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| Number | Title | Issue Date |
| 8163470 | Simulated 5-part differential leukocyte granules, the method for preparing the same and control products and calibrators comprising the same A method for preparing five-part differential leukocyte analogs from red blood cells includes selecting appropriate red blood cells; treating the red blood cells with a multi-functional reagent system for maintenance of a structural integrity of the membranes of the... | 04/24/2012 |
| 8158339 | Method of preserving a platelet concentrate under elevated xenon concentration and pressure with refrigeration Provides are improved methods for storing platelets and compositions that contain stored platelets for use in transfusions. The method entails obtaining a platelet concentrate from blood obtained from an individual and holding the platelet concentrate in at refriger... | 04/17/2012 |
| 8142993 | Method of preparing neutrophil-depleted platelet-rich plasma Methods of producing neutrophil-depleted platelet-rich plasma by passing a blood, platelet or platelet-rich plasma fraction through a narrow, twisted and/or charged environment to remove neutrophils and produce neutrophil-depleted platelet-rich plasma is described. ... | 03/27/2012 |
| 8142992 | Platelet preservation package comprising a short to ultra-short acting antiplatelet agent and anticoagulant with an oxygen carrier The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an antico... | 03/27/2012 |
| 8137903 | Method for magnetic separation of red blood cells from a patient sample A method for separating components from a patient sample is provided. In particular, the present invention provides a method for the separation of red blood cells or red blood cell components from a patient sample by the use of magnetic beads. ... | 03/20/2012 |
| 8129104 | Platelet preservation composition comprising a short to ultra-short acting antiplatelet agent and anticoagulant with hemoglobin The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an antico... | 03/06/2012 |
| 8129103 | Use of a platelet preservation composition comprising a short to ultra-short acting antiplatelet agent and anticoagulant with an oxygen carrier The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an antico... | 03/06/2012 |
| 8114580 | Simulation of normal fresh blood platelets for reference control The present invention provides for novel analogs of fresh human platelets for use in hematological instrument. Methods for preparing such analogs are also described. ... | 02/14/2012 |
| 8097403 | Freeze-dried platelets, method of making and method of use as a diagnostic agent The present invention provides freeze-dried platelets and compositions comprising freeze-dried platelets for use as a diagnostic and calibration reagent for blood coagulation function. The invention also provides methods of diagnosing or monitoring blood coagulation... | 01/17/2012 |
| 8071282 | Method of storing red blood cells with an acidic additive solution under oxygen depletion There is provided compositions and methods for the storage of red blood cells. The compositions are additive solutions comprising adenine, dextrose, mannitol, NaH2PO4, and optionally NaCl and/or NH4Cl. Composition are preferably used... | 12/06/2011 |
| 8067151 | Cold storage of pegylated platelets at about or below 0° C. A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded ... | 11/29/2011 |
| 8062837 | Plasma-depleted, not erythrocyte-depleted, cord blood compositions and method of making The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a ... | 11/22/2011 |
| 8048620 | Method for enhancing the detection of contamination in a cellular blood product by covalently binding a hydrophilic polymer to the cell membrane A method for preventing bacterial biofilm formation in a blood product, the method comprising modifying a blood product with a polymer selected from the group consisting of polyethylene glycol (PEG), PEG derivatives and mixtures thereof. Preventing bacterial biofilm... | 11/01/2011 |
| 8048619 | Method of treating a hematopoietic associated disease or disorder with plasma-depleted, but not erythrocyte-depleted cord blood compositions The umbilical cord blood (UCB) compositions of the present invention possess the unique features of having plasma that is substantially depleted from the UCB unit and red blood cells (RBC) that are not depleted from the UCB unit. Such UCB units can be prepared by a ... | 11/01/2011 |
| 8029978 | Processing method for the long-term stabilization of biological red blood cell volume The present invention relates to a processing method for long-term stabilization of biological red blood cell volume. The red blood cells can be further used in reference materials and calibrators of a hematology analyzer. The method of the present invention compris... | 10/04/2011 |
| 7989159 | Platelet additive solution with a viscosity of 1.128-1.228 centipoise @ 37C comprising hydroxyethyl starch and methods of making and using Disclosed is a platelet additive solution (PAS) comprising a viscosity increasing agent. The use of a PAS comprising such a viscosity increasing agent, especially at concentrations effective to achieve a viscosity similar to that of blood plasma, promotes platelet r... | 08/02/2011 |
| 7981597 | Method for preparing agglutinatable, fixed platelet fragments The present invention relates to a method for preparing agglutinatable platelet fragments, in which native platelets are treated with ultrasound and a fixative. The platelet fragments are suitable for use in diagnostic assay methods which include an agglutination re... | 07/19/2011 |
| 7972767 | Method for culturing mesenchymal stem cell and method for producing biological tissue prosthesis The purpose is to proliferate a mesenchymal stem cell to a sufficient degree while reducing the amount of blood serum contained in a biological tissue progenitor cell to be grafted, and to efficiently differentiate the mesenchymal stem cell into the biological tissu... | 07/05/2011 |
| 7968279 | Reference control for cell by cell analysis A reference control for cell by cell analysis on flow cytometric analyzers contains cellular analogs made of permeated blood cells containing therein aggregated intracellular proteins and preserved antigenic sites thereof, having cellular membrane permeable to antib... | 06/28/2011 |
| 7964339 | Cold storage of modified platelets A method for storing and using platelets and an associated platelet structure. At least one modified platelet is formed. Each modified platelet includes a platelet and at least one polymerated chemical. Each polymerated chemical includes a polymer covalently bonded ... | 06/21/2011 |
| 7964338 | Platelet preservation composition containing eptifibatide, a reversible factor IIa inhibitor and a hemoglobin oxygen carrier The present invention relates to compositions and methods for storing platelets to preserve the function and freshness of the platelets. More particularly, the present invention relates to the use of a preservative composition having an antiplatelet agent, an antico... | 06/21/2011 |
| 7960098 | Methods and compositions for the preservation of cells and tissues Disclosed are methods for the preservation and storage of living biological tissues, organs, and populations of isolated cells. Also disclosed are compositions and methods to permit biological samples (including e.g., cells, cell cultures, tissues, and organs) to be... | 06/14/2011 |
| 7960099 | White blood cell differentiation reagent containing an asymmetric cyanine fluorescent dye and method of use thereof The present disclosure provides a white blood cell differentiation reagent comprising a fluorescent dye compound of Formula I, wherein R1, R2, R3, R4, Y− and n are as defined in the specification. The present ... | 06/14/2011 |
| 7932021 | Lupus anticoagulant testing The present invention relates generally to the field of diagnostic screening and diagnostic assays. In particular, the present invention provides an improved, rapid, and efficient method of screening for antiphospholipid antibodies, such as lupus anticoagulants (LA)... | 04/26/2011 |
| 7927785 | Methods for in vitro expansion of hematopoietic stem cells The invention relates to methods of obtaining compositions for generating multipotent hematopoietic stem progenitor cells comprising expansion of hematopoietic stem cells in the presence of HDACI and IDM. Methods of obtaining compositions enriched in hematopoietic m... | 04/19/2011 |
| 7923203 | Method of use of a platelet/nucleated cell concentrate from bone marrow or blood to treat a bone defect The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specifi... | 04/12/2011 |
| 7897328 | Blood group antigens of different types for diagnostic and therapeutic applications The present invention provides compositions and methods for treating or preventing antibody mediated graft rejection and blood typing. ... | 03/01/2011 |
| 7892725 | Process for storing a sperm dispersion Processes of storing sorted and unsorted spermatozoa, in the form of a sperm dispersion, having reduced motility relative to endogenous ejaculated sperm are disclosed. The immotile spermatozoa of the dispersion tend to have a greater capacity for enduring the rigors... | 02/22/2011 |
| 7892726 | Method for sterilizing lyophilized eukaryotic anuclear cells with gamma irradiation The invention provides a method for the sterilization of a biological preparation comprising desired viable biological entities. The method comprises irradiating a dried (e.g. freeze-dried) biological preparation with ionizing or UV radiation at an intensity and for... | 02/22/2011 |
| 7867699 | Method of synthesizing and purifying Dkk proteins and Dkk proteins obtained thereby The invention relates to a novel method of inexpensively synthesizing large quantities of an essentially pure, biologically active, glycosylated Dkk protein, including mammalian and human Dkk proteins (e.g., human Dkk1). The invention further relates to the syntheti... | 01/11/2011 |
| 7858296 | Preparation of a platelet/nucleated cell concentrate from bone marrow or blood The present invention is directed to methods and compositions regarding the preparation of an cell concentrate, such as, for example, an osteogenic cell concentrate, from a physiological solution, such as bone marrow aspirate, blood, or a mixture thereof. In specifi... | 12/28/2010 |
| 7858295 | Methods for prolonging survival of platelets using UDP-galactose The present invention provides modified platelets having a reduced platelet clearance and methods for reducing platelet clearance. Also provided are compositions for the preservation of platelets. The invention also provides methods for making a pharmaceutical compo... | 12/28/2010 |
| 7851142 | Method of reducing glycolysis in platelet concentrates using L-carnitine, alkanoyl carnitines and salts thereof Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond cu... | 12/14/2010 |
| 7846650 | Methods for reducing levels of pro-inflammatory or anti-inflammatory stimulators or mediators in the blood Devices, systems, and methods reduce levels of pro-inflammatory or anti-inflammatory stimulators or mediators in blood by selective adsorption. The devices, systems, and methods are useful in situations where abnormal levels of or unregulated or excessive interactio... | 12/07/2010 |
| 7846651 | Epitope/peptide recognized by HLA-A2402-restricted Ep-CAM-specific CTL and use of the same A peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:1; a peptide consisting essentially of the amino acid sequence represented by SEQ ID NO:2; or a mutant peptide consisting essentially of an amino acid sequence derived from the amin... | 12/07/2010 |
| 7838210 | Sperm suspensions for sorting into X or Y chromosome-bearing enriched populations Sperm cell suspensions comprising a motility inhibitor are disclosed. The cells contained in such suspensions tend to have a greater capacity for enduring the various process steps typically associated with the sorting of sperm cells into gender enriched populations... | 11/23/2010 |
| 7833697 | Endothelial stem cells, populations, methods of isolation and use thereof The present invention provides stem cells characterized as having the ability to renew and the ability to give rise to endothelial and/or endothelial-like cells, methods of isolating such stem cells and methods of use thereof. Also provided are progeny cells derived... | 11/16/2010 |
| 7820371 | Method for removing viruses and leukocytes from blood using a surface comprising hydroxyl and polyethylene glycol groups It is intended to provide a method whereby a virus and leukocytes can be simultaneously eliminated from virus-containing blood and platelets can be recovered at a high yield, and a material and an apparatus therefor. A water-soluble carrier having surface which is c... | 10/26/2010 |
| 7816073 | Method for inhibiting bacterial growth in a leuko-reduced platelet concentrate by adding L-carnitine Cell membrane maintenance of red blood cells and platelet concentrates is improved by the addition of 1 mM-10 mM L-carnitine and derivatives. This improvement allows extension of the period of viability of packed red blood cells and platelet concentrations beyond cu... | 10/19/2010 |
| 7811749 | Measuring free choline to determine suitability of erythrocytes for transfusion A method of assessing whether or not erythrocytes are suitable for transfusion into a recipient comprising (i) assaying a sample of erythrocytes for free choline, and (ii) comparing the level of free choline in the sample with the level of free choline deemed suitab... | 10/12/2010 |
