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| Number | Title | Issue Date |
| 8158405 | Process for concentrating and processing fluid samples A method of treating a liquid sample having microbiological target species therein to concentrate the species and collect lysate is disclosed. The liquid sample comprises non-target microbiological particles, inorganic particles, and microbiological target species. ... | 04/17/2012 |
| 8003369 | Bacteriolytic agent The present invention is a bacteriolytic agent containing a cationic surfactant (A) of which a counteranion is an acid having a pKa (25° C.) of 0 to 10. As the counterion, a carboxylate anion is preferable. As the cationic surfactant (A), a quaternary ammonium salt... | 08/23/2011 |
| 7829323 | Mixing devices for chemical lysis of cells The invention relates to flow-through devices for mixing fluids and uses thereof for mixing and for lysing cells to release biological compounds of interest. The invention particularly encompasses flow-through methods for mixing and chemical methods for the isolatio... | 11/09/2010 |
| 7425439 | Method for dissociation of cells Disclosed is a method for the dissociation of cells. Cells are processed under conditions of pH, temperature, and shear to thereby yield a mixture of cell wall ghosts and cytoplasm. Preferably, the cells are jet cooked at an alkaline pH to form an intermediate mixtu... | 09/16/2008 |
| 7422868 | Microbial ATP extraction and detection system The present invention is directed to compositions and methods for single-step extraction and detection of ATP levels from microbial cells. The disclosed compositions are formulated to efficiently elicit bioluminescent detection of ATP among a broad variety of differ... | 09/09/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
| 7238522 | Devices and methods for biomaterial production An apparatus and a method for isolating a biologic product, such as plasmid DNA, from cells. The method involves lysing cells in a controlled manner separate insoluble components from a fluid lysate containing cellular components of interest, followed by membrane ch... | 07/03/2007 |
| 7235246 | Dermatomycosis vaccine The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity agains... | 06/26/2007 |
| 7230144 | Methods of making intermediates from polyhydroxyalkanoates Methods of forming intermediates from PHAs are disclosed. ... | 06/12/2007 |
| 7166743 | Methods of making intermediates from polyhydroxyalkanoates Methods of forming acrylic acid by heating a PHA are disclosed. The PHA can be derived from a biomass of a non-fossil source. The PHA can be, for example, poly 3-hydroxypropionate or a 3-hydroxypropionate containing polymer. The methods can include, for example, hea... | 01/23/2007 |
| 7138507 | Method of determining a chemotherapeutic regimen based on glutathione-s transferase pi expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing GST-pi expression levels in fixed or fixed and paraffin embedded tissues and prognostica... | 11/21/2006 |
| 7132238 | Method of determining a chemotherapeutic regimen based on ERCC1 expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and determine a ... | 11/07/2006 |
| 7129344 | Nucleic acid isolation A method for isolating plasmids DNA from a DNA containing material which comprises plasmid DNA and genomic DNA, comprising extracting the plasmid DNA into a water-immiscible organic solvent, a chaotrope and water under conditions to denature the genomic DNA and reco... | 10/31/2006 |
| 7094840 | Compositions comprising low molecular weight polyhydroxyalkanoates and methods employing same Polyhydroxyalkanoate compositions including hot melt adhesive compositions, biodegradable wax compositions, and protective coating compositions are provided and include a low molecular weight polyhydroxyalkanoate, a terminally-modified polyhydroxyalkanoate, or both.... | 08/22/2006 |
| 7078061 | Methods, compositions and kits for biomarker extraction The present invention is directed to methods for extracting markers from biological samples, and to systems, devices, kits and reagents for use in such methods. The invention is also to methods, kits, reagents and compositions for measuring a plurality of different ... | 07/18/2006 |
| 7067639 | Method to provide bacterial ghosts provided with antigens Methods for improving binding of a proteinaceous substance to cell-wall material of a Gram-positive bacterium are disclosed. The proteinaceous substance includes an AcmA cell-wall binding domain, homolog or functional derivative thereof. The method includes treating... | 06/27/2006 |
| 7063969 | Yeast-based process for production of l-pac The invention provides a method of synthesis of a substituted or unsubstituted carbinol compound, comprising the steps of subjecting the corresponding substituted or unsubstituted aromatic aldehyde to acyloin condensation mediated by yeast in the presence of either ... | 06/20/2006 |
| 7052911 | Methods of increasing plant yield This invention provides novel methods for improving plant quality and yield in the presence of pathogens. The method increases the levels of pathogenesis-related proteins, such as PR1, phenylalanine ammonia lyase, or plant cell wall proteins such as hydroxyproline-r... | 05/30/2006 |
| 7049059 | Method of determining a chemotherapeutic regimen based on ERCC1 and TS expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing TS and/or ERCC1 expression levels in fixed or fixed and paraffin embedded tissues and pr... | 05/23/2006 |
| 7041509 | High throughput screening assay systems in microscale fluidic devices The present invention provides novel microfluidic devices and methods that are useful for performing high-throughput screening assays. In particular, the devices and methods of the invention are useful in screening large numbers of different compounds for their effe... | 05/09/2006 |
| 7026468 | Process and equipment for plasmid purification A scalable alkaline lysis process, including procedures and devices for the isolation of large quantities (grams and kilograms) of plasmid DNA from recombinant E. coli cell. Effective, contgrollable, and economical operation, and consistent low level of host ... | 04/11/2006 |
| 7005278 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 02/28/2006 |
| 7001724 | Compositions, methods, and kits for isolating nucleic acids using surfactants and proteases The invention provides compositions and methods for releasing and for isolating nucleic acids from biological samples, preferably from whole tissue, using cationic surfactants and proteases. The surfactant-protease combinations, when used with whole tissue, macerate... | 02/21/2006 |
| 6995246 | Methods for removing suspended particles from soluble protein solutions The present invention provides soluble protein solutions, free of suspended particles in high yield. More particularly, the current invention provides a method for removing suspended particles from soluble protein solutions by filtering the soluble protein solution ... | 02/07/2006 |
| 6987002 | Composition for detecting β-1,3-glucan The present invention relates to a composition for detecting an infinitesimal quantity of β-1,3-glucan, a preparation method thereof and a diagnostic kit detecting β-1,3-glucan. The composition of the present invention shows phenoloxidase activity by β-1,3-glucan... | 01/17/2006 |
| 6956111 | Method of determining dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 10/18/2005 |
| 6955892 | Feeding processes for fermentation Embodiments of the present invention generally relate to novel fed-batch fermentations wherein processes of DO-stat and pH-stat are combined for nutrient feeding control. ... | 10/18/2005 |
| 6951746 | Method of manufacturing polyamine composition After yeast somatic components are digested with nuclease or hydrolyzed with alkali, polyamine is recovered to obtain a polyamine composition in volume efficiently at a high recovery rate from yeast somatic components. ... | 10/04/2005 |
| 6942169 | Micromachined lysing device and method for performing cell lysis A method and device for performing lysing on a cell-containing fluid, in which the fluid flows through a vibrating micromachined tube to physically rupture the cell walls (mechanical lysis), and/or to mix, agitate or homogenize the fluid during chemical lysis, and/o... | 09/13/2005 |
| 6939696 | Cell disruption method using sonication The present invention relates to a method for disrupting cells by subjecting the cells to ultrasonic energy in the absence of beads. The present invention also relates to the enhancement of cell disruption methods using ultrasonic energy by reducing the surface tens... | 09/06/2005 |
| 6933404 | Methods of making intermediates from polyhydroxyalkanoates In some embodiments, this invention relates to a method that includes contacting a PHA with an aprotic catalyst to form an ester. The ester has only one monomer unit from the PHA. In certain embodiments, this invention relates to a method that includes treating a PH... | 08/23/2005 |
| 6924098 | Nucleic acid ladders The present invention provides nucleic acid molecules which may be used as standards for estimating the size (in base pairs) and mass of linear, double-stranded or single-stranded nucleic acid molecules separated by size. The nucleic acid molecules of the invention ... | 08/02/2005 |
| 6905821 | Method of determining Dihydropyrimidine dehydrogenase gene expression The present invention relates to prognostic methods which are useful in medicine, particularly cancer chemotherapy. The object of the invention to provide a method for assessing Dihydropyrimidine dehydrogenase (DPD) expression levels in tissues and prognosticate the... | 06/14/2005 |
| 6893879 | Method for separating analyte from a sample An analyte is separated from a fluid sample by introducing the sample into a cartridge having an extraction chamber containing capture material for capturing the analyte. The sample is forced to flow through the extraction chamber to capture the analyte with the cap... | 05/17/2005 |
| 6881541 | Method for analyzing a fluid sample A method for extracting nucleic acid from a fluid sample comprises the steps of introducing the sample into a cartridge having a sample flow path and a lysing chamber in the sample flow path. The lysing chamber contains at least one filter for separating cells or vi... | 04/19/2005 |
| 6872399 | Dermatomycosis vaccine The present invention relates to the preparation of universal inactivated vaccines and their use in preparing compositions for the prophylaxis and therapy of dermatomycosis. Vaccines according to the present invention have the advantage of conferring immunity agains... | 03/29/2005 |
| 6861230 | Antibiotic sensitivity testing The use of an assay for adenylate kinase in an in vitro test for the effect of external conditions on the growth characteristics of bacterial cells. Such tests in particular include tests for the sensivity of a bacteria to an antibiotic or a biostatic agent, and tes... | 03/01/2005 |
| 6833251 | Bacteria detection using immobilized enzyme substrates Methods of detecting bacteria including the use of an immobilized enzyme substrate are provided. ... | 12/21/2004 |
| 6800476 | Regulated expression of PKC and/or SRB1/psa1 in yeast The present invention relates to yeast cells containing the SRB1/PSA1 gene and/or the PKC1 gene or functional derivatives thereof operatively linked to a heterologous inducible promoter and also to methods of regulating yeast cell lysis and flocculation and methods ... | 10/05/2004 |
| 6780612 | Methods for the propagation of lytic organisms The present invention provides a method for the propagation of lytic organisms which comprises the infection of the cells of a stable cell line within a hollow fibre bioreactor with a lytic organism, wherein after said infection, said organism multiplies within the ... | 08/24/2004 |
