Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8187844 | Anti-fungal composition Natamycin is separated and recovered from a fermentation broth containing biomass and natamycin by adjusting the pH of a natamycin-containing suspension first to dissolve the natamycin in a solvent then adjusting the pH again to precipitate the dissolved natamycin w... | 05/29/2012 |
| 8053217 | Method for producing eritadenine in liquid phase fermentation Method to produce eritadenine by liquid phase fermentation of Lentinus edodes without formation of the fruit body wherein the Lentinus edodes is exposed to shear during its cultivation. ... | 11/08/2011 |
| 7977074 | Method of biosynthesizing tetrodotoxin The present invention relates methods for the biosynthesis of tetrodotoxin (TTX) involving the steps of obtaining a culture possessing one or more of a Vibrio species, such as through a seed culture, inoculating the culture and tissue extract from a textrodot... | 07/12/2011 |
| 7767426 | Method of producing riboflavin A method of producing riboflavin by culturing riboflavin-producing microbes in a culture medium using a plant oil or an animal oil as a carbon source, forming and accumulating riboflavin therein and collecting riboflavin therefrom, wherein a carrier of a clay minera... | 08/03/2010 |
| 7572606 | Biosyntheses of salinosporamide A and its analogs and related methods of making salinosporamide A and its analogs Disclosed are methods of modulating biosynthesis of Salinosporamide A and its analogs, which are useful in treating cancer, inflammatory conditions, and/or infectious disease. The methods involve, for example, genetic manipulation, selection of reagents in the ferme... | 08/11/2009 |
| 7432088 | Methods for the production of ansamitocins A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins. ... | 10/07/2008 |
| 7378268 | Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis o... | 05/27/2008 |
| 7368565 | Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents The present invention discloses a one-step process for the production of cytotoxic conjugates of maytansinoids and cell binding agents. Maytansinoids having a disulfide linker that bears a reactive moiety are linked to cell binding agents, such as antibodies, withou... | 05/06/2008 |
| 7354747 | Carbohydrate derived protein resistant biomaterial Carbohydrate-derived side-chain polyethers that may be synthesized by condensation polymerization of monomers derived from natural occurring carbohydrates. These compounds are protein resistant, biodegradable and may be functionalized at location other that the chai... | 04/08/2008 |
| 7350331 | Method for producing metabolites from plants cultivated in soil-less medium A method for producing molecules from plants, characterized in that the plants are cultivated in soil-less conditions and are supplied with a nutrient solution and/or sprayed with a leaching liquid, the solution and/or the liquid being subsequently recovered and tre... | 04/01/2008 |
| 7316917 | Production of bicyclic-heteroaryl-2-carboxylic acids by selective enzymatic hydrolysis of a mixture of positional esters The invention relates to an enzymatic process for the production of an intermediate, bicyclic-heteroaryl-2-carboxylic acid 7, of the formula wherein X and Y are defined in the specification and which are useful i... | 01/08/2008 |
| 7279314 | Chemical substance having morphogenetic and growth-accelerating activities The present invention relates to a method of producing a novel chemical substance capable of inducing morphogenesis, promoting growth of marine foliate green alga that use the microorganisms, and a culturing media for alga containing these novel chemical substances.... | 10/09/2007 |
| 7276611 | Process for synthesizing beta-lactamase inhibitor intermediates There is provided a process for the preparation of bicyclicheteroaryl carboxaldehydes having the structural Formula I where X and Y are defined in the specification The bicyclic heteroaryl carboxaldehydes are usefu... | 10/02/2007 |
| 7267968 | Microbial n-and o-demethylation of a thebaine derivative The invention provides a process for the N-demethylation or the N- and O-demethylation of a thebaine derivative which process comprises fermenting the derivative with a biocatalyst selected from the filamentous fungi from Cunnin... | 09/11/2007 |
| 7259241 | gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising nucleotide sequences encoding an aveC gene product, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of S. averm... | 08/21/2007 |
| 7252978 | Method for producing L-arginine L-Arginine is produced by culturing a microorganism which has L-arginine producing ability and has been modified so that expression of lysE gene should be enhanced, such a microorganism further modified so that an arginine repressor should not function normally, or ... | 08/07/2007 |
| 7244761 | Nerve regeneration promoters containing semaphorin inhibitor as the active ingredient To provide a semaphorin inhibitor; a peripheral or central nerve regeneration promoter which contains said semaphorin inhibitor as an active ingredient; and a preventive or remedy for a neuropathic disease and a neurodegenerative disease containing said nerve regene... | 07/17/2007 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7241899 | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 07/10/2007 |
| 7241754 | 2-Desmethyl ansamycin compounds 2-Desmethyl ansamycins having a structure according to formula I, where R1, R2, R3, R4, R5 and R6 are as defined herein, and other 2-desmethyl ansamycins are useful as antiproliferative agents ... | 07/10/2007 |
| 7205289 | Combinations of active ingredients with insecticidal and acaricidal properties The invention relates to novel active compound combinations of certain cyclic ketoenols and certain insecticidally active compounds that together have very good insecticidal and acaricidal properties. ... | 04/17/2007 |
| 7196192 | 28-epirapalogs Methods and materials involving 28-epirapamycin analogs are disclosed. ... | 03/27/2007 |
| 7192763 | microorganism and a process for producing the substance GM-95 A compound which has the following formula (1), a process for its production, a pharmaceutical composition comprising the compound as an active ingredient, a method of treating tumor which comprises administering... | 03/20/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 7189419 | Use of active extracts to lighten skin, lips, hair, and/or nails There is provided a composition having at least one of the following active extracts Butea frondosa, Naringi crenulata, Stenoloma chusana, or any combinations thereof. There is also provided a composition having at least one of the following additional extrac... | 03/13/2007 |
| 7183054 | Assay for identifying biological targets of polynucleotide-binding compounds The present invention provides methods and systems for the identification of a biological target of a chemical compound, such as saframycin A, known to bind a polynucleotide. The invention also provides methods of screening chemical compounds for those which act in ... | 02/27/2007 |
| 7172890 | Inactivated enzyme variants and associated process and reagent system The present invention relates to oxidoreductase apoenzyme variants which are enzymatically inactive but have coenzyme-binding properties. Further, the present invention relates to DNA sequences encoding these oxidoreductase apoenzyme variants, expression vectors con... | 02/06/2007 |
| 7132447 | Substance FKI-1083 and process for producing the same The present invention is comprised of culturing microorganism having ability to produce FKI-1083 substance represented by the formula: in a medium, accumulating FKI-1083 substance in the cultured medium, and isol... | 11/07/2006 |
| 7132291 | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants The inventions is drawn towards vectors and methods useful for preparing genetically transformed plant cells that express immunogens from pathogenic organisms which are used to produce immunoprotective particles useful in vaccine preparations. The invention includes... | 11/07/2006 |
| 7122549 | Saframycins, analogues and uses thereof In recognition of the need to develop novel therapeutic agents and efficient methods for the synthesis thereof, the present invention provides novel compounds of general formula (I), and methods for the synthesis thereof. ... | 10/17/2006 |
| 7101702 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as we... | 09/05/2006 |
| 7097840 | Methods of treatment using anti-ErbB antibody-maytansinoid conjugates The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anri-ErbB rece... | 08/29/2006 |
| 7087748 | Process A novel process for the removal of impurities from clavulanic acid using a selective adsorption material, in particular a molecularly imprinted polymer. Novel selective adsorption materials suitable for the process, and a process for the preparation of such selectiv... | 08/08/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
| 7033824 | shuttle vectors The present invention relates, in general, to vectors comprising Ketogulonigenium replicons. More specifically, the present invention relates to vectors comprising a Ketogulonigenium replicon found on the endogenous plasmid contained in Deposit No. NRR... | 04/25/2006 |
| 7029887 | Methods related to gene directing the ratio of B2:B1 avermectins The present invention relates to polynucleotide molecules comprising sequences encoding avec gene products, which polynucleotide molecules can be used to alter the ratio or amount of class 2:1 avermectins produced in fermentation cultures of Streptomyces avermiti... | 04/18/2006 |
| 7018631 | Compositions and methods for sensitizing and inhibiting growth of human tumor cells Polynucleotides encoding a carboxylesterase enzyme and polypeptides encoded by the polynucleotides which are capable of metabolizing a chemotherapeutic prodrug and inactive metabolites thereof to active drug are provided. Compositions and methods for sensitizing tum... | 03/28/2006 |
| 6991925 | Fermentation of clavulanic acid at a controlled level of ammonia A method for the production of clavulanic acid by the fermentation of a clavulanic acid producing microorganism at a controlled level of at least 50 mg/l ammonia has been provided for. Under the application of these reaction conditions surprisingly high produ... | 01/31/2006 |
| 6929933 | Riboflavin synthesis in yeast The invention describes the riboflavin biosynthesis gene and gene products from yeast. Vectors and recombinant preparation processes for riboflavin are furthermore described. Specifically, the invention relates to the genes for riboflavin biosynthesis in yeast, the ... | 08/16/2005 |
| 6878534 | Continuous fermentation process which is useful for the simultaneous optimal production of propionic acid and vitamin B12 The present invention relates to a fermentation process which is useful for the simultaneous production of propionic acid and vitamin B12, characterized in that it employs the culturing, on a suitable culture medium, of at least one microorganism suitable... | 04/12/2005 |
