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| Number | Title | Issue Date |
| 7422867 | Methods of identifying compounds that modulate IL-4 receptor mediated IgE synthesis utilizing a CLLD8 protein The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of usi... | 09/09/2008 |
| 7416856 | High sensitivity assay for detection of nucleoside diphosphate production The present invention provides assays for detecting ADP, GDP and inorganic phosphate. These assays can be used directly to detect the presence of ADP, GDP and inorganic phosphate or can be used as part of a number of methods for identifying candidate agents that bin... | 08/26/2008 |
| 7378254 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high th... | 05/27/2008 |
| 7361286 | Method of detecting etching end-point A method of detecting an etching end-point includes the steps of: forming a mask on a pattern area of an etching object; forming an etching indicator on an etching area of the etching object, which is not covered by the mask; etching the etching object using the mas... | 04/22/2008 |
| 7247435 | Enzymatic fluorometric assay for cAMP and adenylate cyclase The present invention relates to a method for quickly determining cAMP content or an adenylate cyclase activity in a biological sample containing non-cyclic adenine nucleotides without the use of radioactive agents. Particularly, the present invention provide... | 07/24/2007 |
| 7238483 | Method for detecting catalytic activity This invention has as its object a method for detecting catalytic activity of a sample, characterized in that it comprises: the incubation of a substrate (S) with the sample that may have the catalytic activity that it is desired to detect, the addition of a reagent... | 07/03/2007 |
| 7220550 | Molecular wire injection sensors Disclosed is a sensor for sensing the presence of an analyte component without relying on redox mediators. This sensor includes (a) a plurality of conductive polymer strands each having at least a first end and a second end and each aligned in a substantially common... | 05/22/2007 |
| 7202051 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high th... | 04/10/2007 |
| 7192727 | Reagent for measuring alanine aminotransferase activity A reagent for measuring an alanine aminotransferase activity comprising L-alanine, 2-oxoglutaric acid, lactate dehydrogenase, and reduced nicotinamide adenine dinucleotide, characterized by further comprising a substance having an activity of inhibiting lactate dehy... | 03/20/2007 |
| 7172858 | Blood-based assay for dysferlinopathies It has been discovered that dysferlin is expressed in blood and that individuals who lack dysferlin in muscle also lack it in CD14(+) cells. Based on these discoveries, blood-based tests for dysferlin expression and uses of such tests are described. ... | 02/06/2007 |
| 7148046 | Crystal structure of cytochrome P450 The invention provides the crystal structure of the cytochrome P450 3A4 protein molecule. The structure is set out in Table 5. The structure may be used in to model the interaction of compounds such as pharmaceuticals with this protein, and to determine the structur... | 12/12/2006 |
| 7083952 | Nucleotide sequences coding for proteins involved in the biosynthesis of L-serine, an improved method for the microbial production of L-serine and a genetically modified microorganism suitable therefor The present invention relates to nucleotide sequences of coryneform bacteria, coding for proteins involved in the bio-synthesis of L-serine and to methods for the isolation thereof. The invention further relates to an improved method for the production of L-serine. ... | 08/01/2006 |
| 7026136 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, methods of sc... | 04/11/2006 |
| 7018807 | Method and medium for detecting vancomycin-resistant A microbe-specific medium for detection of vancomycin-resistant Enterococci in a test sample within 24 hours and preferably within 18 hours. The testing medium provides a selective growth medium for vancomycin-resistant Enterococci and includes specifi... | 03/28/2006 |
| 7012676 | Laser capture microdissection translation stage joystick Systems and methods for laser capture microdissection are disclosed. An inverted microscope includes a translation stage joystick subsystem. The systems and methods provide the advantages of increased speed and much lower rates of contamination. ... | 03/14/2006 |
| 7001737 | Urinary trypsin inhibitor assay containing a chelating agent Disclosed is an assay for determining the presence and concentration of trypsin inhibitor in urine samples. The assay reagents, which may be used either in the liquid or dry states, include trypsin, a trypsin substrate and a polycarboxylic chelating agent. The inclu... | 02/21/2006 |
| 6995004 | UDP-N-ACETYLGLUCOSAMINE: GALACTOSE-β 1,3-N-ACETYLGALACTOSAMINE-α-R / N-ACETYLGLUCOSAMINE-β 1,3,-N-ACETYLGALACTOSAMINE-α-R (GLCNAC TO GALNAC) β1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE, C2/4GNT A novel gene defining a novel human UDP-GlcNAc: Gal/Gl cNAcβ 1-3GalNAc αβ1, 6GlcNAc-transferase, termed C2/4GnT, with unique enzymatic properties is disclosed. The enzymatic activity of C2/4GnT is shown to be distinct from that of previously identified enzymes of... | 02/07/2006 |
| 6979544 | Molecular wire injection sensors Disclosed is a sensor for sensing the presence of an analyte component without relying on redox mediators. This sensor includes (a) a plurality of conductive polymer strands each having at least a first end and a second end and each aligned in a substantially common... | 12/27/2005 |
| 6979549 | Methods of identifying compounds that modulate IL-4 receptor-mediated IgE synthesis utilizing a CLLD8 protein The present provides compounds capable of modulating IL-4 receptor-mediated IgE production, as well as IL-4 induced processes associated therewith, methods and kits for identifying such compounds that utilize a CLLD8 protein as a surrogate analyte and methods of usi... | 12/27/2005 |
| 6958148 | Linkage of agents to body tissue using microparticles and transglutaminase Methods, products and kits are provided for attaching agents to a body tissue surface via microparticles using endogenous or exogenous transglutaminase. The microparticles have surface available transglutaminase substrate reactive groups. In an embodiment, the group... | 10/25/2005 |
| 6919076 | Conjugates of agents and transglutaminase substrate linking molecules Methods, products, compositions and kits are provided for attaching agents to tissue with a linking molecule in the presence of transglutaminase. The linking molecule and/or agent is a substrate of transglutaminase. The agent can be a nonprotein or an enzyme such as... | 07/19/2005 |
| 6797460 | NMR-solve method for rapid identification of bi-ligand drug candidates Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug candidates are screened from a focused combinatorial library where the speci... | 09/28/2004 |
| 6790605 | Methods for obtaining a desired bioactivity or biomolecule using DNA libraries from an environmental source Disclosed is a process for obtaining an enzyme having a specified enzyme activity derived from a heterogeneous DNA population by screening, for the specified enzyme activity, a library of clones containing DNA from the heterogeneous DNA population which have been ex... | 09/14/2004 |
| 6762026 | Enzymatic fluorimetric assay of camp and adenylate cyclase The present invention relates to a method for quickly determining cAMP content or an adenylate cyclase activity in a biological sample containing non-cyclic adenine nucleotides without the use of radioactive agents. Particularly, the present invention provide... | 07/13/2004 |
| 6756230 | Quantitative analysis Amounts of components in a specimen can be analyzed with excellent quantitativity. The analysis includes: measuring an amount of a component to be analyzed in a specimen; measuring an amount of a standard component present originally and homeostatically in the speci... | 06/29/2004 |
| 6750032 | Method and diagnostic agent for hemostasis diagnosis The invention relates to a method and to a diagnostic agent for detecting hemostasis disturbances, wherein, as a consequence of blood platelet aggregation, clot formation and/or clot dissolution, substances are brought to a distance from each other which permits or ... | 06/15/2004 |
| 6743599 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used in a high th... | 06/01/2004 |
| 6733986 | Method and agent for determining a deaminase enzymatic activity A method and compound for detecting and identifying and/or quantifying a deaminase enzymatic activity of a microorganism, according to which an inoculum suspected of containing a microorganism with a deaminase activity is brought into contact with a culture medium f... | 05/11/2004 |
| 6706489 | Motor proteins and methods for their use The invention provides isolated nucleic acid and amino acid sequences of HsKifC2, antibodies to HsKifC2, methods of screening for HsKifC2 modulators using biologically active HsKifC2, and kits for screening for HsKifC2 modulators. ... | 03/16/2004 |
| 6677133 | Methods of reducing microbial resistance to drugs The instant methods and compositions represent an advance in controlling drug resistance in microbes. AcrAB-like efflux pumps have been found to control resistance to drugs, even in highly resistant microbes. Accordingly, methods of treating infection, me... | 01/13/2004 |
| 6673565 | Enzymatic polymeric sensors A sensor for detecting an analyte enzyme includes at least one substrate compound and at least one indicator compound selected to produce a measurable change of state as a result of the interaction of the substrate and at least one target or analyte enzym... | 01/06/2004 |
| 6664073 | Enzymatic cycling assays for homocysteine and cystathionine The present invention provides an enzymatic cycling assay for assessing the amount of homocysteine and/or cystathionine in a solution such as blood, blood, derivatives, or urine. The assay comprises the steps of contacting the solution containing homocyst... | 12/16/2003 |
| 6645735 | Reagent for GPT assay A two reagent-type kit for assaying GPT by acting GPT on L-alanine and -ketoglutarate in the presence of pyridoxal phosphate, converting the resulting pyruvate into lactate with L-lactate dehydrogenase (LDH) in the presence of reduced nicotinamide ... | 11/11/2003 |
| 6632600 | Altered thermostability of enzymes Provided is a method of screening gene libraries derived from a mixed population of organisms for a bioactivity or biomolecule of interest. The mixed population of organisms can be a cultured population or an uncultured population from, for example, the e... | 10/14/2003 |
| 6620589 | NMR-solve method for rapid identification of Bi-ligand drug candidates Methods for rapidly identifying drug candidates that can bind to an enzyme at both a common ligand site and a specificity ligand site, resulting in high affinity binding. The bi-ligand drug candidates are screened from a focused combinatorial library wher... | 09/16/2003 |
| 6471959 | Human transferase The invention provides three human transferases (HUTRAN) and polynucleotides which identify and encode HUTRAN. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagn... | 10/29/2002 |
| 6465202 | Method for stabilizing aminotransferase activity in a biological fluid Methods and compositions for the stabilization of aminotransferase activity of plasma or serum are provided. Such methods will be useful in the accurate determination of tests associated with liver toxicity.... | 10/15/2002 |
| 6436658 | Method for the determination of homocysteine The invention relates to a method for determining homocysteine concentration in samples in which homocysteine is condensed using an enzyme cystathionine ଲ sythase to form cystathionine. Pyruvate and/or ammonia are released from cystathionine by acti... | 08/20/2002 |
| 6426194 | Homogeneous enzymatic assay for vitamin B6 and improvements in H2S detection Enzymatic methods to determine the concentration of pyridoxal 5'-phosphate (PLP) in biological fluids are described. The methods of the invention are useful to assess risk for cardiovascular disease. The assay can be a homogeneous assay using the ability ... | 07/30/2002 |
| 6410254 | Compositions and assays utilizing ADP or phosphate for detecting protein modulators Described herein are methods which identify candidate agents as binding to a protein or as a modulator of the binding characteristics or biological activity of a protein. Generally, the methods involve the use of ADP or phosphate. The assays can be used i... | 06/25/2002 |
