Did You Know...
...that while attempting to develop a super strong glue, 3M employee Spencer Silver accidentally developed a glue that was so weak it would barely hold two pieces of paper together? However, his colleague Art Fry needed the glue. Fry sang with his church choir and marked the pages of his hymnal with small scraps of paper that often fell out. He used Silver's glue to hold the papers in place. Today we call this invention Post-it Notes.
PatentStorm News
Make the Most of Our Site
See this month's Top Inventors and Most Cited Patents.
Stay on top of the latest innovations by subscribing to an RSS feed.
Registered users: Manage your profile.
| Number | Title | Issue Date |
| 8076107 | Production of monatin stereoisomers Methods and materials for the production of the high intensity sweetener, monatin, in stereoisomerically-pure or stereoisomerically-enriched form are disclosed. For example, methods using stereoisoselective hydrolysis and separation of a monatin-derived lactone este... | 12/13/2011 |
| 8067213 | Production of thebaine and oripavine There is disclosed an improved poppy straw of a stably reproducing Papaver somniferum for the extraction of thebaine and/or oripavine, the threshed straw having thebaine and oripavine constituting about 50% by weight or greater of the alkaloid combination consisting... | 11/29/2011 |
| 8012723 | Process for the production of macrolides using a novel strain, sp. BICC 7522 The present invention discloses a new strain of Streptomyces sp. BICC 7522, its variants or mutants and use of the strain for the production of macrolides, process of production and purification of macrolides. ... | 09/06/2011 |
| 8008049 | DNA coding for polypeptide participating in biosynthesis of pladienolide The present invention provides polypeptides that participate in the biosynthesis of the pladienolide macrolide compounds, DNA that encodes these polypeptides and variants of this DNA, transformants that maintain all or a portion of this DNA or variant thereof, and a... | 08/30/2011 |
| 7901914 | Microbiological method of the biosynthesis of natural blue-violet colorants violacein and deoxyviolacein and the utilization thereof Known microbiological methods are based upon the application of pigment-forming bacteria, in particular Chromobacterium violaceum. The yield of these methods is very low, however, so that large industrial applications are not possible. However, in many fields... | 03/08/2011 |
| RE42191 | Methods for the preparation, isolation and purification of epothilone B, and X-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 03/01/2011 |
| 7807421 | Process for production of biopterin compound The present invention provides a transformed cell which is transformed by at least one gene of enzymes participating in biosynthesis of tetrahydrobiopterin and a process for the production of a biopterin compound using the same. In accordance with the present invent... | 10/05/2010 |
| 7625726 | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional acti... | 12/01/2009 |
| 7504243 | Methods for the production of biliverdin The present invention relates to compositions and methods for the production of biliverdin. In particular, the invention concerns methods for producing biliverdin in yeast, especially Candida albicans, and other microorganisms. ... | 03/17/2009 |
| 7445916 | Process for preparing rapamycin 42-esters and FK-506 32-esters with dicarboxylic acid, precursors for rapamycin conjugates and antibodies Methods for the synthesis of regiospecific rapamycin 42-hemiesters and regiospecific FK506 32-esters with dicarboxylic acids is described. The methods involve catalyzing the reaction between a rapamycin or a FK-506 and a dicarboxylic anhydride or a bifunctional acti... | 11/04/2008 |
| 7432088 | Methods for the production of ansamitocins A process of the large-scale fermentation of a highly productive ansamitocin-producing strains. A method for isolating crude ansamitocins. A method for purifying ansamitocins. ... | 10/07/2008 |
| 7393667 | Stereoselective reduction process for the preparation of pyrrolotriazine compounds The invention relates to a process for the enzymatic, stereoselective reduction of ketone compounds to provide chiral alcohols, for example the compound of formula Ib: ... | 07/01/2008 |
| 7378268 | Endophytic camptothecin and camptothecinoid producing fungi and process of producing the same The present invention relates to a novel source of microorganism for production of Camptothecin and related camptothecinoids. The invention also discloses its isolation, screening for Camptothecin production, growth, fermentation requirements and chemical analysis o... | 05/27/2008 |
| 7365431 | Semiconductor device having multilayer structure and method for manufacturing thereof A semiconductor device having a first wiring layer including first wirings on a substrate, a contact layer on the first wiring layer and including contacts connected to the first wirings, and a second wiring layer on the contact layer and including second wirings co... | 04/29/2008 |
| 7358070 | Process for formation of pattern of polyhydroxyalkanoate A process for forming a fine pattern comprised of a polyhydroxyalkanoate on a substrate is provided. The process comprises steps of applying a polyhydroxyalkanoate-synthesizing enzyme and a 3-hydroxyacyl CoA to coexist in an intended pattern on a substrate, and poly... | 04/15/2008 |
| 7354995 | Magnetic substance-biosubstance complex structure, peptide fragment capable of linking to magnetic substance and gene therefor, and process for producing the complex structure A magnetic substance-biosubstance complex structure comprises a magnetic substance-containing carrier and a bio-substance immobilized on the carrier, the biosubstance being immobilized through a spacer comprising an amino acid sequence on a surface of the carrier. | 04/08/2008 |
| 7348027 | Taste masked veterinary formulation A method of producing a self-take anthelmintic that includes active components that are undesirable to at least one sense of a target animal. The active ingredients including praziquantel are mixed with artificial beef and yeast components and subjected to a first c... | 03/25/2008 |
| 7288272 | Method for manufacture of polyphenols by using grape seeds as starting material To provide a method for the manufacture of polyphenols that enables industrial manufacture of polyphenols containing water-soluble proanthocyanidins from grape seeds. ... | 10/30/2007 |
| 7267974 | Polyhydroxyalkanoate synthesizing microorganism and process of producing polyhydroxyalkanoate using the same Microorganisms showing higher productivity of unusual-polyhydroxyalkanoate (PHA) than ever by using an inexpensive substrate or under specific conditions are obtained from wild strains and mutant strains. The microorganisms are cultured with such substrates to synth... | 09/11/2007 |
| 7265895 | Microcapsule for electrophoretic display device, process for manufacturing the same and use thereof An object of the present invention is to provide a microcapsule for an electrophoretic display device which can suppress reduction in later contrast even when the electrophoretic display device is allowed to stand under the high temperature and high humidity conditi... | 09/04/2007 |
| 7255813 | NADH/NADPH-containing compound The invention relates to a compound containing at least one health promoting isolated antioxidant A having a redox potential of less than 180 mV and at least one stabilising antioxidant B which has a standard redox potential which is less than the standard redox pot... | 08/14/2007 |
| 7244594 | Microbial transformation method for the preparation of an epothilone A microbial method for the preparation of an epothilone containing a terminal hydroxyalkyl group, comprising contacting at least one epothilone having a terminal alkyl group with an enzyme or microorganism capable of catalyzing the selective hydroxylation of said al... | 07/17/2007 |
| 7220560 | Secondary metabolite congener distribution modulation The present invention provides a generalized oxygen-limited cultivation method for myxobacterial strains engineered to heterologously express polyketides synthase (PKS) gene clusters under various oxygen tension conditions, modulating the polyketide congener distrib... | 05/22/2007 |
| 7211417 | Antibiotic P175-A and semisynthetic derivatives thereof This invention relates to a new antibiotic designated P175-A, to production of fermentation of Micromonospora echinospora NRRL 30633, to methods for recovery and concentration from the crude solutions, and to a process for purification and to semisynthetic es... | 05/01/2007 |
| 7196192 | 28-epirapalogs Methods and materials involving 28-epirapamycin analogs are disclosed. ... | 03/27/2007 |
| 7192750 | Mutant strain with increased maytansinoid production A microorganism that is a mutant bacterial strain of the species Actinosynnema pretiosum, designated PF4-4, (ATCC PTA-3921), being capable of producing maytansinoid ansamitocins such as ansamitocin P-3 in improved yield compared to previous known strains, and... | 03/20/2007 |
| 7183253 | Substantially pure glycopeptide antibiotics AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 The invention provides new substantially pure antibiotics designated AC-98-1, AC-98-2, AC-98-3, AC-98-4 and AC-98-5 derived from the microorganism Streptomyces hygroscopicus. ... | 02/27/2007 |
| 7172884 | Methods for the preparation, isolation and purification of epothilone B, and x-ray crystal structures of epothilone B The present invention relates to improved methods for the production, isolation and purification of epothilone B. These methods include, for example, a fermentation process for the production of epothilone B, isolation via adsorption onto a resin, and subsequent pur... | 02/06/2007 |
| 7160706 | Tissue culture of plant material enriched in secondary metabolites Plant material enriched in secondary metabolites is produced in tissue culture under conditions that organogenically produce a proliferation of shoots and leafy material, and harvesting the leafy material and shoots while in a green, actively-growing, non-senescent ... | 01/09/2007 |
| 7115720 | Therapeutic and diagnostic compounds, compositions, and methods The invention provides a complex comprising a) a compound formula I: wherein R1, X and n have any of the values described in the specification, or a pharmaceutically acceptable salt thereof; and b) a r... | 10/03/2006 |
| 7101702 | Fermentative preparation process for and crystal forms of cytostatics The invention relates to a new process for concentrating epothilones in culture media, a new process for the production of epothilones, a new process for separating epothilones A and B and a new strain obtained by mutagenesis for the production of epothilones, as we... | 09/05/2006 |
| 7097823 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/29/2006 |
| 7094885 | Skeletal-targeted radiation to treat bone-associated pathologies The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 08/22/2006 |
| 7091193 | Therapeutic formulations Formulations comprising one or more epothilones together with a pharmaceutically acceptable carrier, in particular such pharmaceutical compositions suitable for oral administration of an epothilone. ... | 08/15/2006 |
| 7083969 | strain There are disclosed a novel microorganism Serratia marcescens strain and a prodigiosin isolated from the microorganism. The prodigiosin is useful as an immunosuppressive in various fields, including the treatment of the diseases requiring immunosuppression an... | 08/01/2006 |
| 7070964 | Epothilone compounds and methods for making the same The present invention provides bioconversion methods for making epothilone analogs. These analogs differ from the starting material by the addition of one or more hydroxyl groups or by the addition of an epoxide. These compounds, in turn, can be further modified by ... | 07/04/2006 |
| 7070759 | High dose radionuclide complexes for bone marrow suppression The present invention relates to a method of suppressing bone marrow (BM) and treating conditions that arise in or near bone such as cancer, myeloproliferative diseases, autoimmune diseases, infectious diseases, metabolic diseases or genetic diseases, with compositi... | 07/04/2006 |
| 7067290 | Method for production of polyketides A method for the production of a polyketide by fermentation comprising the steps of growing a culture of a polyketide-producing organism at a pH value conducive to cell growth for a time sufficient to generate the producing culture, lowering the pH of the culture to... | 06/27/2006 |
| 7060821 | Osteoclast differentiation inhibitors A compound represented by formula (I); a process for producing a compound (substance F-1490) of formula (I), wherein X represents —O— and R represents a hydroxyl group, by using a microorganism belonging to the genus Cunninghamella; and a Cunninghamell... | 06/13/2006 |
| 7052885 | Process for preparing heterocyclic (R)- and (S)-cyanohydrins A process for preparing enantiomer-enriched heterocyclic (R)- and (S)-cyanohydrins of the formula (I), where R1, R2, R3, R4 independently of one another are H, an unsubstituted or substituted C1–C... | 05/30/2006 |
