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| Number | Title | Issue Date |
| 8114640 | Macrocyclization of compounds from solid support using thioesterases A method of preparing macrocycles using solid support chemistry and thioesterases is disclosed. Also disclosed are novel macrocycles. ... | 02/14/2012 |
| 7378268 | Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis o... | 05/27/2008 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7241899 | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 07/10/2007 |
| 7195898 | Method for the production of -hydroxybenzoate in species of pseudomonas and Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences... | 03/27/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 7183098 | Loline alkaloid gene clusters of the fungal endophyte neotyphodium uncinatum Loline alkaloids (LA), which are 1-aminopyrrolizidines with an oxygen bridge, are produced by Epichloë (anamorph=Neotyphodium) species, endophytes of grasses. LA are insecticidal, thus helping protect host plants from insect herbivory. Suppression sub... | 02/27/2007 |
| 7172884 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 02/06/2007 |
| 7090999 | Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use The invention concerns methods for preparing pristinamycin IIA or IIB. ... | 08/15/2006 |
| 7083953 | Method for the production of p-Hydrozybenzoate in species of and Bacterial strains transformed with the pcu genes are useful for the production of para-hydroxybenzoate (PHBA). Applicant has provided the p-cresol utilizing (pcu) and tmoX gene sequences from Pseudomonas mendocina KR-1, the proteins encoded by these sequences... | 08/01/2006 |
| 7070964 | Epothilone compounds and methods for making the same The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by ... | 07/04/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 7015029 | Process for producing optically active (4R)-1,3-tiazolidine-4-carboxylic acid There is provided a novel method for producing an optically active (4R)-1,3-thiazolidine-4-carboxylic acid by allowing cells of a microorganism or a preparation obtained from cells of a microorganism having activity for stereoselectively hydrolyzing an optically act... | 03/21/2006 |
| 6979735 | Agglomerates by crystallization The present invention describes novel agglomerates in crystalline form of β-lactam compounds. Furthermore, a process for the preparation of said agglomerates, wherein a solution or suspension of at least one β-lactam compound in a solvent is mixed with one or more... | 12/27/2005 |
| 6902925 | Selection media for beauveriolide I or beauveriolide III and process for selectively producing these substances The present invention is a process for selective production of beauveriolide I substance or beauveriolide III substance, in which a beauveriolide producing microorganism strain FO-6979 or mutant thereof is cultured in a medium for fungi added with specific amino aci... | 06/07/2005 |
| 6893859 | Epothilone derivatives and methods for making and using the same This invention relates to compounds of formula (I) and to pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, R4, R5, W, X, Y, and Ar are a... | 05/17/2005 |
| 6670157 | Polypeptides involved in the biosynthesis of streptogramins, nucleotide sequences coding for these polypeptides and their use The invention concerns methods for preparing pristinamycin IIB and methods for preparing modified pristinamycin IIB.... | 12/30/2003 |
| 6638758 | Process for the enzymatic resolution of lactams A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the cor... | 10/28/2003 |
| 6573074 | Methods for ansamitocin production Improved purification methods for ansamitocins are disclosed.... | 06/03/2003 |
| 6566106 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 05/20/2003 |
| 6440708 | Fermentation of clavulanic acid at a controlled level of ammonia A method for the production of clavulanic acid by the fermentation of a clavulanic acid producing microorganism at a controlled level of at least 50 mg/l ammonia has been provided for. Under the application of these reaction conditions surprisingly high p... | 08/27/2002 |
| 6361982 | Regulatory gene for clavulanic acid biosynthesis DNA comprising a regulatory gene for clavulanic acid biosynthesis. DNA is no greater than 7 kb in length and has the configuration of restriction sites shown in FIG. 1 or a fragment thereof. Use of DNA in a method for producing clavulanic acid in a host.... | 03/26/2002 |
| 6361979 | Microbial conversion of 2-methylquinoxaline The present invention relates to processes for the microbial oxidation of 2-methylquinoxaline to 2-quinoxalinecarboxylic acid which comprise contacting 2-methylquinoxaline with a microorganism, or a suitable mutant thereof, and incubating the resulting mi... | 03/26/2002 |
| 6277626 | Process for the enzymatic resolution of lactams A method of separating enantiomeric lactam esters. The lactam esters are contacted with a biocatalyst, such as an enzyme or a microorganism, in a solution wherein only one enantiomer is selectively hydrolyzed to give the optically active isomer of the cor... | 08/21/2001 |
| 6207428 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 03/27/2001 |
| 6100052 | Process for the production of clavulanic acid and/or salts thereof by fermentation controlling soluble phosphate concentration A batch fermentation is carried out continuously or semicontinuously using strain of Streptomyces clavuligerus for the production of clavulanic acid. The fermentation process is carried out with strict control of the soluble phosphate in the medium both a... | 08/08/2000 |
| 6066656 | 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane isosteres comprising benzamide, sulfonamide and anthranilamide subunits and methods of using same The present invention provides 2,5-diamino-3,4-disubstituted-1,6-diphenylhexane (DAD) isosteres comprising benzamide, sulfonamide and anthranilamide subunits, a pharmaceutical composition comprising such compounds, a method of using such compounds to... | 05/23/2000 |
| 6043058 | Preparation of cyclic depsipeptide compounds and a novel cyclic depsipeptide Known cyclic depsipeptides which are PE 1022F substance and PF 1022H substance, as well as a novel cyclic depsipeptide, PF 1022G substance, are now prepared simultaneously by cultivating a fungal strain capable of producing PF 1022F substance, PF 1022G su... | 03/28/2000 |
| 5994346 | Use of exochelins in the preservation of organs for transplant Exochelins can be used to prevent damage to organs for transplant from the formation or presence of the .circle-solid.OH radical. In particular, the invention is directed to the administration of exochelins to the organ prior to or coincidental with remov... | 11/30/1999 |
| 5985628 | Generator switch A generator switch includes phase conductors each equipped with one disconnector and one vacuum switch having a horizontally disposed pole gap. At least one vacuum chamber is provided per phase. The disconnector is constructed as a linear-travel disconnec... | 11/16/1999 |
| 5985625 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of Streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microogranism comprises the microfiltration of the broth without pr... | 11/16/1999 |
| 5968788 | Method for producing folic acid Disclosed is a method for producing folic acid, comprising incubating yeast having the ability to produce folic acid of 0.3 mg or more or incubating bacteria having the ability to produce folic acid of 1 mg or more per liter of the culture, thereby accumu... | 10/19/1999 |
| 5945316 | Lactic-acid-containing cyclic depsipeptides having 18 ring atoms as endoparasiticidal agents, and process for their preparation The present invention relates to a process for the preparation of lactic-acid-containing, optically active, cyclic depsipeptides having 18 ring atoms with the aid of fungal strains of the species Fusarium or enzymatic preparations isolated therefrom.... | 08/31/1999 |
| 5945315 | Method for producing cryptophycins by cultivating a Nostoc sp. The present invention provides novel cryptophycin compounds having the following structure: ##STR1## The present invention also provides methods for producing cryptophycins from the Nostoc sp. of blue-green algae (cyanobacteria). Pharmaceutical ... | 08/31/1999 |
| 5914263 | Enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer The invention relates to an enzymatic process for the stereoselective preparation of a hetero-bicyclic alcohol enantiomer, characterized in that a substantially pure enantiomer of the general formula ##STR1## wherein X is O, S, NH, N--(C1 ... | 06/22/1999 |
| 5840683 | Peptides inhibiting the oncogenic action of p21 ras The present invention provides peptides and cyclized peptides which inhibit the oncogenic and/or transforming activity of the p21 ras protein, pharmaceutical compositions containing at least one of the ras-inhibiting peptides, cyclized peptides and peptid... | 11/24/1998 |
| 5837677 | Method for the treatment of cancer with Exochelins of Mycobacterium tuberculosis The invention is directed toward the use of desferri-Exochelins to destroy cancer cells or retard or eliminate the growth of those cancer cells.... | 11/17/1998 |
| 5814495 | Melanin production by streptomyces The present invention is directed to a process for producing melanins, their precursors and their analoges, hereinafter referred to generically as melanins. According to the invention, melanins are produced in amounts greater than about 3.3 grams wet weig... | 09/29/1998 |
| 5801023 | Antiparasitic pyrrolobenzoxazine compounds This invention provides compounds of the following chemical formula or their pharmaceutically-acceptable salts: ##STR1## wherein R is hydrogen or chloro. Also, the present invention provides a process for the production of the compound of formula I, ... | 09/01/1998 |
| 5780274 | Process for the isolation of clavulanic acid and of pharmaceutically acceptable salts thereof from the fermentation broth of streptomyces sp. P 6621 FERM P 2804 A process for the isolation of clavulanic acid and pharmaceutically acceptable salts thereof, such as potassium clavulanate, from the aqueous fermentation broth of a clavulanic acid-producing microorganism comprises the microfiltration of the broth withou... | 07/14/1998 |
