeloperoxidase (MPO) activity in a bodily sample obtain... | 12/02/2008 |
| 7432073 | Method for detecting guaiacol producing bacteria The present invention relates to a method capable of detecting proliferative bacteria in food and beverage, particularly acid or neutral beverage at low cost within a short time, a detection kit which enables simple measurement, and a technology for examination of h... | 10/07/2008 |
| 7422734 | Methods of producing lignin peroxidase and its use in skin and hair lightening Methods of producing lignin peroxidase are provided. Also provided are methods and cosmetic compositions suitable for skin and hair lightening as well as kits and an article-of manufacturing including active ingredients for skin and hair lightening. ... | 09/09/2008 |
| 7419657 | Treatment of atherosclerotic disorders The present invention relates to the identification of lipid oxidizing abzymes as a key pathogenic factor in atherosclerotic disorders. Methods and means for the reduction of abzyme mediated lipid oxidation in the vascular system are provided as therapeutic approach... | 09/02/2008 |
| 7407743 | Kit and method of screening wilson's disease The present invention relates to a method for measuring a ceruloplasmin concentration, and more particularly, to a method for measuring a ceruloplasmin in a blood spot based on a standard concentration curve obtained through an enzyme-linked immunosorbent assay (ELI... | 08/05/2008 |
| 7390670 | Signalling compounds and methods for detecting hydrogen peroxide Methods and compound useful for detecting a source of hydrogen peroxide are disclosed wherein a signalling compound of the formula: is reacted with peroxide. Sig is a non-polymeric organic group, B is a boron atom, and each... | 06/24/2008 |
| 7371247 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe... | 05/13/2008 |
| 7364872 | Test methods using enzymatic deposition and alteration of metals Disclosed are methods and materials for utilizing enzymes to act on metal ions in solution so that the ions are reduced to metal and deposited. These methods enable a wide range of applications including the detection of one or more constituents in a test sample. | 04/29/2008 |
| 7361479 | Assay The present invention provides a method of determining the presence or amount of newly synthesized antibody in a sample in response to an immunogen by detecting the released antibodies or parts thereof in a sample containing lymphocytes which have been disrupted whe... | 04/22/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7354732 | Method of assay with sulfonic acid compound and nitro compound A method for measuring an analyte in a sample by using a redox reaction is provided, which gives values with excellent reliability. Prior to the redox reaction, at least one of a sulfonic acid compound and a nitro compound is added to the sample to eliminate the inf... | 04/08/2008 |
| 7351587 | Method for the online determination of hydrogen peroxide A process for the on-line determination of the hydrogen peroxide content of a mixture obtained in a chemical reaction comprises at least the following steps: (1) admixing the mixture comprising hydrogen peroxide with at least one reagent which is capabl... | 04/01/2008 |
| 7348135 | Assay for detecting changes in mitochondrial membrane permeability and method of using same An assay for assessing the permeability of mitochondrial membranes is provided. The assay is based on enzymatic reactions that produce a detectable signal in the presence of intra-mitochondrial compounds. In some embodiments, the intra-mitochondrial compounds may be... | 03/25/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7335483 | Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally ... | 02/26/2008 |
| 7331931 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato... | 02/19/2008 |
| 7319041 | Applications of acridinium compounds and derivatives in homogeneous assays Chemiluminescent acridinium compounds are used in homogeneous assays to determine the concentration of an analyte in a sample without strong acid or strong base treatment. The chemiluminescent acridinium compounds include acridinium esters with electron donating fun... | 01/15/2008 |
| 7316700 | Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine... | 01/08/2008 |
| 7314711 | Assays employing electrochemiluminescent labels and electrochemiluminescence quenchers This invention pertains to the general field of chemical and biological assays which employ electrochemiluminscence (ECL), also referred to as electrogenerated chemiluminescence. More particularly, the present invention pertains to certain classes of chemical moieti... | 01/01/2008 |
| 7300766 | Polymeric ammonium and or phosphonium salts having added π-electrons and higher molecular weight as enhancers for chemiluminescent systems A compound for enhancing the light output of a chemiluminescent system and, in particular, a stabilized, triggerable 1,2-dioxetane, is obtained by reacting a polyvinylbenzyl halide and a bilinker with either a trisubstituted amine or trisubstituted phosphine. A fluo... | 11/27/2007 |
| 7291117 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to... | 11/06/2007 |
| 7285396 | Aβ-heme peroxidase Aβ-heme peroxidase activity is selectively measured and inhibited, packaged as a pharmaceutical composition with heme biosynthetic cofactors or as an industrial enzyme, and used to oxidize target substrates. ... | 10/23/2007 |
| 7278291 | Trace gas sensor with reduced degradation The degradation over time that is commonly seen with analyte-binding proteins when used as sensors for trace amounts of an analyte in a gaseous mixture is reduced by maintaining the sensor in a low-oxygen or oxygen-free environment. ... | 10/09/2007 |
| 7258693 | Device and method for variable speed lancet A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay... | 08/21/2007 |
| 7247726 | Compounds for generating chemiluminescence with a peroxidase Novel compounds comprising a C—C double bond substituted at one carbon with two sulfur atom-containing groups are disclosed. The compounds are useful in methods and compositions for generating chemiluminescence rapidly by reaction with a peroxidase enzyme and a pe... | 07/24/2007 |
| 7247484 | Hematology reagent and methods A reagent system is provided for substantially lysing red blood cells in a whole blood sample prior to leukocyte analysis, which system includes a first reagent for substantially lysing the red blood cells in the whole blood sample, and a second reagent for quenchin... | 07/24/2007 |
| 7244265 | Method and apparatus for penetrating tissue These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo... | 07/17/2007 |
| 7244264 | Dual blade lancing test strip An integrated lancing test strip includes a pair of blade members that each have a lancing tip that are configured to lance skin. A pair of spacer members connect the blade members together such that the blade members define an internal capillary. A test strip is po... | 07/17/2007 |
| 7241021 | Emergency information lighting system An emergency information lighting system (100/200/300), comprising a primary light source (110/210/310) and a housing (112/212/312) for the primary light source (110/210). The housing (112/212/312) includes a first wall (120/220... | 07/10/2007 |
| 7238483 | Method for detecting catalytic activity This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent... | 07/03/2007 |
| 7235378 | Method of selectively determining glycated hemoglobin A method of determining glycated hemoglobin is provided, by which a ratio of the glycated hemoglobin in a sample can be determined accurately and easily. The ratio of glycated hemoglobin can be determined by degrading a glycated hemoglobin in a whole blood sample se... | 06/26/2007 |
| 7232451 | Method and apparatus for penetrating tissue A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performanc... | 06/19/2007 |
| 7229458 | Method and apparatus for penetrating tissue A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within th... | 06/12/2007 |
| 7226461 | Method and apparatus for a multi-use body fluid sampling device with sterility barrier release A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend ou... | 06/05/2007 |
| 7226753 | Displacement assay for selective biological material detection The present invention relates to displacement assay type bioassay materials useful for the detection of toxic substances and, more particularly, to packaging materials for food and other products, along with methods for their manufacture and use. The invention provi... | 06/05/2007 |
