Did You Know...
...that to encourage use of his new invention, the shopping cart, market owner Sylvan Goldman hired fake shoppers to push the carts around his store in Oklahoma City? Seems his customers were reluctant to give up their hand-carried baskets.
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| Number | Title | Issue Date |
| 8183008 | Evaluating MMP expression in patient stratification and other therapeutic, diagnostic and prognostic methods for cancer Provided are compositions, methods and kits for quantifying the expression and/or activity of MMP-14 and other biomarkers of cancer, which may be used diagnostically and prognostically, e.g., in patient stratification and evaluation of appropriate therapeutic regime... | 05/22/2012 |
| 8148099 | Process for determining S-nitrosothiols in biological fluids A process for determining S-nitrosothiols, in particular S-nitrosoglutathione, in biological fluids that is easy, selective, cheap with respect to the prior art, which requires the use of equipment commonly available in laboratories, at low cost, which can be used b... | 04/03/2012 |
| 7932050 | Enzymatic substrates derived from phenoxazinone and their use as developers in detection of microorganisms with peptidase activity Enzymatic phenoxazinone substrates of formula (I): in reaction media containing the same are used for detecting, identifying and/or quantifying microorganisms expressing at least one peptidase activity. ... | 04/26/2011 |
| 7875436 | Peptide substrates recognizable by a botulinum toxin A, BoNT/A and the use thereof A peptide substrate selectively recognisable by a botulinum toxin A, BoNT/A containing a Nop-(Z)-Pya fragment in the peptide structure thereof, wherein Z is an aminoacid chain, preferably RA and the fragment is cleaved by the toxin. ... | 01/25/2011 |
| 7771962 | CD10-activated prodrug compounds The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide, a stabilizing group and, optionally, a linker group. The prodrug is cleavable by the CD10 enzyme. Met... | 08/10/2010 |
| 7741068 | Methods for differentiation between cardiac and pulmonary causes of chronic dyspnea The present invention relates to a method for differentiating in a subject suffering from chronic shortness of breath (dyspnea) between (i) a pulmonary disease, (ii) a cardiovascular complication, (iii) a cardiovascular complication accompanied by a pulmonary diseas... | 06/22/2010 |
| 7695930 | Method for the detection, identification and/or quantification of microoganisms with peptidase activity using phenoxazinone derivatives as enzyme substrates The present invention relates to methods for the detection, identification and/or quantification of microorganisms with peptidase activity using enzymatic substrates with the following general formula: ... | 04/13/2010 |
| 7534582 | Method for measuring the amount of natriuretic peptides in a sample A method for accurately measuring an amount of natriuretic peptides in a sample that has stood for at least 24 hours, in a plastic tube or a tube coated with silicone. This method makes it possible to measure natriuretic peptides stably and conveniently. Also provid... | 05/19/2009 |
| 7445907 | Methods for mass spectrometry detection and quantification of specific target proteins in complex biological samples Mass spectrometry-based methods are described for the detection or quantification of targeted proteins in biological samples e.g., plants, animals, and microorganisms, parts (e.g., tissue or cells) thereof, and products derived from plants, animals or microorganisms... | 11/04/2008 |
| 7432071 | Method of diagnosing periodontitis by determining γ-glutamyltranspeptidase The inventor discovered that γ-GTP (γ-glutamyl transpeptidase) was scarcely contained in the gingival crevicular fluid of patients with gingivitis, but was contained in the gingival crevicular fluid of patients with periodontitis. Thus, the inventor provides a det... | 10/07/2008 |
| 7427498 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transm... | 09/23/2008 |
| 7425425 | Method for the detection of enzyme-catalyzed cleavage reactions by fluorescence spectroscopy A method involves the detection of enzyme-catalyzed cleavage reactions using modular chemical compounds as substrates for the enzymes involved, and detection is effected by use of molecular-weight-sensitive methods. ... | 09/16/2008 |
| 7422867 | Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of usi... | 09/09/2008 |
| 7405280 | Chromogenic substances and use thereof for the determination of carboxypeptidase activities The invention relates to chromogenic compounds and the use thereof for the determination of enzymes of the family of carboxypeptidases N and carboxypeptidases U. The above is more specifically a compound of formula (I) in which A=(1), (2), (3), (4) or (5), R1, R2=H,... | 07/29/2008 |
| 7402423 | Apparatus for the detection of pepsin An apparatus for detecting pepsin comprising a solid support, and a peptide chain wherein the peptide chain is operatively configured to be cleaved by pepsin, and the peptide chain is disposed on a surface of the solid support. ... | 07/22/2008 |
| 7402407 | Chemically targeted positional identification of post-translationally phosphorylated peptides Methods are provided for determining the position of a post-translationally modified (PTM) amino acid residue such as a phosphorylated amino acid residue or an O-glycosylated amino acid residue in a peptide. Also provided are methods for determining the identity of ... | 07/22/2008 |
| 7384758 | Bioluminescent protease assay with modified aminoluciferin or derivatives thereof A sensitive bioluminescent assay to detect proteases, including caspases and proteases that specifically cleave a peptide substrate having aspartate, is provided. In one embodiment, the assay employs an aminoluciferin or a carboxy-terminal protected derivative there... | 06/10/2008 |
| 7361315 | Micro-reactor for biological substance inspection and biological substance inspection device The object of the present invention is to provide a micro-reactor, equipped with a high-precision liquid feed system of simple structure, capable of high-precision analysis of at least one item. The present invention provides a micro-reactor for biological substance... | 04/22/2008 |
| 7358088 | Peptides and compositions which modulate apoptosis The present invention is directed to novel peptides and compositions capable of modulating apoptosis in cells, and to methods of modulating apoptosis employing the novel peptides and compositions of the invention. In one aspect, the invention is directed to a novel ... | 04/15/2008 |
| 7354731 | Method of screening for potential anti-bacterial agents The invention provides a method of screening for potential anti-bacterial agents being antagonists of one or both of the transglycosylase and the transpeptidase enzymes involved in peptidoglycan biosynthesis in bacteria. The method is suitable for high throughput sc... | 04/08/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7355045 | Isotopically enriched N-substituted piperazine acetic acids and methods for the preparation thereof In some embodiments, this invention pertains to isotopically enriched N-substituted piperazine acetic acids. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazine acetic acids. ... | 04/08/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7344852 | Crystallization of dipeptidyl peptidase IV (DPPIV) Provided are crystals relating to DPPIV and its various uses. ... | 03/18/2008 |
| 7338777 | Method for determining the biological activity of defibrotide Method for determining the biological activity of defibrotide by a) bringing into contact defibrotide, plasmin and a substrate specific for the plasmin which, by reaction with the plasmin, provides a measurable product; and b) measuring the amount of product formed ... | 03/04/2008 |
| 7332296 | Screening assay for enzymes involved in pathophysiology using SELDI-TOF mass spectrometry The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying aspects of the renin-angiotensin system. The methods may be utilized ... | 02/19/2008 |
| 7332326 | Centripetally-motivated microfluidics system for performing in vitro hybridization and amplification of nucleic acids This invention relates to methods and apparatus for performing microanalytic and microsynthetic analyses and procedures. The invention provides a microsystem platform and a micromanipulation device for manipulating the platform that utilizes the centripetal force re... | 02/19/2008 |
| 7329506 | Apparatuses and methods for determining protease activity The present invention relates to compositions and an apparatuses for determining protease activity. The compositions of the invention contain a reporter protein fused to at least one protease cleavage sequence, and a linker for attaching the protease cleavage sequen... | 02/12/2008 |
| 7329507 | Prodrug compounds with isoleucine The compounds of the invention are modified forms of therapeutic agents. A typical prodrug compound of the invention comprises a therapeutic agent, an oligopeptide having an isoleucine residue, a stabilizing group and, optionally, a linker group. The prodrug is clea... | 02/12/2008 |
| 7329489 | Methods for drug discovery, disease treatment, and diagnosis using metabolomics The small molecule profiles of cells are compared to identify small molecules which are modulated in altered states. Cellular small molecule libraries, methods of identifying tissue sources, methods for treating genetic and non-genetic diseases, and methods for pred... | 02/12/2008 |
| 7320878 | Protease assay for therapeutic drug monitoring The present invention concerns a further development and use of biological assays to determine the amount or concentration of an active ingredient present in a sample. The enzyme assay of the present invention determines the amount or concentration of protease inhib... | 01/22/2008 |
| 7312302 | Compositions for the detection of enzyme activity in biological samples and methods of use thereof The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone conjugated to two fluorophores such that the fluorophores are located opposite ... | 12/25/2007 |
| 7309578 | Therapeutic treatment of chronic obstructive pulmonary disease The present invention provides a method of treating or preventing a chronic obstructive pulmonary disease in a subject, comprising administering to said subject an amount of an agent affective to inhibit apoptosis of the subject's lung cells and thus treat or preven... | 12/18/2007 |
| 7300753 | Immunoaffinity isolation of modified peptides from complex mixtures The invention provides methods for isolating a modified peptide from a complex mixture of peptides, the method comprising the steps of: (a) obtaining a proteinaceous preparation from an organism, wherein the preparation comprises modified peptides from two or more d... | 11/27/2007 |
| 7291494 | Regulation of target protein activity through modifier proteins The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain an... | 11/06/2007 |
| 7279317 | Modulation of COP9 signalsome isopeptidase activity Methods for identifying agents that can increase or decrease the isopeptidase activity of a COP9 signalsome (CSN) are provided, as are agent identified using such screening assays. In addition, methods of ameliorating a pathologic condition such as a cancer or an au... | 10/09/2007 |
| 7256013 | Kit for determining the acetylation level of a peptide based on sensitivity of the peptide to peptidase The acetylation level of a peptide is determined utilizing the fact that the changes in the acetylation level are reflected in the sensitivity of the substrate peptide to a peptidase. This method can be used for measuring activities of deacetylase and acetylase, and... | 08/14/2007 |
| 7238483 | Method for detecting catalytic activity This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent... | 07/03/2007 |
| 7238491 | Pregnane X receptor method The present invention relates to a novel human orphan nuclear receptor that binds to a cytochrome P-450 monooxygenase (CYP) promoter and that is activated by compounds that induce CYP gene expression. The invention further relates to nucleic acid sequences encoding ... | 07/03/2007 |
| 7223865 | Chromogenic compounds, and use thereof as enzyme substrates The present invention relates to novel chromogenic substrates which are used to detect aminopeptidase activity in microorganisms or to determine whether at least one bacterium belongs to the Gram-positive group or to the Gram-negative group according to the color th... | 05/29/2007 |
