Class 435/194 - Transferring phosphorus containing group (e.g., kineases, etc.(2.7))

Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter wherein the functional group transferred
No. of patents: 1609
Last issue date: 05/01/2012

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Number	Title	Issue Date
8168383	Gene defects and mutant ALK kinase in human solid tumors Novel gene deletions and translocations involving chromosome 2 resulting in fusion proteins combining part of Anaplastic Lymphoma Kinase (ALK) kinase with part of a secondary protein have now been identified in human solid tumors, e.g. non-small cell lung carcinoma ...	05/01/2012
8163528	Nucleic acid molecules encoding thymidine kinase fusion proteins The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside bi...	04/24/2012
8148126	Polymerase The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 90° C. up to 113° C., such as those derived from Pyrolobus fumaria, and to polynucleotides encoding the polymerases In addition, methods of design...	04/03/2012
8143044	Crystal structure of the influenza virus polymerase PAC-PB1complex and uses thereof Provided are the expression method of influenza virus polymerase PAc-PB1N complex, the co-crystallization method of the complex and the three-dimendional structure of the crystal of PAc-PB1N complex. Also provided are the compounds binding to t...	03/27/2012
8129164	Crystallographic structure of Mnk-1 and Mnk-2 proteins The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain. ...	03/06/2012
8124392	Crystal structure of Aurora-2 protein and binding pockets thereof The present invention provides crystalline molecules or molecular complexes which comprise binding pockets of Aurora-2 or its homologues. The invention also provides crystals comprising Aurora-2. The present invention also relates to a computer comprising a data sto...	02/28/2012
8124391	Thermostable polymerases from The invention relates to a thermostable polymerase based on thermococcus pacificus; DNA molecules which code for one such polymerase; expression vectors; host cells; methods for producing one such polymerase and the use thereof for polymerising nucleic acid, ...	02/28/2012
8105814	DNA replication factors A DNA polymerase reaction system which provides high DNA polymerase activity even at a high temperature and at a high salt concentration. A DNA polymerase reaction system that is constructed from a DNA polymerase, a clamp, and a clamp loader without intein sequence,...	01/31/2012
8105813	Materials and methods for the generation of fully 2′-modified nucleic acid transcripts Materials and methods are provided for producing aptamer therapeutics having fully modified nucleotide triphosphates incorporated into their sequence. ...	01/31/2012
8093030	Thermostable viral polymerases and methods of use Thermostable viral polymerases exhibiting a combination of activities selected from, proofreading (3′-5′) exonuclease activity, nick translating (5′-3′) nuclease activity, synthetic primer-initiated polymerase activity, nick-initiated polymerase activity, re...	01/10/2012
8088611	Kinase domain polypeptide of human protein kinase B gamma (AKT3) The present invention provides, in part, AKT3 polypeptides and methods of use thereof along with nucleic acids encoding the polypeptides. For example, methods for screening for AKT3 inhibitors are provided herein. ...	01/03/2012
8048663	Crystal of pregnane X receptor fused to steroid receptor coactivator-1 The present invention relates to Pregnane X receptor (PXR) polypeptides and crystals that are useful, for example, for crystallization and in assays for identification of modulators of PXR. ...	11/01/2011
8030047	Active truncated form of the RNA polymerase of The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymera...	10/04/2011
8030046	Mutations in OAS1 genes Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided. ...	10/04/2011
8026091	DNA polymerases and related methods Disclosed are mutant DNA polymerases having improved extension rates relative to a corresponding, unmodified polymerase. The mutant polymerases are useful in a variety of disclosed primer extension methods. Also disclosed are related compositions, including recombin...	09/27/2011
8008054	Thermostable nucleic acid polymerase from A purified thermostable enzyme is derived form the thermophilic archaebacterium Thermococcus gorgonarius. The enzyme can be native or recombinant, retains approximately 90% of its activity after incubation for two hours at 95° C. in the presence of stabilizi...	08/30/2011
8008053	Allosteric control of proteins by manipulating mechanical tension A method of altering the conformation of a polypeptide having a known three-dimensional structure is described. The method comprises attaching a first end of a polymer to a first portion of the polypeptide, attaching a second end of the polymer to a second portion o...	08/30/2011
7998718	Identification and functional characterization of a novel ribosomal S6 protein kinase A novel S6 kinase, p70βS6k is described, along with methods of making and using p70βS6k protein and related nucleic acids. The invention also discloses methods of identifying agents which modulate the activity of p70βS6k protein a...	08/16/2011
7972830	Thermostable Taq polymerase fragment It was found that a fragment of native Thermus aquaticus DNA polymerase (TaqWT) lacking 288 N-terminal amino acids (TaqΔ288) possesses an increased thermostability over TaqWT, TaqΔ279, and TaqΔ289. The present invention therefore provides TaqΔ288, recombi...	07/05/2011
7960158	Kinase inhibition models and their uses The present invention provides a c-Met inhibition model. The invention further provides a method to derive inhibition models for other kinases. The kinase inhibition models of the present invention can be used to design or screen for inhibitors for kinases. ...	06/14/2011
7960157	DNA polymerase blends and uses thereof The present invention discloses novel blends of chimeric and non-chimeric thermostable DNA polymerases for use in PCR, DNA sequencing and mutagenesis protocols. The invention allows for PCR reactions with shorter extension times that will facilitate PCR amplificatio...	06/14/2011
7943357	Crystallographic structure of Mnk-1 and Mnk-2 proteins The present invention relates to crystalline Mnk-1 and Mnk-2 kinases and, in particular, to the crystal structure of Mnk-1 and Mnk-2 kinase domain. ...	05/17/2011
7932070	High fidelity DNA polymerase compositions and uses therefor The subject invention relates to compositions comprising an enzyme mixture which comprises a first enzyme and a second enzyme, where the first enzyme comprises a DNA polymerization activity and the second enzyme comprises an 3′-5′ exonuclease activity and a redu...	04/26/2011
7919296	Nucleic acid modifying enzymes This invention provides for an improved generation of novel nucleic acid modifying enzymes. The improvement is the fusion of a sequence-non-specific nucleic-acid-binding domain to the enzyme in a manner that enhances the ability of the enzyme to bind and catalytical...	04/05/2011
7906308	Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex In certain aspects, the invention relates to methods for identifying compounds which modulate Akt activity mediated by the rictor-mTOR complex and methods for treating or preventing a disorder that is associated with aberrant Akt activity. ...	03/15/2011
7897371	Activation of mutated RAC-PK The invention concerns RAC-PK and fragments thereof, as well as activators and inhibitors of RAC-PK for use as medicaments, particularly in the treatment of diseases concerned with abnormalities in processes modulated by insulin, such as cellular proliferation, insu...	03/01/2011
7888091	Fusion proteins having thymidine kinase and guanylate kinase activities The present invention provides isolated nucleic acid molecules encoding a Herpesviridae thymidine kinase enzyme comprising one or more mutations, at least one of the mutations encoding an amino acid substitution located toward the N-terminus from a DRH nucleoside bi...	02/15/2011
7883880	DNA polymerase lambda and uses thereof The present invention relates to the identification and isolation of a DNA polymerase and uses of this polymerase. In particular, the present invention describes the nucleotide sequence of the human gene for DNA polymerase lambda (Pol λ), the amino acid sequence of...	02/08/2011
7883881	Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes The present invention relates to inhibitors of GSK-3 and methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors and methods of utilizing those compositions in the treatment and prevention of various ...	02/08/2011
7842488	Polynucleotides encoding a human 3-phosphoinositide- dependent protein kinase The present invention provides for isolated polynucleotides encoding a human 3-phosphoinositide-dependent protein kinase, and vectors and host cells comprising the isolated polynucleotides. ...	11/30/2010
7820423	Method and a system for predicting protein functional site, a method for improving protein function, and a function-modified protein The present application provides a method for predicting the functional site of a protein using data of the entire proteins of an organism of which genome data or cDNA data is known. More specifically, the present application provides a method for predicting a prote...	10/26/2010
7807430	GSK3 polypeptides The invention provides truncated GSK3 polypeptides capable of crystallization, including GSK3α and GSK3β polypeptides, and use of these polypeptides to identify and optimize GSK3 inhibitors. Also provided are GSK3 polypeptides having at least one substituted amino...	10/05/2010
7803595	Mammalian sphingosine kinase type 2 isoforms, cloning, expression and methods of use thereof Nucleic acids encoding mouse and human sphingosine kinase type 2 isoforms, methods for detecting agents or drugs which inhibit or promote sphingosine activity and therapeutic agents containing peptides or antibodies to peptides encoded by such nucleic acids. ...	09/28/2010
7803596	Enzyme derived from thermophilic organisms that functions as a chromosomal replicase, and preparation and uses thereof A DNA Polymerase has been identified in a thermophile that functions as a chromosomal replicase. The specific enzyme is a holoenzyme III that has been identified in Thermus thermophilus, and corresponds to Polymerase III in E. coli. The genes and the p...	09/28/2010
7794996	Recombinant murine leukemia virus reverse transcriptases, the genes encoding and the method for expressing it This invention provides recombinant murine leukemia virus reverse transcriptases, genes encoding these proteins and expression methods. The said murine leukemia virus reverse transcriptases are a series of MLV-RT proteins wherein the 84th amino acid residue (Q84) fr...	09/14/2010
7794995	Purified PKB Ser 473 kinase and uses thereof This invention provides purified PKB Ser 473 kinase and methods of purifying it. The methods involve the use of several sequential steps, including subcellular fractionation to isolate a plasma membrane fraction and the use of gel filtration or chromatography that s...	09/14/2010
7785852	Cleavage of nucleic acids The present invention relates to means for cleaving a nucleic acid cleavage structure in a site-specific manner. Enzymes, including 5′ nucleases and 3′ exonucleases, are used to detect and identify nucleic acids derived from microorganisms. Methods are provided ...	08/31/2010
7781198	Polymerase-encoding nucleic acids and method of making and using them The invention relates to thermostable polymerases that have polymerase activity temperatures in the range from 90° C. up to 113° C., such as those derived from Pyrolobus fumaria, and to polynucleotides encoding the polymerases In addition, methods of design...	08/24/2010
7781199	Identification of a JAK2 mutation involved in Vaquez Polyglobulia The present invention concerns the V617F variant of the protein-tyrosine kinase JAK2, said variant being responsible for Vaquez Polyglobulia. The invention also relates to a first intention diagnostic method for erythrocytosis and thrombocytosis allowing their assoc...	08/24/2010
7754459	Poly(ADP-ribose) polymerase-gene The invention relates to poly(ADP-ribose)polymerase (PARP) homologs which have an amino acid sequence which has a) a functional NAD+ binding domain and b) no zinc finger sequence motif of the general formula CX2	07/13/2010

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Class 435/194 - Transferring phosphorus containing group (e.g., kineases, etc.(2.7))