Celebrity Inventors
Mark Twain (Samuel L. Clemens) received Patent No. 121,992 for "An Improvement in Adjustable and Detachable Straps for Garments." He later received two more patents: one for a self-pasting scrapbook and one for a game to help players remember important historical dates.
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| Number | Title | Issue Date |
| 8389249 | Method for production of L-amino acid An L-amino acid can be produced by culturing a bacterium which belongs to the Enterobacteriaceae family, and has an enhanced ability to use a fatty acid. The bacterium is capable of producing the L-amino acid in a culture medium containing a fatty acid or a hydrolys... | 03/05/2013 |
| 8354254 | Method for producing an L-amino acid An L-amino acid is produced by culturing a bacterium having an L-amino acid-producing ability in a medium containing a processed product of a microalga which promotes production and accumulation of the L-amino acid by the bacterium. The process product is produced b... | 01/15/2013 |
| 8323932 | Expression of granular starch hydrolyzing enzymes in and process for producing glucose from granular starch substrates The present invention relates to filamentous fungal host cells and particularly Trichoderma host cells useful for the production of heterologous granular starch hydrolyzing enzymes having glucoamylase activity (GSHE). Further the invention relates to a method... | 12/04/2012 |
| 8293505 | L-amino acid-producing microorganism and a method for producing an L-amino acid An L-amino acid is produced by culturing a microorganism which belongs to the family Enterobacteriaceae and is able to produce an L-amino acid, wherein the bacterium has been modified to enhance orotate phosphoribosyltransferase activity is enhanced, in a medium to ... | 10/23/2012 |
| 8283141 | Methods and systems for biomass conversion to carboxylic acids and alcohols The disclosure includes a method, process and apparatus for the conversion of biomass to carboxylic acids and/or primary alcohols. The system may include a pretreatment/fermentation subsystem operable to produce a fermentation broth containing carboxylic acid salts ... | 10/09/2012 |
| 8232081 | Methods and microorganisms for production of panto-compounds The present invention features methods of producing panto-compounds (e.g., pantothenate) using microorganisms in which the pantothenate biosynthetic pathway and/or the isoleucine-valine biosynthetic pathway and/or the coenzymeA biosynthetic pathway has been manipula... | 07/31/2012 |
| 8227214 | Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene codi... | 07/24/2012 |
| 8202710 | Lactic acid bacterium capable of producing Y-aminobutyric acid The present invention provides a lactic acid bacterium which can produce γ-aminobutyric acid (GABA) even under a coexisting condition of lactic acid and common salt in a medium at time of commencement of culturing, and a method for producing a culture mixture compr... | 06/19/2012 |
| 8187842 | Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals The invention provides microbial strains possessing improved properties for production of aspartate-derived amino acids and chemicals. Methods of making such strains are provided. These methods include altering expression of the aceBAK operon, the glcB gene, or both... | 05/29/2012 |
| 8183017 | Method of producing L-lysine The ability and speed with which a coryneform bacterium can produce L-lysine are improved when the coryneform bacterium contains an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized. This is accomplished by successi... | 05/22/2012 |
| 8183016 | Synthesis method of aromatic amino acids A method for synthesizing aromatic amino acids according to one aspect of the present invention includes processes of: (a) of preparing a thermostable a Thermus thermophilus aspartate aminotransferase by culturing an E. coli BL21(DE3) cell transformed ... | 05/22/2012 |
| 8153404 | Alleles of the zwf gene from coryneform bacteria The invention relates to mutants and alleles of the zwf gene of coryneform bacteria, which encode variants of the Zwf subunit of glucose 6-phosphate dehydrogenase (EC: 1.1.1.49), and to processes for preparing amino acids, in particular L-lysine and L-tryptophan, by... | 04/10/2012 |
| 8137938 | Method for producing an L-amino acid An L-amino acid is produced by culturing a bacterium belonging to the family Enterobacteriaceae, which is able to produce the L-amino acid, and is modified so that the activity of ribonuclease G is decreased in a medium containing glycerol as the carbon source, and ... | 03/20/2012 |
| 8119372 | Method of production of L-amino acids An isolated polynucleotide encodes a polypeptide comprising the amino acid sequence of SEQ ID NO: 2, with the L-aspartic acid at position 5 of the amino acid sequence replaced by another proteinogenic amino acid, and possesses citrate synthase activity. In addition,... | 02/21/2012 |
| 8114639 | Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of the sfmACDFH-fimZ cluster or the fimZ gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the sfmACDF... | 02/14/2012 |
| 8105806 | Process for preparing optically active amino acids using a whole-cell catalyst The present invention relates to a process for preparing, in particular, enantiomerically enriched L-α-amino acids, in particular those of the general formula (I). In this connection, the process according to the invention uses 2-ketocarboxylic acids which are conv... | 01/31/2012 |
| 8088606 | Method for producing an L-amino acid using bacterium of the family with attenuated expression of a gene coding for small RNA The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of a gene codi... | 01/03/2012 |
| 8080395 | Alleles of the PRPD1 gene from coryneform bacteria An isolated mutant of coryneform bacteria comprising a gene encodes a polypeptide having 2-methylcitrate dehydratase activity, where the polypeptide comprises an amino acid sequence in which one of the proteinogenic amino acids except L-proline is present at positio... | 12/20/2011 |
| 8076106 | Method to increase the yield and improve purification of products from transaminase reactions A process for producing high yields of enantioselective amino acids and chiral amines by reacting a keto acid or ketone and an amino acid donor in the presence of a transaminase biocatalyst to produce a keto acid by-product and an amino acid or amine product. Furthe... | 12/13/2011 |
| 8067210 | Method of producing lysine by culturing a host cell expressing a polynucleotide encoding a feedback resistant aspartokinase from The invention provides methods to increase the production of an amino acid from Corynebacterium species by way of the amplification of amino acid biosynthetic pathway genes in a host cell chromosome. The invention also provides novel processes for the product... | 11/29/2011 |
| 8058034 | Mutated D-aminotransferase and method for producing optically active glutamic acid derivatives using the same A D-aminotransferase can be modified so as to efficiently produce (2R,4R)-monatin having high sweetness intensity from 4-(indol-3-ylmethyl)-4-hydroxy-2-oxoglutaric acid by substituting an amino acid at least at one of positions (positions 100, 180 to 183, 243 and 24... | 11/15/2011 |
| 8048647 | Aldolase, and method for producing optically active IHOG and monatin The present invention relates to a method for producing optically active IHOG, which can in turn be used for the production of monatin. The present invention further relates to a method for producing optically active monatin, and aldolase used for these methods. As ... | 11/01/2011 |
| 8043836 | Process for producing amino acid derivative from hydroxyimino acid The present invention is to provide an industrially advantageous method for producing an amino acid derivative. Provided is a method for producing an amino acid derivative including contacting a microorganism and/or an enzyme with a hydroxyimino acid represented by ... | 10/25/2011 |
| 8012722 | Method for producing L-amino acid L-amino acids such as L-glutamic acid, L-glutamine, L-proline, L-arginine, L-leucine, and L-cysteine are produced by culturing in a medium a bacterium having an L-amino acid-producing ability and wherein the bacterium has been modified so that the phosphotransacetyl... | 09/06/2011 |
| 8008047 | L-amino acid producing bacterium which has enhanced expression of at least one of the nhaA gene, the nhaB gene, the nhaR gene, the chaA gene, the mdfA gene and a method of producing L-amino acid L-amino acid is produced by culturing a bacterium belonging to the Enterobacteriaceae family which has L-amino acid-producing ability and is modified so that expression of the nhaA gene, nhaB gene, nhaR gene, chaA gene, mdfA gene, or combinations thereof is enhanced... | 08/30/2011 |
| 7989188 | Conjugates for cancer therapy and diagnosis The present invention relates to conjugates of a drug and an amino acid or an amino acid derivative or analog, pharmaceutical compositions that include the conjugates and methods of use thereof. In particular, the present invention relates to conjugates of anti-prol... | 08/02/2011 |
| 7989187 | Microorganisms and processes for enhanced production of pantothenate The present invention features improved methods for the enhanced production of pantoate and pantothenate utilizing microorganisms having modified pantothenate biosynthetic enzyme activities and having modified methylenetetrahydrofolate (MTF) biosynthetic enzyme acti... | 08/02/2011 |
| 7977073 | Polynucleotide encoding a thermostable amide hydrolase and methods for producing an L-α-amino acid The present invention relates to an amide hydrolase which is with excellent thermostability and stereoselectively hydrolyzes an α-amino acid amide; a gene encoding the enzyme protein; a novel recombinant vector containing the gene; a transformant containing the rec... | 07/12/2011 |
| 7939301 | Enzyme reactions in miniemulsions The present invention is directed towards an asymmetric enzymic process for preparing optically active organic compounds. The process according to the invention is carried out in what are termed miniemulsions. The invention also relates to an enzymic reaction mixtur... | 05/10/2011 |
| 7919284 | L-amino acid producing microorganism and a method for producing an L-amino acid A microorganism belonging to the family Enterobacteriaceae, which has an L-amino acid-producing ability and has been modified so that the kdp system is enhanced, is cultured in a medium to produce and accumulate an L-amino acid in the medium or cells of the microorg... | 04/05/2011 |
| 7919282 | Method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family with attenuated expression of the gene The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of the cpxR ge... | 04/05/2011 |
| 7919283 | Method for producing an L-amino acid using a bacterium of the enterobacteriaceae family with attenuated expression of any of the cynT, cynS, cynX or cynR gene or combination thereof The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging to genus Escherichia or Pantoea, which has been modified to attenuate expression of one or more... | 04/05/2011 |
| 7901913 | Process for the preparation of L-amino acids by overexpressing the tal gene encoding transaldolase The invention is directed to DNA sequences from coryneform bacteria, particularly Corynebacterium glutamicum, which encode a protein having transaldolase enzymatic activity. The invention also encompasses processes for the fermentative production of L-amino a... | 03/08/2011 |
| 7871801 | L-amino acid-producing bacterium and a method for producing L-amino acids A method for producing an L-amino acid is provided which includes culturing in a medium a microorganism of the Enterobacteriaceae family which has an ability to produce an L-amino acid and which has been modified so as to enhance the mannose PTS activity, accumulati... | 01/18/2011 |
| 7858349 | Anti-cancer compounds The invention provides bradykinin antagonists and pharmaceutically acceptable salts thereof having anti-cancer activity. These anti-cancer compounds are particularly useful for inhibiting the growth of lung and prostate cancers. ... | 12/28/2010 |
| 7858348 | N-acetyl-(R,S)-beta-amino acid acylase gene The present invention provides genes that encode the N-acetyl-(R,S)-β-amino acid acylases. The N-acetyl-(R,S)-β-amino acid acylases were isolated and purified from bacterial cells and the nucleotide sequences were determined. A host, such as Escherichia coli | 12/28/2010 |
| 7855060 | Method for producing an L-amino acid using a bacterium of the family by inactivating a gene encoding a toxin of a bacterial toxin-antitoxin pair The present invention provides a method for producing an L-amino acid using a bacterium of the Enterobacteriaceae family, particularly a bacterium belonging the genus Escherichia or Pantoea, wherein said bacterium has attenuated expression of a gene en... | 12/21/2010 |
| 7846698 | Method of producing L-lysine The L-lysine-producing ability and the L-lysine-producing speed are improved in a coryneform bacterium harboring an aspartokinase in which feedback inhibition by L-lysine and L-threonine is substantially desensitized, by successively enhancing DNA coding for a dihyd... | 12/07/2010 |
| 7833760 | Process for the production of β-amino acids using acylase The present invention relates to a Variovorax sp. which produces an acylase having an asymmetric hydrolysis activity on an N-acetyl β-amino acid to selectively produce an R-β-amino acid, and a Burkholderia sp. which produces both an acylase having an... | 11/16/2010 |
| 7833761 | Amino acid producing microorganism and a method for producing an amino acid A microorganism is provided which has an ability to produce an L-amino acid such as L-lysine, L-tryptophan, L-phenylalanine, L-valine, L-leucine, L-isoleucine and L-serine, and has been modified to increase the activity of pyruvate synthase or pyruvate:NADP+ | 11/16/2010 |
