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Class 435/11 - Involving cholesterol


Subclass of Class 435 - Chemistry: molecular biology and microbiology
Definition: Subject matter where the material to be measured or tested
No. of patents: 345
Last issue date: 05/15/2012


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NumberTitleIssue Date
8178311Multiple quantification of cholesterol in low density lipoprotein
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipopr...
05/15/2012
8163512Method for determination of cholesterol in small dense low-density lipoprotein
A method for determination of sdLDL-C in a reaction solution containing a surfactant that preferentially inhibits the reaction of sdLDL-C with enzymes for cholesterol measurement such as cholesterol ester hydrolase. In the method, the enzymes for cholesterol measure...
04/24/2012
8158375Polymer and method of measuring cholesterol therewith
It is an object of the present invention to provide the method for determining cholesterol in lipoprotein and reagent for determining cholesterol comprising the polymer, and the present invention relates to the reagent for determining cholesterol in lipoproteins suc...
04/17/2012
8124367Device for applying a detector reagent to the skin for measuring cholesterol
The present invention provides a method and apparatus for non-invasive measurement of skin cholesterol. More particularly, one aspect of the invention provides for a device to apply a detector reagent to a selected area of skin. Another aspect of the invention provi...
02/28/2012
8119360Method, reagent and kit for determination of cholesterol in remnant-like particles (RLP)
The present invention provides a method, a reagent and a kit for simple and sensitive determination of cholesterol in remnant-like particles without separation of components of a sample. A method for quantitatively determining remnant-like particle cholesterol in a ...
02/21/2012
7989179LXR ligand testing method
A method of easily measuring whether or not an LXR ligand has the function of effecting, e.g., increasing, plasma triglyceride concentration and/or LDL cholesterol concentration in a mammal by using the binding activity between LXR and a coactivator, and a method of...
08/02/2011
7939287Methods of identifying a subject having or at risk of having or developing coronary artery disease
Provided herein are compositions and methods for identifying individuals at risk for developing coronary artery disease (CAD). ...
05/10/2011
7851174Method for quantitatively determining cholesterol in high density lipoproteins and reagents therefor
A method for quantitatively determining cholesterol in high-density lipoprotein in a sample, which comprises: reacting a sample with i) cholesterol esterase and cholesterol oxidase or ii) cholesterol esterase, an oxidized coenzyme and cholesterol dehydrogenase in an...
12/14/2010
7824879Device and method for measuring LDL-associated cholesterol
An assay device and method for determining the concentration of low density lipoprotein (LDL)-associated cholesterol (LDL-C) in a body-fluid sample, such as a blood sample is described. ...
11/02/2010
7811780Method for measurement of cholesterol in high-density lipoprotein
The present invention provides a method, a reagent and a kit for the simple and accurate measurement of HDL cholesterol. The method for the measurement of cholesterol in high-density lipoprotein in a sample comprises reacting the sample with i) cholesterol esterase ...
10/12/2010
7811779Method of multiquantification for cholesterol of low-density lipoprotein
Provided is a method of stabilizing a reagent that allows simultaneous quantification of LDL cholesterol and total cholesterol by a single measurement by suppressing spontaneous color development thereof. A method of quantification for cholesterol in low density lip...
10/12/2010
7799537Cholesterol measuring reagent containing a cholesterol esterase
There are provided a method and reagent for measuring cholesterol in remnant-like lipoprotein in a sample with high sensitivity by more simple operation. The method for measuring cholesterol in remnant-like lipoprotein uses a cholesterol esterase, in which the activ...
09/21/2010
7575884Test piece for measuring high-density lipoprotein (HDL) cholesterol
The present invention relates to a test piece having a simple structure, by which HDL cholesterol can be measured easily using a small amount of specimen. A reagent layer (2) is formed on a support (1), and an enzyme reagent for measuring cholesterol, ...
08/18/2009
7507551Multiple quantification method for cholesterol in low-density lipoproteins
The present invention is intended to provide a method for simultaneously measuring cholesterol in low density lipoprotein and total cholesterol as test components in blood. Specifically, a method is used for simultaneously measuring cholesterol in low density lipopr...
03/24/2009
7402404Assay method for measurement of net cholesterol flux
The present invention relates to an assay for determining net cholesterol flux from lipid loaded cells in the presence of an acceptor (e.g., serum). The present invention also relates to a method for evaluating efficacy of a therapeutic agent for stimulating or inhi...
07/22/2008
7371247Method and apparatus for penetrating tissue
A tissue penetrating system includes a plurality of penetrating members each having a tip. A penetrating member driver is coupled to the plurality of penetrating members. Each tip of a penetrating member is uncovered during launch of the penetrating member by the pe...
05/13/2008
7368555Sequence-determined DNA fragments encoding EF-hand calcium-binding proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR ...
05/06/2008
7361482Method for detecting intracellular cholesterol
The present invention relates to a method of detecting intracellular cholesterol. The method provides contacting a permeabilized cell with labeled cθ complex. Methods of using this detection method to identify agents which modulate cholesterol accumulation in a cel...
04/22/2008
7355026Sequence-determined DNA fragments encoding SRF-type transcription factor proteins
The present invention provides DNA molecules that constitute fragments of the genome of a plant, and polypeptides encoded thereby. The DNA molecules are useful for specifying a gene product in cells, either as a promoter or as a protein coding sequence or as an UTR ...
04/08/2008
7347971Spreading layers and their use in test strips
A spreading material is described which comprises a porous flat-shaped structure impregnated with a wetting agent, wherein the wetting agent is N-oleoyl-sarcosinate. ...
03/25/2008
7348158Method of quantifying cholesterol in high density lipoprotein and reagent compositions
A method for specifically quantifying HDL cholesterol in which cholesterol in lipoproteins other than HDL is erased in the first step, and HDL cholesterol is specifically quantified in the second step, by which accurate values can be obtained even in measurements of...
03/25/2008
7348183Self-contained microelectrochemical bioassay platforms and methods
Methods and devices for improved chemical and biomass detection assays combined well defined microstructures having independently addressable electrodes with various surface immobilization electrochemical assays. Combining known chemical detection immobilization ass...
03/25/2008
7335483Method of pretreatment of sample for quantitating cholesterol and method for quantitating cholesterol in specific lipoproteins by using the same
A method of a pretreatment of a sample for quantitating cholesterol characterized by, before measuring cholesterol contained in specific lipoproteins, treating the sample containing lipoproteins with an enzyme, the substrate of which is free cholesterol, optionally ...
02/26/2008
7331931Method and apparatus for penetrating tissue
These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes an electrically powered drive force generator. A penetrating member is operatively coupled to the force generator. The force generato...
02/19/2008
7320893Lipoprotein fingerprinting methods using metal ion chelate salts
Methods are disclosed which separate and identify lipoproteins in biological samples. An ultracentrifuge density gradient is used to separate lipoprotein fractions. The fractions are visualized, resulting in a lipoprotein profile. The fractions can be further analyz...
01/22/2008
7316700Self optimizing lancing device with adaptation means to temporal variations in cutaneous properties
A lancing device, an embodiment of which controls the advancement and retraction of a lancet by monitoring the position of the lancet in conjunction with a lancet controller which incorporates a feedback loop for modulating the lancet driver to follow a predetermine...
01/08/2008
7300633Specimen collection container
The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ...
11/27/2007
7291117Method and apparatus for penetrating tissue
These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a voice coil based penetrating member driver. A plurality of penetrating members are included. A transport mechanism is configured to...
11/06/2007
7282367Method for verifying amount of sample solution, method for controlling measurement system and method for measuring concentration of solution in apparatus for measuring optical characteristic
A verification method of a sample solution amount includes the steps of: detecting at least one of a transmitted light component, a scattered light component and a reflected light component of a light by a photosensor while irradiating a sample solution, which is be...
10/16/2007
7279297Ex vivo method for determination of CETP activity and efficacy of heart disease treatment
The present invention relates to a novel method to determine CETP activity in a bodily fluid sample wherein the sample may contain an inhibitor of CETP activity. The effect of the inhibitor is preserved to provide a more accurate determination of CETP activity in th...
10/09/2007
7279296Compositions and methods for lipoprotein uptake assays
Provided herein are compositions and methods for lipoprotein uptake assay. These compositions and methods may be used for the lipoprotein uptake assays, including high-throughput assays. The disclosed compositions and method may further be used to characterize the a...
10/09/2007
7270971Fluorescence assay for measuring the rate of cholesterol ester transfer
An improved method of obtaining fluorescence measurements which may be used as a measure of the CETP-catalyzed rate of transfer of a lipophilic non-polar fluorescent cholesteryl ester between lipoprotein particles is disclosed. The method may be used in assays for s...
09/18/2007
7270959Specimen collection container
The present invention recognizes that sample handling devices, particularly those used for testing for substances of abuse, do not allow for a separation of the bulk sample from a sample thereof to be tested. The present invention provides such a device and methods ...
09/18/2007
7258693Device and method for variable speed lancet
A method of penetrating tissue is provided. The method comprises using a lancet driver to advance a lancet into the tissue; advancing the lancet at a first desired velocity in a first layer of tissue; advancing the lancet at a second desired velocity in a second lay...
08/21/2007
7250304Functional assay of high-density lipoprotein
This invention provides novel assays that are prognostic and/or diagnostic for atherosclerosis or risk of atherosclerosis. It was discovered that high density lipoprotein (HDL) or components thereof can prevent the oxidation of lipids (e.g., lipids present in LDLs) ...
07/31/2007
7244265Method and apparatus for penetrating tissue
These and other objects of the present invention are achieved in a body fluid sampling system for use on a tissue site that includes a drive force generator and a penetrating member operatively coupled to the force generator. The force generator moves the member alo...
07/17/2007
7238494Direct assay of cholesterol in skin samples removed by tape stripping
Skin cholesterol is measured by applying an adhesive tape onto a selected area of the skin to adhere the tape to the selected skin area and stripping the tape off the selected skin area to obtain a sample representative of the outer stratum corneum layer of the skin...
07/03/2007
7232451Method and apparatus for penetrating tissue
A skin penetrating system has a housing member and a plurality of penetrating members positioned in the housing member. A tissue stabilizing device is coupled to the housing member. A user interface is configured to relay at least one of, skin penetrating performanc...
06/19/2007
7229458Method and apparatus for penetrating tissue
A tissue penetrating system includes a plurality of cartridges each with a distal port and a proximal port. A plurality of penetrating members are provided, each coupled to a cartridge and having a sharpened distal tip and a shaft portion slidably disposed within th...
06/12/2007
7226461Method and apparatus for a multi-use body fluid sampling device with sterility barrier release
A device for use with a gripper is provided. A cartridge is provided that defines a plurality of cavities. A plurality of penetrating members are at least partially contained in the cavities of the cartridge. The penetrating members are slidably movable to extend ou...
06/05/2007
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