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| Number | Title | Issue Date |
| 7371562 | Guided mode resonant filter biosensor using a linear grating surface structure Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 05/13/2008 |
| 7372565 | Spectrometer measurement of diffracting structures A normal incidence reflectometer includes a rotatable analyzer/polarizer for measurement of a diffracting structure. Relative rotation of the analyzer/polarizer with respect to the diffracting structure permits analysis of the diffracted radiation at multiple polari... | 05/13/2008 |
| 7354733 | Method for sorting and separating living cells We disclose methods of sorting or separating mixtures of living cells (e.g., eukaryotic, prokaryotic, mammalian, pathogenic, bacterial, viral, etc.). We perform our methods by activating cell-selective photophoric labels, which photosensitize and chemically reduce a... | 04/08/2008 |
| 7351437 | Pet food compositions comprising electrostatically charged gelatin Animal feed compositions comprising amounts of protein, carbohydrate, fat and a functional ingredient for preventing hairball formation are provided. The functional ingredient comprises at least one member selected from the group consisting of electrostatically char... | 04/01/2008 |
| 7347617 | Mixing in microfluidic devices Mixing of liquids in a microfluidic device is accomplished by dispensing the liquids into a first chamber to produce combined liquid. The liquids are thereafter discharged through at least one capillary from the first chamber into a second chamber for complete mixin... | 03/25/2008 |
| 7327454 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 02/05/2008 |
| 7312090 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 12/25/2007 |
| 7304735 | Broadband wavelength selective filter An optical filter for the selective attenuation of specific wavelengths of light includes at least one spectrally dispersive element, such as a diffraction grating or prism, in combination with an optical filter. A dispersive element separates broadband light into a... | 12/04/2007 |
| 7301628 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 11/27/2007 |
| 7300803 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 11/27/2007 |
| 7292336 | Method and instrument for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of... | 11/06/2007 |
| 7288320 | Microstructured taggant particles, applications and methods of making the same Microstructured taggant particles, their applications and methods of making the same are described. Precisely formed taggant particles can be formed, in the range of 500μ and smaller, from either inert polymers or biodegradable materials bearing information indicia... | 10/30/2007 |
| 7285363 | Photoactivators, methods of use, and the articles derived therefrom A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiet... | 10/23/2007 |
| 7265161 | Multi-photon reactive compositions with inorganic particles and method for fabricating structures A multi-photon reactive composition including: (a) at least one reactive species; and (b) multi-photon photoinitiator system; and (c) a plurality of substantially inorganic particles, wherein the particles have an average particle size of less than about 10 microns ... | 09/04/2007 |
| 7264973 | Label-free methods for performing assays using a colorimetric resonant optical biosensor The instant invention provides compositions and methods for determining cell interactions that are faster than conventional methods and that require the use of fewer reagents than conventional methods. ... | 09/04/2007 |
| 7253909 | Phase shift measurement using transmittance spectra An apparatus and method for determining a physical parameter of features on a substrate by illuminating the substrate with an incident light covering an incident wavelength range Δλ, e.g., from 190 nm to 1000 nm, where the substrate is at least semi-transparent. A... | 08/07/2007 |
| 7247507 | Method for forming LOCOS layer in semiconductor device A method for forming a LOCOS layer in a semiconductor device includes steps of oxidizing a high voltage region of the semiconductor device to form a LOCOS layer in the high voltage region; and etching the LOCOS layer according to a pattern. ... | 07/24/2007 |
| 7239390 | Modulated scatterometry An apparatus for scatterometry measurements is disclosed. The apparatus includes a modulated pump source for exciting the sample. A separate probe beam is directed to interact with the sample and the modulated optical response is measured. The measured data is subje... | 07/03/2007 |
| 7236244 | Alignment target to be measured with multiple polarization states An alignment target includes periodic patterns on two elements. The periodic patterns are aligned when the two elements are properly aligned. By measuring the two periodic patterns at multiple polarization states and comparing the resulting intensities of the polari... | 06/26/2007 |
| 7233390 | Scatterometry for samples with non-uniform edges A method for simulating the optical properties of samples having non-uniform line edges includes creating a model for the sample being analyzed. To simulate roughness, lines within the model are represented as combinations of three dimensional objects, such as circu... | 06/19/2007 |
| 7230705 | Alignment target with designed in offset An alignment target includes periodic patterns on two elements. The alignment target includes two locations, at least one of which has a designed in offset. In one embodiment, both measurement locations have a designed in offset of the same magnitude but opposite di... | 06/12/2007 |
| 7223505 | Method for forming micropatterns A method for forming micropatterns includes forming a thin film consisting of a single layer or of plural layers on a substrate, irradiating an energy beam to the thin film to elevate the temperature of a region to a predetermined temperature or higher to thereby mo... | 05/29/2007 |
| 7217574 | Method and apparatus for biosensor spectral shift detection Performing high-resolution determination of the relative shift of the spectral properties of a biosensor. The shift in the resonance peak of the biosensor is indicative of the amount of material bound to the surface of the biosensor. A preferred biosensor is a Guide... | 05/15/2007 |
| 7212293 | Optical determination of pattern feature parameters using a scalar model having effective optical properties Optical characterization of lateral features of a pattern is provided. A plane-wave optical response is calculated for each feature. At least one of these plane-wave responses is calculated from an effective optical property (e.g., a waveguide modal refractive index... | 05/01/2007 |
| 7202076 | Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 04/10/2007 |
| 7176428 | Laser-based, multiphoton-excitation-type optical examination apparatus The invention provides a multiphoton-excitation-type examination apparatus that efficiently generates a multiphoton-excitation effect, that makes the measurement head compact, and that can be easily adjusted when the measurement head is replaced. The multiphoton-exc... | 02/13/2007 |
| 7175980 | Method of making a plastic colorimetric resonant biosensor device with liquid handling capabilities Methods of producing liquid handling biosensor devices are provided. The liquid handling biosensor devices allow detection of biomolecular interactions in liquid. The use of labels is not required and the methods can be performed in a high-throughput manner. ... | 02/13/2007 |
| 7173699 | Spectroscopic scatterometer system Before the diffraction from a diffracting structure on a semiconductor wafer is measured, where necessary, the film thickness and index of refraction of the films underneath the structure are first measured using spectroscopic reflectometry or spectroscopic ellipsom... | 02/06/2007 |
| 7170599 | Method and instrument for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An instrument system for detecting a biochemical interaction on a biosensor. The system includes an array of... | 01/30/2007 |
| 7166409 | Multipass multiphoton absorption method and apparatus A method of increasing the efficiency of a multiphoton absorption process and apparatus. The method includes: providing a photoreactive composition; providing a source of sufficient light for simultaneous absorption of at least two photons; exposing the photoreactiv... | 01/23/2007 |
| 7158230 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 01/02/2007 |
| 7153702 | Label-free methods for performing assays using a colorimetric resonant reflectance optical biosensor Methods are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also relates to optical devices. ... | 12/26/2006 |
| 7148964 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 12/12/2006 |
| 7145664 | Global shape definition method for scatterometry A method for modeling samples includes the use of control points to define lines profiles and other geometric shapes. Each control point used within a model influences a shape within the model. Typically, the control points are used in a connect-the-dots fashion whe... | 12/05/2006 |
| 7145654 | Method and apparatus to reduce spotsize in an optical metrology instrument The measurement spot size of small-spot reflectometers, ellipsometers, and similar instruments can be reduced by placing an optical fiber along the optical path of the instrument, such as between an illumination source and a sample or the sample and a detector. The ... | 12/05/2006 |
| 7142296 | Method and apparatus for detecting biomolecular interactions Method and apparatus for detecting biomolecular interactions. The use of labels is not required and the methods may be performed in a high-throughput manner. An apparatus for detecting biochemical interactions occurring on the surface of a biosensor includes a light... | 11/28/2006 |
| 7125711 | Method and apparatus for splitting of specimens into multiple channels of a microfluidic device A microliter liquid sample, particularly a biological sample, is analyzed in a device employing centrifugal and capillary forces. The sample is moved by capillary forces into one or more metering wells which define the amount of the sample to be analyzed in subseque... | 10/24/2006 |
| 7123792 | Configurable aperiodic grating device The invention relates to the field of grating structures. The invention provides a longitudinal grating having an aperiodic structure, wherein the grating has a selected response characteristic and any repeated unit cell in the structure is significantly longer than... | 10/17/2006 |
| 7118710 | Label-free high-throughput optical technique for detecting biomolecular interactions Methods and compositions are provided for detecting biomolecular interactions. The use of labels is not required and the methods can be performed in a high-throughput manner. The invention also provides optical devices useful as narrow band filters. ... | 10/10/2006 |
| 7115858 | Apparatus and method for the measurement of diffracting structures A normal incidence reflectometer includes a rotatable analyzer/polarizer, which permits measurement of a diffracting structure. Relative rotation of the analyzer/polarizer with respect to the diffracting structure permits analysis of the diffracted radiation at mult... | 10/03/2006 |
