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| Number | Title | Issue Date |
| 7955824 | Methods of making epothilones The invention provides novel compounds that may be used as intermediates in the preparation of epothilones, epothilone analogs and derivative, as well as new synthetic methods for producing the intermediates and products. ... | 06/07/2011 |
| 7807422 | Production of flavonoids by recombinant microorganisms Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosynthetic pathway for the conversion of phenylpropanoids to various flav... | 10/05/2010 |
| 7794991 | Stemphones and production thereof The present invention relates to novel stemphones having enhancing effect of β-lactam antibiotic used as an antibacterial agent, and a process for production thereof. The process is comprised of culturing microorganism belonging to genus Aspergillus and havi... | 09/14/2010 |
| 7700329 | Methods for making simvastatin and intermediates The invention provides synthetic chemical and chemoenzymatic methods of producing simvastatin and various intermediates. In one aspect, enzymes such as hydrolases, e.g., esterases, are used in the methods of the invention. ... | 04/20/2010 |
| 7439046 | Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one α-hydrogen atom and a substituted or unsubstituted aldehyde i... | 10/21/2008 |
| 7439045 | pH controlled fermentation process for pseudomonic acid production An improved fermentation process for preparing pseudomonic acid A (mupirocin) is disclosed. The metabolically controlled fermentation process provides culturing a Pseudomonas sp. strain in a submerged medium at a temperature within about 20-30° C. The pH of ... | 10/21/2008 |
| 7432089 | DNA encoding favin-adenine-dinucleotide-dependent-D-erythronate-4-phosphate-de-hydrogenase, pdxR, and microbial production of vitamin B The present invention relates to a DNA encoding a novel flavin adenine dinucleotide (FAD)-dependent D-erythronate 4-phosphate (EN4P) dehydrogenase originated from Sinorhizobium meliloti, which is involved in vitamin B6 biosynthesis, and a recombinant microorg... | 10/07/2008 |
| 7416865 | Process for the preparation of dihydroxy esters and derivatives thereof A process is provided for the preparation of a compound of formula (1) wherein R and R′ represent optionally substituted hydrocarbyl groups and X represents a hydrocarbyl linking group. The process comprises either the st... | 08/26/2008 |
| 7396667 | Enzymatic depolymerization process of polylactic acid, and producing process of polylactic acid using depolymerization product A depolymerizing process of polylactic acid, wherein the polylactic acid is depolymerized in the presence of a hydrolase in an organic solvent or a supercritical fluid, thereby producing a re-polymerizable oligomer. A producing process of polylactic acid, wherein th... | 07/08/2008 |
| 7351558 | Solventless extraction process The present invention provides a method for extracting lipids from microorganisms without using organic solvent as an extraction solvent. In particular, the present invention provides a method for extracting lipids from microorganisms by lysing cells and removing wa... | 04/01/2008 |
| 7338791 | Production of flavonoids by recombinant microorganisms Methods and compositions are provided for production of flavonoids in microbial hosts. The compositions comprises a set of genes which encode for enzymes involved in one or more steps in the biosymthetic pathway for the conversion of phenylpropanoids to various flav... | 03/04/2008 |
| 7335815 | Nucleic acid sequences to proteins involved in isoprenoid synthesis Methods are provided for producing plants and seeds having altered isoprenoid content and compositions. The methods find particular use in increasing the isoprenoid levels in plants, and in providing desirable isoprenoid compositions in a host plant cell. ... | 02/26/2008 |
| 7267970 | Production of gluconate salts A method for producing substantially pure ammonium gluconate or metal gluconate that includes separating reagents for reuse from the enzymatically converted gluconate by ultrafiltration. ... | 09/11/2007 |
| 7238348 | Method of treatment of osteoporosis with compositions of red rice fermentation products Methods are disclosed for using red rice fermentation products for the treatment or prevention of osteoporosis and abnormal bone mass conditions. Particular Monascus strains yield fermentation products with the desired biological activities. ... | 07/03/2007 |
| 7232908 | Process for the production of piperidine derivatives with microorganisms The present invention relates to a process for the production of piperidine derivatives with microorganisms. This is carried out by incubating starting compounds in the presence of a microorganism under conditions effective to produce piperidine derivative products.... | 06/19/2007 |
| 7223590 | Process for preparing pravastatin sodium The present invention relates to a process for preparing pravastatin sodium. More specifically, in the process for preparing pravastatin sodium by adding a precursor of the pravastatin to a microorganism-culturing medium to obtain pravastatin sodium, the precursor o... | 05/29/2007 |
| 7202062 | Strains of , process for producing pravastain using the strains and isolation process of (HMG)-CoA reductase The present invention provides two new microorganism strains of Saccharothrix, designated as YS-44442 and YS-45494, a process of producing pravastatin using the strains, and an improved process for isolation of (HMG)-CoA reductase inhibitors. ... | 04/10/2007 |
| 7189558 | Process for producing pravastatin sodium salt using dsm 14455 In one aspect, the present invention provides an improved method for the manufacture of Pravastatin sodium salt by fermentation under optimal fermentation parameters using a new strain of Streptomyces flavidovirens. ... | 03/13/2007 |
| 7141602 | Process for obtaining HMG-CoA reductase inhibitors of high purity Lovastatin, pravastatin, simvastatin, mevastatin, atorvastatin, and derivatives and analogs thereof are known as HMG-CoA reductase inhibitors and are used as antihypercholesterolemic agents. The majority of them are produced by fermentation using microorganisms of d... | 11/28/2006 |
| 7129067 | Method for producing lactone This invention relates to a method for producing a lactone comprising culturing Candida sorbophila in a medium containing at least one selected from the group consisting of a hydroxy fatty acid, a hydroxy fatty acid derivative, and a hydrolysate of a hydroxy ... | 10/31/2006 |
| 7125692 | Process for producing monomer A process for producing a monomer for resists represented by the following general formula 1: wherein R1 represents hydrogen or an optionally substituted alkyl group; R2 | 10/24/2006 |
| 7118895 | Process for producing aglycon by using diglycosidase and flavor-improved food containing the aglycon and converting agent to be used in the process A physiologically active substance of aglycon type, in particular, aglycon isoflavone, can be efficiently produced, without resort to any acid/alkali treatment or fermentation and substantially without changing the physical properties of a material, by treating the ... | 10/10/2006 |
| 7118690 | Dispersible polymer powders Disclosed herein is a water-dispersible powder consisting essentially of polymers T comprising recurring thiophene units and at least one further polyanionic polymer P and process for preparing and using the same. ... | 10/10/2006 |
| 7078223 | Process for the preparation of pseudomonic acid a antibiotic by microbiological method A procedure for the preparation of pseudomonic acid A comprising submerged cultivation of a Pseudomonas bacterium strain capable of biosynthesis of the substantially pure pseudomonic acid A in aerated conditions via fermentation; and isolation of the desired ... | 07/18/2006 |
| 7067304 | mutants and their use in preparing fermentation products having blood pressure lowering activity The invention relates to Monascus purpureus mutants, which are useful in the preparation of fermentation products having blood pressure lowering activity with a very low amount of citrinin. The invention also provides a process for preparing the fermen... | 06/27/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7056540 | Enzymatic process for the preparation of optically active alcohols from ketones using tuberous root The present invention relates to an enzymatic process for the preparation of optically active chiral alcohols using tuberous root Daucus carota; particularly invention relates to an enzymatic process for the preparation of optically active alcohols by enantio... | 06/06/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 7052886 | Process for the isolation of lovastatin The process for the preparation and isolation of the hypolipaemic active substance lovastatin in substantially pure form having a purity of at least 95% which comprises lactonizing the mevinolinic acid to lovastatin in a totally aqueous medium. ... | 05/30/2006 |
| 7049111 | Process for producing HMG-CoA reductase inhibitor The present invention relates to a protein derived from a microorganism belonging to the genus Bacillus, which has an activity of hydroxylating a compound represented by the formula (I-a): wherein R1 ... | 05/23/2006 |
| 7037672 | Process for producing a bran pickles flavoring solution The present invention relates to a novel flavoring solution for making pickles having a flavor of foods pickled in rice bran paste (hereinafter referred to as a bran pickles flavoring solution), a clear bran pickles flavoring solution, processes for producing said s... | 05/02/2006 |
| 7034054 | Methods for the prevention and treatment of cerebral ischemia using non-alpha tocopherols The present invention provides method for the treatment of a symptom of neuronal damage associated with cerebral ischemia comprising administering gamma-, beta-, or delta-tocopherol enriched tocopherol compositions. ... | 04/25/2006 |
| 7033621 | Isoflavone compositions produced from legumes Processes for the production of isoflavones are described wherein plant material from plants of the genus leguminosae are contacted with water, an enzyme which cleaves isoflavone glycosides to the aglucone form and a C2-C10 organic solve... | 04/25/2006 |
| 6972191 | Method for production of geranylgeraniol and analogous compounds thereof by microorganisms The present invention provides a method for producing geranylgeraniol and analogous compounds thereof, which comprises culturing yeast cells (ascomycetes and deuteromycetes), bacterial cells, actinomycete cells or filamentous fungus cells, all of which are capable o... | 12/06/2005 |
| 6964863 | Process for the preparation of 2,4-dideoxyhexoses and 2,4,6-trideoxyhexoses The invention relates to a process for the preparation of a 2,4-dideoxyhexose or a 2,4,6-trideoxyhexose from a substituted or unsubstituted carbonyl compound with at least 2 carbon atoms and at least one α-hydrogen atom and a substituted or unsubstituted aldehyde i... | 11/15/2005 |
| 6946270 | Process for producing HMG-CoA reductase inhibitors The present invention relates to a process for producing a compound (II-a) or a compound (II-b), each of which is a hydroxylated product of a compound represented by the formula (I-a) (hereinafter referred to as compound (I-a)): ... | 09/20/2005 |
| 6943017 | Method of producing antihypercholesterolemic agents A method of increasing the production of lovastatin or monacolin J in a lovastatin-producing or non-lovastatin-producing organism is disclosed. In one embodiment, the method comprises the steps of transforming an organism with the A. terreus D4B segment, wher... | 09/13/2005 |
| 6936731 | Pravastatin sodium substantially free of pravastatin lactone and epi-pravastatin, and compositions containing same The present invention provides pravastatin sodium substantially free of pravastatin lactone and epiprava, the C-6 epimer of pravastatin. The present invention further provides a novel process for recovering pravastatin sodium from a fermentation broth in such high p... | 08/30/2005 |
| 6913917 | Anti-cocaine catalytic antibody Disclosed are catalytic antibodies and polypeptides capable of degrading cocaine. Said catalytic antibodies and polypeptides are characterized by the amino acid sequence of their complementary determining regions and framework regions. The present invention also dis... | 07/05/2005 |
| 6903227 | Synthesis of 2-acyl substituted chromanes and intermediates thereof Novel processes for producing enantiomerically enriched and enantiomerically pure compositions of 2-acyl substituted chromane compounds, and 2-acylchromane compounds that are intermediates for producing platelet aggregation inhibitors and/or are themselves potent pl... | 06/07/2005 |
