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| Number | Title | Issue Date |
| 8153414 | Microbial delivery system The present invention provides methods and compositions for treating or preventing allergic responses, particularly anaphylactic allergic responses, in subjects who are allergic to allergens or susceptible to allergies. Methods of the present invention utilize admin... | 04/10/2012 |
| 8043842 | Bacteria with reduced genome The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to 14% smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present in... | 10/25/2011 |
| 8039243 | Insertion sequence-free bacteria The present invention provides a bacterium having a genome that is genetically engineered to be smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provi... | 10/18/2011 |
| 7871808 | Isolated microorganism having an ability to produce L-histidine The present invention provides a method for producing an amino acid selected from the group consisting of L-alanine, L-valine, L-leucine, L-isoleucine, L-methionine, L-phenylalanine, L-proline, glycine, L-serine, L-threonine, L-cysteine, L-tyrosine, L-asparagine, L-... | 01/18/2011 |
| 7504251 | Bacterial strain, processed plant extracts, compositions containing same, processes for their preparation and their therapeutic and industrial applications The present invention discloses: (i) a non-pathogenic probiotic microorganism and its probiotic/therapeutic uses; (ii) a formulation comprising an aqueous solution of a volatile fraction (VF) prepared from the extract of at least one plant derived material and its t... | 03/17/2009 |
| 7435560 | Method for producing purine nucleoside by fermentation A microorganism which has a gene encoding an enzyme in which feedback inhibition is desensitized by substitution of one or two amino acids in PRPP amidotransferase encoded by purF of Escherichia coli, a gene encoding a protein which is an inactivated represso... | 10/14/2008 |
| 7432095 | Formate dehydrogenase tolerant to halogen compounds and process for producing the same The invention provides a formate dehydrogenase having high specific activity, small Km values for formate and NAD, broad temperature and pH ranges of stability, broad temperature and pH ranges for action, and capable of regenerating a coenzyme with good efficiency i... | 10/07/2008 |
| 7432091 | Highly efficient hydrogen production method using microorganism It is intended to obtain anaerobic microbial cells in an amount sufficient for hydrogen generation reaction, impart a hydrogen generation function to an aerobic microorganism within a short time and provide an industrial advantageous method of producing hydrogen. | 10/07/2008 |
| 7425429 | Method for the identification of tissue-specific regulatory sequences The invention relates to a method for the identification of regulatory sequences in genomes of micro-organisms, isolated ex vivo from infected tissues. The invention further relates to promoters in salmonellae identified by said method. ... | 09/16/2008 |
| 7381545 | Method for controlling metallophosphate precipitation in high cell density fermentations The invention relates to the use of a phosphate glass as a phosphorous source in the media of high cell density bacterial fermentation processes in order to reduce metallophosphate precipitation reactions. The methods of the invention demonstrate a practical method ... | 06/03/2008 |
| 7381553 | Highly active xylose reductase from A new xylose reductase encoding gene from Neurspora crassa was heterologously expressed in E. coli as a His-tag fusion protein and subsequently purified in high yield. This xylose reductase was shown to have a high turnover rate and catalytic efficienc... | 06/03/2008 |
| 7368277 | Method for assay of antibodies and antibody assay device The invention relates to a technology by which antibodies directed to sources of infection in body fluids can be assayed with high accuracy, expediency and specificity. More particularly, the invention provides an antibody immunoassay method in which the antigen-ant... | 05/06/2008 |
| 7358070 | Process for formation of pattern of polyhydroxyalkanoate A process for forming a fine pattern comprised of a polyhydroxyalkanoate on a substrate is provided. The process comprises steps of applying a polyhydroxyalkanoate-synthesizing enzyme and a 3-hydroxyacyl CoA to coexist in an intended pattern on a substrate, and poly... | 04/15/2008 |
| 7354592 | Genetically modified tumor-targeted bacteria with reduced virulence The present invention is directed to mutant Salmonella sp. having a genetically modified msbB gene in which the mutant Salmonella is capable of targeting solid tumors. The invention is also directed to Salmonella sp. containing a genetically mod... | 04/08/2008 |
| 7338791 | Production of flavonoids by recombinant microorganisms Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosymthetic pathway for the conversion of phenylpropanoids to various flav... | 03/04/2008 |
| 7335502 | Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E... | 02/26/2008 |
| 7329519 | Glucose dehydrogenase β subunit and DNA encoding the same A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequnece of a N-terminal signal sequence region of a GDH β subunit derived from Burkholderia cepacia KS1 strain. ... | 02/12/2008 |
| 7314734 | Muteins of placental growth factor type 1, preparation method and application thereof The present invention relates to chemically stable muteins of type 1 Placental Growth Factor (PLGF-1) bearing the substitution or elimination of a cysteine residue from the wild type protein amino acid sequence, their preparation, their therapeutic and cosmetic uses... | 01/01/2008 |
| 7314733 | Saitohin gene and uses of same The present invention provides an isolated nucleic acid sequence encoding saitohin (STH), an isolated nucleic acid sequence that hybridizes to said sequence, and a purified protein encoded by said nucleic acid sequences. The present invention also provides a purifie... | 01/01/2008 |
| 7309599 | Aerobic fermentation method A method and apparatus for effectively aerating large-scale cultures of microorganisms is disclosed. ... | 12/18/2007 |
| 7303906 | Competent bacteria The present invention discloses that a bacterium having a genome that is genetically engineered to be at least 10% smaller than the genome of its native parent strain has better transformation competence. Specific E. coli strains, having significantly reduced... | 12/04/2007 |
| 7294494 | Nucleic acids encoding mutants of MAW motifs of RecA protein homologs RecA protein mutants and RecA homolog protein mutants which contain one or more mutations in the MAW motif are presented. The mutants rely on replacement of wildtype amino acid residues in the MAW motif with specific replacement residues to alter the three-dimension... | 11/13/2007 |
| 7267974 | Polyhydroxyalkanoate synthesizing microorganism and process of producing polyhydroxyalkanoate using the same Microorganisms showing higher productivity of unusual-polyhydroxyalkanoate (PHA) than ever by using an inexpensive substrate or under specific conditions are obtained from wild strains and mutant strains. The microorganisms are cultured with such substrates to synth... | 09/11/2007 |
| 7268215 | Photoprotein derived from okinawan squid and gene encoding the photoprotein By using a bioluminescence, a method for detection of a monovalent cation is provided and the method is a high sensitive and simple method. According to the present invention, an amino acid sequence of symplectin and a base sequence encoding the protein are provided... | 09/11/2007 |
| 7262056 | Enhancing intermolecular integration of nucleic acids using integrator complexes We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents. ... | 08/28/2007 |
| 7250274 | IL-21 production in prokaryotic hosts The expression vectors and methods using an E. coli expression system for the large scale production of IL-21 are described. The vectors utilize the IL-21 coding sequence with specific changes in nucleotides in order to optimize codons and mRNA secondary stru... | 07/31/2007 |
| 7241572 | Method for isolating and purifying nucleic acids A method for isolating and purifying nucleic acids with an improved recovery yield is provided. A mixed solution containing the nucleic acids, salts, and an organic solvent is contacted with an adsorption support to cause the nucleic acids to be adsorbed on the supp... | 07/10/2007 |
| 7227010 | Recombinant light chains of botulinum neurotoxins and light chain fusion proteins for use in research and clinical therapy Botulinum neurotoxins, the most potent of all toxins, induce lethal neuromuscular paralysis by inhibiting exocytosis at the neuromuscular junction. The light chains (LC) of these dichain neurotoxins are a new class of zinc-endopeptidases that specifically cleave the... | 06/05/2007 |
| 7226767 | Process for producing cytidine diphosphate choline A substantially pure culture of a microorganism having enzyme activities of pyrG and CCT and carrying a recombinant DNA composed of a DNA fragment containing genes encoding pryG and CCT and a vector. ... | 06/05/2007 |
| 7217543 | Method for producing L-amino acid using methylotroph The present invention describes a method for producing an L-amino acid comprising culturing a microorganism having an ability to produce an L-amino acid in a medium, whereby the L-amino acid accumulates in the medium, and collecting the L-amino acid from the medium,... | 05/15/2007 |
| 7195757 | Modulation of immune responses to foreign antigens expressed by recombinant attenuated bacterial vectors The present invention relates to immunogenic compositions comprising a live attenuated derivative of a pathogenic Enterobacteriaceae bacteria. The attenuated derivative of a pathogenic Enterobacteriaceae bacteria comprises a polynucleotide that encodes a foreign ant... | 03/27/2007 |
| 7195897 | Feedback-resistant homoserine transsuccinylases having a modified c-terminus The invention relates to a homoserine transsuccinylase, which exhibits reduced sensitivity towards L-methionine or SAM in comparison with a homoserine transsuccinylase wild-type enzyme, whereby the latter comprises an amino acid sequence containing a TyrGlnXaaThrPro... | 03/27/2007 |
| 7189557 | Process for the intracellular over-production of streptokinase using genetically engineered strain of An improved process for the production of streptokinase using a genetically engineered strain of Escherichia coli which overproduces streptokinase intracellularly and more particularly, the overall process disclosed herein, concerns with an improvement in the... | 03/13/2007 |
| 7183098 | Loline alkaloid gene clusters of the fungal endophyte neotyphodium uncinatum Loline alkaloids (LA), which are 1-aminopyrrolizidines with an oxygen bridge, are produced by Epichloë (anamorph=Neotyphodium) species, endophytes of grasses. LA are insecticidal, thus helping protect host plants from insect herbivory. Suppression sub... | 02/27/2007 |
| 7175997 | BMP-11 compositions Purified BMP-11 proteins and processes for producing them are disclosed. Recombinant DNA molecules encoding the BMP-11 proteins are also disclosed. The proteins may be useful in regulating follicle stimulating hormone, such as for contraception. In addition, the pro... | 02/13/2007 |
| 7163820 | strain for an oral vaccine against post-weaning diarrhea in pigs The invention relates to a strain suitable for producing a live, orally applicable Escherichia coli vaccine for the prevention of post-weaning diarrhoea in pigs, and the procedure suitable for producing that strain. The essence of the strain is that the enter... | 01/16/2007 |
| 7163819 | Bacterial hemoglobin genes and their use to increase carotenoid production Genes encoding bacterial oxygen binding proteins are provided. Recombinant expression of at least one of the present bacterial hemoglobin genes increased the growth characteristics and/or carotenoid production levels in microbial host cells grown under microaerobic ... | 01/16/2007 |
| 7153676 | Transacylases of the paclitaxel biosynthetic pathway Transacylase enzymes and the use of such enzymes to produce paclitaxel, related taxoids, as well as intermediates in the paclitaxel biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the transacylase enzymes. ... | 12/26/2006 |
| 7144724 | Process for the production of L-amino acids by fermentation using coryneform bacteria A process for the production of an L-amino acid wherein coryneform bacteria (e.g. Coryneform glutamicum) in which expression of the mqo gene coding for malate quinone oxidoreductase is attenuated are fermented to produce a desired amino acid, and the amino ac... | 12/05/2006 |
| 7132283 | PRO273 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 11/07/2006 |
