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| Number | Title | Issue Date |
| 8163531 | Purification of vaccinia viruses using hydrophobic interaction chromatography The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a v... | 04/24/2012 |
| 8137948 | Methods for producing preparations of recombinant AAV virions substantially free of empty capsids Methods for separating AAV empty capsids from mixtures of AAV vector particles and AAV empty capsids are described. The methods use column chromatography techniques and provide for commercially viable levels of recombinant AAV virions. ... | 03/20/2012 |
| 8058050 | Cellular permissivity factor for viruses and uses thereof The present invention provides methods and compositions related to the generation of host cells permissive for virus growth, particularly Porcine Reproductive and Respiratory Syndrome (PRRS) virus. ... | 11/15/2011 |
| 8058049 | Process for producing poxviruses and poxvirus compositions The present invention relates to compositions and pharmaceutical compositions comprising poxviruses and more particularly extracellular enveloped viruses. The present invention also relates to a process for producing poxviruses and poxviruses obtained thereof. Moreo... | 11/15/2011 |
| 8012738 | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines The present invention relates to methods for purification of Vaccinia viruses (W) and/or Vaccinia virus (W) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a vir... | 09/06/2011 |
| 8012736 | Multi plasmid system for the production of influenza virus Vectors and methods for the production of influenza viruses suitable as recombinant influenza vaccines in cell culture are provided. Bi-directional expression vectors for use in a multi-plasmid influenza virus expression system are provided. ... | 09/06/2011 |
| 8012737 | Methods of producing influenza vaccine compositions Methods and compositions for the optimization and production of influenza viruses, e.g., ca influenza B strains, in eggs and host cells suitable as influenza vaccines are provided. ... | 09/06/2011 |
| 8003364 | Purification of vaccinia viruses using hydrophobic interaction chromatography The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a v... | 08/23/2011 |
| 8003363 | Purification of vaccinia virus- and recombinant vaccinia virus-based vaccines The present invention relates to methods for purification of Vaccinia viruses (VV) and/or Vaccinia virus (VV) particles, which can lead to highly pure and stable virus preparations of predominantly biologically active viruses. The invention encompasses purifying a v... | 08/23/2011 |
| 7901921 | Viral purification methods The present invention is directed to an improved method of purifying virus, particularly reovirus. Infectious virus can be extracted from a cell culture with a detergent to produce high titers of virus, and the virus can then be purified by simple steps such as filt... | 03/08/2011 |
| 7888098 | Scalable process for protein purification The invention provides a process for the purification recombinantly expressed, self-assembled VLP from the homogenate of a bacterial host, wherein the process can be scaled up to a commercial production scale in a cost effective manner. The process comprises a first... | 02/15/2011 |
| 7875446 | Purification processes for isolating purified vesicular stomatitis virus from cell culture A process is described for purifying vesicular stomatitis virus (VSV) from cell culture fluid of a mammalian cell culture infected with VSV, the process comprising: clarifying the cell culture fluid by low-speed centrifugation and recovering the VSV in the supernata... | 01/25/2011 |
| 7851196 | Methods for purifying adeno-associated virus particles The present invention provides methods of purifying encapsidated virus, e.g., viral particles comprising viral nucleic acid, from compositions comprising encapsidated viral nucleic acid and viral particles that lack viral nucleic acid; methods for reducing the parti... | 12/14/2010 |
| 7833774 | Screening methods for identifying viral proteins with interferon antagonizing functions and potential antiviral agents The present invention relates, in general, to a screening method for identifying novel viral proteins with interferon antagonizing function using a transfection-based assay, and the use of such proteins in isolating various types of attenuated viruses for the develo... | 11/16/2010 |
| 7807438 | Preparation of purified exosomes comprising HCV RNA The invention relates to a method for isolation of hepatitis C virus. The method comprises the separation of particles termed exosomes from the blood plasma of an individual infected with hepatitis C virus (HCV) and the extraction or RNA from these exosome particles... | 10/05/2010 |
| 7776580 | Magnetism based rapid cell separation This invention relates generally to the field of cell seperation. In particular, the invention provides processes for isolating a target cell, cellular organelle or virus from a sample, using inter alia, nonspecific binding between a target cell, cellular organelle ... | 08/17/2010 |
| 7759104 | Paramyxoviridae virus preparations This document involves methods and materials related to obtaining Paramyxoviridae virus preparations. ... | 07/20/2010 |
| 7723094 | Recombinant influenza vectors with a polII promoter and ribozymes for vaccines and gene therapy The invention provides a composition useful to prepare influenza viruses, e.g., in the absence of helper virus, using vectors which include PolII promoters and multiple ribozyme sequences. ... | 05/25/2010 |
| 7704721 | Compositions and methods to prevent AAV vector aggregation Compositions and methods are provided for preparation of concentrated stock solutions of AAV virions without aggregation. Formulations for AAV preparation and storage are high ionic strength solutions (e.g. μ˜500 mM) that are nonetheless isotonic with the intended... | 04/27/2010 |
| 7598072 | Assay to detect viral uncoating A cell-free viral uncoating assay is provided. ... | 10/06/2009 |
| 7592170 | Selective precipitation of viruses using polyectrolytes The invention provides new methods for purifying and concentrating viruses. The inventors have discovered that high molecular weight proteoglycans present in retroviral stocks are co-concentrated with the retroviruses, and can inhibit retroviral transduction. The ne... | 09/22/2009 |
| 7588929 | Production of bacteriophage compositions for use in phage therapy The present invention relates to the use of bacteriophages to treat infectious diseases. The invention provides a method for intermediate to large scale commercial production of bacteriophage compositions, wherein the method reduces the production volume and elevate... | 09/15/2009 |
| 7579181 | Purification of adenovirus and AAV The present invention relates to the purification of large scale quantities of active (infectious) adenovirus and AAV, especially for use in therapeutic applications. In particular, the invention provides improved methods for contacting such viruses with suitable ch... | 08/25/2009 |
| 7449324 | Metapneumovirus strains and their use in vaccine formulations and as vectors for expression of antigenic sequences The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phyl... | 11/11/2008 |
| 7445924 | Modified Vaccinia Ankara virus variant and cultivation method The present invention provides an attenuated virus, which is derived from Modified Vaccinia Ankara virus and characterized by the loss of its capability to reproductively replicate in human cell lines. It further describes recombinant viruses derived from this virus... | 11/04/2008 |
| 7439058 | HBV/HCV virus-like particle Chimeric antigens derived from hepatitis B virus (HBV) and hepatitis C virus (HCV) are described which form virus-like particles when co-expressed with an excess of hepatitis B virus surface antigen (HBsAg). The chimeric antigens are fusion proteins containing an im... | 10/21/2008 |
| 7429485 | Method of producing infectious reovirus A simple and efficient method of producing mammalian reovirus is developed using HEK 293 cells. The method provides for fast production of reovirus in high yield. Furthermore, this method provides for a simpler purification procedure of the produced reovirus. ... | 09/30/2008 |
| 7425437 | Vaccines against West Nile Virus The present invention relates to novel vaccines containing (whole-inactivated) West Nile Viruses and/or West Nile viral proteins derived therefrom, produced on human cells, wherein the human cells comprise a sequence encoding at least one early region-1 (E1) gene pr... | 09/16/2008 |
| 7419817 | Scalable purification of AAV2, AAV4 or AAV5 using ion-exchange chromatography The present invention provides methods of purifying adeno-associated virus (AAV) particles. These AAV particles include AAV2, AAV4 and AAV5 particles. The present invention also provides AAV particles purified by the methods of the present invention. ... | 09/02/2008 |
| 7413889 | Production of a parvovirus vaccine in plants as viral coat protein fusions The present invention relates to foreign peptide sequences fused to recombinant plant viral structural proteins and a method of their production. Fusion proteins are economically synthesized in plants at high levels by biologically contained tobamoviruses. The fusio... | 08/19/2008 |
| 7393527 | Method for limiting the growth of cancer cells using an attenuated measles virus A method for treating cancer cells is provided comprising directly or systemically administering a therapeutically effective dose of an attenuated measles virus. In one embodiment, the therapeutically effective dose is from about 103 pfus to about 10... | 07/01/2008 |
| 7364893 | Recombinant infectious laryngotracheitis virus and uses thereof The present invention provides recombinant and/or isolated infectious laryngotracheitis virus glycoproteins, including gD, gI, gG and gE. ... | 04/29/2008 |
| 7361496 | Rescue of mumps virus from cDNA This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the mumps virus... | 04/22/2008 |
| 7357936 | Adjuvant systems and vaccines The present invention provides vaccine and adjuvant formulation comprising an immunostimulant and a metal salt. The immunostimulant is adsorbed onto a particle of metal salt and the resulting particle is essentially devoid of antigen. ... | 04/15/2008 |
| 7344723 | Self-replicating RNA molecule from hepatitis C virus A unique HCV RNA molecule is provided having an enhanced efficiency of establishing cell culture replication. Novel adaptive mutations have been identified within the HCV non-structural region that improves the efficiency of establishing persistently replicating HCV... | 03/18/2008 |
| 7338759 | HCV variants HCV variants are described. The variants include polynucleotides comprising non-naturally occurring HCV sequences and HCV variants that have a transfection efficiency and ability to survive subpassage greater than HCV that have wild-type polyprotein coding regions. ... | 03/04/2008 |
| 7332176 | viruses Unique Solenopsis invicta viruses (SINV) have been identified and their genome sequenced. Oligonucleotide primers have been developed using the isolated nucleic acid sequences of the SINV. The viruses are used as a biocontrol agent for control of fire ants. | 02/19/2008 |
| 7326555 | Methods of adenovirus purification A process for purifying virus particles, especially recombinant adenovirus vector particles, is presented. The process relies on various combinations of cell lysis, detergent-based precipitation of host cell contaminants away from the virus, depth filtration or cent... | 02/05/2008 |
| 7319002 | Method for purification of viral vectors having proteins which bind sialic acid A method for isolating, from a mixture, a virus having a surface protein with a binding site for sialic acid is provided. The method involves contacting the mixture with mucin which has been linked to a solid support and washing the solid support to remove material ... | 01/15/2008 |
| 7314746 | Apparatus and method for preparative scale purification of nucleic acids Apparatus and methods are described for pharmaceutical grade manufacture extrachromosomal nucleic acids from cell lysates using flotation to separate and eliminate undesired insoluble cellular debris including chromosomal DNA from the lysates. A gas is introduced to... | 01/01/2008 |
