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| Number | Title | Issue Date |
| 7838275 | Anti-HIV and anti-tumor peptides and fragments of lysozyme A fragment of lysozyme which contains a minimum nine amino acid sequence with antiviral, anti-tumor and bactericidal activities but lacking muramidase activity is provided. The invention also relates to pharmaceutical compositions containing this fragment and method... | 11/23/2010 |
| 7662607 | Chalaropsis lysozyme protein and its method of use in anti-bacterial applications A Chalaropsis lysozyme (Lysozyme Ch) is provided which has a corrected amino acid sequence and which can be utilized to prepare recombinant proteins having higher activity than those proteins using the incorrect sequence. Methods are also provided to reduce immunoge... | 02/16/2010 |
| 7208295 | Multiplex oligonucleotide addition and target amplification Methods for appending oligonucleotides directly to nucleic acid templates, particularly to defined sites internal to single-stranded templates, are described. Appending first and second common priming sites to each of a plurality of templates of distinct sequence al... | 04/24/2007 |
| 7205393 | Process for the isolation and purification of a glycoprotein Avidin The present invention provides a process for the preparation of Avidin having a high purity of 98% from egg white, the said process comprising lyophilizing the homogenized egg white with buffer followed by equilibrating the lyophilized material with cation exchanger... | 04/17/2007 |
| 7141582 | Method for enhancing mutant enzyme activities in Gaucher disease Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method ... | 11/28/2006 |
| 7115385 | Media and methods for cultivation of microorganisms The present invention provides culture media and methods for culturing organisms, preferably microorganisms, more preferably fastidious microorganisms. Also provided are methods of isolating and detecting organisms using the inventive culture media. ... | 10/03/2006 |
| 7087421 | Pro1278 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 08/08/2006 |
| 7087737 | Pro1278 nucleic acids The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 08/08/2006 |
| 7084255 | PRO1278 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 08/01/2006 |
| 7034128 | Method for recovering proteins from the interstitial fluid of plant tissues A method for extracting proteins from the intercellular space of plants is provided. The method is applicable to the large scale isolation of many active proteins of interest synthesized by plant cells. The method may be used commercially to recover recombinantly pr... | 04/25/2006 |
| 7001994 | Methods for introducing mannose 6-phosphate and other oligosaccharides onto glycoproteins Methods to introduce highly phosphorylated mannopyranosyl oligosaccharide derivatives containing mannose 6-phosphate (M6P), or other oligosaccharides bearing other terminal hexoses, to carbonyl groups on oxidized glycans of glycoproteins while retaining their biolog... | 02/21/2006 |
| 6916829 | Method for enhancing mutant enzyme activity in gaucher disease Method for enhancing in a mammalian cell the activity of an enzyme associated with Gaucher Disease by administering a competitive inhibitor of glucocerebrosidase in an amount effective to enhance the activity of the enzyme. Preferred compounds for use in the method ... | 07/12/2005 |
| 6858425 | Human acid alpha glucosidase gene and bovine alpha-S1 casein gene sequences The invention provides polynucleotide sequences from the human acid alpha glucosidase gene and the bovine alpha S1 casein gene. These sequences are useful for designing transgenes for expression of human acid alpha glucosidase in the milk of transgenic animals. The ... | 02/22/2005 |
| 6846656 | Process for producing N-acetylneuraminic acid The present invention provides a process for economically producing N-acetylneuraminic acid without using expensive materials such as pyruvic acid and phosphoenolpyruvic acid. The process comprises: allowing (i) a culture of a microorganism having N-acetylneuraminic... | 01/25/2005 |
| 6838271 | Low temperature expression chitinase cDNAs and method for isolating the same A winter wheat-derived chitinase cDNA is provided which has a nucleotide sequence corresponding to an amino acid sequence listed as SEQ. ID. No.1 in FIG. 1. Another winter wheat-derived chitinase cDNA is provided which has a nucleotide sequence corresponding ... | 01/04/2005 |
| 6838239 | Chitobiase as a reporter enzyme The present invention relates to reporter gene constructs encoding a cytoplasmic form of chitobiase (N,N′-diacetylchitobiase) and methods of using these reporter gene constructs. The use of a cytoplasmic form of chitobiase as a reporter enzyme is generally applica... | 01/04/2005 |
| 6776989 | Intratracheal administration of lysozyme The subject invention is directed to the treatment of respiratory disorders by intratracheal administration of an effective amount of lysozyme. Respiratory disorders include emphysema, pneumonia, respiratory distress syndrome, bronchopulmonary dysplasia, interstitia... | 08/17/2004 |
| 6743617 | Human lysozyme gene, its encoded polypeptide and the method for preparing them The invention relates to a novel member LYC3 of lysozyme gene family. The invention provides the cDNA sequence encoding for the novel lysozyme, the polypeptide encoded by the sequence, as well as the method for producing said novel human lysozyme utilizing recombina... | 06/01/2004 |
| 6677137 | Avian and reptile derived polynucleotide encoding a polypeptide having heparanase activity Avian and reptile derived heparanase and nucleic acids encoding same.... | 01/13/2004 |
| 6660512 | Human lysozyme gene, it's encoded polypeptide and the method of preparing them The invention relates to LYC4, a novel member of the lysozyme gene family. The invention provides the cDNA sequence encoding the novel lysozyme, the polypeptide encoded by the sequence, as well as methods for producing said novel human lysozyme utilizing ... | 12/09/2003 |
| 6653109 | Method of producing derivatives of lactosamine Disclosed is a method of producing a compound with 댡-4 linkage which contains the lactosamine structure involving reacting at least one donor substance GalଲOR where R is an organic group, and at least one acceptor substance which is a glucopy... | 11/25/2003 |
| 6583158 | Method for enhancing mutant enzyme activities in lysosomal storage disorders Method for enhancing in a mammalian cell the activity of an enzyme associated with a lysosomal storage disorder by administering a competitive inhibitor of the enzyme in an amount effective to enhance the activity of the enzyme. Preferred compounds for us... | 06/24/2003 |
| 6566114 | Mannanases Novel mannanases comprising e.g. an amino acid sequence as shown in positions 31-330 of SEQ ID NO:2 or their homologues may be derived from e.g. Bacillus sp. I633, or may be encoded by polynucleotide molecules comprising a nucleotide sequence as shown in ... | 05/20/2003 |
| 6541233 | ଲ-glucanase from a bacillus A ଲ-Glucanase enzyme capable of hydrolytically cleaving mixed glucans is presented. The ଲ-Glucanase is sufficiently stable under alkaline conditions for use in industrial cleaning processes, especially in the brewing industry.... | 04/01/2003 |
| 6534632 | Sialidase localized in plasma membrane DNA coding for the same The present invention provides a protein defined in the following (A) or (B), and DNA coding for the same: (A) a protein which has the amino acid sequence of SEQ ID NO: 2 or SEQ ID NO: 4, or (B) a protein which has the amino acid sequence including substitutio... | 03/18/2003 |
| 6521435 | Nucleic acid sequences encoding cell wall-degrading enzymes and use to engineer resistance to Fusarium and other pathogens The invention is directed to nucleic acid sequences derived from Fusarium fungal genes which encode the cell wall-degrading enzymes glucanase, endochitinase, and exochitinase; isolated polypeptides having glucanase, endochitinase or exochitinase activity;... | 02/18/2003 |
| 6515106 | Lysozyme-analogous polypeptides with an anti-microbial effect, their production and use The present invention relates to polypeptides exhibiting antibiotic, and anti-viral and anti-cancer effects. In particular, the invention relates to modified T4 lysozyme, polypeptides comprising fragments of T4 lysozyme and to the production and use there... | 02/04/2003 |
| 6500658 | Xyloglucanase from Malbranchea An isolated or purified polypeptide having xyloglucanase activity which is obtained from a strain of the genus Malbranchea and has xyloglucanase activity in the pH range 4-11, measured at 50° C.; and/or a molecular mass of 25&#b1;10 kDa, as determined by... | 12/31/2002 |
| 6436688 | Human lysozyme gene, its encoding polypeptide and the method preparing for them The invention relates to a novel member LYC2 of lysozyme gene family. The invention provides the cDNA sequence encoding for the novel lysozyme, the polypeptide encoded by the sequence, as well as the method for producing said novel human lysozyme utilizin... | 08/20/2002 |
| 6426208 | Recombinant -L-iduronidase, methods for producing and purifying the same and methods for treating diseases caused by deficiencies thereof The present invention provides a recombinant -L-iduronidase and biologically active fragments and mutants thereof, methods to produce and purify this enzyme as well as methods to treat certain genetic disorders including- -L-iduronidase defi... | 07/30/2002 |
| 6416754 | Anaerobe targeted enzyme-mediated prodrug therapy A genetically-engineered anaerobic organism is provided which, under anaerobic conditions present in a solid tumor, produces an enzyme capable of catalyzing the conversion of a prodrug to its highly cytotoxic product in situ and methods of treating tumors... | 07/09/2002 |
| 6391549 | Monitoring gene expression A method and system for detecting a parameter of a host cell, a cell culture or medium is provided. A host cell is transfected with an expressible DNA sequence which is under expression control of an inducible promoter sequence. The promoter sequence is i... | 05/21/2002 |
| 6329185 | Enzyme with galactanase activity The present invention relates to an enzyme with galactanase activity, a DNA construct encoding the enzyme, a method of producing the enzyme, an enzyme composition comprising the enzyme, and the use of the enzyme and enzyme composition for a number of indu... | 12/11/2001 |
| 6319498 | Modulators of amyloid aggregation Compounds that modulate the aggregation of amyloidogenic proteins or peptides are disclosed. The modulators of the invention can promote amyloid aggregation or, more preferably, can inhibit natural amyloid aggregation. In a preferred embodiment, the compo... | 11/20/2001 |
| 6316236 | Lysozyme dimer A method is provided for preparing a highly purified lysozyme dimer product which comprises dimerizing the lysozyme monomer with a suberimidate coupling reagent in a buffer solution adjusted to pH 10, stopping the dimerization at a given point by lowering... | 11/13/2001 |
| 6274565 | Inhibitor of activation of .beta.-glucan recognition protein The present invention relates to an inhibitor of an activation of .beta.-glucan recognition protein in a body fluid of an insect comprising a sugar compound comprising plural member of sugar residues, at least one of which have a substituent at the 6-posi... | 08/14/2001 |
| 6270827 | Infant formula compositions and method of making Compositions containing human milk proteins, including the so-called host resistance factors of human milk, prepared by chemically synthesizing the human milk proteins or by genetic engineering techniques for producing recombinant human milk proteins, are... | 08/07/2001 |
| 6255096 | Synthetic mammalian -n-acetylglucosaminidase and genetic sequences encoding same The present invention relates generally to mammalian -N-acetyglucosaminidase and to genetic sequences encoding same and to their use in the investigation, diagnosis and treatment of subjects suspected of or suffering from -N-acetylglucosamin... | 07/03/2001 |
| 6194201 | Expression system for anaerobic gene expression in higher plants The present invention relates to an expression system for anaerobic gene expression in higher plants. The expression system comprises the promoter GapC4 or a fragment or variant and a gene to be expressed. A concrete field of application of the present in... | 02/27/2001 |
| 6159719 | Pan-bacterial and pan-fungal identification reagents and methods of use thereof Murein binding polypeptide and antibiotic diagnostic reagents, methods and kits for detecting eubacteria and fungus in biological samples.... | 12/12/2000 |
