Quotables
"It is my heart-warmed and world-embracing Christmas hope and aspiration that all of us, the high, the low, the rich, the poor, the admired, the despised, the loved, the hated, the civilized, the savage (every man and brother of us all throughout the whole earth), may eventually be gathered together in a heaven of everlasting rest and peace and bliss, except the inventor of the telephone. "
Mark Twain ; Christmas greetings, 1890
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| Number | Title | Issue Date |
| 8124389 | Crystal structure of aldehyde dehydrogenase and methods of use thereof The present disclosure provides a crystal structure of aldehyde dehydrogenase (ALDH) with a modulator of ALDH bound thereto. The present disclosure provides a computer readable medium comprising atomic coordinates for an ALDH polypeptide and a modulator bound to a s... | 02/28/2012 |
| 8088610 | Ketoreductases for the production of (S,E)-methyl 2-(3-(3-(2-(7-chloroquinolin-2-yl)vinyl)phenyl)-3-hroxypropyl)benzoate The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of ex... | 01/03/2012 |
| 8071347 | Ketoreductases and uses thereof The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of ex... | 12/06/2011 |
| 8017370 | Manipulation of organic acid biosynthesis and secretion The present invention relates to nucleic acid fragments encoding amino acid sequences for organic acid biosynthetic enzymes in plants, and the use thereof for the modification of, for example, organic acid biosynthesis and secretion in plants. In particularly prefer... | 09/13/2011 |
| 8012729 | Mutant glucose dehydrogenase Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475. ... | 09/06/2011 |
| 7989191 | Mutant 6-phosphogluconate dehydrogenase The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution... | 08/02/2011 |
| 7964382 | DNA encoding a protein having D-lactate dehydrogenase activity and uses thereof This invention provides a polynucleotide that encodes a protein having lactate dehydrogenase activity and such protein that can be used for producing D-lactic acid. This polynucleotide has the nucleotide sequence as shown in SEQ ID NO: 1 (a), and it hybridizes under... | 06/21/2011 |
| 7943356 | Alcohol dehydrogenase for the stereoselective production of hydroxy compounds The invention relates to a DNA sequence encoding an NADP-dependent alcohol dehydrogenase, to a vector containing at least one copy of the DNA sequence and to prokaryotic or eukaryotic host cells that are transformed or transfected with the DNA sequence. The inventio... | 05/17/2011 |
| 7939308 | Bio-based method for making mannitol Mannitol is produced in a highly efficient fermentative method using Lactobacillus intermedius NRRL B-30560, or in a biochemical method using mannitol dehydrogenase isolated from this strain. Fructose serves as the primary carbon substrate in both the ferment... | 05/10/2011 |
| 7939309 | Glucose dehydrogenase polypeptides and related polynucleotides The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleot... | 05/10/2011 |
| 7932069 | Process for producing lactoperoxidase A process for producing lactoperoxidase, including: a step (1) for bringing one or more milk materials into contact with a cation exchanger having weakly acidic groups as ion exchange groups to thereby effect adsorption treatment; a step (2) for washing the cation e... | 04/26/2011 |
| 7927852 | Aggregate-free urate oxidase for preparation of non-immunogenic polymer conjugates A naturally occurring or recombinant protein, especially a mutein of porcine urate oxidase (uricase), that is essentially free of large aggregates can be rendered substantially non-immunogenic by conjugation with a sufficiently small number of strands of polymer suc... | 04/19/2011 |
| 7892804 | Arabinitol dehydrogenases from Stable and active arabinitol dehydrogenases (LAD) from Neurospora crassa and mutants thereof are disclosed. Arabinitol dehydrogenases are useful in the production of xylitol and ethanol from an arabinose containing substrate. Recombinant and heterologously ex... | 02/22/2011 |
| 7867742 | Glucose dehydrogenase and method for producing the dehydrogenase A glucose dehydrogenase having high substrate specificity can be produced at a low cost by culturing a microorganism belonging to the genus Burkholderia. The glucose dehydrogenase is isolated from the medium and/or cells of the microorganism. The glucose dehy... | 01/11/2011 |
| 7820421 | Ketoreductases and uses thereof The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of ex... | 10/26/2010 |
| 7816111 | Glucose dehydrogenase polypeptides and related polynucleotides The present invention is directed to glucose dehydrogenase (GDH) polypeptides that have enhanced GDH activity and/or thermostability relative to the backbone wild-type glucose dehydrogenase polypeptide. In addition, the present invention is directed to a polynucleot... | 10/19/2010 |
| 7803592 | Mutant glucose dehydrogenase Substrate specificity for glucose of a glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 13 is improved by substituting another amino acid residue for the amino acid residue at position 472 and/or 475. ... | 09/28/2010 |
| 7794994 | Enzyme-based system and sensor for measuring acetone Described are enzyme systems specific for acetone and methods of using these enzyme systems to detect acetone in biological or environmental samples. Biosensors containing these enzyme systems are disclosed, in which detection of acetone may be achieved by linking e... | 09/14/2010 |
| 7781196 | Thermostable mutants of pyrroloquinoline quinone dependent glucose dehydrogenase The present invention relates to a mutant protein of PQQ-dependent s-GDH characterized in that in at least one of the positions 122 and 124 the amino acid lysine is present, wherein these positions correspond to the amino acid positions known from the A. calcoace... | 08/24/2010 |
| 7776575 | Mutant glucose dehydrogenase A mutant glucose dehydrogenase having the amino acid sequence of SEQ ID NO: 3 or an amino acid sequence of SEQ ID NO: 3 including substitution, deletion, insertion or addition of one or more amino acid residues other than the amino acid residue at the 365th position... | 08/17/2010 |
| 7741090 | Glucose dehydrogenase and process for producing the dehydrogenase A novel glucose dehydrogenase, which is an enzyme that has high substrate specificity, can be produced at a low cost, is not affected by oxygen dissolved in a measurement sample and, in particular, has superior thermal stability is obtained by culturing a microorgan... | 06/22/2010 |
| 7732179 | Mutants of pyrroloquinoline quinone dependent soluble glucose dehydrogenase A mutant of PQQ-dependent soluble glucose dehydrogenase (s-GDH; EC 1.1.5.2) is provided with improved specificity for glucose as compared to maltose, having a substitution of threonine at position 348 by either glycine, alamine or serine, wherein said mutant additio... | 06/08/2010 |
| 7723089 | PEG-urate oxidase conjugates and use thereof A naturally occurring or recombinant urate oxidase (uricase) covalently coupled to poly(ethylene glycol) or poly(ethylene oxide) (both referred to as PEG), wherein an average of 2 to 10 strands of PEG are conjugated to each uricase subunit and the PEG has an average... | 05/25/2010 |
| 7695946 | Polynucleotides encoding useful polypeptides in The present invention provides novel polypeptides and polynucleotides useful as biotechnological tools, specifically identified in a coryneform bacterium Corynebacterium glutamicum ssp. lactofermentum and methods of producing substances in organisms ha... | 04/13/2010 |
| 7662600 | Modified flavin adenine dinucleotide dependent glucose dehydrogenase An object of the present invention is to provide a more practically advantageous enzyme usable as a reagent for measuring blood glucose than the known enzymes used as blood glucose sensors. A modified flavin adenine dinucleotide dependent glucose dehydrogenas... | 02/16/2010 |
| 7642078 | Methods to obtain recombinant proteins with increased sialylation from cells that express adenovirus E1A protein, and proteins obtained thereby The invention provides compositions comprising one or more isoforms of an erythropoietin (EPO) comprising glycans linked thereto, characterized in that said glycans comprise LewisX structures and on average at least 6 sialic acid moieties per EPO molecule. The inven... | 01/05/2010 |
| 7611879 | 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 molecules and uses therefor The invention provides isolated nucleic acids molecules, designated 27877, 18080, 14081, 32140, 50352, 16658, 14223, 16002, 50566, 65552 and 65577 nucleic acid molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors co... | 11/03/2009 |
| 7604969 | Mutant glucose dehydrogenase A mutant glucose dehydrogenase having an improved substrate specificity to glucose, which is a protein comprising the amino acid sequence depicted in SEQ ID NO:3 or an amino acid sequence having the substitution, deletion, insertion or addition of one or more amino ... | 10/20/2009 |
| 7582460 | 3-phosphoglycerate dehydrogenase variants whose inhibition by L-serine is reduced, and genes encoding them A 3-phosphoglycerate dehydrogenase (PGD) which exhibits a susceptibility to inhibition by serine which is reduced a as compared with that of an Escherichia coli wild-type PGD and which possesses an amino acid sequence which differs from the amino acid sequenc... | 09/01/2009 |
| 7569375 | Alcohol dehydrogenases with increased solvent and temperature stability The invention relates to biocatalysts showing alcohol dehydrogenase activity obtainable from Rhodococcus ruber, their preparation, their use in the oxidation of secondary alcohols and/or the reduction of ketones, as well as nucleic acids coding for these alco... | 08/04/2009 |
| 7553649 | Method for producing glucose dehydrogenase from The present invention effectively produces glucose dehydrogenase derived from Aspergillus oryzae, and provides more practical glucose dehydrogenase. ... | 06/30/2009 |
| 7547534 | Methods for making a composition to treat a wood, a pulp or a paper The invention relates to xylanases and to polynucleotides encoding the xylanases. In addition, methods of designing new xylanases and methods of use thereof are also provided. The xylanases have increased activity and stability at increased pH and temperature. ... | 06/16/2009 |
| 7547535 | Forms of soluble pyrroloquinoline quinone-dependent glucose dehydrogenase The present invention relates to improved variants of soluble pyrroloquinoline quinone (PQQ)-dependent glucose dehydrogenases (s-GDH), to genes encoding mutated s-GDH, to mutant proteins of s-GDH with improved substrate specificity for glucose, and to different appl... | 06/16/2009 |
| 7527952 | Crystals of inosine monophosphate dehydrogenase/oxidized inosine monophosphate thiomidate intermediate/mycophenolic acid (IIMPDH/XMP*/MPA) The present invention relates to a data storage medium encoded with the corresponding structure coordinates of molecules and molecular complexes which comprise the active site binding pockets of IMPDH. Such data storage material is capable of displaying such molecul... | 05/05/2009 |
| 7524667 | Mutated 6-phosphogluconate dehydrogenase The present invention relates to a polypeptide having a modified amino acid sequence of 6-phosphogluconate dehydrogenase (hereinafter abbreviated as GND) derived from a microorganism belonging to the genus Corynebacterium, said modification being substitution... | 04/28/2009 |
| 7517677 | Recombinant D-amino acid oxidases The present invention discloses two novel D-amino acid oxidases, whose activities of converting cephalosporin C to glutaryl-7-aminocephalosporanic acid are at least 25% higher than that of wild-type Trigonopsis variabilis D-amino acid oxidase and the encoding... | 04/14/2009 |
| 7494794 | Glucose dehydrogenase The present invention provides glucose dehydrogenase which is excellent in heat resistance and substrate specificity and is not affected by dissolved oxygen. Specifically, the present invention relates to glucose dehydrogenase characterized by being derived from an ... | 02/24/2009 |
| 7494793 | 21686, dehydrogenase The invention provides isolated nucleic acids molecules, designated DHDR nucleic acid molecules, which encode novel DHDR-related dehydrogenase molecules. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing DHDR nuc... | 02/24/2009 |
| 7479383 | Modified pyrroloquinoline quinone (PQQ) dependent glucose dehydrogenase excellent in substrate specificity PQQGDH having an improved substrate specificity or having an improved specific activity in an assay system using ferricyanide ion as a mediator is provided. Modified PQQGDH having the enhanced substrate specificity by introducing an amino acid mutation in a particul... | 01/20/2009 |
| 7479384 | Nematode MDH-like sequences Disclosed are two nucleic acid molecules from M. incognita encoding malate dehydrogenase-like (MDH-like) polypeptides. The MDH-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of MDH-like nucleot... | 01/20/2009 |
