Quotables
"The abolishment of pain in surgery is a chimera. It is absurd to go on seeking it...knife and pain are two words in surgery that must forever be associated in the consciousness of the patient."
Dr. Alfred Velpeau, French surgeon ; 1839
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 7807445 | Antibiotic compound Fermentation of a nutrient medium with a eubacterium Streptomyces sp. yields a novel antibacterial compound of structural formula (I). ... | 10/05/2010 |
| 7432074 | Method for extracting a macrolide from biomatter Provided is a method for obtaining a macrolide, especially tacrolimus, from biomatter. ... | 10/07/2008 |
| 7344875 | Streptomyces strain that decomposes proteins recalcitrant to proteolysis The invention provides novel biologically pure cultures of microorganisms high in protease activity and capable of decomposing proteins recalcitrant to proteolysis as contained in garbage, waste water, organic waste liquids, industrial wastes and the like, a proteas... | 03/18/2008 |
| 7329741 | Polynucleotides that hybridize to DP-75 and their use The present invention is a novel nucleic acid sequence which hybridizes to SEQ ID NO:6 or fragments thereof under stringent conditions, or fragments thereof. The invention also includes diagnostic assays, expression vectors, control sequences, antisense molecules, r... | 02/12/2008 |
| 7294486 | Enzymatic process for the synthesis of organo-fluorine compounds There is described a process for the synthesis of a fluoronucleoside compound, said process comprising mixing a substrate and an enzyme from Streptomyces cattelya as catalyst. The process may be used to produce an 18F labelled fluoronucleoside comp... | 11/13/2007 |
| 7285406 | Nucleic acid fragments encoding nitrile hydratase and amidase enzymes from 5-MGAM-4D and recombinant organisms expressing those enzymes useful for the production of amides and acids The invention relates to the isolation, sequencing, and recombinant expression of genes encoding either a nitrile hydratase (NHase) or amidase (Am) from Comamonas testosteroni 5-MGAM-4D, where the NHase is useful for catalyzing the hydration of nitrites to th... | 10/23/2007 |
| 7259241 | gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm... | 08/21/2007 |
| 7256024 | Tyrissamycin antibiotic A novel tyrosyl diester antibiotic is obtained from fermentation of a recombinant strain of Streptomyces lividans designated Stretomyces lividans WD 15684 (ATCC-202143). The new antibiotic, designated tyrissamycin, exhibits antibacterial activity, part... | 08/14/2007 |
| 7241601 | Process for the preparation of Fexofenadine A process for the preparation of a compound of the formula by means of bioconversion with a microorganism culture of a compound of the formula ... | 07/10/2007 |
| 7232486 | Crystallization and purification of macrolides Provided is a method for crystallization and purification of a macrolide such as tacrolimus, sirolimus, pimecrolimus, or everolimus that includes the step of providing a combination of a macrolide, and a polar solvent, dopolar aprotic solvent, or hydrocarbon solvent... | 06/19/2007 |
| 7196192 | 28-epirapalogs Methods and materials involving 28-epirapamycin analogs are disclosed. ... | 03/27/2007 |
| 7192763 | microorganism and a process for producing the substance GM-95 A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering... | 03/20/2007 |
| 7189558 | Process for producing pravastatin sodium salt using dsm 14455 In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens. ... | 03/13/2007 |
| 7090999 | Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use The invention concerns methods for preparing pristinamycin IIA or IIB. ... | 08/15/2006 |
| 7067300 | Process for the biological production of 1,3-propanediol with high titer The present invention provides an improved method for the biological production of 1,3-propanediol from a fermentable carbon source in a single microorganism. In one aspect of the present invention, an improved process for the conversion of glucose to 1,3-propanedio... | 06/27/2006 |
| 7049107 | Method of producing phosphatidylserine A novel method of producing PS is described herein. The method first involves producing PLD enzyme through the use of enzyme-producing microorganisms. The PLD enzyme is reacted with a lecithin and source of serine to produce the phosphatidylserine (PS). The method d... | 05/23/2006 |
| 7029887 | Methods related to gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti... | 04/18/2006 |
| 7011826 | Control of acidosis The present invention relates to a vaccine for the prevention of lactic acidosis in a vertebrate, said vaccine comprising at least one isolated microorganism, or fragment or fragments thereof, wherein said microorganism is capable of producing lactic acid within the... | 03/14/2006 |
| 6984515 | Macrolide analogs A polyketide or glycosylated polyketide which has the formula: wherein R* is methyl or ethyl; each of R1-R6 is methyl; X1 is OH or H; and/or X2 ... | 01/10/2006 |
| 6927057 | Macrolide analogs Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically active compoun... | 08/09/2005 |
| 6902915 | Heat-stable D-aminoacylase The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms belonging ... | 06/07/2005 |
| 6878532 | Method of producing phosphatidylserine A novel method of producing PS is described herein. The method first involves producing PLD enzyme through the use of enzyme-producing microorganisms. The PLD enzyme is reacted with a lecithin and source of serine to produce the phosphatidylserine (PS). The method d... | 04/12/2005 |
| 6867032 | Enzymatic unhairing agent for use in tanning for producing leather and method for enzymatic unhairing treatment The invention provides an enzymatic unhairing agent for use in an unhairing step in tanning for producing leather comprising an alkaline protease as an active component; a treatment solution comprising a pH-adjusting agent and the enzymatic unhairing agent; a method... | 03/15/2005 |
| 6852317 | Metabolite from streptomyces strain NRRL accession No. B-30145 and mutants thereof for controlling plant diseases A novel antibiotic-producing Streptomyces sp. is provided that exhibits antifungal activity only on certain specific plant pathogens. Also provided is a method of treating or protecting plants from fungal infections comprising applying an effective amount of ... | 02/08/2005 |
| 6844183 | Antibiotics RK-1061 and process for preparing the same Antibiotics RK-1061s having a novel chemical structure and a method of production thereof. They have a structural formula represented by general formula(I) wherein A represents R1 or R1CH(OR2)CH2. R2 repr... | 01/18/2005 |
| 6825013 | Isolation of biosynthesis genes for pseudo-oligosaccharides from Streptomyces glaucescens GLA.O, and their use The invention relates to a recombinant DNA molecule which comprises genes for biosynthesizing acarbose and homologous pseudo-oligosaccharides; to oligonucleotide primers for the PCR amplification of the molecule; to proteins which can be obtained by expressing the g... | 11/30/2004 |
| 6818422 | Substances K97-0239 and process for producing the same A microorganism capable of producing substances K97-0239 comprising K97-0239A represented by the following formula [I]: and K97-0239B represented by the following formula [II]: is cultured in a medium and the substances K97-0239 thus accumulated in the medium are co... | 11/16/2004 |
| 6737245 | Luciferase expression cassettes and methods of use The present invention relates to bacterial luciferase expression cassettes suitable for conferring bioluminescence properties on Gram-positive bacteria, cells transformed with such cassettes, and methods of making and using such cassettes. ... | 05/18/2004 |
| 6692945 | Process for the production of polyhydroxyoctanoate by streptomyces lividans The present invention relates to a process for the production of polyhydroxyoctanoate, said method involving construction of a multifunctional Escherichia coli--Streptomyces conjugative shuttle vector, development of a recombinant vector designated as pCA... | 02/17/2004 |
| 6682925 | Streptomyces strain with insecticidal activity and method of using as an insecticide A novel strain of Streptomyces galbus that produces metabolites and exhibits pesticidal activity is disclosed. In addition, a supernatant of the novel strain with pesticidal activity is disclosed. An ethyl acetate-soluble, small molecular weight, alkali s... | 01/27/2004 |
| 6660510 | Transglutaminase gene of Streptoverticillium ladakanum and the transglutaminase encoded therefrom The invention provides a DNA molecule encoding transglutaminase of Streptoverticillium ladakanum, the encoded transglutaminase and the use of the transglutaminase in industrial process.... | 12/09/2003 |
| 6613550 | Microbial process for preparation of optically active 3-hydroxypyrrolidine derivatives The present invention is directed to a process for the production of compounds of the formula: ##STR1## from a compound of the formula ##STR2## comprising hydroxylating a compound of the formula I in the presence of an enzyme produced by a mi... | 09/02/2003 |
| 6596528 | Heat-stable D-aminoacylase The present invention provides a novel D-aminoacylase, as well as method for producing a D-amino acid using the same. In order to achieve the above objective, the present inventors have succeeded in purifying heat-stable D-aminoacylase from microorganisms... | 07/22/2003 |
| 6573084 | Process for the deacylation of cyclic lipopeptides There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of produci... | 06/03/2003 |
| 6558931 | Process for the preparation of Fexofenadine The invention concerns a method for preparing Fexofenadine from Terfenadine by a bioconversion process using Absidia corymbifera LCP 63-1800 or Stepromyces platensis NRRL 2364 strain.... | 05/06/2003 |
| 6558940 | Streptomyces strain with potential anti-microbial activity against phytopathogenic fungi The present invention relates to a new strain of Streptomyces sp., called CIMAP A1 isolated from the soil of geranium (Pelargonium graveolens) planted in the experimental fields of CIMAP and having the accession No. ATCC PTA-4131 and capable of... | 05/06/2003 |
| 6558942 | Combinatorial polyketide libraries produced using a modular PKS gene cluster as scaffold Combinatorial libraries of polyketides can be obtained by suitable manipulation of a host modular polyketide synthase gene cluster such as that which encodes the PKS for erythromycin. The combinatorial library is useful as a source of pharmaceutically act... | 05/06/2003 |
| 6548288 | Method for producing high density antagonistic microbe base material and high density antagonistic microbes produced by the same The present invention discloses high density antagonistic microbe base materials and a method of producing the same, more particularly, a method for preparing high density antagonistic microbe base material comprising the steps of: inoculating a mixture o... | 04/15/2003 |
| 6537789 | Process for the deacylation of cyclic lipopeptides There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the following general formula [I] with effectiveness as well a method of produci... | 03/25/2003 |
| 6514748 | Strain of streptomyces for the preparation of an alkaline protease inhibitor The present invention provides a novel strain of Streptomyces sp. having Accession Number PTA 973 and a process for the preparation of an alkaline protease inhibitor employing the said strain.... | 02/04/2003 |
