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...that Kleenex tissue was originally designed to be a gas mask filter? It was developed at the beginning of World War I to replace cotton, which was then in short supply as a surgical dressing.
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| Number | Title | Issue Date |
| 7968327 | Nucleic acid quantitation from tissue slides This invention provides methods of quantitating nucleic acids from problematic samples, such as aged samples, formalin fixed samples, paraffin embedded samples, samples with aneuploid cells, and cells with fragmented nucleic acids. Methods include techniques to effi... | 06/28/2011 |
| 7897376 | Method for extracting a target product from a host cell employing zwitterionic detergent combinations The present invention provides lysis reagents, containers, methods and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the invention provides combinations of zwitterionic compounds that may... | 03/01/2011 |
| 7811807 | Nucleic acid purification A process for purifying plasmid DNA from a nucleic acid containing sample comprising plasmid DNA and contaminants, which process comprises a step of contaminant removal, comprising: (a) treating the sample to form a nucleic acid so... | 10/12/2010 |
| 7687254 | Phenol-free method of isolating DNA A phenol-free method of isolating DNA from biological material includes homogenizing a biological material with a homogenization buffer to form a homogenate. Proteins and non-DNA organic molecules are extracted from the homogenate by mixing a first extraction buffer... | 03/30/2010 |
| 7553658 | Recovery of plasmids in an aqueous two-phase system The present invention is a method for the purification of plasmid DNA comprising to provide a composition comprising a first polymer having inverse solubility characteristics and a second polymer immiscible in the first polymer; contacting said solution with an aque... | 06/30/2009 |
| 7429470 | Method for purification of nucleic acids by phase separation using laser and beads An apparatus and method for purification of nucleic acids of cells or viruses are provided. The nucleic acid purification apparatus includes: a cell lysis capillary having a sample inlet through which samples and magnetic beads are introduced; a vibrator attached to... | 09/30/2008 |
| 7351378 | Nucleic acid extraction device The present invention provides an apparatus for extracting nucleic acid from a specimen, including traditionally difficult specimens, in preparation for polymerase chain reaction (PCR) analysis. The apparatus includes: a shaker, a centrifugal separator, a particle s... | 04/01/2008 |
| 7349158 | Diffraction grating-based encoded micro-particles for multiplexed experiments Microparticles 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 having a plurality of colocated pitches Λ which represent a unique identification digital code that is detected... | 03/25/2008 |
| 7323298 | Microarray for determining the relative abundances of polynuceotide sequences A method of determining the relative amounts of individual polynucleotides in a complex mixture of different-sequence polynucleotides is disclosed. The polynucleotides, after fluorescent labeling, are contacted under hybridization conditions with an array of differe... | 01/29/2008 |
| 7318998 | Tissue decellularization The present invention relates, in general, to tissue decellularization and, in particular to a method of treating tissues, for example, heart valves, tendons and ligaments, so as to render them acellular and thereby limit mineralization and/or immunoreactivity upon ... | 01/15/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
| 7291457 | Electrochemical detection of mismatch nucleic acids A method and system for specifically detecting perfectly matched probe-target hybrids by annealing a hairpin-based probe to a nucleic acid target under conditions favoring the formation of perfectly matched targets over mismatched targets, and electrochemically dete... | 11/06/2007 |
| 7282361 | Systems and methods for transgenic and targeted mutagenesis screening The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 10/16/2007 |
| 7282475 | Compositions and methods employing zwitterionic detergent combinations The present invention provides lysis reagents, containers, methods and kits relating to the extraction or the extraction and isolation of a cellular component from a host cell. More specifically, the invention provides combinations of zwitterionic compounds that may... | 10/16/2007 |
| 7247721 | Materials and methods for binding nucleic acids to surfaces Surfaces containing high purity silica (silicon dioxide) exhibit high loading potential for nucleic acids. Formulations containing nucleic acids and materials which mask the electrostatic interactions between the nucleic acids and surfaces are disclosed. By m... | 07/24/2007 |
| 7241572 | Method for isolating and purifying nucleic acids A method for isolating and purifying nucleic acids with an improved recovery yield is provided. A mixed solution containing the nucleic acids, salts, and an organic solvent is contacted with an adsorption support to cause the nucleic acids to be adsorbed on the supp... | 07/10/2007 |
| 7235358 | Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection, particularly cardiac transplant rejection, in a patient by detecting the expression level of one or more genes in a patient, are described. Diagnostic oligonucleotides for diagnosing or monitoring transplant ... | 06/26/2007 |
| 7214508 | Method for coarse purification of cell digests from microorganisms The present invention relates to the coarse clarification of lysed cell material from microorganisms and particularly to a method of obtaining nucleic acids. In certain embodiments, the present invention provides a method of coarsely clarifying cell lysate from micr... | 05/08/2007 |
| 7190522 | Chemical synthesis using diffraction grating-based encoded optical elements An optical identification element having a synthesized chemical attached thereto includes an optical substrate having at least one diffraction grating disposed therein, the grating having a resultant refractive variation at a grating location, said grating being emb... | 03/13/2007 |
| 7148343 | Compositions and methods for using a solid support to purify RNA Reagents, methods and kits for the purification of RNA from biological materials are provided. ... | 12/12/2006 |
| 7125673 | CpG retrieval of DNA from formalin-fixed pathology specimen for promoter methylation analysis The present invention provides a method, referred to as CpG retrieval, to overcome incomplete bisulfite modification of DNA recovered from formalin-fixed tissue samples. The method involves boiling deparaffinized tissue samples in citrate buffer, followed by DNA ext... | 10/24/2006 |
| 7126755 | Method and apparatus for labeling using diffraction grating-based encoded optical identification elements A method and apparatus for labeling an item using diffraction grating-based encoded optical identification elements 8 includes an optical substrate 10 having at least one diffraction grating 12 disposed therein. The grating 12 has one or ... | 10/24/2006 |
| 7122304 | Methods for the storage and synthesis of nucleic acids using a solid support The invention relates to storage of nucleic acid (particularly mRNA) on a solid support and to using such nucleic acid in nucleic acid synthesis or amplification reactions. In a preferred aspect, the invention provides synthesis of cDNA and cDNA libraries. ... | 10/17/2006 |
| 7109322 | Process for the depletion or removal of endotoxins A process for the depletion or removal of endotoxins from preparations containing active ingredients designated for therapeutical use which are obtained from natural sources by genetic engineering and/or biotechnology by treatment with chromatographic material where... | 09/19/2006 |
| 7106513 | Diffraction grating-based encoded particle An encoded particle 8 includes a particle substrate 10; at least a portion of the substrate having at least one diffraction grating disposed therein, the grating having a resultant refractive index variation at a grating location, the grating being emb... | 09/12/2006 |
| 7092160 | Method of manufacturing of diffraction grating-based optical identification element A method for manufacturing a diffusion grating-based optical identification element is provided. The optical identification element includes a known fiber substrate, having a diffraction grating disposed therein the grating being indicative of a code when exposed to... | 08/15/2006 |
| 7087732 | Nucleotides and analogs having photoremovable protecting groups A synthetic strategy for the creation of large scale chemical diversity. Solid-phase chemistry, photolabile protecting groups, and photolithography are used to achieve light-directed spatially-addressable parallel chemical synthesis. Binary masking techniques are ut... | 08/08/2006 |
| 7078224 | Cell concentration and lysate clearance using paramagnetic particles Methods are disclosed for using paramagnetic particles to concentrate or harvest cells. Methods are also disclosed for clearing a solution of disrupted biological material, such as a lysate of cells or a homogenate of mammalian tissue. Methods are also disclosed for... | 07/18/2006 |
| 7063975 | Shallow trench power MOSFET and IGBT A power semiconductor device includes a substrate having an upper surface and a lower surface. The substrate has a trench. First and second doped regions are provided proximate the upper surface of the substrate. A first source region is provided within the first do... | 06/20/2006 |
| 7026121 | Methods and compositions for diagnosing and monitoring transplant rejection Methods of diagnosing or monitoring transplant rejection or cytomegalovirus infection in a patient by detecting the expression level of one or more genes or surrogates derived therefrom in the patient are described. Diagnostic oligonucleotides for diagnosing or moni... | 04/11/2006 |
| 7026468 | Process and equipment for plasmid purification A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective, contgrollable, and economical operation, and consistent low level of host ... | 04/11/2006 |
| 7011943 | Method for detecting a designated genetic sequence in murine genomic DNA The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 03/14/2006 |
| 6989249 | Method for extracting DNA from organisms A method for the indirect extraction of DNA greater than 300 kb in size from non-cultivatable organisms contained in an environmental sample is disclosed. The method comprises isolating the organisms from the sample and embedding the isolated organisms in a block of... | 01/24/2006 |
| 6977178 | System and method for transgenic and targeted mutagenesis screening The present invention provides a method and apparatus for to conduct transgenic and targeted mutagenesis screening of genomic DNA. This invention also provides a system for screening DNA for a designated genetic sequence. The system includes a computer having a proc... | 12/20/2005 |
| 6969603 | Method for isolating DNA Method for isolating DNA contained in a biological sample. The method includes combining in a solution a DNA-containing biological sample, a salt, a cationic surfactant, and a DNA-binding carrier, the solution having a salt concentration higher than the DNA precipit... | 11/29/2005 |
| 6958372 | Magnetic, silanised polyvinylalcohol-based carrier materials The present invention relates to magnetic, polymeric polyvinylalcohol-based carrier materials. The surface of said materials is at least partially silanised. The invention also relates to a method for silanising the surface of such materials and to the use of the ma... | 10/25/2005 |
| 6958392 | Methods for the isolation of nucleic acids and for quantitative DNA extraction and detection for leukocyte evaluation in blood products A method for isolating nucleic acid which comprises: (a) applying a sample comprising cells containing nucleic acid to a filter, whereby the cells are retained as a retentate and contaminants are removed; (b) lysin... | 10/25/2005 |
| 6933379 | Method for linking nucleic acids and/or glycosaminoglycans to polar/hydrophilic materials The invention relates to a method for linking nucleic acid and/or glycosaminoglycan or glycosaminoglycan mimetics to a polar/hydrophilic material, characterized by contacting a nucleic acid and/or glycosaminoglycan and a polar/hydrophilic material with each other in... | 08/23/2005 |
| 6919200 | Purification method and apparatus A purification apparatus, kit and method for purifying DNA, RNA, proteins, antigens, antibodies and cells. The apparatus has a wand and a reservoir tube. The wand is made of a cap, a sample collection assembly and an elongated shaft connecting the cap to the sample ... | 07/19/2005 |
| 6919211 | Polypeptide arrays The present invention provides methods and apparatus for sequencing, fingerprinting and mapping biological macromolecules, typically biological polymers. The methods make use of a plurality of sequence specific recognition reagents which can also be used for classif... | 07/19/2005 |
