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| Number | Title | Issue Date |
| 7148327 | Production of soluble keratin derivaties A process for the preparation of soluble proteins of high molecular weight with little or no damage to the structural integrity of the proteins. The process is economically and environmentally acceptable by virtue of the cost of reagents that are used, and the recyc... | 12/12/2006 |
| 7091180 | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are admini... | 08/15/2006 |
| 7025916 | Process of making bioengineered collagen fibrils The invention is directed to a class of fiber or strand suspension compositions that may be processed further into viscoelastic pastes or porous solids. The preferred compositions of the invention comprise biologically derived or biologically compatible materials, s... | 04/11/2006 |
| 6916910 | Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof The present invention relates to a process for the production of marine invertebrate type V telopeptide containing collagen preparations from marine invertebrates, compositions containing preparations, and methods of using these preparations. The collagen preparatio... | 07/12/2005 |
| 6780841 | Hyaluronic acid and chondroitin sulfate based hydrolyzed collagen type II and method of making same Hydrolyzed collagen type II powder compositions for inducing cartilage formation in an individual, method of preparing the compositions and use of the compositions in treating connective tissue disorder, replenishing skin viscoelasticity. The compositions are admini... | 08/24/2004 |
| 6679918 | Implantable putty material The present invention provides compositions for an implantable putty material for delivery of active compounds to a patient. More specifically, the present invention provides a material having a pH of between about 3 and 6 and possessing putty-like physic... | 01/20/2004 |
| 6346515 | Collegan-based matrix A collagen matrix comprises collagen fibrils which are cross-linked to one another by reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.... | 02/12/2002 |
| 6323319 | Method of making hydrolyzed collagen type II Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an individual in need of cartilage augmentation in a daily dosage ... | 11/27/2001 |
| 6183741 | Method for reducing insolubles in a gelatin solution The present invention is a process for reducing gelatin insolubles which includes providing a gelatin solution and adding to the gelatin solution amylase in an amount to provide a concentration of amylase of at least 0.1 ppm for a time sufficient to reduc... | 02/06/2001 |
| 6184011 | Method of releasing solid matrix affinity adsorbed particulates A method of releasing particulates from a solid matrix is provided. The method is effected adding to the solid matrix a degrading enzyme capable of degrading the solid matrix, to thereby release the particulates from the solid matrix.... | 02/06/2001 |
| 6100381 | Enzyme method of manufacturing gelatin The present invention is a process for the manufacture of gelatin which includes providing a collagen containing material and demineralizing the collagen containing material to produce ossein. An enzyme solution containing protease at a concentration of a... | 08/08/2000 |
| 6096346 | Method of obtaining extract of shark's cartilage A method of obtaining an extract of shark's cartilage is provided wherein a shark's cartilage is processed through five steps. The five steps are smashing, cleaning, purifying, deodorizing, and sterilizing. The result of this process is a pure white produ... | 08/01/2000 |
| 6080843 | Gelatin and method of manufacture The present invention is a gelatin composed of a high molecular weight fraction (>250,000) of from 0 to 25 wt %, a beta fraction (150,000-250,000) of from 0 to 20 wt % and an alpha fraction (50,000-150,000) of from 15 to 55 wt %. The gelatin has a Gel str... | 06/27/2000 |
| 6043078 | Method for the reduction of biological growth in solution The present invention is a process for reducing biological growth in aqueous solutions. An aqueous solution is provided. An amylase solution is added to the aqueous solution to provide an amylase concentration of greater than 1 unit/ml enzyme activity the... | 03/28/2000 |
| 6040155 | Multifunctional protein and DNA sequence encoding same The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein having "multifunctional activity," is defined herein as i... | 03/21/2000 |
| 6037451 | Method of degreasing bone for gelatin manufacture The present invention is a process for degreasing bone for the manufacture of gelatin. A lipase solution at a concentration of greater than 0.1 ppm is added to a collagen containing material and treated for a time sufficient to solubilize the fat containe... | 03/14/2000 |
| 6025327 | Hydrolyzed collagen type II and use thereof Hydrolyzed collagen type II powder compositions, method of preparing the compositions and use of the compositions in treating cartilage defects. The compositions are orally administered to an individual in need of cartilage augmentation in a daily dosage ... | 02/15/2000 |
| 6020474 | ATP synthase subunits The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and hos... | 02/01/2000 |
| 5973130 | Ras-like protein The present invention provides a human Ras-like protein (RLP) and polynucleotides which identify and encode RLP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods ... | 10/26/1999 |
| 5955438 | Collagen-based matrix A collagen matrix comprise collagen fibrils which are cross-linked to one another by a reducing sugar or a reducing sugar derivative. The collagen matrix may be formed into a membrane useful in guided tissue regeneration.... | 09/21/1999 |
| 5861495 | Human zinc binding proteins The present invention provides three zinc binding proteins (designated individually as ZB-1, ZB-2, and ZB-3, and collectively as ZB) and polynucleotides which identify and encode ZB. The invention also provides genetically engineered expression vectors an... | 01/19/1999 |
| 5847093 | Human apoptosis regulator The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encodi... | 12/08/1998 |
| 5831052 | New human translocation associated protein The present invention provides a human translocation associated protein (Gp25L-H) and polynucleotides which identify and encode Gp25L-H. The invention also provides expression vectors, host cells, antibodies and antagonists. The invention also provides me... | 11/03/1998 |
| 5831049 | Human thioredoxin The present invention provides a human thioredoxin (TRDX) and polynucleotides which identify and encode TRDX. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding TRDX and a me... | 11/03/1998 |
| 5830660 | Tumorigenesis protein The present invention provides a human tumorigenesis protein (HTAP) and polynucleotides which identify and encode HTAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, and antagonists. The invention also provid... | 11/03/1998 |
| 5810970 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 09/22/1998 |
| 5744002 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 04/28/1998 |
| 5736010 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 04/07/1998 |
| 5714042 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 02/03/1998 |
| 5711853 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 01/27/1998 |
| 5707491 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 01/13/1998 |
| 5700353 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 12/23/1997 |
| 5700354 | Paper strengthened with solubilized collagen and method A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 12/23/1997 |
| 5686262 | Recycle process for the production of low-cost soluble collagen The invention includes a method that provides a low cost aqueous solution of solubilized collagen by the steps of: (a) providing an aqueous ground slurry of insoluble collagen and adjusting the pH of said slurry to obtain activity for a proteolytic enzyme... | 11/11/1997 |
| 5670369 | Method for the production of soluble collagen The invention includes an improved method for producing an aqueous solution of soluble collagen. The method comprises the steps of: (A) providing an aqueous ground slurry of insoluble collagen containing insoluble collagen at a first concentration and at a pH ... | 09/23/1997 |
| 5667839 | Human recombinant collagen in the milk of transgenic animals Production of human procollagen or collagen in cells which ordinarily do not produce these molecules is effected by constructing expression systems compatible with mammary glands of non-human mammals. For example, expression systems can be microinjected i... | 09/16/1997 |
| 5647957 | Method of preparing paper strengthened with solubilized collagen A method for making a collagen strengthened cellulosic sheet by providing a cellulosic pulp slurry; adding solubilized collagen to the pulp slurry, and mixing for a time effective for interaction of the cellulosic pulp slurry and solubilized collagen; for... | 07/15/1997 |
| 5606019 | Synthetic protein as implantables Copolymers are provided having varying ratios of elastin and fibroin repeating units. By varying the length of segments of the elastin and fibroin repeating units, the absorption can be greatly varied. Tensile strengths remain relatively constant regardle... | 02/25/1997 |
| 5460967 | Recycle process for the production of low-cost soluble collagen The invention includes a method that produces a low cost aqueous solution of solubilized collagen by the steps of: (a) providing an aqueous ground slurry of insoluble collagen and adjusting the pH of said slurry to obtain activity for a proteolytic enzyme... | 10/24/1995 |
| 5418157 | Recombinant 68,000 dalton collagenase of Clostridium histolyticum Genetically engineered E. coli carry vectors containing inserts that code for Clostridium histolyticum collagenase. These inserts code for: (a) a form of collagenase having a molecular weight of about 68,000 daltons in the essential absence of larger form... | 05/23/1995 |
