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| Number | Title | Issue Date |
| 8187853 | β-galactoside-α2,6-sialyltransferase, a gene encoding thereof, and a method for enhancing enzyme activity The present invention provides an extremely useful and novel β-galactoside-α2,6-sialyltransferase having an optimum reaction pH in a neutral to alkaline range, and a nucleic acid encoding the sialyltransferase. The present invention further provides a vector carry... | 05/29/2012 |
| RE43425 | Mutant prenyl diphosphate synthase A mutant prenyl diphosphate synthase capable of synthesizing prenyl diphosphates, shorter than those synthesized by the original enzyme, by modifying the amino acid sequence in and upstream of the aspartic acid-rich domain DDXX (XX)D (X denotes any amino acid, and X... | 05/29/2012 |
| 8168417 | chromosome The present invention relates to an isolated polynucleotide of the complete chromosome of Bacillus licheniformis. The present invention also relates to isolated genes of the chromosome of Bacillus licheniformis which encode biologically active substanc... | 05/01/2012 |
| 8168416 | Modified lecithin-cholesterol acyltransferase enzymes The invention provides compounds, pharmaceutical compositions and methods for treating atherosclerosis, coronary heart disease, thrombosis, and for decreasing or prevention of accumulation of cholesterol in a subject by modifying LCAT polypeptide. ... | 05/01/2012 |
| 8158400 | Polypeptides having lipase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for... | 04/17/2012 |
| 8148125 | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed. ... | 04/03/2012 |
| 8148124 | Regulation of gene expression by protein methylation The invention relates to the cDNA and deduced amino acid sequence of the Coactivator Associated arginine (R) Methyltransferase protein, CARM1. A method is described for the use CARM1 to regulate gene expression in vivo. CARM1 has also been used to methylate arginine... | 04/03/2012 |
| 8124390 | Aromatic prenyltransferases, nucleic acids encoding same and uses therefor In accordance with the present invention, a novel aromatic prenyltransferase, Orf2 from Streptomyces sp. strain CL190, involved in naphterpin biosynthesis has been identified and the structure thereof elucidated. This prenyltransferase catalyzes the formation... | 02/28/2012 |
| 8114653 | Thermostable Y-family polymerases and chimeras The present disclosure is related to thermostable Y-family polymerases, in particular several novel Y-family polymerases and chimeras made therefrom, as well as methods of identifying other Y-family polymerases, methods of generating other chimeric Y-family polymera... | 02/14/2012 |
| 8114654 | Site-specific incorporation of redox active amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate redox active amino acids into proteins are provided.... | 02/14/2012 |
| 8114652 | Genetically programmed expression of selectively sulfated proteins in eubacteria The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the unnatural amino acid sulfotyrosine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited... | 02/14/2012 |
| 8110388 | Lysophosphatidic acid acyltransferase genes The present invention provides novel lysophosphatidic acid acyltransferase genes. A nucleic acid comprising the nucleotide sequence shown in SEQ ID NO: 1, 3, 36 or 37 or a fragment thereof. ... | 02/07/2012 |
| 8101390 | Mutant-type acetyltransferase Mpr1 The present invention provides a mutant-type acetyltransferase Mpr1: which comprises an amino acid sequence of a yeast wild-type Mpr1 represented by SEQ ID NO:1, wherein at least one amino acid at positions 63 to 65 and 117 of the amino acid sequence is substituted ... | 01/24/2012 |
| 8097443 | Nucleotidyltransferases with enhanced nucleotide triphosphate flexibility The present invention provides mutant RmlA enzymes possessing an increased purine/pyrimidine bias in nucleotide triphosphate substrate specificity as compared to a corresponding non-mutated RmlA enzyme. Such enzymes expand the types of substrates that can be used in... | 01/17/2012 |
| 8067218 | Polypeptides having lipase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for... | 11/29/2011 |
| 8058046 | Sesquiterpene synthases from patchouli The invention relates to sesquiterpene synthases from Patchouli plants (Pogostemon cablin), and methods of their production and use. In one embodiment, the invention provides nucleic acids comprising a nucleotide sequence as described herein that encodes for ... | 11/15/2011 |
| 8030044 | Lipid acyltransferases The present invention relates to a method of producing a variant lipid acyltransferase enzyme by selecting a parent enzyme which is a lipid acyltransferase enzyme having the amino acid sequence motif GDSX, modifying one or more amino acids to produce a variant lipid... | 10/04/2011 |
| 8030045 | Beta-alanine/alpha-ketoglutarate aminotransferase for 3-hydroxypropionic acid production The present disclosure provides novel beta-alanine/alpha ketoglutarate aminotransferase nucleic acid and protein sequences having increased biological activity. Also provided are cells containing such enzymes, as well as methods of their use, for example to produce ... | 10/04/2011 |
| 8030043 | β-galactoside-α2,3-sialyltransferase, a gene encoding thereof, and a method for producing thereof The present invention provides a novel β-galactoside-α2,3-sialyltransferase and a nucleic acid encoding the sialyltransferase. The present invention also provides a microorganism producing the sialyltransferase, as well as a method for producing the sialyltransfer... | 10/04/2011 |
| 8026090 | Modified chondroitin synthase polypeptide and crystal thereof Disclosed are: (A) a polypeptide consisting of the amino acid sequence of SEQ ID NO:2, or (B) a polypeptide comprising an amino acid sequence of SEQ ID NO:2 including deletion, substitution or addition of one or several amino acid residues and having chondroitin syn... | 09/27/2011 |
| 8017593 | Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, ... | 09/13/2011 |
| 8003572 | Method for the treatment of a ubiquitin conjugating disorder The present invention provides methods for identifying compounds that selectively bind one or more active sites within an ubiquitin conjugating enzyme. The compounds identified by the methods are useful in the treatment of disorders attributed to dysregulated ubiqui... | 08/23/2011 |
| 7998717 | Mitigation of photodamage in analytical reactions Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating differen... | 08/16/2011 |
| 7993895 | Mitigation of photodamage in analytical reactions Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating differen... | 08/09/2011 |
| 7981653 | Highly efficient hyperthermophilic DNA ligase Disclosed is a modified hyperthermophilic DNA ligase having improved DNA binding ability and reactivity. The modified hyperthermophilic DNA ligase has an amino acid sequence corresponding to the amino acid sequence of a heat-resistant DNA ligase derived from a therm... | 07/19/2011 |
| 7972828 | Stabilized compositions of thermostable DNA polymerase and anionic or zwitterionic detergent The present invention provides compositions, methods, and kits for protecting thermostable DNA polymerase during amplification reactions conducted at a temperature ranging from about 40° C. to greater than 100° C. The composition comprises a thermostable DNA polym... | 07/05/2011 |
| 7972829 | Process for producing transglutaminase The present invention relates to a process for secretory production of a foreign protein, in particular, transglutaminase by a coryneform bacterium. According to the present invention, a process is provided for the secretory production of a foreign protein, i... | 07/05/2011 |
| 7955830 | Polypeptides having lipase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for... | 06/07/2011 |
| 7947481 | Chondroitin synthase, method for producing the same and method for producing saccharide chain-extended chondroitin A vector of the present invention has DNA encoding a protein or a product having the same effect as the protein, the protein containing an amino acid sequence from amino acid numbers 47 to 802 in SEQ. ID. NO:2. Expression of the DNA gives human chondroitin synthase.... | 05/24/2011 |
| 7927853 | DNA ligase mutants It is intended to obtain DNA ligase improved in binding ability and reactivity with DNA, particularly thermostable DNA ligase improved in binding ability and reactivity with DNA. The present invention provides a DNA ligase mutant improved in binding ability and reac... | 04/19/2011 |
| 7910346 | Human diacylglycerol acyltransferase 2 (DGAT2) family members and uses therefor The present invention relates to compositions and methods for the diagnosis and treatment of obesity and related metabolic disorders. The invention provides isolated nucleic acids molecules, designated DGAT2 family member nucleic acid molecules, which encode diacylg... | 03/22/2011 |
| 7910345 | Site specific incorporation of keto amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods... | 03/22/2011 |
| 7906307 | Variant lipid acyltransferases and methods of making The present invention relates to a method for the production of a variant lipid acyltransferase comprising the steps of: (i) selecting a parent enzyme which is a lipid acyltranserase enzyme; (ii) modifying one or more amino acids to produce a variant lipid acyltrans... | 03/15/2011 |
| 7906460 | Active-site engineering of nucleotidylyltransferases and general enzymatic methods for the synthesis of natural and “unnatural” UDP- and TDP-nucleotide sugars The present invention provides mutant nucleotidylyl-transferases, such as Ep, having altered substrate specificity; methods for their production; and methods of producing nucleotide sugars, which utilize these nucleotidylyl-transferases. The present inven... | 03/15/2011 |
| 7901917 | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis Compositions comprising truncated tryptophanyl-tRNA synthetase polypeptides useful for regulating angiogenesis, as well as nucleic acids encoding such tRNA synthetase polypeptides are described. Methods of making and using such compositions are also disclosed. ... | 03/08/2011 |
| 7888090 | Mutants of O-alkylguanine-DNA alkyltransferase The invention relates to AGT mutants showing, when compared to the wild type human AGT, two or more advantageous properties selected from (a) reduced DNA interaction; (b) localisation of the expressed protein in eukaryotic cells that is no longer restricted to the n... | 02/15/2011 |
| 7879586 | Gene encoding methylated catechin synthase A gene encoding a methylated catechin synthase that can effectively synthesize methylated catechins having high antiallergic activity. The gene encoding a methylated catechin synthase contains at least one nucleotide sequence selected from the group consistin... | 02/01/2011 |
| 7871805 | Glucose dehydrogenase The present invention provides glucose dehydrogenase which is excellent in heat resistance and substrate specificity and is not affected by dissolved oxygen. Specifically, the present invention relates to glucose dehydrogenase characterized by being derived from an ... | 01/18/2011 |
| 7871804 | Method for producing polyunsaturated long-chain fatty acids in transgenic organisms The invention relates to a method for producing polyunsaturated fatty acids in an organism, according to which nucleic acids coding for polypeptides with an acyl-CoA:lysophospholipid-acyltransferase activity are introduced into the organism. Advantageously, the nucl... | 01/18/2011 |
| 7858351 | S-adenosylmethionine synthetase mutants, the DNAs encoding the same and uses of the mutants The invention discloses a series of Methanococcus jannaschii S-adenosylmethionine synthetase mutants with improved thermostability and high catalytic activity obtained by using gene mutation technique, characterized in that these mutants refer to an enzyme us... | 12/28/2010 |
