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Class 435/13 - Involving blood clotting factor (e.g., involving thrombin, thromboplastin, fibrinogen, etc.)


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter where the material to be measured or tested
No. of patents: 616
Last issue date: 05/08/2012


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NumberTitleIssue Date
8173384Methods for analyzing or processing a heparin sample
The invention relates to methods and products for analyzing or processing a heparin sample. In one embodiment, the methods comprise contacting the sample with heparinase I, heparinase II and heparinase III, determining the amount of a signature component in the samp...
05/08/2012
8163513Method for determining the total clotting activity of a blood or plasma sample
The invention relates to a method for determining the total clotting activity of a blood or plasma sample, characterized in that a highly specific, reversible thrombin inhibitor is added to a blood or plasma sample in a defined amount, the clotting of the blood or p...
04/24/2012
8133696Method for determining thrombin activity
Methods and kits to determine thrombin activity are provided. They have the great advantage that there is no need to measure the whole calibrator curve in each individual medium, since a single-point measurement is adequate. ...
03/13/2012
8058023Assessment of cardiac health and thrombotic risk in a patient
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to assessing risk of thrombotic events in patients with coronary artery ...
11/15/2011
8021854Method of treating vascular disease
A method for attenuating the incidence and severity of endovascular disease, arrhythmias and malignancy via a reduction in the total circulating platelet volume is presented. The method will achieve the reduced rates of acute coronary syndromes observed in patients ...
09/20/2011
7939288Method for differentiating between factor XIII deficiency states and fibrinogen deficiency states by means of thrombelastographic techniques
The invention relates to a method for determining a factor XIII deficiency, a method for determining a fibrinogen deficiency, and a method for differentiating between a factor XIII deficiency and a fibrinogen deficiency by means of thrombelastographic techniques. On...
05/10/2011
7935498Methods for identifying patients with increased risk of an adverse cardiovascular event
Methods, compositions and kits are disclosed for identifying patients with an increased risk of experiencing an adverse cardiovascular event where the patient is undergoing aspirin antiplatelet therapy. A platelet-containing sample from the patient is evaluated for ...
05/03/2011
7923217Specificity in the determination of antithrombin
Methods and reagents for determining antithrombin III (AT) in body fluids by adding an AT binding partner to the sample and determining the free AT binding partner. ...
04/12/2011
7906299Assay for low molecular weight heparin
A prothrombin time reagent for determination of low molecular weight heparin in fresh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture in...
03/15/2011
7803569Marburg I mutant of factor VII activating protease (FSAP) as risk factor for arterial thrombosis and methods of detecting FSAP and FSAP mutations
An arterial thrombosis risk factor comprising one or more of the identified mutants of coagulation factor VII activating protease (FSAP) is described. In addition, diagnostic determination methods for detecting these mutants which are identified as risk factors are ...
09/28/2010
7803570Method for determining the concentration of thrombin inhibitors
The invention relates to a method for determining the concentration of thrombin inhibitors in a non-turbid body liquid or a non-turbid extract from a body liquid. It comprises the following steps. The body liquid is taken from a living body, and the body liquid is s...
09/28/2010
7790410Method and apparatus for determining hemocompatibility
Provided herein are techniques for screening materials for hemocompatibility. Hemocompatible materials may be advantageous when incorporated into devices that may come into direct contact with blood or other bodily fluids. Such techniques take advantage of conformat...
09/07/2010
7790409Blood coagulation accelerator and container for blood examination
The present invention provides a blood coagulation accelerator excellent under severe conditions at ordinary or higher temperatures and capable of exhibiting high blood coagulation performance stably over a long period of time, as well as a container for blood exami...
09/07/2010
7785820Method for automatically determining the endogenous thrombin potential
The present invention relates to a method for automatically determining the endogenous thrombin potential of a blood or plasma sample. ...
08/31/2010
7759082Electroprocessed fibrin-based matrices and tissues
The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may b...
07/20/2010
7759083Screening method for a growth inhibitor or promoter of a vascular smooth muscle cell
It was found that TAT which has not been known biological activity has a role as a new blood vessel smooth muscle proliferation factor, and then a screening method vascular of an inhibitor or promoter of a smooth muscle cell growth with TAT is established. ...
07/20/2010
7727736Soluble phospholipids for use in clotting factor assays
The present invention provides a soluble phospholipid reagent and assays of clotting activity using the same. The methods of the invention can be used to carry out any clotting assay or other assay of clotting activity that traditionally relies on platelet membranes...
06/01/2010
7723064Methods for monitoring patients for efficacy of an antiplatelet therapy regimen
Methods are disclosed for monitoring patients utilizing Mean Platelet Component values during therapeutic intervention. ...
05/25/2010
7682808Coagulation and fibrinolytic cascades modulator
A thromboplastin reagent comprises (i) TF, (ii) a phospholipid, and (iii) a polyP TFPI blocker. ...
03/23/2010
7595169Method for determining percent platelet aggregation
A method for obtaining a percent aggregation or inhibition of platelets resulting from anti-platelet using a single blood sample is achieved. An assay device is provided. The assay device has multiple channels, each coupled to a common introduction port. A first pla...
09/29/2009
7585642Methods for evaluating the quality of a heparin sample
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminogly...
09/08/2009
7498146Stable factor VIII/von willebrand factor complex
There are disclosed a stable factor VIII/vWF-complexes, particularly comprising high-molecular vWF multimers, being free from low-molecular vWF molecules and from proteolytic vWF degradation products, as well as methods of producing these complexes. ...
03/03/2009
7494782Assay for measuring factor viia-antithrombin complexes
A method for determining the concentration of factor VIIa-antithrombin complexes is disclosed which has application to estimating the level of intravascular exposure of tissue factor, assessing patient risk for hypercoagulation or other coagulopathies, and monitorin...
02/24/2009
7442514Mutants of the factor VII-activating protease and detection methods using specific antibodies
Mutants of the DNA sequence coding for the protease (FSAP) which activates blood clotting factor VII and single-chain plasminogen activators, the mutants comprising a G/C base exchange at nucleotide position 1177 and/or a G/A base exchange at nucleotide position 160...
10/28/2008
7439069Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., thrombin time, PT, aPTT, and ACT, of a blood sample deposited in a test cartridge is disclosed. The test cartridge includes a blood receptacle that is open to the atmosphere into which a blood sample is t...
10/21/2008
7432352Hybrid molecules having Factor VII/VIIa activity
The present invention relates to novel human coagulation Factor VII/VIIa proteins having coagulant potential/activity as well as pharmaceutical compositions comprising the proteins, uses thereof, and methods of treatment therewith. In particular, the present inventi...
10/07/2008
7422905Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test chambe...
09/09/2008
7399604Methods and products related to evaluating the quality of a polysaccharide
The invention relates to methods and products for characterizing and using polysaccharides. Low molecular weight heparin products and methods of use are described. Methods for characterizing purity and activity of polysaccharide preparations including glycosaminogly...
07/15/2008
7399637Blood coagulation test cartridge, system, and method
A system and method for determining a coagulation time, e.g., TT, PT, aPTT, and ACT, of a blood test sample deposited in a test cartridge is disclosed. A cartridge housing having upper and lower major sides and a minor sidewall encloses a test chamber having a test ...
07/15/2008
7381536Assessment of cardiac health and thrombotic risk in a patient
The invention features methods and compositions for assessing risk, particularly immediate risk, of thrombotic events in patients with suspected or known vascular disease, and more particularly to assessing risk of thrombotic events in patients with coronary artery ...
06/03/2008
7378393Recombinant anticoagulant proteins
Novel recombinant anticoagulation proteins, methods of their use and methods of their production are described. In particular, recombinant fusions of annexin V (ANV) and Kunitz protease inhibitors (KPI) that possess potent anticoagulant activity are provided. The fu...
05/27/2008
7361306Device and method for measuring coagulation time and platelet activity
The present invention refers to a novel device for measuring coagulation time and platelet activity wherein the patient can measure his or her coagulation time and platelet activity without the aid of medical professionals due to the fact that this device is fully a...
04/22/2008
7361480Method and means for detecting gluten-induced diseases
The invention is directed to a method of detecting gluten-induced diseases such as e.g. celiac disease and dermatitis herpetiformis. Said diseases are indicated by the presence of autoantibodies against tissue transglutaminase tTG in the blood The test is carried ou...
04/22/2008
7357916Method for creating a uniform vascular wound in zebrafish or zebrafish larva
Disclosed are improved methods for creating a uniform vascular wound in a zebrafish larva or zebrafish. The methods illustratively include subjecting a zebrafish larva to laser irradiation in an amount and for a period of time effective to cause a uniform vascular w...
04/15/2008
7358337Assay for low molecular weight heparin
A prothrombin time reagent for determination of low molecular weight heparin in frsh whole blood and in anti-coagulant treated blood is provided. The reagent is composed of recombinant animal tissue factor, and a mixture of synthetic phospholipids, which mixture inc...
04/15/2008
7357016Process and device for determining viscosity
A process and a device for determining the viscosity of a fluid are proposed. Very simple and accurate determination is enabled in that the magnetic particles in the fluid are set into vibration by a magnetic field which varies over time. A measurement of the amplit...
04/15/2008
7341697Reaction cell and operation method thereof
A reaction cell is provided with a vessel-like cell main body and a circular piezoelectric/electrostrictive oscillator fixed to an outside of a bottom surface of the cell main body. The cell main body includes a circular bottom plate portion and a circumferential wa...
03/11/2008
7332469Intrapleural single-chain urokinase alone or complexed to its soluble receptor protects against pleural adhesions
The present invention relates to methods of preventing or decreasing the severity of scarring in a subject comprising: obtaining a pharmaceutical composition comprising a single chain urokinase plasminogen activator molecule (scuPA) or a scuPA mimetic; and administe...
02/19/2008
7332303Product quality enhancement in mammalian cell culture processes for protein production
The present invention describes methods and processes for the production of proteins, particularly glycoproteins, by animal cell or mammalian cell culture, illustratively, but not limited to, fed-batch cell cultures. The methods comprise feeding the cells with D-gal...
02/19/2008
7323315Method for reducing effect of hematocrit on measurement of an analyte in whole blood
A method for determining the presence and/or amount of an analyte in a sample of whole blood comprises the step of treating the sample with a nonlytic hypertonic salt composition to reduce the hematocrit by reducing the size of the red blood cells. In optical detect...
01/29/2008
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