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| Number | Title | Issue Date |
| 8183023 | DNA polymerases The present invention relates to a thermophilic polymerase, wherein the DNA polymerase has an in-vitro primer extension rate that is >35 bases/second and faster relative to the primer extension rate of a DNA polymerase comprising amino acid sequences SEQ ID NO: 2 or... | 05/22/2012 |
| 8178333 | Biocatalytic processes for the preparation of substantially stereomerically pure fused bicyclic proline compounds The present disclosure provides monoamine oxidase enzymes and methods of their use in biocatalytic processes for the preparation of substantially enantiomerically pure heterobicyclic compounds of the following structural formulas, | 05/15/2012 |
| 8178301 | Mutant SepRS, and method for site-specific introduction of phosphoserine into protein using the same A mutant SepRS which is suitable for a site-specific introduction of phosphoserine into a protein is prepared by analyzing the structure and functions of a phosphoseryl-tRNA synthetase (SepRS) derived from an archaebacterium. A mutant SepRS composed of an amino acid... | 05/15/2012 |
| 8168414 | Beta-galactosidase with transgalactosylating activity The present invention concerns a new β-galactosidase with transgalactosylating activity isolated from Bifidobacterium bifidum. The β-galactosidase is capable of converting lactose to a mixture of galactooligosaccharides which are β-linked and unexpectedly ... | 05/01/2012 |
| 8137943 | Heat-resistant DNA ligase with high reactivity Thermostable DNA ligases with enhanced DNA binding activity and reaction activity are obtained. These modified thermostable DNA ligases having enhanced DNA binding activity compared to the wild type can be obtained by substituting a negatively charged amino acid (fo... | 03/20/2012 |
| 8129160 | Method of screening for inhibitors of glutaminyl cyclase activity Novel glutaminyl-peptide cyclotransferase-like proteins (QPCTLs), which are isoenzymes of glutaminyl cyclase (QC, EC 2.3.2.5), and to isolated nucleic acids coding for these isoenzymes, all of which are useful for the discovery of new therapeutic agents, for measuri... | 03/06/2012 |
| 8129161 | Bardet-Biedl susceptibility gene and uses thereof The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation,... | 03/06/2012 |
| 8124388 | Production of 3-hydroxypropionic acid using beta-alanine/pyruvate aminotransferase Methods of using beta-alanine/pyruvate aminotransferase to produce 3-hydroxypropionic acid and derivatives thereof, from beta-alanine, are disclosed. Cells and recombinant nucleic acids that can be used to practice the methods are also disclosed. ... | 02/28/2012 |
| 8114649 | L-cysteine producing microorganism and a method for producing L-cysteine L-cysteine is produced by culturing an Escherichia bacterium having L-cysteine producing ability and containing a gene encoding an O-acetylserine sulphydrylase B or MalY regulatory protein that is modified so that cysteine desulfhydrase activity is reduced or... | 02/14/2012 |
| 8114648 | In vivo incorporation of unnatural amino acids The invention provides methods and compositions for in vivo incorporation of unnatural amino acids. Also provided are compositions including proteins with unnatural amino acids. ... | 02/14/2012 |
| 8101389 | Bacterial glutamine synthetases and methods of use Compositions and methods for conferring herbicide resistance to and improving nitrogen utilization of bacteria, plants, plant cells, tissues and seeds are provided. Compositions comprising a coding sequence for a polypeptide that confers resistance or tolerance to h... | 01/24/2012 |
| 8093028 | Engineered glycosyltransferases with expanded substrate specificity The present invention provides engineered glycosyltransferase enzymes and method for making and using the same possessing an expanded substrate specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such enzymes expand the variety of subst... | 01/10/2012 |
| 8088608 | Endoglucanases The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase. ... | 01/03/2012 |
| 8071344 | Site specific incorporation of keto amino acids into proteins Compositions and methods of producing components of protein biosynthetic machinery that include orthogonal tRNAs, orthogonal aminoacyl-tRNA synthetases, and orthogonal pairs of tRNAs/synthetases, which incorporate keto amino acids into proteins are provided. Methods... | 12/06/2011 |
| 8062874 | GFP fusion proteins and their use The present invention provides fusion proteins including a green fluorescent protein inserted into the internal amino acid sequence of a Gαs protein and further provides method of using the fusion protein construct to follow activation of a G-protein receptor by a ... | 11/22/2011 |
| 8048662 | Sulfotransferase 1E1 sequence variants Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are desc... | 11/01/2011 |
| 8048661 | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes A non-naturally occurring microbial organism includes a microbial organism having a reductive TCA or Wood-Ljungdahl pathway in which at least one exogenous nucleic acid encoding these pathway enzymes is expressed in a sufficient amount to enhance carbon flux through... | 11/01/2011 |
| 8030042 | Polyamino acid synthetase and gene encoding the same The present invention provides an enzyme which catalyzes amino acid polymerization in the form of a non-ribosomal peptide synthetase (NRPS) and a gene encoding the same. ... | 10/04/2011 |
| 8026088 | Angiogenic tyrosyl tRNA synthetase compositions and methods The present invention provides an isolated tyrosyl tRNA synthetase (TyrRS) polypeptide variant which comprises (a) a Rossmann fold region or a portion thereof, preferably including an 5 coil; and (b) an anticodon recognition domain or portion thereof, preferably inc... | 09/27/2011 |
| 8012728 | Thrombin preparations and process for their production The production of a thrombin preparation which is obtained from prothrombin which is, after activation to thrombin without the addition of thromboplastin, purified by a hydrophobic interaction chromatography, it being possible subsequently also to inactivate or remo... | 09/06/2011 |
| 8003357 | Acidophilic enzymes The present invention relates to enzymes having catalytic activity at a pH below 5.0. The present invention provides hydrolyzing enzymes obtainable from archaeobacteria, in detail to hydrolytic enzymes obtainable from the archaeobacterium Ferroplasma acidiphilum | 08/23/2011 |
| 7993893 | Haemocoagulase The present invention provides a venene haemocoagulase gene and its expression for the functional protein. The haemocoagulase gene of the present invention has a nucleotide sequence shown by the sequence list SEQ ID NO: 1 or the mutated nucleotide sequence formed by... | 08/09/2011 |
| 7989190 | Composition for analyzing nucleic acid The present invention provides a firefly luciferase for inexpensive, highly accurate and highly sensitive nucleic acid analysis that uses dATP instead of an expensive reagent having low reactivity to DNA polymerase in the manner of dATPαS, a method of analyzing nuc... | 08/02/2011 |
| 7981650 | Fusion proteins between plant cell-wall degrading enzymes, and their uses The invention relates to the use of fusion proteins between at least two plant cell-wall degrading enzymes, the enzymes being such that they do not contain a C-terminal carbohydrate-binding-molecule (CBM), and optionally a CBM, the enzymes and CBM being recombinant ... | 07/19/2011 |
| 7960154 | Polyester-based-plastic-degrading bacteria, polyester-based-plastic-degrading enzymes and polynucleotides encoding the enzymes The present invention relates to a novel microorganism and a method for degrading plastics or for collecting monomers through biological treatment using the microorganism. The present invention also relates to a novel polyester-based plastic-degrading enzyme and a p... | 06/14/2011 |
| 7955828 | Use of methionine synthase inhibitors for the treatment of fungal diseases of crops The invention relates to the use of methionine synthase inhibitors for the treatment of fungal diseases of crops. The invention further relates to methods for treatment of crops against fungal diseases comprising the application of a methionine synthase inhibitor al... | 06/07/2011 |
| 7951568 | Bi-directional selection markers with improved activity The present invention discloses a polypeptide selected from the group consisting of: a polypeptide having an amino acid sequence according to SEQ ID NO 3, a polypeptide having an amino acid sequence according to SEQ ID NO 6, a polypeptide having an amino acid that i... | 05/31/2011 |
| 7947479 | Bardet-Biedl susceptibility gene and uses thereof The present invention relates to the identification of a gene, now designated negevin (ngvn), that is involved in the genetic disease Bardet Biedl Syndrome (BBS), which is characterized by such diverse symptoms as obesity, diabetes, hypertension, mental retardation,... | 05/24/2011 |
| 7943355 | Sulfotransferase 1E1 sequence variants Isolated sulfotransferase nucleic acid molecules that include a nucleotide sequence variant and nucleotides flanking the sequence variant are described, as well as sulfotransferase allozymes. Methods for determining if a mammal is predisposed to cancer also are desc... | 05/17/2011 |
| 7943354 | Method to remove bisulfite by-products from enzyme compositions Provided are methods of removing bisulfite material from a composition that contains a bisulfite material and an enzyme. The method includes contacting the composition with a compound containing at least one aldehyde functional group to form an aldehyde-bisulfite co... | 05/17/2011 |
| 7939306 | Antibacterial dentifrice exhibiting antiplaque and breath freshening properties A dual component antiplaque oral composition having antimalodor properties in which a first component contains an antibacterial agent and the second component contains a proteolytic enzyme, the first and second components are simultaneously combined for application ... | 05/10/2011 |
| 7939305 | PUFA-PKS genes from The invention relates to genes which are coded for sequences specific to polyketide synthases (PKS). The thus synthesized PKS is characterized by the enzymatic capacity thereof to produce PUFAs (polyunsaturated fatty acids). The invention also relates to the identif... | 05/10/2011 |
| 7939304 | Mutant MT-SP1 proteases with altered substrate specificity or activity MT-SP1 mutein proteases with altered specificity for the target molecules they cleave can be used to treat human diseases, such as cancer. Cleaving VEGF or VEGFR at certain substrate sequences with wild-type and mutein MT-SP1 proteases can be used to treat pathologi... | 05/10/2011 |
| 7935508 | Production and use of monoglycerides A higher-yielding process for the production of monoglycerides in which triglycerides are enzymatically reacted with a catalytic amount of an esterase, preferably lipase, that has been activated by the addition of alkaline salts, in the presence of linear or branche... | 05/03/2011 |
| 7927850 | Composition containing trehalose synthase and methods of use thereof The present invention relates to the isolation and functional identification of a novel acid and heat resistant trehalose synthase enzyme cloned from Picrophilus torridus. More particularly, the present invention discloses the DNA sequence for the Picrophi... | 04/19/2011 |
| 7927849 | Laccase enzyme and use thereof The present invention relates to a novel laccase enzyme obtainable from the strains of genus Thielavia. The invention relates also to the nucleic acid sequence encoding the enzyme, a recombinant host into which the nucleic acid sequence has been introduced an... | 04/19/2011 |
| 7923230 | Neurodegenerative protein aggregation inhibition methods and compounds Methods and compositions are provided for reducing aggregation of neurodegenerative proteins associated with neurotoxicity or other proteins. The compounds comprise a first domain or targeting element for binding to the target proteins linked to a second domain or r... | 04/12/2011 |
| 7906306 | Pullulanase variants and methods for preparing such variants with predetermined properties The present invention relates to pullulanase variants, wherein the variants have improved properties, for example, altered pH optimum, improved thermostability, altered substrate specificity, increased specific activity or altered cleavage pattern. ... | 03/15/2011 |
| 7892802 | Fibrinogen-based tissue adhesive containing an elastase inhibitor The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor. ... | 02/22/2011 |
| 7888087 | Fusion protein of Fc-binding domain and calcium-binding photoprotein, gene encoding the same and use thereof The invention provides a calcium-binding photoprotein which has a high ability to bind to IgG and is capable of more sensitively detecting IgG. A fusion protein of the present invention composed of a ZZ domain having the ability to bind to the Fc region of IgG and t... | 02/15/2011 |
