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| Number | Title | Issue Date |
| 8168415 | Axl fusion proteins as Axl tyrosine kinase inhibitors Disclosed are novel inhibitors of the Axl receptor tyrosine kinase (RTK) and methods of using such inhibitors in a variety of therapeutic approaches in the areas of cancer therapy and anti-thrombosis (anti-clotting) therapy. ... | 05/01/2012 |
| 8133709 | Target sequences for synthetic molecules The invention is based on the discovery that certain biarsenical molecules react with specified target sequences, thereby providing a facile means for labeling polypeptides containing the target sequence. The invention is useful in creating stable mammalian cell lin... | 03/13/2012 |
| 8110386 | Lipase powder, methods for producing the same and use thereof A lipase powder which is a granulated substance containing a lipase and a solid content of animal milk, a lipase composition wherein said lipase powder is immersed or impregnated in fatty oil, and a method for producing the lipase powder which comprises the step of ... | 02/07/2012 |
| 8071346 | System for the mitigation of photodamage in analytical reactions Compositions, devices, systems and methods for reducing and/or preventing photodamage of one or more reactants in illuminated analytical reactions by one or more of incorporating photodamage mitigating agents within the reaction mixture and/or interrogating differen... | 12/06/2011 |
| 8071345 | Stabilized subtilisin composition The present invention relates to a liquid detergent composition comprising a surfactant, a subtilisin and a protease stabilizer that is 3-chlorobenzoic acid, 4-chlorobenzoic acid, 3-chlorophenylacetic acid, 3,5-dichlorobenzoic acid, 3-(3-chlorophenyl)propionic acid ... | 12/06/2011 |
| 8067217 | Method for preserving reduced coenzyme Q10 The present invention has its object to provide a method for stably preserving a capsule containing reduced coenzyme Q10, which is useful as foods, functional nutritive foods, specific health foods, nutritional supplements, nutrients, animal drugs, drinks... | 11/29/2011 |
| 7919294 | Process for preparing stabilized reaction mixtures which are partially dried, comprising at least one enzyme, reaction mixtures and kits containing said mixtures The invention relates to a method consisting of bringing into contact, in one container, (a) an aqueous solution of a reaction mixture comprising at least one enzyme, and (b) an aqueous solution of a stabilizing mixture comprising (i) at least one protective agent a... | 04/05/2011 |
| 7833766 | Stabilized compositions of proteins having a free thiol moiety Compositions of proteins having free thiols, and methods of making and using such compositions, are described. ... | 11/16/2010 |
| 7799549 | Methods for increasing protein polyethylene glycol (PEG) conjugation The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, with... | 09/21/2010 |
| 7741088 | Immobilized microbial nitrilase for production of glycolic acid The present invention is directed to a process for improving the specific activity of a dehydrated enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid upon rehydration. In particular, a process is provided comprising pretreati... | 06/22/2010 |
| 7700335 | Stabilization of enzymes in an emulsion by cross-linking A process for producing enzymes structures includes providing an emulsion of droplets of a first liquid phase dispersed in a second liquid phase. The one liquid phase is a hydrophilic phase, while the other liquid phase is a hydrophobic phase which is immiscible wit... | 04/20/2010 |
| 7695945 | Immobilized microbial nitrilase for production of glycolic acid The present invention provides a process for preparing an enzyme catalyst having nitrilase activity for hydrolysis of glycolonitrile to glycolic acid with improved retention of recovered catalyst activity in consecutive batch reactions with catalyst recycle, said pr... | 04/13/2010 |
| 7592167 | Functional peptide fiber, production thereof and method for recovering peptide chains This invention provides a functional peptide fiber which comprises a plurality of peptide structure units each containing at least one peptide chain, wherein peptide chains contained in each adjacent peptide structure units do not form peptide bond but are structure... | 09/22/2009 |
| 7566556 | Enhancing enzyme thermostability by mixing with sorghum liquor waste A composition containing a thermolabile protein admixed with a liquor waste. Also disclosed is a method of preparing such a composition which contains a protein with enhanced thermostability. ... | 07/28/2009 |
| 7482145 | Deglycosylated enzymes for conjugates By deglycosylating an enzyme derived from a eukaryotic organism prior to forming a conjugate, i.e. prior to attaching the enzyme to a molecule capable of binding to a target molecule, the sensitivity of an assay for detecting the presence or determining the quantity... | 01/27/2009 |
| 7419811 | Use of specifically engineered enzymes to enhance the efficacy of prodrugs The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with enhanced activity towards nucleoside analogs used in cancer chemotherapy, and delivering the enzymes to specific target cells in a patient. The invention also... | 09/02/2008 |
| 7419600 | Method for purifying a branched water-soluble polymer Multi-armed, monofunctional, and hydrolytically stable polymers are described having the structure wherein Z is a moiety that can be activated for attachment to biologically active molecules such as proteins and wherein P a... | 09/02/2008 |
| 7416869 | Enzyme delivery systems, application in water based products Aqueous enzyme delivery systems as well as aqueous cosmetics and personal care products were provided which comprise at least one stabile enzyme and a polyglycerol containing at least 15 carbons. In addition, stabile non-aqueous enzyme delivery systems which are dis... | 08/26/2008 |
| 7413739 | Conjugate addition reactions for the controlled delivery of pharmaceutically active compounds The invention features polymeric biomaterials formed by nucleophilic addition reactions to conjugated unsaturated groups. These biomaterials may be used for medical treatments. ... | 08/19/2008 |
| 7393698 | Magnetic fine particles and process for producing the same The present invention relates to magnetic fine particles having immobilized thereto a polymer having an upper critical solution temperature, and a process for producing the same, a method of separating or concentrating a microorganism, a method of purifying, detecti... | 07/01/2008 |
| 7358052 | Catalytic amplification of multiplexed assay signals Methods, compositions, kits, and a system are disclosed for detecting one or more analytes in a sample. A mixture comprising the (i) sample, (ii) a first binding reagent comprising a cleavage-inducing moiety and a first binding agent specific for an analyte, and (ii... | 04/15/2008 |
| 7354750 | Methods for separating molecules The present invention provides compositions and methods for the separation of metals or molecules such as polypeptides, nucleic acids, or endotoxins using a metal-modified solid support. The metals or molecules are isolated from a starting material using the modifie... | 04/08/2008 |
| 7351787 | Process for the preparation of activated polyethylene glycols A process for preparing activated polyethylene glycols is disclosed. In some embodiments, the process includes reacting a molten polyethylene glycol with an activator. In other embodiments, the process includes reacting a polyethylene glycol with an activator in the... | 04/01/2008 |
| 7351586 | Method of making stable calibrators or controls for measuring human natriuretic peptides The present invention relates methods for making stable calibrators and controls that can be used in ligand-binding assays. ... | 04/01/2008 |
| 7351798 | Stabilized protein crystals, formulations comprising them and methods of making them This invention relates to methods for the stabilization, storage and delivery of biologically active macromolecules, such as proteins, peptides and nucleic acids. In particular, this invention relates to protein or nucleic acid crystals, formulations and composition... | 04/01/2008 |
| 7348169 | Method of making bioactive catalytic material A bioactive catalytic material is disclosed for providing protection from chemical exposure. The material is composed of enzymes immobilized within polyelectrolyte multilayers and a polymerizable end-capping layer to render stability to enzymes. Also disclosed is th... | 03/25/2008 |
| 7345149 | Cysteine substitution variants of beta interferon The growth hormone supergene family comprises greater than 20 structurally related cytokines and growth factors. A general method is provided for creating site-specific, biologically active conjugates of these proteins. The method involves adding cysteine residues t... | 03/18/2008 |
| 7338770 | Human procalcitonin and the preparation and use thereof The invention relates to human procalcitonin and the preparation and use thereof. In particular, a process for preparing human procalcitonin is described wherein a gene coding for a polypeptide comprising the amino acid sequence of human procalcitonin is inserted in... | 03/04/2008 |
| 7335741 | Means for use in diagnostics and/or therapy The present invention relates to a specific reagent for the detection of the CD30 molecule, whereby this reagent is suitable in particular for the diagnosis of lymphomas. ... | 02/26/2008 |
| 7329516 | Methods for increasing protein polyethylene glycol (PEG) conjugation The present invention relates to highly conjugated proteins and methods for making such proteins. In particular, the present invention relates to methods for linking additional sites to a protein for conjugation with activated polyethylene glycol (PEG) linkers, with... | 02/12/2008 |
| 7329528 | Enzyme multimer and process of producing same An enzyme multimer is provided which comprises a plurality of monomer units including a first monomer unit having enzymatic activity and a second monomer unit having enzymatic activity, wherein each of the first monomer unit and the second monomer unit comprise a cy... | 02/12/2008 |
| 7323345 | Liquid microvolume handling system The present invention relates to a microfluidic device comprising a microchannel (2, 4) providing for solvent contact between an open microarea (MA) carrying a microvolume (1) of a solvent and a reservoir (3) for the solvent, said reservoir (... | 01/29/2008 |
| 7323167 | Method of treatment with modified arginine deiminase The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis. ... | 01/29/2008 |
| 7321828 | System of components for preparing oligonucleotides Interative, preferably computer based iterative processes for generating synthetic compounds with desired physical, chemical and/or bioactive properties, i.e., active compounds, are provided. During iterations of the processes, a target nucleic acid sequence is prov... | 01/22/2008 |
| 7319032 | Non-sugar sweeteners for use in test devices The present invention provides methods, compositions, and kits for rapid detection of analytes in a sample. Surprisingly, it has been found that bulking materials having non-sugar sweeteners effectively enhance chromatographic detection methods by providing componen... | 01/15/2008 |
| 7312056 | Enhancement of enzyme activity through purification and immobilization An improved method of making an immobilized enzyme comprising (a) treating an immobilization support with an aqueous solution comprising a cross-linking agent and polymeric aldehyde species and active centre species to produce a modified support; (b) isolating the m... | 12/25/2007 |
| 7309588 | Nucleic acid assays The present invention relates to the detection of specific nucleic acid sequences after an amplification process, or directly without amplification. In particular, the invention provides for the automation of the amplification and detection process, the amplificatio... | 12/18/2007 |
| 7304016 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7304015 | Compositions for separating molecules The present invention provides compositions for the separation of metals or biomolecules such as polypeptides, nucleic acids, or endotoxins using modified solid supports. ... | 12/04/2007 |
| 7300779 | Preparation of a granule containing protein, corn starch and sugar layered on an inert particle Granules that include a protein core are described. The protein core includes a protein matrix which includes a protein mixed together with a starch. The protein matrix can be layered over a seed particle or the protein core can be homogeneous. The protein can be an... | 11/27/2007 |
