Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8124393 | Compositions and methods for inducing or inhibiting activities of selected human cells Polynucleotides encoding a mutant human carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing cells t... | 02/28/2012 |
| 8080400 | Crystal structure of monoacylglycerol lipase (MGLL) A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized form of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The e... | 12/20/2011 |
| 8067220 | Alternative crystal form of monoacylglycerol lipase (MGLL) A number of soluble engineered forms of MGLL that are suitable for high-throughput screening and protein crystallization, as well as a crystallized forms of monoacylglycerol lipase protein (MGLL) and descriptions of the X-ray diffraction patterns are disclosed. The ... | 11/29/2011 |
| 8003361 | Production of monatin enantiomers Methods for preferentially hydrolyzing one stereoisomer of an isoxazoline diester over another, as well as an enzyme for facilitating the preferential hydrolysis are provided. Also provided are methods for providing mixtures of (RR) and (RS) monatin as well as (SS) ... | 08/23/2011 |
| 7932072 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error... | 04/26/2011 |
| 7927854 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error... | 04/19/2011 |
| 7923233 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error... | 04/12/2011 |
| 7910347 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritima acetyl xylan esterase gene was modified using error... | 03/22/2011 |
| 7803597 | Thermally-tolerant pectin methylesterase Enzymes accumulated in plant cell walls serve diverse physiological functions including metabolism, polysaccharide structure modification, and molecular communication in interactions with other organisms. Pectin methylesterases are economically important enzymes for... | 09/28/2010 |
| 7595181 | Thermostable esterases from thermophilic bacteria The present invention relates to a newly identified hydrolase from thermophilic microorganisms having thermostable properties, and more specifically, to a novel thermostable hydrolase showing high activity at high temperatures. ... | 09/29/2009 |
| 7556954 | MOS transistor and manufacturing method thereof Disclosed are a MOS transistor having a low resistance ohmic contact characteristic and a manufacturing method thereof capable of improving a drive current of the MOS transistor. A gate oxide layer, a gate electrode, and a spacer are formed on a silicon substrate, a... | 07/07/2009 |
| 7510859 | Subtilisin variants with improved perhydrolase activity The invention relates to novel perhydrolases, derived from the protease Carlsberg by amino acid exchange in positions 11, 15, 21, 38, 50, 54, 58, 77, 83, 89, 93, 96, 107, 117, 120, 134, 135, 136, 140, 147, 150, 154, 155, 160, 161, 171, 179, 180, 181, 194, 205, 208, ... | 03/31/2009 |
| 7438904 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 10/21/2008 |
| 7422887 | Phospholipase Aand gene thereof To provide a novel phospholipase A2 (PLA2) associated with psoriasis, a nucleic acid encoding the same, a method for characterizing, identifying or screening an inhibitor for the PLA2 or a medicament; and a novel method for diagnosis... | 09/09/2008 |
| 7416867 | Enzymatic production of (meth)acrylic acid esters A method for the production of partially esterified (meth)acrylic acid esters of polyalcohols and the use thereof. ... | 08/26/2008 |
| 7405070 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is select... | 07/29/2008 |
| 7381556 | Nucleic acids encoding deallergenized proteins and permuteins Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed... | 06/03/2008 |
| 7365173 | Method for the production of pure virally inactivated butyrylcholinesterase The present invention provides a method for purifying butyrylcholinesterase from various biological fluids. Biological fluids include, e.g., blood, blood fractions, plasma, and bioreactor broths, and other such mixtures containing butyrylcholinesterase. In one embod... | 04/29/2008 |
| 7335502 | Chlorohydrin and hydroxycarboxylic ester asymmetric hydrolase gene The present invention is to provide a gene having asymmetric hydrolase activity which is useful for synthesis of an optically active carboxylic acid, its antipode ester, and lactone, and a hydroxycarboxylic ester asymmetric hydrolase enzyme (EnHCH) derived from E... | 02/26/2008 |
| 7329519 | Glucose dehydrogenase β subunit and DNA encoding the same A DNA fragment encoding a β subunit is obtained by inverse PCR using primers designed based on the nucleotide sequnece of a N-terminal signal sequence region of a GDH β subunit derived from Burkholderia cepacia KS1 strain. ... | 02/12/2008 |
| 7312062 | Lipolytic enzyme variants The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, t... | 12/25/2007 |
| 7304129 | Peptides that stimulate cell survival and axon regeneration Peptides which consist of or comprise the tetrameric peptide structural unit: Xaa-Xaa-Xaa-Xaa in which Xaa at position 1 represents Glu or Asp, Xaa at position 2 represents any amino acid, Xaa at position 3 represents any amino acid and Xaa at p... | 12/04/2007 |
| 7288400 | Nucleic acids encoding esterases and methods of making and using them The invention relates to esterases and to polynucleotides encoding the esterases. In addition methods of designing new esterase method of use thereof are also provided. The esterases have increased activity and stability at increased pH and temperature. ... | 10/30/2007 |
| 7285405 | Biosynthetic gene cluster for jerangolids Domains of jerangolid polyketide synthase and modification enzymes and polynucleotides encoding them are provided. Methods to prepare jerangolid in pharmaceutically useful quantities are described, as are methods to prepare jerangolid analogs and other polyketides u... | 10/23/2007 |
| 7273620 | Triggered release of liposomal drugs following mixing of cationic and anionic liposomes Methods and compositions for triggering the delivery of an encapsulated therapeutic agent from a liposome are provided. Liposomes of opposite charge and incorporating lipids which favor non-lamellar structures are contacted in vivo. At least one of the liposome enca... | 09/25/2007 |
| 7270984 | Polynucleotides encoding a 6-phosphogluconolactonase polypeptide from corynebacterium glutamicum Isolated nucleic acid molecules, designated sugar metabolism and oxidative phosphorylation (SMP) nucleic acid molecules, which encode novel SMP proteins from Corynebacterium glutamicum, are described. The invention also provides antisense nucleic acid molecul... | 09/18/2007 |
| 7271198 | Method of treating autoimmune diseases A method of treating an autoimmune disease comprising administering to the subject a treatment effective amount of a histone hyperacetylating agent, or a pharmaceutically acceptable salt thereof. ... | 09/18/2007 |
| 7241608 | Cat kidney disease marker In view of the increase in the number of cases with nephropathy in aged animals of the cat family, the invention provides a marker for early diagnosis of feline nephropathy which can substitute for the conventional complicated methods of diagnosing nephropathy such ... | 07/10/2007 |
| 7238511 | Preparation of deallergenized proteins and permuteins Modified proteins are disclosed that maintain enzymatic and insecticidal activity while displaying reduced or eliminated allergenicity. Epitopes which bind to anti-patatin antibodies were identified, and removed via site directed mutagenesis. Tyrosines were observed... | 07/03/2007 |
| 7238503 | Process for making fluoroleucine ethyl esters The instant invention describes a novel reaction that includes spontaneous racemization of an azalactone via enol tautomerization. This racemization results in improved yield and ee over other reactions previously described. ... | 07/03/2007 |
| 7229817 | Recombinant porcine liver esterases, their use and a method for the production thereof The invention relates to biotechnologically expressible, enzymically active recombinant porcine liver esterases, to a biotechnological method for the preparation thereof and to the use thereof in organic synthesis. The monomeric subunits of recombinant porcine liver... | 06/12/2007 |
| 7226768 | Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45... | 06/05/2007 |
| 7226771 | Phospholipases, nucleic acids encoding them and methods for making and using them The invention provides novel polypeptides having phospholipase activity, including, e.g., phospholipase A, B, C and D activity, patatin activity, lipid acyl hydrolase (LAH) activity, nucleic acids encoding them and antibodies that bind to them. Industrial methods, e... | 06/05/2007 |
| 7223582 | Esterase, its DNA, its overexpression and production of optically active aryl propionic acids using the same The present invention relates to an esterase, its DNA, its overexpression and a method for preparing an optically active aryl propionic acid of formula (1) using the same in high yield, wherein R1 repr... | 05/29/2007 |
| 7220563 | Glucose 6-oxidases Glucose oxidase enzymes are provided, including novel variants of galactose oxidase enzymes. The polynucleotides that encode these novel variants can be expressed in recombinant host cell expression systems. The novel variant oxidase enzymes are capable of oxidizing... | 05/22/2007 |
| 7211387 | DNA molecule encoding a variant paraoxonase and uses thereof This invention is directed to a DNA sequence comprising a nucleotide sequence encoding a variant paraoxonase protein and to said variant paraoxonase protein as well as a method and a kit for detecting a risk of cancer, coronary or cerebrovascular disease, hypertensi... | 05/01/2007 |
| 7192736 | Nucleic acid molecules encoding cytotoxic conjugates that contain a chemokine receptor targeting agent Nucleic acid moleucles that encode conjugates containing as a ligand a chemokine receptor targeting agent, such as a chemokine, and a targeted agent, such as a toxin are provided. These conjugates are used to treat inflammatory responses associated with activation, ... | 03/20/2007 |
| 7176010 | Isolated human protein having esterase activity and DNA encoding the same The present invention provides novel esterase proteins, Specifically, the present invention provides proteins having the same or substantially the same amino acid sequence as the amino acid sequence represented by SEQ ID NO: 1 or SEQ ID NO: 7, or salts thereof; thei... | 02/13/2007 |
| 7176011 | Lipid cleavage enzyme A membranous enzyme not yet described in the state-of-the-art can be extracted from cellular membrane fractions of blood leukocytes or monocytes/macrophages. Also disclosed is the use of substrates of this enzyme to prepare medicaments that contain these substrates ... | 02/13/2007 |
| 7166703 | PRO1561 polypeptides The present invention is directed to novel polypeptides and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of ... | 01/23/2007 |
