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| Number | Title | Issue Date |
| 8187831 | Determination of ions using ion-sensitive enzymes The invention relates generally to the field of sodium and lithium ion detection. In particular, the invention provides chimeric proteins, nucleic acids encoding chimeric proteins, methods and kits for assaying for sodium ions and for lithium ions in a sample, using... | 05/29/2012 |
| 8173385 | Method for stabilization of peptides in a biological sample The present invention provides a simple method for the stabilization of a peptide in a biological sample and a reagent for the stabilization, a simple method for the preservation of a biological sample comprising a peptide and a reagent for the preservation, and a m... | 05/08/2012 |
| 8163514 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 04/24/2012 |
| 8153391 | Hydrolases, nucleic acids encoding them and methods for making and using them Provided are hydrolases, including lipases, saturases, palmitases and/or stearatases, and polynucleotides encoding them, and methods of making and using these polynucleotides and polypeptides. Further provided are polypeptides, e.g., enzymes, having a hydrolase acti... | 04/10/2012 |
| 8148096 | Microtitration plates comprising wells coated with a lipid substrate and a method of preparing A method for the detection and/or measurement in vitro of a lipase or phospholipase activity, including the addition of a sample likely to contain said lipase or phospholipase into the wells of microtitration plates coated with a layer of a lipid substrate which is ... | 04/03/2012 |
| 8148098 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 04/03/2012 |
| 8148097 | Screening method for identification of compounds with calcium-independent phospholipase Aβ (iPLAβ) modulating activity An in vitro screening method for identifying a compound with iPLA2β modulating activity. ... | 04/03/2012 |
| 8143015 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/27/2012 |
| 8143016 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/27/2012 |
| 8143014 | CD38 and obesity This document provides methods and materials relating to obesity. For example, methods and materials related to treating obesity and identifying agents having the ability to treat obesity are provided. ... | 03/27/2012 |
| 8133697 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/13/2012 |
| 8129133 | Devices and methods for the rapid, reliable detection and determination of acrylamide concentration in food substances and prevention of acrylamide formation in the same A device and associated analytical method to use for the sensitive detection and accurate, rapid determination of acrylamide in food substances is presented. Also described is the use of a kit device and associated analytical method in which a user can quickly and e... | 03/06/2012 |
| 8129134 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 03/06/2012 |
| 8124369 | Method of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/28/2012 |
| 8119361 | Methods of cleaving DNA with rationally-designed meganucleases Rationally-designed LAGLIDADG meganucleases and methods of making such meganucleases are provided. In addition, methods are provided for using the meganucleases to generate recombinant cells and organisms having a desired DNA sequence inserted into a limited number ... | 02/21/2012 |
| 8088741 | Compounds for enzyme inhibition Peptide-based compounds including heteroatom-containing, three-membered rings efficiently and selectively inhibit specific activities of N-terminal nucleophile (Ntn) hydrolases. The activities of those Ntn having multiple activities can be differentially inhibited b... | 01/03/2012 |
| 8080386 | Polypeptides having endoglucanase activity and polynucleotides encoding same The present invention relates to isolated polypeptides having endoglucanase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as meth... | 12/20/2011 |
| 8071327 | Screening assays for agents that alter inhibitor of apoptosis (IAP) protein regulation of caspase activity The present invention relates to an action between an inhibitor of apoptosis (IAP) protein and members of the caspase family of cell death proteases, for example, an interaction of the X chromosome linked IAP (XIAP) and caspase-3, caspase-7 or caspase-9, wherein the... | 12/06/2011 |
| 8043828 | Modified endoglucanase II and methods of use Described herein is a modified EGII cellulase having the amino acid sequence shown in SEQ ID NO:1, compositions comprising the modified EGII and methods of use. ... | 10/25/2011 |
| 8034579 | Proteins with enhanced functionality and methods of making novel proteins using circular permutation The present disclosure is relates to novel proteins and peptides having novel and/or enhanced functions and/or behaviors with respect to a native protein or peptide, and methods of making the novel proteins and peptides using techniques of circular permutation and p... | 10/11/2011 |
| 7985563 | HIFαprolyl hydroxylation assay The present invention provides methods of identifying compounds that decrease proline hydroxylation of the alpha subunit of hypoxia inducible factor (HIFα). ... | 07/26/2011 |
| 7972806 | Phospholipase The present invention is related to a method for producing a phospholipase by processing an expressed fungal peptide and to certain specified phospholipases. Furthermore the invention provides a method for producing cheese with a phospholipase. ... | 07/05/2011 |
| 7951552 | Method of preparing non-human tissues for xenotransplantation using α-galactosidase This invention relates to novel α-galactosidases for the enzymatic removal of the immunodominant monosaccharides on blood products and tissues. Specifically this invention provides a novel family of α3 glycosidases, used for the enzymatic removal of type B antigen... | 05/31/2011 |
| 7943336 | Cutinase for detoxification of feed products The present invention relates to a method comprising treatment with cutinase for detoxification of feed products contaminated by the mycotoxin zearalenone. ... | 05/17/2011 |
| 7943335 | Process for the production of diacylglycerol The present invention provides a process for producing a diacylglycerol, which comprises, reacting triacylglycerol with water and an enzyme preparation to obtain a mixture comprising of diacylglycerol, monoacylglycerol and free fatty acid; removing water content in ... | 05/17/2011 |
| 7935500 | Identifying calcineurin activators for treatment of schizophrenia The present invention provides targets, methods, and reagents for the diagnosis and treatment of schizophrenia and related conditions. The invention provides methods for the diagnosis of schizophrenia and susceptibility to schizophrenia by detection of polymorphisms... | 05/03/2011 |
| 7906300 | Methods for diagnosing an attention-deficit/Hyperactivity disorder Changes that occur in Na+K+ ATPase regulation and therefore in the membrane potential in cells from bipolar individuals, as compared to cells from unaffected control individuals, are utilized to provide a diagnostic assay for bipolar I and bipo... | 03/15/2011 |
| 7897363 | Methods of screening an agent for an activity in an isolated eye of a teleost The present invention provides methods of screening an agent for an activity in an isolated organ, e.g., eye, from a teleost, e.g., zebrafish. Methods of isolating eyes from zebrafish are provided. Methods of screening an agent for an ocular activity in the isolated... | 03/01/2011 |
| 7888059 | Highly purified and stabilized Na,K-ATPase isoforms and methods of producing same A composition of matter comprising active Na,K-ATPase is disclosed, each Na,K-ATPase comprising an α and β subunit, the Na,K-ATPase being at least 85% purified. Methods of purifying same and uses thereof are also disclosed. ... | 02/15/2011 |
| 7883862 | Diglyceride solutions for lipase activity determination Diglyceride solutions for lipase activity determination, comprising at least one diglyceride, a low concentration buffer, and a nonionic surfactant. ... | 02/08/2011 |
| 7851176 | Lipolytic enzyme variants The substrate specificity of a lipolytic enzyme can be modified by making alterations to the amino acid sequence in a defined region of the lipolytic enzyme, so as to increase the level of a desired activity or to decrease the level of an undesired activity. Thus, t... | 12/14/2010 |
| 7807399 | Methods for detecting thiol-containing nucleotide diphosphates with thiol-reactive fluorescent reagents Disclosed are methods for detecting thiol-containing nucleotide diphosphates. The methods utilize thiol-reactive fluorescent reagents. ... | 10/05/2010 |
| 7799538 | Method for identifying agents which modulate GTPase activity involved in insulin-stimulated GLUT4 translocation The present invention is a method for identifying agents that modulate the GTPase activity of AS160. In the instant assay, AS160 or the GAP domain thereof is contacted with a test agent, in the presence of GTP-bound Rab (2A, 8A, 8B, 10, or 14), and the AS160 GAP dom... | 09/21/2010 |
| 7763440 | Diagnosis of pre-eclampsia The present invention provides a method for diagnosis of pre-eclampsia which comprises measuring urate in a biological sample. The sample is preferably maternal saliva. ... | 07/27/2010 |
| 7759086 | Diagnostic method for chronic fatigue syndrome by measuring elastase The present invention relates to methods and kits for the diagnosis and confirmation of Chronic Fatigue Syndrome (CFS) by measuring elastase activity in a patient sample, preferably a PBMC sample. The assays of the invention can also be used to characterize CFS, to ... | 07/20/2010 |
| 7749724 | Fluorogenic selective and differential medium for isolation of Particular aspects provide novel compositions and methods useful for the growth, isolation and detection of microorganisms that have α-glucosidase activity (e.g., the bacterium E. sakazakii). Certain embodiments provide a novel growth and/or plating media, c... | 07/06/2010 |
| 7736866 | Enzyme-based time temperature indicator A time temperature indicator for indicating temperature change over time is provided, comprising an immobilized enzyme and a substrate of the enzyme, wherein the reaction of the substrate catalyzed by the enzyme produces a reaction product in a time and temperature ... | 06/15/2010 |
| 7732162 | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases The present invention provides novel physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for... | 06/08/2010 |
| 7727738 | Methods for generating analogs of coenzyme A Methods to generate analogs of coenzyme A in vitro and in vivo are disclosed. The methods comprise reacting pantetheine or a derivative thereof with a reporter to form labeled pantetheine or a derivative thereof, phosphorylating the labeled pantetheine or derivative... | 06/01/2010 |
| 7691596 | Methods for determining GTP cyclohydrolase I or II activity The present invention relates to methods for determining GTP Cyclohydrolase I or II activity in a sample. ... | 04/06/2010 |
