Bizarre Patents
Wearable Device For Feeding and Observing Birds and Other Flying Animals
A device for feeding and observing flying animals comprising a hat, a support mounted on the hat and extending outward from the hat, and a feeder mounted on the support.
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| Number | Title | Issue Date |
| 8182991 | FEN-1 endonucleases, mixtures and cleavage methods The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to improved cleavage means for the detection and characterization of nucleic ... | 05/22/2012 |
| 8119382 | Variant of KpnI restriction endonuclease Methods are provided for making restriction endonucleases with reduced star activity by one or more targeted mutations to a catalytic site within the restriction endonuclease. Examples of modifications to restriction endonucleases with significant sequence identity ... | 02/21/2012 |
| 8034597 | Microorganism-derived psychrophilic endonuclease A polypeptide having an endonuclease activity derived from a psychrophilic microorganism Shewanella sp. strain Ac10, which exhibits high activity at low temperatures, can remove any nucleic acid present in a protein solution and can reduce the viscosity of a ... | 10/11/2011 |
| 8034598 | Engineered cleavage half-domains Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion p... | 10/11/2011 |
| 8008055 | Thermotolerant ribonuclease H Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides. ... | 08/30/2011 |
| 7960159 | Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches ar... | 06/14/2011 |
| 7897372 | I-I meganuclease variants with modified specificity, method of preparation and uses thereof Method of preparing 1-CreI meganuclease variants having a modified cleavage specificity, variants obtainable by said method and their applications either for cleaving new DNA target or for genetic engineering and genome engineering for non-therapeutic purposes. Nucl... | 03/01/2011 |
| 7842489 | Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof A single chain homing endonuclease, comprising a first variant of I-CreI having the amino acid sequence of accession number pdb 1g9y (SEQ ID NO: 23 is residues 1-153 of pdb Ig9y) and a second variant of I-CreI variant having the amino acid sequence of accession numb... | 11/30/2010 |
| 7807431 | Detection of nucleic acid differences using combined endonuclease cleavage and ligation reactions The present invention is a method for detecting DNA sequence differences including single nucleotide mutations or polymorphisms, one or more nucleotide insertions, and one or more nucleotide deletions. Labeled heteroduplex PCR fragments containing base mismatches ar... | 10/05/2010 |
| 7527956 | Modified human acid sphingomyelinase having increased activity, and methods for making the same Deficiencies in the enzymatic activity of acid sphingomyelinase (ASM) result in Niemann-Pick disease. A variety of modifications which eliminate the activity of the free thiol on the C-terminal cysteine residue of ASM all result in substantially increased specific a... | 05/05/2009 |
| 7491524 | Human RNase III and compositions and uses thereof The present invention provides polynucleotides encoding human RNase III and polypeptides encoded thereby. Methods of using said polynucleotides and polypeptides are also provided. ... | 02/17/2009 |
| 7473542 | Cysteinized ribonuclease and targeting moiety conjugated thereto A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue. ... | 01/06/2009 |
| 7459298 | Purification, cloning and biochemical characterization of XendoU, endoribonucleasic activity involved in small nuclear RNA splicing-independent biosynthesis in Xenopus laevis Cloning and characterization of the gene for Mn++ dependent RNA-sc endoribonucleasic activity able to generate 2′-3′ cyclic phosphate and 5′OH ends. ... | 12/02/2008 |
| 7442535 | Fusion protein incorporating a cysteinized ribonuclease A fusion protein contains a cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1. ... | 10/28/2008 |
| 7442536 | Cysteinized ribonuclease and targeting moiety conjugated thereto A cysteinized variant of an RNase disclosed in U.S. Pat. No. 6,239,257 B1 is disclosed. A targeting moiety can be conjugated to the cysteine residue. ... | 10/28/2008 |
| 7439035 | Method of identifying or characterizing a compound that modulates ribonuclease H activity The invention relates to a substrate and method for the assay of ribonuclease H activity. The substrate comprises a DNA/RNA heteroduplex molecule having fluorophore and quencher molecules in close proximity, which emit a background level of fluorescence in the absen... | 10/21/2008 |
| 7432308 | Therapeutic compositions for the treatment of a respiratory tract disease The equilibrium between G actin and F actin is shifted towards the F actin confirmation with compounds such as the ionic form of magnesium or potassium. The higher amount of F actin decreases the inhibition of nucleases such as DNAse I by monomeric G actin. The incr... | 10/07/2008 |
| 7432365 | DNA molecules encoding beta clamp proteins of gram positive bacteria The present invention relates to beta protein-encoding genes from Gram positive bacterium. Expression systems and host cells containing these genes are also disclosed. ... | 10/07/2008 |
| 7429468 | Mutant B-type DNA polymerases exhibiting improved performance in PCR The present invention relates to thermostable mutants of B-type DNA polymerases comprising a Y-GG/A amino acid motif between the N-terminal 3′-5′-exonuclease domain and the C-terminal polymerase domain whereas the tyrosine of the Y-GG/A amino acid motif is mutat... | 09/30/2008 |
| 7422889 | Dre recombinase and recombinase systems employing Dre recombinase The invention provides a Dre/rox recombinase system. In particular, the invention provides Dre polypeptides that can catalyze site-specific recombination at rox sites but not at lox sites. The Dre/rox system can be utilized in a number of genetic manipulations eithe... | 09/09/2008 |
| 7422888 | Thermotolerant ribonuclease H Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides. ... | 09/09/2008 |
| 7410647 | Antigenic polypeptides A method for the identification of antigenic polypeptides, typically opsonic antigens, expressed by pathogenic microbes; vaccines comprising said antigens; and therapeutic antibodies directed to said antigenic polypeptides. ... | 08/12/2008 |
| 7399476 | Nucleic acid free ghost preparations The invention relates to preparations of bacterial ghosts which are substantially free of living bacterial cells and/or nucleic acids and their use in pharmaceutical preparations. ... | 07/15/2008 |
| 7378262 | Reversibly modified thermostable enzymes for DNA synthesis and amplification in vitro The invention relates to a composition comprising a first modified thermostable enzyme exhibiting 3′exonuclease activity but essentially no DNA polymerase activity and a second modified thermostable enzyme exhibiting DNA polymerase activity, whereas the fidelity o... | 05/27/2008 |
| 7354708 | Invasion assays The present invention relates to means for the detection and characterization of nucleic acid sequences, as well as variations in nucleic acid sequences. The present invention also relates to methods for forming a nucleic acid cleavage structure on a target sequence... | 04/08/2008 |
| 7341999 | Povidone-containing carriers for polypeptide growth factors A liquid carrier medium is provided which is suitable for solubilizing growth factors, such as mixtures of bone morphogenetic proteins, that are found to induce an angiogenic response in ischemic tissues. The liquid medium comprises an aqueous solution of polyvinyl ... | 03/11/2008 |
| 7332275 | Methods for detecting methylated nucleotides A method for detecting methylated nucleotides within a nucleic acid sample is provided. The method includes the steps of splitting a nucleic acid sample into separate reaction vessels; contacting nucleic acid in one reaction vessel with bisulfite; amplifying the nuc... | 02/19/2008 |
| 7332277 | Methods for detection of genetic disorders The invention provides a method useful for detection of genetic disorders. The method comprises determining the sequence of alleles of a locus of interest, and quantitating a ratio for the alleles at the locus of interest, wherein the ratio indicates the presence or... | 02/19/2008 |
| 7332497 | Pyrazolopyrimidines as therapeutic agents The present invention provides compounds of Formula I, including pharmaceutically acceptable salts and/or prodrugs thereof, where G, Ra, R2, and R3 are defined as described herein... | 02/19/2008 |
| 7329728 | Ligand activated transcriptional regulator proteins Fusion proteins for use as ligand-dependent transcriptional regulators are provided. The fusion proteins include a nucleotide binding domain operatively linked to a ligand-binding domain. They also can include a transcription regulating domain. The nucleotide bindin... | 02/12/2008 |
| 7309573 | Methods for detection of a nucleic acid by sequential amplification The invention relates to methods and compositions for detecting a target nucleic acid. The methods include subjecting a target, template, cleavage agent, polymerase and first, second and third oligonucleotide to reaction conditions that permit: (1) formation of a du... | 12/18/2007 |
| 7285626 | PRO1076 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 10/23/2007 |
| 7276597 | Compositions and kits for detection of a nucleic acid by sequential amplification The invention relates to nucleic acid compositions for use in sequential amplification detection assays which permit the detection of a nucleic acid target in a sample. ... | 10/02/2007 |
| 7273696 | Kits for the detection of target sequences The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided ... | 09/25/2007 |
| 7273832 | Alkali metal tungstate compositions and uses thereof Fluids, such as completion fluids, containing at least one alkali metal tungstate and optionally at least one chelating agent are described. Methods of removing a filter cake from a well bore surface, which may include one or more alkaline earth metal sulfates, is a... | 09/25/2007 |
| 7247464 | CspCI restriction endonuclease A novel restriction endonuclease has been identified from Citrobacter species 2144 (NEB#1398) which can cleave at nt sequence 5′-CAANNNNNGTGG-3′ (SEQ ID NO:13) in double-stranded DNA molecules. ... | 07/24/2007 |
| 7244603 | Purified HpyC1I and its use as a restriction endonuclease Disclosed is a novel type II restriction endonuclease. Such enzyme recognizes a particular non-palindromic sequence of 5 oligonucleotides and cleaves DNA downstream of the DNA recognition sequence of nucleotides at the fourth base in the upper strand and the fifth b... | 07/17/2007 |
| 7245247 | Analog to digital signal converter having sampling circuit with divided integrating capacitance An analog-to-digital converter (ADC) includes a modulator and a decimation filter. The modulator includes a sampling circuit, integrator, a quantizer, and feedback circuitry. The sampling circuit includes at least one sampling capacitor and a plurality of dump capac... | 07/17/2007 |
| 7241587 | Method of uncoupling the catabolic pathway of glycolysis from the oxidative membrane bound pathway of glucose conversion The invention provides methods for producing products comprising improved host cells genetically engineered to have uncoupled productive and catabolic pathways. In particular, the present invention provides host cells having a modification in nucleic acid encoding a... | 07/10/2007 |
| 7238853 | Molecular mechanisms for gene containment in plants The present invention provides a molecular mechanism for gene containment in sexually reproducing transgenic plants. The mechanism is achieved with a molecular construct comprising a blocking construct (BC) that is inserted fully or partially into an intron of a tra... | 07/03/2007 |
