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| Number | Title | Issue Date |
| 8178334 | Variant form of urate oxidase and use thereof The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate ... | 05/15/2012 |
| 8148123 | Methods for lowering elevated uric acid levels using intravenous injections of PEG-uricase A method for lowering elevated uric acid levels in patients is disclosed and consists of administering to the patients an intravenous injection of PEG-uricase having a dosage from about 4 to about 12 mg. ... | 04/03/2012 |
| 8133710 | Oligoadenylate synthetase (OAS) The invention describes novel pharmaceutical compositions for the treatment of virus infections and cancer. The pharmaceutical compositions include mutant oligoadenylate synthetases (OAS) that have either enhanced cell permeability, reduced oxidative potential, impr... | 03/13/2012 |
| 8129162 | Ketol-acid reductoisomerase using NADH Methods for the evolution of NADPH binding ketol-acid reductoisomerase enzymes to acquire NADH binding functionality are provided. Specific mutant ketol-acid reductoisomerase enzymes isolated from Pseudomonas that have undergone co-factor switching to bind NA... | 03/06/2012 |
| 8129163 | Gene suitable for alcohol dehydrogenase, vector and transformant An object of the present invention is to provide a novel alcohol dehydrogenase, a gene for the alcohol dehydrogenase, a vector including the gene, a transformant transformed with the vector, and a method for producing an optically active alcohol by utilizing them. A... | 03/06/2012 |
| 8119380 | Methods and materials for making and using transgenic dicamba-degrading organisms The invention provides isolated and at least partially-purified dicamba-degrading enzymes, isolated DNA molecules coding for dicamba-degrading enzymes, DNA constructs coding for dicamba-degrading enzymes, transgenic host cells comprising DNA coding for dicamba-degra... | 02/21/2012 |
| 8114650 | Nucleic acid and its use effecting ciliate tetrahymena bifunctional dihydrofolate reductase-thymidylate synthase deficiency A method for producing a ciliate cell with reduced or essentially no dihydrofolate reductase (DHFS) activity or reduced or essentially no thymidylate synthase (TS) activity or both reduced or essentially no dihydrofolate reductase and thymidylate synthase (DHFR-TS) ... | 02/14/2012 |
| 8114651 | Method for producing 4-hydroxy-L-isoleucine A highly active L-isoleucine dioxygenase from Bacillus thuringiensis is provided. A method for manufacturing (2S,3R,4S)-4-hydroxy-L-isoleucine or a salt thereof by reacting L-isoleucine in an aqueous solvent in the presence of L-isoleucine dioxygenase and iso... | 02/14/2012 |
| 8110387 | Polypeptide having NADH dependent HMF reductase activity The invention relates to an isolated polypeptide having NADH dependent HMF reductase activity, wherein said polypeptide shows 80% homology to the amino acid sequence shown in SEQ ID NO:2 and which differs from SEQ ID NO:2 in that at least S117L and Y295 or S110 is s... | 02/07/2012 |
| 8105812 | Laccases, compositions and methods of use Novel laccases, nucleic acid sequences encoding such laccases, and vectors and host cells for expressing the laccases are described. The novel laccase enzymes may be employed in conjunction with mediators to provide an improved method for bleaching denim fabrics. | 01/31/2012 |
| 8097442 | Laccases, nucleic acids encoding them and methods for making and using them The invention provides laccases, polynucleotides encoding these enzymes, the methods of making and using these polynucleotides and polypeptides. ... | 01/17/2012 |
| 8093029 | Bilirubin oxidase mutant having thermal stability A heat-resistant bilirubin oxidase mutant is disclosed. The bilirubin oxidase mutant is obtained by deletion, replacement, addition or insertion of at least one amino acid residue of a wild type amino sequence of SEQ. ID. No. 1 of a bilirubin oxidase derived from an... | 01/10/2012 |
| 8076114 | Cytochrome P450 oxygenases Nucleic acids encoding cytochrome P450 variants are provided. The cytochrome P450 variants of have a higher alkane-oxidation capability, alkene-oxidation capability, and/or a higher organic-solvent resistance than the corresponding wild-type or parent cytochrome P45... | 12/13/2011 |
| 8034594 | Variant form of urate oxidase and use thereof The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate ... | 10/11/2011 |
| 8034593 | Multimeric oxidoreductases The present invention concerns multimeric oxidoreductase complexes which function in the enzymatic conversion of a carbon substrate, said complexes having a dehydrogenase subunit and a cytochrome C subunit. The invention further relates to polynucleotides coding for... | 10/11/2011 |
| 8026089 | Mutant Δ8 desaturase genes engineered by targeted mutagenesis and their use in making polyunsaturated fatty acids The present invention relates to mutant Δ8 desaturase genes, which have the ability to convert eicosadienoic acid [20:2 ω-6, EDA] to dihomo-γ-linolenic acid [20:3, DGLA] and/or eicosatrienoic acid [20:3 ω-3, ETrA] to eicosatetraenoic acid [20:3 ω-3, ETA]. Isola... | 09/27/2011 |
| 8021866 | Therapeutic use of ADPase enhanced apyrases The present invention provides for design and therapeutic use of ADPase enhanced polypeptides, pharmaceutical compositions, and methods useful for preventing and reversing platelet aggregation and recruitment for the treatment and prevention of vascular disorders in... | 09/20/2011 |
| 8003358 | Two-step enzyme method for preparing 7-aminocephalosporanic acid The present invention discloses a two-step enzyme method for preparing 7-aminocephalosporanic acid from cephalosporin C, wherein D-amino acid oxidase used is purified D-amino acid oxidase mutant of yeast Trigonopsis variabilis, having a specific activity of 1... | 08/23/2011 |
| 8003359 | Eukaryotic amadoriase having excellent thermal stability, gene and recombinant DNA for the eukaryotic amadoriase, and process for production of eukaryotic amadoriase having excellent thermal stability Disclosed are: a eukaryotic amadoriase which is prepared by introducing a mutation into DNA encoding a eukaryotic amadoriase derived from a microorganism belonging to the genus Coniochaeta or Eupenicillium so as to introduce a substitution into a speci... | 08/23/2011 |
| 7993894 | Nematode fatty acid desaturase-like sequences Nucleic acid molecules from nematodes encoding fatty acid desaturase polypeptides are described. Fatty acid desaturase-like polypeptide sequences are also provided, as are vectors, host cells, and recombinant methods for production of fatty acid desaturase-like nucl... | 08/09/2011 |
| 7981651 | nucleic acids and uses thereof Lactobacillus acidophilus NCFM nucleic acid molecules, polypeptides, fragments and variants thereof are provided in the current invention. In addition, fusion proteins, antigenic peptides, and antibodies are encompassed. The invention also provides recombinan... | 07/19/2011 |
| 7981652 | Modified cytochrome P450 monooxygenases The present invention relates to modified cytochrome P450 monooxygenases with an altered substrate profile, to nucleic acid sequences coding therefor, to expression constructs and vectors, to recombinant microorganisms which comprise these vectors, and to processes ... | 07/19/2011 |
| 7977078 | Ketoreductase polypeptides for the production of ()-3-hydroxythiolane The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of ex... | 07/12/2011 |
| 7964381 | Variant form of urate oxidase and use thereof The present invention relates to genetically modified proteins with uricolytic activity. More specifically, the invention relates to proteins comprising truncated urate oxidases and methods for producing them, including PEGylated proteins comprising truncated urate ... | 06/21/2011 |
| 7960155 | Cytochrome p450 monooxygenases and their use for oxidizing organic compounds The invention relates to novel cytochrome P450 monooxygenases comprising a modified substrate specificity, to nucleotide sequences which code therefor, to expression constructs and vectors containing these sequences, and to microorganisms transformed therewith. The ... | 06/14/2011 |
| 7960156 | Glucose dehydrogenase and method for producing the dehydrogenase A DNA encoding a glucose dehydrogenase enzyme with high substrate specificity and recombinant vectors and transformants for expression of the DNA are disclosed. By culturing the transformant, the glucose dehydrogenase enzyme can be produced at a low cost. The glucos... | 06/14/2011 |
| 7947480 | Everninomicin biosynthetic genes This invention is directed to nucleic acids which encode the proteins that direct the synthesis of the orthosomycin everninomicin and to use of the nucleic acids and proteins to produce compounds exhibiting antibiotic activity based on the everninomycin structure. T... | 05/24/2011 |
| 7939307 | Deletion mutant of multi-copper oxidase and its use in dyeing Modified CueO having excellent enzymatic activity and a composition for dyeing keratin fiber which contains the enzyme. A recombinant protein having an enzymatic activity for oxidizing p-phenylenediamine, the protein is obtained by removing from CueO at least one me... | 05/10/2011 |
| 7932067 | Detection, isolation and uses of renalase (monoamine oxidase C) The present invention provides for the identification, isolation and uses of mammalian Monoamine Oxidase C (MAO-C), also known as renalase. ... | 04/26/2011 |
| 7927851 | Compositions having ent-kaurenoic acid 13-hydroxylase activity and methods for producing same The present invention relates to nucleotide sequences encoding ent-kaurenoic acid 13-hydroxylase polypeptides and polypeptides having ent-kaurenoic acid 13-hydroxylase activity. The invention also relates to methods of producing steviol and steviol glycosides. ... | 04/19/2011 |
| 7923231 | Production of glucuronic acid using myo-inositol oxygenase from cryptococcus neoformans A method is disclosed for increasing the specific activity of myo-inositol oxygenase. The method includes incubating a mixture including myo-inositol oxygenase and a non-sulfur containing reductant under conditions effective to increase the specific activity of the ... | 04/12/2011 |
| 7919295 | Polyol oxidases The present invention provides compositions and methods for producing a polyol oxidase in microorganisms, and the use of polyol oxidases in cleaning compositions. The invention includes cleaning compositions that contain combinations of two or more POx oxidases, and... | 04/05/2011 |
| 7915022 | Carbonyl reductase, gene thereof and method of using the same The present invention relates to a polypeptide having an activity to asymmetrically reduce (3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanone to produce (2R,3S)-1-chloro-3-tert-butoxycarbonylamino-4-phenyl-2-butanol isolated from a microorganism belonging ... | 03/29/2011 |
| 7915021 | Mutant firefly luciferase This invention relates to: the development of a mutant firefly luciferase in order to use dATP as a DNA polymerase substrate upon pyrosequencing, such luciferase being subjected to substrate specificity modification in a manner such that the dATP-induced activity al... | 03/29/2011 |
| 7910344 | Proteins having tyrosinase activity Extracellular tyrosinases obtainable from Trichoderma spp. and methods for producing them by recombinant technology. The enzymes are particularly useful in cross-linking food proteins. ... | 03/22/2011 |
| 7897370 | Process for producing HMG-CoA reductase inhibitor The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 repre... | 03/01/2011 |
| 7892803 | Gene and uses therefor to modify pasture qualities of crops The invention relates generally to isolated leucoanthocyanidin reductase LAR polypeptides of the Reductase-Epimerase-Dehydrogenase (RED) protein family, and nucleic acid molecules encoding same and their use in regulating the biosynthesis and accumulation of proanth... | 02/22/2011 |
| 7888089 | eNOS mutations useful for gene therapy and therapeutic screening The present invention relates to new NOS variants or mutants which contain structural alterations in the site of Akt dependent phosphorylation. The altered NOS proteins or peptides, especially the human eNOS proteins or peptides, Akt proteins or polypeptides and the... | 02/15/2011 |
| 7888088 | Superoxide dismutase (SOD) gene and a method of identifying and cloning thereof The present invention provides a superoxide dismutase gene from Potentilla atrosanguinea, a construct containing the gene coding for superoxide dismutase and transformed E. coli producing the SOD protein. ... | 02/15/2011 |
| 7883879 | Ketoreductase polypeptides for the production of azetidinone The present disclosure provides engineered ketoreductase enzymes having improved properties as compared to a naturally occurring wild-type ketoreductase enzyme. Also provided are polynucleotides encoding the engineered ketoreductase enzymes, host cells capable of ex... | 02/08/2011 |
