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| Number | Title | Issue Date |
| 8034595 | Nitrilases and methods for making and using them The invention provides nitrilases and methods for making and using them, and in one aspect, provides methods for producing enantiomerically pure α-substituted carboxylic acids, such as, for example, α-amino acids and α-hydroxy acids. In one aspect, methods of the... | 10/11/2011 |
| 8034596 | Method for producing cellulase and hemicellulase having high hydrolytic activity The present invention provides a novel cellulase-producing fungus, i.e. Acremonium cellulolyticus CF-2612 strain or a mutant thereof, which has an ability to produce cellulase so highly, a method for producing cellulase and/or hemicellulase by culturing said ... | 10/11/2011 |
| 8030048 | Enantioselective epoxide hydlrolase and method for preparing and enantiopure epoxide using the same The present invention relates to enantioselective epoxide hydrolase proteins isolated from marine microorganisms, which has high enantioselectivity to various epoxide substrates, and a method of preparing the epoxides with high enantio-purity by using the epoxide hy... | 10/04/2011 |
| 8012730 | Specific lysis of pathogens by bacteriophage phi11 endolysin The Staphylococcus aureus bacteriophage phi11 endolysin has two peptidoglycan hydrolase domains (endopeptidase and amidase) and a SH3b cell wall-binding domain. In turbidity reduction assays, the purified protein can lyse untreated staphylococcal mastitis-cau... | 09/06/2011 |
| 7989192 | Modified beta-lactamase and method for its preparation The invention relates to targeted post translational modification of metallo-beta-lactamase by truncation and insertion of a dipeptide at the amino terminal end to reduce amino terminal heterogeneity in a recombinant DNA production system. A protein K-T-E-ΔBL is ex... | 08/02/2011 |
| 7943359 | Polynucleotides which code for cyanide-tolerant nitrile hydratase and compositions thereof Disclosed herein are cyanide-tolerant nitrile hydratases especially from Pseudomonas putida or Pseudomonas marginalis strains which exhibit increased cyanide tolerance. Also disclosed are methods of preparing amides from nitriles in the presence of cya... | 05/17/2011 |
| 7943358 | Polymerase enhancing factor (PEF) extracts, PEF protein complexes, isolated PEF protein, and methods for purifying and identifying The invention provides novel extracts, proteins, and complexes that improve the polymerization activity of nucleic acid polymerases. Included within the aspects of the invention are methods for identifying compositions with a polymerase enhancing activity, methods f... | 05/17/2011 |
| 7879587 | Lipolytic enzyme variants Variants with increased acyl transferase activity can be designed on the basis of a three-dimensional model by making amino acid alterations near the active Ser of lipolytic enzymes such as C. antarctica lipase A or the lipase/acyl transferase from C. para... | 02/01/2011 |
| 7816112 | Castable diffusion membrane for enzyme-based sensor application The invention relates to a diffusion membrane for an enzyme-based sensor, a sensor comprising the diffusion membrane as well as the use of the enzyme-based sensor for the detection and/or determination of a substance, in particular an enzyme substrate, e.g., glucose... | 10/19/2010 |
| 7785853 | Polypeptides having cellobiohydrolase I activity and polynucleotides encoding same The present invention relates to polypeptides having cellobiohydrolase I activity and polynucleotides having a nucleotide sequence which encodes for the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucle... | 08/31/2010 |
| 7754460 | Enzyme for the production of long chain peracid The present invention provides methods and compositions comprising at least one perhydrolase enzyme for cleaning and other applications. In some embodiments, the present invention provides methods and compositions for generation of long chain peracids. Certain embod... | 07/13/2010 |
| 7745190 | Endoribonuclease A novel endoribonuclease activity exhibiting polypeptide; a nucleic acid coding for the polypeptide; a recombinant DNA comprising the nucleic acid; a transformant obtained by transformation using the recombinant DNA; a process for producing the polypeptide, characte... | 06/29/2010 |
| 7727753 | Plant dihydroorotase The present invention relates to a DNA encoding a polypeptide with dihydroorotase (EC 3.5.2.3) activity. Also, the invention relates to the use of this nucleic acid for the generation of an assay system. ... | 06/01/2010 |
| 7709240 | AMP deaminase originating streptomyces and utilization thereof It is intended to provide a thermostable AMP deaminase originating in a microorganism. Namely, an AMP deaminase having the following characteristics. (1) Catalyzing the reaction: 5′-adenylic acid+H2O→5′-inosinic acid+NH3; (2) being stable... | 05/04/2010 |
| 7670817 | Dynamin mediated diseases and associated methods and products This invention relates generally to the treatment of cathepsin or dynamin mediated diseases, such as proteinuria, cancer, and cognitive disease and related products. Diagnostic and other assays are also provided, as well as methods for podocyte cell gene transfer. | 03/02/2010 |
| 7553651 | Crystal structure of SNAP-25 in complex with botulinum neurotoxin and uses thereof The present invention provides a crystallized form of the E223Q Y365F mutant of the light chain of botulinum neurotoxin serotype A (BoNT/A) protein as well as the atomic structure of this mutant protein. The present invention also provides crystals of the E223Q Y365... | 06/30/2009 |
| 7507568 | Three dimensional coordinates of HPTPbeta The crystal structures of catalytic domain of HPTPbeta, both ligand-bound and ligan-free are described. These structures are useful in computer aided drug design for identifying compounds that bind or activate HPTPbeta and thereby modulate angiogenesis mediated diso... | 03/24/2009 |
| 7498157 | Three-dimensional structure of dipeptidyl peptidase IV A crystal of a dipeptidyl peptidase IV; a three-dimensional structural coordinate of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional coordinate of a homolog protein of the dipeptidyl peptidase IV; a method for obtaining a three-dimensional st... | 03/03/2009 |
| 7442534 | Nucleic acids and polypeptides which resemble Rho and which interact with cell signalling pathways and proteins The present invention relates to an isolated full-length Chp polypeptide, a biologically-active polypeptide fragment thereof, and nucleic acids which code for it. This polypeptide has various activities in regulating cell signaling and signal transduction pathways, ... | 10/28/2008 |
| 7442372 | Delivery of therapeutic compounds to the brain and other tissues The present invention relates to the intrathecal (IT) administration of recombinant enzyme to treat lysosomal storage disorders. In an exemplary embodiment, intrathecal administration of human α-L-iduronidase (rhIDU) injections in MPS I affected animals resulted in... | 10/28/2008 |
| 7439034 | Alginases, systems containing alginases and methods of cloning, purifying and/or utilizing alginases The present invention relates to cell wall degradative systems, in particular to systems containing enzymes that bind to and/or depolymerize cellulose. These systems have a number of applications. ... | 10/21/2008 |
| 7435572 | Methods and compositions for DNA manipulation Methods and compositions are provided for generating a single-stranded extension on a polynucleotide molecule, the single-stranded extension having a desired length and sequence composition. Methods for forming single-stranded extensions include: the use of a casset... | 10/14/2008 |
| 7435420 | Dipeptidyl peptidase IV inhibitors for the treatment of anxiety The present invention discloses a method for therapeutically treating an animal, including a human, for psychosomatic, depressive and neuropsychiatric diseases, such as anxiety, depression, insomnia, schizophrenia, epilepsy, spasm and chronic pain. Administra... | 10/14/2008 |
| 7429472 | Method of immobilizing a protein or molecule via a mutant dehalogenase that is bound to an immobilized dehalogenase substrate and linked directly or indirectly to the protein or molecule A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 09/30/2008 |
| 7427498 | Composition, methods and reagents for the synthesis of a soluble form of human PHEX This invention relates to a soluble form of PHEX, PHEX being a type II integral membrane glycoprotein. This enzyme is the gene product of a phosphate-regulating gene with homologies to endopeptidases on the X chromosome. To produce a soluble form of PHEX, the transm... | 09/23/2008 |
| 7425436 | Covalent tethering of functional groups to proteins and substrates therefor A mutant hydrolase optionally fused to a protein of interest is provided. The mutant hydrolase is capable of forming a bond with a substrate for the corresponding nonmutant (wild-type) hydrolase which is more stable than the bond formed between the wild-type hydrola... | 09/16/2008 |
| 7422888 | Thermotolerant ribonuclease H Polypeptides having an RNase H activity highly useful in genetic engineering; genes encoding these polypeptides; and a process for genetic engineeringly producing these polypeptides. ... | 09/09/2008 |
| 7407785 | Human DNase I hyperactive variants The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantit... | 08/05/2008 |
| 7407779 | Modification of solid 3-sn-phosphoglycerides Methods for hydrolyzing solid ungranulated lysophosphatidylcholine with phospholipase A2 are provided. Also disclosed are methods for making a lipid matrix of lysophosphatidylcholine, monoglyceride and fatty acid, and lipid matrices of particular structur... | 08/05/2008 |
| 7405070 | Method for preparing (s)-indoline-2-carboxylic acid and (s)-indoline-2-carboxylic acid methyl ester using hydrolytic enzyme Disclosed is a method for preparing (S)-indoline-2-carboxylic acid and (S)-indoline-2-carboxylic acid methyl ester using an inexpensive industrially available enzyme capable of assuring superior optical purity and yield. At this time, the hydrolytic enzyme is select... | 07/29/2008 |
| 7402406 | Methods of evaluating phosphatase inhibitors The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these ... | 07/22/2008 |
| 7396667 | Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a re-polymerizable oligomer. A producing process of polylactic acid, wherein th... | 07/08/2008 |
| 7396533 | Polypeptides and nucleic acids encoding same DNAs are provided, whose genes are induced at least by Wnt-1. Also provided are nucleic acid molecules encoding those polypeptides, as well as vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides ... | 07/08/2008 |
| 7381549 | Method for zymotic production of fine chemicals (mety) containing sulphur The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene. ... | 06/03/2008 |
| 7371523 | Phenylethanolamine-N-methyltransferase sequence variants Isolated PNMT nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as PNMT allozymes. Methods for determining if a subject is predisposed to multiple sclerosis, early-onset Alzheimer's... | 05/13/2008 |
| 7371366 | GlcNAc phosphotransferase of the lysosomal targeting pathway The present invention provides nucleotide and amino sequences of the lysosomal targeting pathway enzyme GlcNAc-phosphotransferase, methods of producing and methods of purifying this enzyme. ... | 05/13/2008 |
| 7368272 | Expression of proteolytic enzymes in koji mold in the presence of carbon sources The present invention refers to a koji mold capable of expressing proteolytic enzymes in the presence of a carbon source in at least the same amount as in the absence thereof. In particular, the present invention pertains to a mutation in the creA gene as a tool to ... | 05/06/2008 |
| 7364848 | Integrated microarray analysis The present invention relates to methods for identifying analyte nucleic acids present in a sample comprising nucleic acid molecules, said method comprising the steps of: (a) providing a porous substrate, said substrate comprising a plurality of micro-channels, wher... | 04/29/2008 |
| 7361494 | Tetrahydropyrimidine dioxygenase gene, polypeptides encoded by said gene and method for producing the same The present invention relates to enzymes having tetrahydropyrimidine dioxygenase activity, to the genes coding therefor, to the homologous and heterologous expression of these genes, to processes for preparing enzymes having tetrahydropyrimidine dioxygenase activity... | 04/22/2008 |
| 7361495 | Polypeptide from a cellulolytic fungus having cellulolytic enhancing activity The present invention relates to isolated polypeptides having cellulolytic enhancing activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as wel... | 04/22/2008 |
