"That the automobile has practically reached the limit of its development is suggested by the fact that during the past year no improvements of a radical nature have been introduced."
Scientific American ; Jan. 2 edition, 1909
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| Number | Title | Issue Date |
| 8187843 | Method for production of L-glutamine According to the present invention, it is possible to provide a microorganism belonging to the genus Corynebacterium, wherein the activity of (1) a protein having the amino acid sequence shown by any one of SEQ ID NO:1 to 3, or (2) a protein having a homology... | 05/29/2012 |
| 8129151 | L-glutamic acid-producing bacterium and method for producing L-glutamic acid L-Glutamic acid is produced by culturing in a liquid culture medium a microorganism belonging to the genus Pantoea or Serratia and having an ability to produce L-glutamic acid, which increases in an activity of enzyme catalyzing a reaction for L-glutam... | 03/06/2012 |
| 8110381 | L-glutamic acid-producing bacterium and method for production of L-glutamic acid A method for producing L-glutamic acid by culturing a coryneform bacterium in which the gluX is inactivated in a medium to produce L-glutamic acid in the medium or cells, and collecting L-glutamic acid from the medium. ... | 02/07/2012 |
| 8067211 | Method for production of L-glutamine A polypeptide comprising an amino acid sequence in which one or more amino acids are deleted, substituted or added in the amino acid sequence of a glutamine synthetase 2 derived from a microorganism belonging to a coryneform bacterium, wherein the coryneform bacteri... | 11/29/2011 |
| 7955823 | Microorganism producing glutamic acid in high yield and a process of producing glutamic acid using the same Disclosed herein are mutant strains, KCCM-10784P and KCCM-10785P, which are obtained through gene manipulation of Corynebacterium glutamicum KFCC-11074, and a process of producing L-glutamic acid using the mutant strains. The mutant strains are capable of pro... | 06/07/2011 |
| RE42350 | Method for producing L-glutamic acid by fermentation accompanied by precipitation A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount... | 05/10/2011 |
| 7927844 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic... | 04/19/2011 |
| 7879583 | Process for producing L-glutamic acid L-glutamic acid is produced by culturing a microorganism in a liquid medium containing L-glutamic acid at a saturation concentration, wherein the microorganism can metabolize a carbon source at a specific pH, and also has an ability to accumulate L-glutamic acid in ... | 02/01/2011 |
| RE41800 | Method for producing l-glutamic acid A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability in a liquid medium of which pH is adjusted to a condition under which L-glutamic acid produced by the microorganism is allowed ... | 10/05/2010 |
| 7794989 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid A coryneform bacterium that is modified by using a yggB gene so that L-glutamic acid-producing ability is enhanced as compared to a non-modified strains is cultured in a medium to cause accumulation of L-glutamic acid in the medium or bacterial cells, and L-glutamic... | 09/14/2010 |
| 7785845 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid ... | 08/31/2010 |
| 7608437 | Method of constructing amino acid producing bacterial strains, and method of preparing amino acids by fermentation with the constructed amino acid producing bacterial strains A method of producing coryneform bacteria having an improved amino acid or nucleic acid-productivity comprises the steps of introducing a mutation in a promoter sequence of amino acid- or nucleic acid-biosynthesizing genes on a chromosome of a coryneform bacterium s... | 10/27/2009 |
| 7432085 | Method for producing L-amino acid In a method for producing an L-amino acid by culturing a microorganism having an ability to produce an L-amino acid in a medium to produce and accumulate the L-amino acid in the medium and collecting the L-amino acid from the medium, a Gram-negative bacterium having... | 10/07/2008 |
| 7402412 | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same A D-aminotransferase can be modified so as to efficiently produce (2R, 4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 2... | 07/22/2008 |
| 7399617 | Method for producing an L-amino acid in an bacterium via altering expression levels of target proteins A bacterium belonging to the genus Escherichia which has an ability to produce an L-amino acid, wherein the ability to produce the L-amino acid is increased by increasing expression of an L-amino acid excretion protein is described. A method for producing the... | 07/15/2008 |
| 7368268 | Coryneform bacterium transformant and process for producing dicarboxylic acids using the same The present invention provides an aerobic coryneform bacterium transformant in which a lactate dehydrogenase gene is disrupted, and a pyruvate carboxylase gene is recombined so as to be highly expressed by a genetic engineering method. The aerobic coryneform bacteri... | 05/06/2008 |
| 7364875 | Method for producing medical and commercial grade poly-gamma-glutamic acid of high molecular weight Methods for producing high molecular weight poly-gamma-glutamic acid (PGA). The PGA is produced by fermentation, and purified by use of tangential flow filtration, followed by diafiltration, as necessary, to yield a product of the desired purity. Product obtained ma... | 04/29/2008 |
| 7354744 | Process for producing L-glutamic acid L-glutamic acid is produced by culturing in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source a microorganism that can metabolize a carbon source at a specific pH, and wherein said microorganism has an ability to accumula... | 04/08/2008 |
| 7344874 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid L-Glutamic acid is produced by culturing a microorganism in which an expression of L-glutamic acid-export gene, a yhfK gene, is enhanced or overexpressed, in a medium to produce and cause accumulation of L-glutamic acid in the medium, and collecting L-glutamic acid ... | 03/18/2008 |
| 7335497 | Process for producing theanine A method for efficiently producing theanine is provided, wherein glutamine and ethylamine are reacted by Pseudomonas citronellosis GEA FERM BP-8353, which is newly separated/selected from natural soil, belongs to the genus, Pseudomonas, and the ... | 02/26/2008 |
| 7329514 | Process for producing n-acetylneuraminic acid In the process for producing N-acetylneuraminic acid by using a microorganism having the ability to produce N-acetylneuraminic acid, the present invention provides economical and efficient process for producing N-acetylneuraminic acid by using a microorganism in whi... | 02/12/2008 |
| 7323321 | Metabolic engineering of amino acid production The present invention is directed towards the fermentative production of amino acids, providing microorganisms, methods and processes useful therefor. Microorganisms of the invention are capable of converting glucose to amino acids other than L-isoleucine, L-leucine... | 01/29/2008 |
| 7319025 | Method for producing L-glutamic acid A method for producing L-glutamic acid by fermentation, which comprises culturing a microorganism having L-glutamic acid-producing ability in a liquid medium of which pH is adjusted to a condition under which L-glutamic acid produced by the microorganism is allowed ... | 01/15/2008 |
| 7300776 | L-amino acid-producing bacterium and a method for producing L-amino acid An L-amino acid-producing strain of Escherichia coli is bred by modifying an Escherichia coli K12 strain or a derivative thereof so as to become resistant to L-valine and have an ability to produce one or more L-amino acids selected from the group cons... | 11/27/2007 |
| 7300777 | Feedback-resistant pyruvate carboxylase gene from corynebacterium The present invention relates to a mutated pyruvate carboxylase gene from Corynebacterium. The mutant pyruvate carboxylase gene encodes a pyruvate carboxylase enzyme which is resistant to feedback inhibition from aspartic acid. The present invention also rela... | 11/27/2007 |
| 7294491 | Method for producing L-glutamic acid The present invention provides a method for producing L-glutamic acid by fermentation, by culturing in a liquid medium a microorganism that can metabolize a carbon source at a specific pH, and wherein said medium contains a carbon source and L-glutamic acid at a sat... | 11/13/2007 |
| 7267967 | Nucleic acid encoding pyruvate carboxylase from coryneform glutamicum A pyruvate carboxylase gene having SEQ ID NO:1 as well as an amino acid sequence having SEQ ID NO:2 expressed by the pyruvate carboxylate gene are disclosed. Also disclosed is a method for microbial production of amino acids of the aspartate and/or glutamate family ... | 09/11/2007 |
| 7262035 | Method for producing L-glutamine by fermentation and L-glutamine producing bacterium L-Glutamine is produced by culturing a coryneform bacterium which has L-glutamine producing ability and has been modified so that its intracellular glutamine synthetase activity should be enhanced, preferably which has been further modified so that its intracellular... | 08/28/2007 |
| 7247459 | L-glutamic acid producing bacterium and process for producing L-glutamic acid L-glutamic acid is produced by culturing in a medium a microorganism belonging to enterobacteria and having L-glutamic acid productivity, into which a citrate synthase gene derived from a coryneform bacterium is introduced to produce and accumulate L-glutamic acid i... | 07/24/2007 |
| 7235388 | Isolated nucleic acid encoding L-lysine: 2-oxoglutaric acid 6-aminotransferase Provided are an isolated gene capable of participating in the production of L-homoglutamic acid, and a production system of L-homoglutamic acid by using this gene. The gene is derived from the genome of Flavobacterium lutescens. ... | 06/26/2007 |
| 7217543 | Method for producing L-amino acid using methylotroph The present invention describes a method for producing an L-amino acid comprising culturing a microorganism having an ability to produce an L-amino acid in a medium, whereby the L-amino acid accumulates in the medium, and collecting the L-amino acid from the medium,... | 05/15/2007 |
| 7211421 | Gene encoding dihydrodipicolinate reductase from An Escherichia coli mutant strain deficient in dihydrodipicolinate synthase or dihydrodipicolinate reductase is transformed with a chromosomal gene library of Bacillus methanolicus, and a transformant strain which can grow on a minimal medium is select... | 05/01/2007 |
| 7208296 | Method for producing L-glutamic acid by fermentation accompanied by precipitation A microorganism is provided which can metabolize a carbon source at a specific pH in a liquid medium containing L-glutamic acid at a saturation concentration and the carbon source, and which has ability to accumulate L-glutamic acid in an amount exceeding the amount... | 04/24/2007 |
| 7205132 | L-glutamic acid-producing microorganism and a method for producing L-glutamic acid A coryneform bacterium which has an L-glutamic acid-producing ability and grows at least at the same growth rate as a non-mutated strain or a wild-type strain and has intracellular α-ketoglutarate dehydrogenase activity which is less than half that of the non-mutat... | 04/17/2007 |
| 7198943 | Organic nitrogen-containing composition and fertilizer comprising the same An organic nitrogen-containing composition comprising fermentation mother liquor obtained by culturing a microorganism having L-glutamic acid-producing ability in a liquid medium of which pH is adjusted to a condition under which L-glutamic acid is allowed to be pre... | 04/03/2007 |
| 7192760 | Microorganisms and processes for producing L-glutamine The present invention provides novel microorganisms, Brevibacterium lactofermentum CJJA21 (Accession No. KCCM-10222), which is resistant to sodium azide, and Brevibacterium lactofermentum CJJA22 (Accession No. KCCM-10223), which is resistant to α-amin... | 03/20/2007 |
| 7192747 | Methods for producing L-amino acids A methane-utilizing microorganism capable of producing L-amino acid, for example, bacteria belonging to type I, type X or type II in the taxonomic categorization methane-utilizing bacteria such as Methylomonas albus, Methylococcus capsulatus and Methylosin... | 03/20/2007 |
| 7163810 | Method for producing target substance In a method for producing a target substance by using a microorganism comprising culturing a microorganism having an ability to produce the target substance in a medium to produce and accumulate the target substance in the medium or cells of the microorganism and co... | 01/16/2007 |
| 7160703 | Nucleotide sequences coding for the PtsI protein The present invention provides nucleotide sequences from Coryneform bacteria which code for the PtsI protein and a process for the fermentative preparation of amino acids using bacteria in which the ptsI gene is enhanced. ... | 01/09/2007 |
| 7160704 | Method for producing target substance The present invention discloses a method for producing a target substance using a coryneform bacterium comprising culturing a coryneform bacterium having an ability to produce the target substance in a medium, resulting in accumulation of the target substance in the... | 01/09/2007 |