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| Number | Title | Issue Date |
| 8178335 | Intracellular production of a nuclease Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and a truncated nuclease in a soluble form in the cytoplasm of a host ce... | 05/15/2012 |
| 8163529 | Nicking endonuclease methods and compositions A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or glutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. ... | 04/24/2012 |
| 8143045 | Mutant phytase polypeptide The present invention relates to enzymes and processes. In particular, there is described an isolated polypeptide comprising the amino acid sequence corresponding to Citrobacter freundii phytase or a homologue, a modified form, a functional equivalent or an e... | 03/27/2012 |
| 8143046 | Variant sp. phytases having altered properties The present invention relates to variant phytase enzymes having altered properties. ... | 03/27/2012 |
| 8119381 | Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/21/2012 |
| 8101391 | Polypeptides having phytase activity and polynucleotides encoding same The present invention relates to polypeptides having phytase activity. These polypeptides have an amino acid sequence which has at least 70% identity to either of three phytases derived from the bacterium Buttiauxella, and which comprises at least one of the ... | 01/24/2012 |
| 8076115 | Polypeptides having phytase activity and polynucleotides encoding same The invention relates to Citrobacter phytases derived from Citrobacter amalonaticus, Citrobacter gillenii, and related phytases. The phytases belong to the acid histidine phosphatase family, are acid-stable, and expectedly of a high specific activity. ... | 12/13/2011 |
| 8071348 | Protein tyrosine phosphatase substrate-trapping double mutant and uses thereof The present invention provides protein tyrosine phosphatases (PTP) in which the invariant aspartate residue and the invariant glutamine residue are each replaced with a replacement amino acid residue, wherein the replacement residues together cause a reduction in ca... | 12/06/2011 |
| 8067219 | Polynucleotide encoding an ATP binding cassette transporter 1 (ABC1) polypeptide The invention features ABC1 nucleic acids and polypeptides for the diagnosis and treatment of abnormal cholesterol regulation. The invention also features methods for identifying compounds for modulating cholesterol levels in an animal (e.g., a human). ... | 11/29/2011 |
| 8062875 | Perhydrolases for enzymatic peracid generation Disclosed herein are variants enzymes that are structurally classified as CE-7 enzymes and have perhydrolysis activity. Also disclosed herein is a process for producing peroxycarboxylic acids from carboxylic acid esters using the aforementioned variant enzymes as we... | 11/22/2011 |
| 8053221 | Enzymes The present invention relates to enzymes and processes. In particular, there is described a host cell transformed or transfected with a nucleic acid encoding a bacterial phytase enzyme and variants thereof. ... | 11/08/2011 |
| 8048664 | Polynucleotides encoding modified DNA cleavage enzymes and host cells therefor Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at le... | 11/01/2011 |
| 8039240 | Recombinant human T2 RNase and uses thereof The cloning and heterologous expression of human T2 RNase6PL are disclosed. Further disclosed are methods for preventing, inhibiting and/or reversing cell motility, actin filament assembly or disassembly, proliferation, colonization, differentiation, accumulation an... | 10/18/2011 |
| 8021867 | Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity Rationally-designed LAGLIDADG (SEQ ID NO: 37) meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a... | 09/20/2011 |
| 8012731 | Phosphodiesterase and gene thereof The present invention is to provide a novel phosphodiesterase and a gene thereof, specifically, Type 11 phosphodiesterase (PDE11) and a gene thereof, more specifically, a phosphodiesterase selected from (A) a protein having an amino acid sequenced shown by SEQ.ID.NO... | 09/06/2011 |
| 8003360 | phytase Polypeptides comprising a polypeptide chosen from the group consisting of the polypeptide of SEQ ID No. 2 and a polypeptide exhibiting at least 90% identity with the polypeptide of SEQ ID No. 2. Polynucleotides selected from the group consisting of the polynucleotid... | 08/23/2011 |
| 7998719 | Crystal of a phosphatase of regenerating liver 1 (PRL-1) polypeptide and method of crystallization thereof The present invention relates to a crystal structure of PRL-1 (Phospatase of Regenerating Liver) protein and a method of crystallization thereof. It has been found that the PRL-1 protein has a tertiary structure having 5 strands of beta-sheet surrounded by 6 alpha-h... | 08/16/2011 |
| 7977079 | Nucleic acid constructs encoding cytotoxic ribonuclease variants This invention relates to altered forms of members of the RNase A superfamily. An RNase A can be modified to be cytotoxic by altering its amino acid sequence so that it is not bound easily by the ribonuclease inhibitor while still retaining catalytic properties. Whi... | 07/12/2011 |
| 7972831 | Lipases from thermophilic anaerobes The inventors have identified polypeptides having lipase activity in anaerobic thermophilic bacteria. Accordingly, the invention provides a process for hydrolyzing an ester bond in a substrate, which comprises treating the substrate with a particular lipase (a polyp... | 07/05/2011 |
| 7964383 | Perhydrolase providing improved peracid stability An acetyl xylan esterase variant having perhydrolytic activity is provided for producing peroxycarboxylic acids from carboxylic acid esters and a source of peroxygen. More specifically, a Thermotoga maritime acetyl xylan esterase gene was modified using error... | 06/21/2011 |
| 7951569 | Thermostable duplex-specific nuclease The present invention provides a thermostable duplex-specific nuclease (DSN) and a method for digesting a nucleic acid using said DSN, namely, a protein having a Brachyura-derived duplex-specific nuclease activity, a gene encoding for said protein, a recombinant vec... | 05/31/2011 |
| 7935509 | Intracellular production of a nuclease Methods and compositions are provided that relate to obtaining a recombinant DNA and RNA cleaving nuclease. This involves the over-expression of a fusion protein between maltose-binding protein and a truncated nuclease in a soluble form in the cytoplasm of a host ce... | 05/03/2011 |
| 7932071 | Thermostable ribonuclease H from A polypeptide having an RNaseH activity from Archaeoglobus profundus and being highly useful in gene engineering; a gene encoding this polypeptide; and a genetic engineering process for producing the polypeptide. ... | 04/26/2011 |
| 7923232 | Hafnia phytase The present invention relates to isolated polypeptides having phytase activity and isolated polynucleotides encoding the polypeptides. The polypeptides are related to a phytase derived from Hafnia alvei, the amino acid sequence of which is shown in the append... | 04/12/2011 |
| 7919297 | Mutants of PhyA phytase and phytase The present invention is directed to an isolated nucleic acid molecule encoding mutant phytases and the isolated mutant phytases themselves. The present invention further relates to methods of using the isolated nucleic acid molecules and the isolated mutant phytase... | 04/05/2011 |
| 7883882 | Renewable chemical production from novel fatty acid feedstocks Disclosed herein are methods of manufacturing renewable chemicals through the manufacture of novel triglyceride oils followed by chemical modification of the oils. Methods such as transesterification, hydrogenation, hydrocracking, deoxygenation, isomerization, inter... | 02/08/2011 |
| 7867743 | Polypeptides having phytase activity and polynucleotides encoding same The invention relates to a phytase derived from Citrobacter braakii and related phytases. The phytases belong to the acid histidine phosphatase family, are acid-stable, of an excellent performance in animal feed, of a high specificity towards the substrate ph... | 01/11/2011 |
| 7863031 | Phytases and methods of making and using them The invention provides a purified, isolated, synthetic or recombinant phytase enzyme (e.g., SEQ ID NO:2) initially derived from Escherichia coli B. The enzyme has a molecular weight of about 47.1 kilodaltons and has phytase activity (SEQ ID NO:2). The enzyme ... | 01/04/2011 |
| 7851192 | Modified DNA cleavage enzymes and methods for use Compositions and methods are provided that relate to a modified DNA cleaving enzyme having at least 35% amino acid sequence identity with T7 Endo I. The modified enzyme includes two catalytic centers separated by a β-bridge where the β-bridge contains at least one... | 12/14/2010 |
| 7846704 | Flap endonuclease mutants A mutation is introduced into the substrate-binding site of flap endonuclease to prepare a mutant with modified substrate specificity. Using the mutant as a reagent for the analysis of genetic polymorphism, the analysis of genetic polymorphism can be performed more ... | 12/07/2010 |
| 7838274 | Phospholipases and uses thereof The invention relates to a newly identified polynucleotide sequence comprising a gene that encodes a novel phospholipase isolated from Aspergillus niger. The invention features the full length nucleotide sequence of the novel gene, the cDNA sequence comprisin... | 11/23/2010 |
| 7833769 | McrA variants and uses thereof Compositions and methods are provided in which the composition is a protein with at least 50% but less than 100% amino acid sequence identity with McrA or is a variant McrA protein with at least one amino acid sequence modification. The variant or protein has the pr... | 11/16/2010 |
| 7833768 | Polypeptides having phytase activity The invention relates to Citrobacter phytases derived from Citrobacter amalonaticus, Citrobacter gillenii, and related phytases. The phytases belong to the acid histidine phosphatase family, are acid-stable, and expectedly of a high specific activity. ... | 11/16/2010 |
| 7829318 | Overexpression of phytase genes in yeast systems The present invention relates to a method of producing a heterologous protein or polypeptide having phytase activity in a yeast system. The invention also provides proteins having phytase activity which have increased thermostability. Yeast strains which produce a h... | 11/09/2010 |
| 7824895 | Phytases, nucleic acids encoding them and methods for making and using them The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to ai... | 11/02/2010 |
| 7820424 | Nicking endonuclease methods and compositions A nicking endonuclease is described which has an amino acid sequence with at least 70% identity to SEQ ID NO:6 and comprising a mutation at least one of an arginine or glutamic acid corresponding to position 507 and position 546 respectively in SEQ ID NO:6. ... | 10/26/2010 |
| 7763449 | Nucleic acid encoding a novel ribonuclease having an amino acid sequence made up of the amino acid sequence of a known ribonuclease and an N-terminal leader sequence that is at least one residue long A nucleic acid encodes a novel RNase. The RNase has an amino acid sequence in which an amino acid sequence disclosed in U.S. Pat. No. 6,239,257 B1 is preceded by a different N-terminal residue or leader sequence. ... | 07/27/2010 |
| 7754461 | Large-scale production of human serum butyrylcholinesterase as a bioscavenger Disclosed herein are methods for the large-scale preparation of human butyrylcholinesterase (HuBChE) preparations from Cohn Fraction IV-4. As disclosed, the methods provide HuBChE preparations that are about 99% or more pure with recovery yields of about 60%. Also d... | 07/13/2010 |
| 7745191 | Method of producing heterodimer derivative of protein phosphatase type 2A enzyme The purpose of the invention is to provide an activated protein phosphatase 2A (PP2A) in large quantities with high purity by a genetic engineering and to provide a method for producing a heterodimer derivative of PP2A which comprises infecting insect cultured cells... | 06/29/2010 |
| 7638317 | Lipolytic enzymes variants The inventors have developed improved polypeptides by substituting or deleting specified amino acids in fungal lipolytic enzymes. More particularly, the polypeptides result in a reduction of dough stickiness when they are added to a dough. The polypeptides may parti... | 12/29/2009 |
