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Class 435/208 - Acting on alpha-galatose-glycoside bond (e.g., alpha-galactosidase, etc.)


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the enzyme catalyzes the hydrolysis
No. of patents: 110
Last issue date: 11/15/2011


1      
NumberTitleIssue Date
8058047α-galactosidase with transgalactosylating activity
The present invention concerns a new α-galactosidase with transgalactosylating activity isolated from Bifidobacterium bifidum. The α-galactosidase is capable of converting mellibiose to α-galactobiose disaccharides which may be incorporated into numerous f...
11/15/2011
7560262Polynucleotide sequences encoding alkaline α-galactosidases and methods of using same
The present invention provides a method of identifying alkaline-α-galactosidases. Also provided are polynucleotide sequences encoding polypeptides having an alkaline-α-galactosidase activity, oligonucleotides and oligonucleotide analogs derived from the polynucleo...
07/14/2009
7341720Targeting of glycoprotein therapeutics
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polyme...
03/11/2008
7329524Agarase and gene thereof
Production of efficiently producing agaro-oligosaccharide; a polypeptide having an agarase activity which is usable in, for example, efficiently extracting a substance such as a nucleic acid from an agarose gel; the amino acid sequence of the polypeptide; a gene enc...
02/12/2008
7238858Coffee plant with reduced α-D-galactosidase activity
The present invention relates to the modification of galactomannans present in the green coffee bean by reducing the endogenous level of α-D-galactosidase activity. In particular, the present invention pertains to a plant cell with reduced α-D-galactosidase activi...
07/03/2007
7223570Branched cyclic tetrasaccharide, process for producing the same, and use
The object of the present invention is to provide a novel glycosyl derivative of cyclotetrasaccharide represented by cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→}, and it is solved by provi...
05/29/2007
7192746α-Isomaltosyltransferase, process for producing the same and use thereof
The object of the present invention is to provide an α-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1...
03/20/2007
7148054Evolution of whole cells and organisms by recursive sequence recombination
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties Examples of such properties include enhanced recombinogenicity, genome copy number,...
12/12/2006
7141582Method for enhancing mutant enzyme activities in Gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method ...
11/28/2006
7074605α-N-acetylgalactosaminidase from
An isolated and purified α-N-acetyl-D-galactosaminidase from Clostridium perfringens and homologs thereof are disclosed. A method for purifying and isolating the α-N-acetylgalactosaminidase from Clostridium perfringens by removing neuramidases is dis...
07/11/2006
7067127GIcNAc phosphotransferase of the lysosomal targeting pathway
The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ...
06/27/2006
7059993Thermal tolerant cellulase from
The invention provides a thermal tolerant cellulase that is a member of the glycoside hydrolase family. The invention further discloses this cellulase as GuxA. GuxA has been isolated and characterized from Acidothermus cellulolyticus. The invention further pr...
06/13/2006
7058515Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ...
06/06/2006
7056691Assays for identifying α-galactosidases
The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increas...
06/06/2006
7049105Modified alternan
Four new Penicillium spp. isolates (NRRL 21966, NRRL 21967, NRRL 21968, and NRRL 21969) are capable of essentially quantitative conversion of native alternan to a polymeric modified form having a lower apparent molecular weight than native alternan. A fifth i...
05/23/2006
7034128Method for recovering proteins from the interstitial fluid of plant tissues
A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr...
04/25/2006
7024312Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ...
04/04/2006
7011831Recombinant α-galactosidase A therapy for Fabry disease
Fabry disease results from an X-linked deficiency in the enzyme α-galactosidase A. The present invention is directed to recombinant human α-galactosidase A and provides baculovirus expression vectors and recombinant virus that provide stable expression of extracel...
03/14/2006
7001994Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins
Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biolog...
02/21/2006
6987009αgalactosidases and methods of using them
A thermostable alpha-glycosidase derived from various Thermococcus, alcaliphilus AEDII12RA is disclosed. The enzymes are produced from native or recombinant host cells and can be utilized in the food processing industry. ...
01/17/2006
6987016α-galactosidases and methods for making and using them
The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increas...
01/17/2006
6949369α-galactosidases and methods for making and using them
The invention relates to α-galactosidase and to polynucleotides encoding the α-galactosidase. In addition methods of designing new α-galactosidases and method of use thereof are also provided. The α-galactosidases have increased activity and stability at increas...
09/27/2005
6936454Compositions for fracturing subterranean formations
A method of fracturing a subterranean formation which surrounds a well bore comprises the steps of providing a fracturing fluid, and injecting the fracturing fluid into the well bore at a pressure sufficient to form fractures in the subterranean formation which surr...
08/30/2005
6917882Methods for making character strings, polynucleotides and polypeptides having desired characteristics
“In silico” nucleic acid recombination methods, related integrated systems utilizing genetic operators and libraries made by in silico shuffling methods are provided. ...
07/12/2005
6916829Method for enhancing mutant enzyme activity in gaucher disease
Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method ...
07/12/2005
6905856Soluble GlcNAc phosphotransferase
The present invention relates to a soluble GlcNAc phosphotransferase, a method of making the same and a method of phosphorylating with the same. ...
06/14/2005
6890748Production of lysosomal enzymes in plants by transient expression
The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc...
05/10/2005
6887696Production of lysosomal enzymes in plants by transient expression
The invention relates to α-galactosidase truncated at the carboxy terminus and the production of enzymatically active recombinant human and animal lysosomal enzymes involving construction and expression of recombinant expression constructs comprising coding sequenc...
05/03/2005
6846656Process for producing N-acetylneuraminic acid
The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic...
01/25/2005
6838271Low temperature expression chitinase cDNAs and method for isolating the same
A winter wheat-derived chitinase cDNA is provided which has a nucleotide sequence corresponding to an amino acid sequence listed as SEQ. ID. No.1 in FIG. 1. Another winter wheat-derived chitinase cDNA is provided which has a nucleotide sequence corresponding ...
01/04/2005
6774135Method of enhancing lysosomal α-galactosidase A
A method of enhancing the activity of lysosomal α-Galactosidase A (α-Gal A) in mammalian cells and for treatment of Fabry disease by administration of 1-deoxy-galactonojirimycin and related compounds. ...
08/10/2004
6740509Method for the production of mucin-type glycopeptide
Methods for the production of a mucin-type glycopeptide comprising a transglycosylation using a sugar acceptor such as peptide and a sugar donor as an oligosaccharide with an endo-α-N-acetylgalactosaminidase under a given condition is disclosed. The method provides...
05/25/2004
6677137Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity
Avian and reptile derived heparanase and nucleic acids encoding same....
01/13/2004
6630339Glycine and phaseolus ଱-D-galactosidases
A DNA (SEQ ID No.:2) and amino acid (SEQ ID No.:4) sequences of Glycine ଱-D-galactosidase are provided as well as the DNA sequence (SEQ ID No:5) and mature length amino acid sequence (SEQ ID No:7) of Phaseolus....
10/07/2003
6607901Alkaline alpha-galactosidase
An enzyme isolated from an organism that metabolizes alpha-galactosyl containing saccharides, comprising an alpha-galactosidase (E.C. 3.2.1.22, alpha-D-galactoside galatohydrolase) with optimal activity in the neutral to alkaline pH range, and which hydro...
08/19/2003
6599919Method for enhancing mutant enzyme activities in lysosomal storage disorders
Method fore enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for u...
07/29/2003
6589964Method for enhancing mutant enzyme activities in lysosomal storage disorders
Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for us...
07/08/2003
6583158Method for enhancing mutant enzyme activities in lysosomal storage disorders
Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for us...
06/24/2003
6573076Gene, group of genes, and novel ଲ-glucosidase
An object of the present invention is to provide novel genes and gene group involved in cellulose synthesis of microorganisms. The present invention relates to a gene group encoding cellulase, cellulose synthase complex, ଲ-glucosidase and the like, and t...
06/03/2003
6566114Mannanases
Novel mannanases comprising e.g. an amino acid sequence as shown in positions 31-330 of SEQ ID NO:2 or their homologues may be derived from e.g. Bacillus sp. I633, or may be encoded by polynucleotide molecules comprising a nucleotide sequence as shown in ...
05/20/2003
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