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| Number | Title | Issue Date |
| 8187855 | Large-scale production of soluble hyaluronidase Provided are methods for preparing large-scale preparations of soluble hyaluronidases. The methods employ cells that contain a plurality of active copies of nucleic acid encoding the soluble hyaluronidase and a plurality of feedings and temperature changes, whereby ... | 05/29/2012 |
| 8124394 | Polypeptides having cellobiohydrolase II activity and polynuleotides encoding same The present invention relates to isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as ... | 02/28/2012 |
| 8030049 | Galactosidase with α-galactosyltransferase activity The present invention concerns a β-galactosidase with transgalactosylating activity isolated from Bifidobacterium bifidum. The β-galactosidase is capable of converting lactose to a mixture of oligosaccharides which are β-linked and unexpectedly produces th... | 10/04/2011 |
| 8017371 | Hybrid polypeptide of a maltogenic alpha-amylase and a cyclodextrin glucanotransferase The inventors realized that the diversity generated by conventional methods may be limited by steric hindrance between amino acid residues in the three-dimensional structures of the resulting polypeptides. The steric hindrance may occur between amino acid residues a... | 09/13/2011 |
| 7892805 | Method of enhancing enzyme activity and enzyme solution having enhanced activity A method of enhancing the intrinsic activity of an enzyme in a raw enzyme solution, the method comprising treating the raw enzyme solution with an effective amount of a purifying agent, most preferably, activated carbon, to effect the enhancement and provide an enzy... | 02/22/2011 |
| 7855063 | Partially deglycosylated glucocerebrosidase polypeptide and crystals thereof A method of identifying a compound capable of correcting an impaired enzymatic activity of a mutant glucocerebrosidase molecule, the method comprising: (a) obtaining a first set of structure coordinates, the first set of structure coordinates defining a 3D structure... | 12/21/2010 |
| 7785855 | Nucleic acids encoding polypeptides having amylase activity and methods of making and using them The invention relates to nucleic acids encoding polypeptides having amylase activity, and methods for making and using them. In one aspect, the polypeptides having amylase activity have increased activity and stability at acidic, neutral and alkaline pH and increase... | 08/31/2010 |
| 7785856 | Acid alpha-glucosidase and fragments thereof Targeted acid alpha-glucosidase therapeutics that localize to the lysosome are provided. The targeted therapeutics include a therapeutic agent, GAA, and a targeting moiety that binds a receptor on an exterior surface of the cell, permitting proper subcellular locali... | 08/31/2010 |
| 7781201 | Polypeptides having amylase activity and methods of making and using them This invention relates generally to polypeptides and peptides having an amylase activity, e.g., enzymes, polynucleotides encoding the enzymes, the use of such polypeptides and peptides. In one aspect, the polypeptides having amylase activity have increased activity ... | 08/24/2010 |
| 7767429 | Soluble hyaluronidase glycoprotein (sHASEGP), process for preparing the same, uses and pharmaceutical compositions comprising thereof The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGP's), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally ... | 08/03/2010 |
| 7695947 | Modified xylanases exhibiting increased thermophilicity and alkalophilicity The present invention pertains to modified xylanase enzymes that exhibit increased thermostability and alkalophilicity, when compared with their native counterparts. Several modified xylanases exhibiting these properties are disclosed including xylanases with at lea... | 04/13/2010 |
| 7670819 | Polynucleotides encoding polypeptides having beta-glucosidase activity The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as m... | 03/02/2010 |
| 7670820 | Chitinase and uses thereof Disclosed herein are novel chitinase polypeptides and nucleic acids encoding the polypeptides. Also disclosed are related vectors, host cells, compositions, and uses. ... | 03/02/2010 |
| 7662606 | β-agarase isolated from , preparation process and uses thereof The present invention relates to the cloning and expression of a novel β-agarase gene, agaB1, and a novel β-agarase, AgaB1, encoded from the gene. The present invention also provides a method for producing the β-agarase, and the utilization of the β-agarase.... | 02/16/2010 |
| 7655449 | β-fructofuranosidase variants An object of the present invention is to provide a β-fructofuranosidase variant whose reaction specificity is improved to be suitable for the production of fructooligosaccharides. According to the present invention, there is provided a β-fructofuranosidase variant... | 02/02/2010 |
| 7629158 | Cleaning and/or treatment compositions This invention relates to compositions comprising certain amylase variants and processes for making and using such compositions including the use of such compositions to clean and/or treat a situs. ... | 12/08/2009 |
| 7582463 | Non-reducing saccharide-forming enzyme, trehalose-releasing enzyme, and process for producing saccharides using the enzymes A non-reducing saccharide-forming enzyme and a trehalose-releasing enzyme, which have an optimum temperature in a medium temperature range, i.e., a temperature of over 40 or 45° C. but below 60° C.; and an optimum pH in an acid pH range, i.e., a pH of less than 7.... | 09/01/2009 |
| 7527958 | Truncated 1,3-1,4-β-D-glucanase A truncated 1,3-1,4-β-D-glucanase. Also disclosed are related nucleic acid, vector, host cell, and preparation method. ... | 05/05/2009 |
| 7510860 | Xylanases with enhanced thermophilicity and alkalophilicity The present invention provides a xylanase, or a modified xylanase enzyme comprising at least one substituted amino acid residue at a position selected from the group consisting of amino acid 11, 116, 118, 144 and 161, the position determined from sequence alignment ... | 03/31/2009 |
| 7445922 | -derived endoglucanase enzyme lacking cellulose-binding domain This invention relates to a protein that is a Zygomycetes-derived endoglucanase lacking the cellulose-binding domain and exhibits endoglucanase activity, and a method for using the same. This invention can enhance effects of an endoglucanase enzyme on fabric ... | 11/04/2008 |
| 7432099 | Amylase variants The present invention relates to variants (mutants) of polypeptides, in particular Termamyl-like alpha-amylases, which variant has alpha-amylase activity and exhibits an alteration in at least one of the following properties relative to said parent alpha-amylase: su... | 10/07/2008 |
| 7407677 | Enzymes having alpha amylase activity and methods of use thereof The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at acidic, neutral ... | 08/05/2008 |
| 7393929 | Inhibitors of cellulolytic, xylanolytic and β-glucanolytic enzymes The present invention concerns an inhibitor of xylanolytic and/or β-glucanolytic enzymes, method for obtaining the inhibitor, said inhibitor and processes for obtaining micro-organism, plant or plant material wherein the activity of the inhibitor according to the i... | 07/01/2008 |
| 7378264 | α-amylase mutants The present invention relates to a method of constructing a variant of a parent Termamyl-like α-amylase, which variant has α-amylase activity and at least one altered property as compared to the parent α-amylase, comprises i) an... | 05/27/2008 |
| 7371552 | Polypeptide We disclose a food additive comprising a PS4 variant polypeptide, in which the PS4 variant polypeptide is derivable from a parent polypeptide having non-maltogenic exoamylase activity, in which the PS4 variant polypeptide comprises substitutions at the following pos... | 05/13/2008 |
| 7354576 | Methods of treating diseases caused by deficiencies of recombinant α-L-iduronidase The present invention provides a formulation comprising a pharmaceutical composition comprising a human recombinant α-L-iduronidase or biologically active or muteins thereof with a purity of greater than 99%, or in combination with a pharmaceutically acceptable car... | 04/08/2008 |
| 7351410 | Treatment of Pompe's disease The invention provides methods of treating Pompe's disease using human acid alpha glucosidase. A preferred treatment regime comprises administering greater than 10 mg/kg body weight per week to a patient. ... | 04/01/2008 |
| 7335503 | Expression of granular starch hydrolyzing enzyme in The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity. ... | 02/26/2008 |
| 7323322 | Ethanol production from transformed microorganisms This invention provides transformed microorganisms which can produce ethanol from cellooligosaccharide, by introducing β-glucosidase gene by recombinant DNA method, into microorganisms belonging to genus Zymobacter which cannot utilize cellooligosaccharide. | 01/29/2008 |
| 7312056 | Enhancement of enzyme activity through purification and immobilization An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and active centre species to produce a modified support; (b) isolating the m... | 12/25/2007 |
| 7273740 | Enzymes having alpha amylase activity and methods of use thereof The invention relates to alpha amylases and to polynucleotides encoding the alpha amylases. In addition methods of designing new alpha amylases and methods of use thereof are also provided. The alpha amylases have increased activity and stability at increased pH and... | 09/25/2007 |
| 7273741 | Copper tolerant yeast and pectinases produced by the yeast The object of the present invention is to provide a yeast which is tolerant to copper and which can incorporate copper at a high concentration, and also a method of removing or recovering copper from extracellular solution. The present invention is copper-tolerant y... | 09/25/2007 |
| 7262041 | Expression of granular starch hydrolyzing enzyme in The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity. ... | 08/28/2007 |
| 7259232 | Preferred segments of neural thread protein The invention is directed to preferred repeat sequences of Neural Thread Protein (NTP), peptides, mimetics, antibodies, and nucleic acids of the preferred sequences, and diagnostic and therapeutic methods of using such preferred NTP sequences. ... | 08/21/2007 |
| 7244605 | Polypeptides having beta-glucosidase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having beta-glucosidase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as m... | 07/17/2007 |
| 7241442 | Method for producing proteins suitable for treating lysosomal storage disorders The present invention is based on the discovery that proteins produced in insect cell cultures are glycosylated in a unique manner that causes them to be selectively imported by cells that express mannose receptors on their membranes, particularly macrophages. Prote... | 07/10/2007 |
| 7220695 | Supported activator This invention relates to supported activators comprising the product of the combination of an ion-exchange layered silicate, an organoaluminum compound, and a heterocyclic compound, which may be substituted or unsubstituted. This invention further relates to cataly... | 05/22/2007 |
| 7214373 | Methods, compositions and kits relating to chitinases and chitinase-like molecules and inflammatory disease The present invention includes compositions and methods for the treatment of inflammatory disease (e.g., asthma, COPD, inflammatory bowel disease, atopic dermatitis, atopy, allergy, allergic rhinitis, scleroderma, and the like), relating to inhibiting a chitinase-li... | 05/08/2007 |
| 7205120 | Substrates and assays for β-secretase activity The present invention is directed to novel substrates for Hu-Asp. More particularly, the invention provides peptide substrates and fusion polypeptide substrates comprising a β-secretase cleavage site. Methods and compositions for making and using the peptides are d... | 04/17/2007 |
| 7192746 | α-Isomaltosyltransferase, process for producing the same and use thereof The object of the present invention is to provide an α-isomaltosyl-transferring enzyme which forms a cyclotetrasaccharide having the structure of cyclo{→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1→6)-α-D-glucopyranosyl-(1→3)-α-D-glucopyranosyl-(1â... | 03/20/2007 |
