Class 435/218 - Elastase

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the enzyme catalyzes the hydrolysis
No. of patents: 69
Last issue date: 06/10/2008

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Number	Title	Issue Date
7384787	Increasing perhydrolase activity in esterases and/or lipases The invention provides for methods of modifying n esterase or a lipase enzyme to introduce perhydrolase activity or to increase the already-existing perhydrolase activity. The invention also provides for methods of converting an polypeptide having predominantly este...	06/10/2008
7361335	Methods for using an elastase The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy...	04/22/2008
7182945	Anti-inflammatory peptides derived from C-reactive protein A peptide corresponding to positions 62–71 of the sequence of human C-reactive protein (CRP) of the formula: Glu62-Ile-Leu-Ile-Phe-Trp-Ser-Lys-Asp-Ile71 and modifications thereof obtained by substitution, deletion, or addition of amino acids,...	02/27/2007
7153505	Methods for enlarging the diameter of an artery or vein in a human subject The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy...	12/26/2006
7063838	Methods for treating an artery or vein in a human subject The invention provides methods for treating an obstructed biological conduit that include administering to the conduit an agent that can degrade extracellular matrix of obstructing tissue. Particular methods include delivery of an enzyme or a mixture of several enzy...	06/20/2006
7037705	Isolated human protease proteins, nucleic acid molecules encoding human protease proteins, and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of ide...	05/02/2006
7029901	Isolated human protese proteins, nucleic acid molecules encoding human protease proteins and uses thereof The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the protease peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of ide...	04/18/2006
6855689	Enzyme-activated anti-tumor prodrug compounds Disclosed are enzyme-activated anti-tumor and anti-metastatic prodrug compounds. The specific enzymes are collagenase(IV) and elastase. Also disclosed are methods of making and using such compounds. ...	02/15/2005
6855513	Quorum sensing signaling in bacteria The invention provides methods for identifying a modulator of quorum sensing signaling in bacteria, and for identifying a quorum sensing controlled gene in bacteria. In addition, the invention provides quorum sensing controlled genetic loci in Pseudomas aeruginos...	02/15/2005
6849441	Hyperthermostable protease gene There are provided hyperthermostable proteases having an amino acid sequences represented by SEQ ID NOs: 1, 3 and 5 of the Sequence Listing or functional equivalents thereof and hyperthermostable protease genes encoding those hyperthermostable protease. There is als...	02/01/2005
6846656	Process for producing N-acetylneuraminic acid The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic...	01/25/2005
6569636	Assay for modulators of metallo-enzyme activity An assay is disclosed for determining whether a test compound modulates the activity of an enzyme having a metallated active site. The assay method employs a comparison of the binding ability of the metallated and unmetallated forms of the enzyme to the t...	05/27/2003
6569662	Nucleic acids and polypeptides The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof....	05/27/2003
6528618	Anti-inflammatory peptides derived from C-reactive protein A peptide corresponding to positions 62-71 of the sequence of human C-reactive protein (CRP) of the formula: Glu62 -Ile-Leu-Ile-Phe-Ser-Lys-ASP-Ile71 and modifications thereof obtained by substitution, deletion, or addition of amino ...	03/04/2003
6489143	Mutant plasminogen activator-inhibitor type 1 (PAI-1) proteins Mutants of the human PAI-1 protein are described which are inhibitors of neutrophil elastase or are inhibitors of vitronectin (Vn)-dependent cell migration These mutants preferably comprise one or two amino acid substitutions in the reactive center loop o...	12/03/2002
6485956	Testis-specific human SVPH1-8 proteinase The disclosure provides purified and isolated SVPH1-8 polypeptides, nucleic acids encoding such polypeptides, processes for production of recombinant forms of such polypeptides, antibodies generated against such polypeptide, and fragmented peptides derive...	11/26/2002
6399759	Ant proteases and methods of inhibition The present invention provides polypeptides, including chymotrypsin-like polypeptides and elastase-like polypeptides, having amidolytic acitivity for cleavage of a peptide bond present in a target polypeptide. The polypeptides can be isolated from ants, i...	06/04/2002
6277618	Recombinant blood-coagulation proteases The invention relates to a non-glycosylated protein with enzymatic and serin protease activity, the zymogenous form thereof comprising the following domains of a protease of the factor IX family: (a) a catalytic domain, N-terminal bonded with (b) a zymoge...	08/21/2001
6239106	Family of protease inhibitors, and other biologic active substances The invention relates to novel protease-inhibitors which are obtainable from leeches. It also relates to uses thereof, for instance as a medicament, thus pharmaceutical preparations are provided, as are derivatives, mutants, genes encoding, vectors compri...	05/29/2001
6184021	Catalytically-active gelatinase mutant A truncated mutant of the 92 kDa gelatinase is disclosed which is catalytically active comparable to the full-length enzyme but, unlike the full-length enzyme, is essentially inactive against insoluble elastin. The truncated mutant preferably comprises re...	02/06/2001
6184346	Protease inhibitors derived from guamerin The present invention relates to peptides inhibiting elastase and subtilisin activity, which are derived from Guamerin, an elastase-inhibiting protein isolated from a Korean leech, Guameri(Hirudo nipponia). Since the peptides of the invention permit their...	02/06/2001
6150152	Human macrophage metalloelastase A novel 54 kDa human macrophage metalloelastase (HME) having elastolytic activity and the cDNA which encodes for this enzyme are disclosed....	11/21/2000
6146626	Defined enzyme mixtures for obtaining cells and treating wounds The invention relates to the use of mixtures of defined composition of purified enzymes from Clostridium histolyticum for obtaining, in a reproducible, standardized manner, cells or tissue fragments from human or animal tissues, and to these enzymes and m...	11/14/2000
6107075	Human elastase IV Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial wa...	08/22/2000
6103498	Mutant plasminogen activator-inhibitor type 1 (PAI-1) and uses thereof Mutants of the human PAI-1 protein are described which are inhibitors of neutrophil elastase or are inhibitors of vitronectin (Vn)-dependent cell migration. These mutants preferably comprise one or two amino acid substitutions in the reactive center loop ...	08/15/2000
6040155	Multifunctional protein and DNA sequence encoding same The present invention provides nucleic acid and corresponding amino acid sequences of a multifunctional protein that has been found to be useful in numerous medical and cosmetic contexts. A protein having "multifunctional activity," is defined herein as i...	03/21/2000
6020151	Process for the production of 7-ADCA via expandase activity on penicillin G A process is taught for the preparation and recovery of 7-aminodesacetoxycephalosporanic acid (7-ADCA) via enzymatic ring expansion activity on penicillin G, using a Penicillium chrysogenum transformant strain expressing expandase....	02/01/2000
6011001	Method of protein therapy by orally administering crosslinked protein crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin...	01/04/2000
6004768	Biosensors, extracorporeal devices and methods for detecting substances using crosslinked protein crystals Proteins such as enzymes and antibodies are immobilized by crosslinking crystals of the proteins such as microcrystals having a cross-section of 10-1 mm or less with a multifunctional crosslinking agent. The crosslinked protein crystals may be ...	12/21/1999
5976529	Methods of enzyme therapy by orally administering crosslinked enzyme crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin...	11/02/1999
5900400	Serine protease inhibitor analogs Analogs of the serine protease inhibitors in which the amino acid sequence is varied slightly are disclosed, which analogs variously show improved properties including improved resistance to oxidative inactivation, improved ability to inhibit pancreatic e...	05/04/1999
5858357	Pharmaceutical composition containing an isolated protease proenzyme, amylase, and aprotinin The invention is directed to a pharmaceutical preparation with a modulatory effect on malignant tumors, which contains a combination of protease proenzymes and amylases in a ratio between 1:100 and 100:1 in enzymatic activity units, and a protease inhibit...	01/12/1999
5851814	Human elastate IV Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial wa...	12/22/1998
5849296	Crosslinked protein crystals A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent. The crosslinked protein crystals may be lyophilized for storage. A preferred protein is an enzyme such as thermolysin...	12/15/1998
5811252	Modified proenzymes as substrates for proteolytic enzymes Detection or determination of a protease in a sample by incubating the sample with a substrate of the protease and observing proteolytic cleavage of said substrate. The substrate is a modified proenzyme containing a recognition site, e.g., an activation s...	09/22/1998
5801022	Method of producing a product with crosslinked crystals of thermolysin A protein such as an enzyme or antibody is immobilized by crosslinking crystals of the protein with a multifunctional crosslinking agent such as glutaraldehyde, and if desired lyophilizing the crosslinked crystals for storage. Crosslinking of the protein ...	09/01/1998
5736512	Serine protease variants having peptide ligase activity The invention relates to serine protease variants derived from precursor serine proteases via recombinant and/or chemical methods to form protease variants having improved peptide ligase activity. The invention also includes novel ligation substrates whic...	04/07/1998
5734034	Nucleic acid ligand inhibitors of human neutrophil elastase Methods are described for the identification and preparation of nucleic acid ligands to human neutrophil elastase. Included in the invention are specific RNA and DNA ligands to elastase identified by the SELEX method....	03/31/1998
5714342	Compositions for the detection of protease in biological samples and methods of use therefo The present invention provides for novel reagents whose fluorescence increases in the presence of particular proteases. The reagents comprise a characteristically folded peptide backbone each end of which is conjugated to a fluorophore. When the folded pe...	02/03/1998
5710035	Human elastase IV Human elastase IV polypeptides and DNA (RNA) encoding such polypeptides and a procedure for producing such polypeptide by recombinant techniques and utilizing such polypeptide for therapeutic purposes, for example, restoration of elasticity of arterial wa...	01/20/1998

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Class 435/218 - Elastase