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| Number | Title | Issue Date |
| 8088609 | CAB molecules The present invention relates to CAB molecules, ADEPT constructs directed against CEA, and their use in therapy. ... | 01/03/2012 |
| 7524663 | Covalently reactive transition state analogs and methods of use thereof Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed. ... | 04/28/2009 |
| 7456000 | Deactivation of linking moieties in antibody-enzyme conjugates In some embodiments, the present invention pertains to a method for conjugating a first compound to a second compound wherein the conjugation involves an electrophilic moiety. The method comprises reacting the first compound with the second compound to form a conjug... | 11/25/2008 |
| 7413884 | Immunological control of β-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of β-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using β-amyloid peptides which incorporate transition state analogs are also ... | 08/19/2008 |
| 7410755 | ADP detection using an enzyme-coupled reaction Methods and compositions are provided for determining ADP in the presence of ATP. These comprise including among the assay reagents at least one of the correcting components creatine phosphokinase and phosphocreatine, pyruvate kinase and phosphoenolpyruvate, peroxid... | 08/12/2008 |
| 7348403 | Peptides and methods for deactivation of organophosphorus-based nerve agents and insecticides This invention provides methods and peptides for the inactivation of organophosphorus-based insecticides and chemical warfare agents. The instant methods include peptide screening methods, peptides and peptide libraries, related compositions of matter, articles of m... | 03/25/2008 |
| 7341720 | Targeting of glycoprotein therapeutics Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polyme... | 03/11/2008 |
| 7335717 | Methods, compositions, and biomimetic catalysts for the synthesis of silica, polysilsequioxanes, polysiloxanes, non-silicon metalloid-oxygen networks, polymetallo-oxanes, and their organic or hydrido conjugates and derivatives The in vitro polymerization of silica, silicone, non-silicon metalloid-oxane and metallo-oxane polymer networks, by combining a catalyst and a substrate to polymerize the substrate to form silica, polysiloxanes, polymetalloid-oxanes polymetallo-oxanes (metal oxides)... | 02/26/2008 |
| 7226991 | Phenylalanine derivatives Disclosed herein are phenylalanine derivative compounds of the following formula W—Y—(AA)n—Z wherein Y is a phenylalanyl radical, AA is an amino acid, n is an integer of 1 to 15, and substituent variables W and Z are as described... | 06/05/2007 |
| 7205136 | Catalytic antibodies A method for increasing the rate of chemical reactions involving the conversion of at least one reactant to at least one product involves contacting the reactant with an appropriate monoclonal antibody under conditions permitting the formation of a complex between t... | 04/17/2007 |
| 7148028 | Methods and means relating to atherosclerosis The present invention relates to the identification of lipid oxidising antibodies as a key pathogenic factor in atherosclerotic disorders. The presence of such antibodies is a important marker for the diagnosis and prognosis of such disorders and methods and means f... | 12/12/2006 |
| 6972327 | Regeneration of chromatography material The invention provides improved methods of regenerating and using affinity chromatography material, in particular Protein A affinity chromatography resins. ... | 12/06/2005 |
| 6946272 | Transition state analogs Antigens capable of eliciting antibodies which can catalyze chemical reactions, in particular, the cleavage or formation of a peptide linkage, comprising a hapten or a hapten and a suitable carrier molecule are disclosed. Haptens include, among others, silicon and b... | 09/20/2005 |
| 6913917 | Anti-cocaine catalytic antibody Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also dis... | 07/05/2005 |
| 6913896 | Assay with reduced background In as assay, an analyte is specifically associated with a reporter adenylate kinase, ADP is added and then formation of ATP is monitored. Prior to addition of ADP, adenylate kinase other than reporter adenylate kinase is removed. Assay apparatus comprises a solid ph... | 07/05/2005 |
| 6872554 | Immunological control of β-amyloid levels in vivo Disclosed are bispecific antibodies comprising a first antibody binding specificity which confers the ability of the bispecific antibody to cross the blood-brain barrier, and a second antibody specificity conferring the ability of the bispecific antibody to bind to ... | 03/29/2005 |
| 6867002 | Sample treating kit and sample treating method using the same for analysis with a biosensor A sample solution treating instrument is provided for facilitating rapid and simplified adjustment of the condition of a sample solution proper for analysis with a biosensor before supplying the solution to the biosensor. The sample solution treating instrument incl... | 03/15/2005 |
| 6855804 | Covalently reactive transition state analogs and methods of use thereof Improved methods for the production, selection and inhibition of catalytic antibodies are disclosed. ... | 02/15/2005 |
| 6855528 | Methods for identifying inducers and inhibitors of proteolytic antibodies, compositions and their uses Covalently reactive antigen analogs are disclosed herein. The antigens of the invention may be used to stimulate production of catalytic antibodies specific for predetermined antigens assocated with particular medical disorders. The antigen analogs may also be used ... | 02/15/2005 |
| 6846654 | Catalytic antibodies as chemical sensors A system for detecting physical or chemical changes in an environment is disclosed. The system comprises means for conducting a chemical reaction; an active biological molecule whose physiological function is noncatalytic which is capable of catalyzing a chemical re... | 01/25/2005 |
| 6720171 | Combinatorial preparation and testing of heterogeneous catalysts A process for preparing arrays of two or more heterogeneous catalysts, heterogeneous catalyst precursors, or combinations thereof in a body having preferably parallel through-channels. In this process, a solution, emulsion or dispersion of elements present in the ca... | 04/13/2004 |
| 6702705 | Prodrugs activated by targeted catalytic proteins Catalytic antibodies are disclosed. The catalytic antibodies are specific for prodrug compounds. The catalytic antibodies enhance cleavage of an active drug moiety from a prodrug residue, thereby activating the drug.... | 03/09/2004 |
| 6696415 | Treatment of ocular neovascularization and related diseases Tubedown-1 (tbdn-1), a protein associated with acetyltransferase activity has been characterized and its cDNA isolated. Tbdn-1 regulates endothelial differentiation through protein acetylation, DNA-binding or by interacting with and/or acetylating other p... | 02/24/2004 |
| 6670438 | Methods, compositions, and biomimetic catalysts for in vitro synthesis of silica, polysilsequioxane, polysiloxane, and polymetallo-oxanes Methods, compositions, and biomimetic catalysts, such as silicateins and block copolypeptides, used to catalyze and spatially direct the polycondensation of silicon alkoxides, metal alkoxides, and their organic conjugates to make silica, polysiloxanes, po... | 12/30/2003 |
| 6670144 | Compositions and methods for monitoring the phosphorylation of natural binding partners This invention relates to methods and compositions for monitoring the interaction of binding partners as a function of the addition or subtraction of a phosphate group to or from one of the binding partners by a protein kinase or phosphatase.... | 12/30/2003 |
| 6589766 | Aldol consensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent d... | 07/08/2003 |
| 6590080 | Catalytic antibodies and a method of producing same The present invention relates generally to a growth factor precursor and its use to select production of antigen specific catalytic antibodies. Such catalytic antibodies are produced following B cell activation and proliferation induced by catalytic cleav... | 07/08/2003 |
| 6582945 | Immunological control of ଲ-amyloid levels in vivo Disclosed are antibodies which catalyze hydrolysis of ଲ-amyloid. Antibodies generated are characterized by the amide linkage which they hydrolyze. Methods of generating the antibodies by using ଲ-amyloid peptides which incorporate transition st... | 06/24/2003 |
| 6521432 | Methods for enhancing the rate of modification of metastable bonds Antigens capable of eliciting antibodies which can enhance the rate of chemical reactions at peptide bonds are disclosed. In particular, the rate of cleavage or formation of metastable peptide bonds, such as ASN-X, ASP-X, GLN-X, GLU-X, LYS-X, and HIS-Y-X,... | 02/18/2003 |
| 6521741 | Catalytic antibodies and a method of producing same The present invention is directed generally to catalytic antibodies and, more particularly, to a novel method of producing same. The method of the present invention is predicated in part on the exploitation of the products of catalysis to induce B cell mi... | 02/18/2003 |
| 6489418 | Preparation and application of artificial anti-idiotypic imprints This patent application describes the use of molecular imprinting as a means for preparation of anti-idiotypic imprint matrices. With this technique, imprints of artificial or natural molecules including their recognition sites, such as of molecularly imp... | 12/03/2002 |
| 6479265 | Catalytic antibodies which hydrolyze primary amides and methods for eliciting and use of such antibodies Described and claimed are compounds of the formula ##STR1## wherein: Y is a polypeptide, R1 is bonded to the N-terminus of Y and is hydrogen or a branched or linear, substituted or unsubstituted, C1-21 alkyl, alkene, or alkyne group,... | 11/12/2002 |
| 6451980 | Signal enhancement of bispecific antibody-polymer probe for immunoassay use An immunoassay method including reacting a sample from a patient with a bispecific antibody, wherein the bispecific antibody includes one antibody specific for a compound to be detected and a second antibody specific for a compound foreign to said patient... | 09/17/2002 |
| 6440710 | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds Methods are provided for deuteration, tritiation, dedeuteration or detritiation of a carbonyl compound. A catalytic antibody that catalyzes an aldol addition reaction is contacted with a carbonyl compound to exchange at least one hydrogen atom of the carb... | 08/27/2002 |
| 6387674 | Catalytic monoclonal antibodies with protease activity for selective lysis of protein component of plaques aggregates pathological conditions Catalytic monoclonal antibodies (abzymes) with selective protease activity in the pathologies characterized by the presence of plaques and fibrillar aggregates with protein component; methods for the preparation thereof and the use thereof as medicaments ... | 05/14/2002 |
| 6368839 | Aldolase catalytic antibody Antibodies that catalyze the aldol reaction are generated by immunization with a reactive compound that covalently traps a Lysine (Lys) residue in the binding pocket of the antibody by formation of a stable vinylogous amide, i.e., a covalent antibody/hapt... | 04/09/2002 |
| 6326176 | Aldol condensations by catalytic antibodies Catalytic antibodies, including 38C2 and 33F12, are capable of efficiently catalyzing a wide variety of ketone-ketone, ketone-aldehyde, aldehyde-ketone, and aldehyde-aldehyde intermolecular aldol reactions, and in some cases to catalyze their subsequent d... | 12/04/2001 |
| 6326179 | Catalytic antibodies and a method of producing same The present invention is directed generally to catalytic antibodies and, more particularly, to a novel method of producing same. The method of the present invention is predicated in part on the exploitation of the products of catalysis to induce B cell mi... | 12/04/2001 |
| 6309881 | Antibody catalysis of enantio- and diastereo-selective aldol reactions Nine efficient aldolase antibodies were generated using hapten 2. This hapten combines, in a single molecule, structural components employed for reactive immunization with structural components employed for forming a transition state analog of the aldol r... | 10/30/2001 |
| 6294374 | Use of catalytic antibodies for synthesizing epothilone Three monoclonal aldolase antibodies, generated against a ଲ-diketone hapten by reactive immunization, catalyzed rapid and highly enantioselective retro-aldol reactions providing ent-9a-k by kinetic resolution. Compounds 9a, 9g and 9k were resolved i... | 09/25/2001 |
