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A self defense weapon formed as a memo pad and which is easily held by a person's fingers, therefore making it possible to provide protection from a mugger and also to quickly and easily write a record or a message without failure of missing or forgetting significant information under a stressful situation.
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| Number | Title | Issue Date |
| 7323224 | Liquid dispense method and microarray manufacturing method A method for discharging a liquid containing a biological material includes adding as a dispense stabilizer a polymer composed of phosphorylcholine-group-containing unsaturated compound units or a copolymer including same to the liquid containing the biological mate... | 01/29/2008 |
| 7256259 | Methods for ligation of molecules to surfaces The present invention is a method for a covalent ligation of one or more molecules to one or more surfaces, that is site-specific and both rapid and high yielding. The covalent ligation to the surface is based on the reaction of an azide and a phosphinothioester to ... | 08/14/2007 |
| 7108891 | Random array of microspheres A method of making a microarray comprising the steps of: providing a support; coating on the support a receiving layer to receive microspheres, the receiving layer being capable of undergoing sol/gel transition; | 09/19/2006 |
| 6923432 | Side nail puller A nail puller mounted on the side of the head of a hammer. The nail puller may be incorporated into a metal hammer head and consist of a groove mounted substantially in line with the handle of the hammer. The nail puller consists of a V-shaped opening suitable for e... | 08/02/2005 |
| 6923978 | Multilayer materials The invention is directed to a composite material, especially a biomedical device, e.g. an ophthalmic device, preferably a contact lens, with one or more wettable surfaces capable of holding a continuous layer of aqueous fluid thereon which composite material compri... | 08/02/2005 |
| 6767928 | Mineralization and biological modification of biomaterial surfaces Disclosed are advantageous methods for patterning and/or mineralizing biomaterial surfaces. The techniques described are particularly useful for generating three-dimensional or contoured bioimplant materials with patterned surfaces or patterned, mineralized surfaces... | 07/27/2004 |
| 6767544 | Methods for treating cardiovascular diseases with botulinum toxin The present invention provides for methods of treating cardiovascular diseases in a mammal. The methods include a step of administering an effective amount of a botulinum toxin directly to a blood vessel of a mammal thereby treating a cardiovascular disease. ... | 07/27/2004 |
| 6756234 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used for immunoassays and other binding assays for separation of the desired analyte. By ... | 06/29/2004 |
| 6692790 | Proteinaceous coating The invention relates to a method for providing a proteinaceous coating on a medical implant, comprising the steps of: submersing the implant in a first aqueous solution comprising a protein and magnesium, calcium and phosphate ions through which a gaseou... | 02/17/2004 |
| 6669981 | Light stabilized antimicrobial materials Methods of enhancing the photostabilizing of silver in medical materials are described. More particularly, the methods increase the photostabilization of silver in certain materials comprising hydrophilic, amphoteric and anionic polymers by subjecting the... | 12/30/2003 |
| 6579847 | Method and apparatus for vascular neuromuscular blockade Method and apparatus of vascular neuromuscular blockade including percutaneous delivery of a quantity of neurotransmitter inhibiting agent to an affected region of a vessel.... | 06/17/2003 |
| 6544796 | System for producing multiple diagnostic test elements A system for producing multiple diagnostic test elements has a support (1) with an analytical region (3) to which diagnostic test spots (8) are applied, one or several stop edges (11-13) for each direction in space for positioning the support, a first hol... | 04/08/2003 |
| 6468667 | Ophthalmic molding The invention relates to an ophthalmic molding such as a contact lens or any kind of ocular prostheses comprising an organic bulk material having covalently bonded to its surface an acceptor saccharide to which is enzymatically attached one or more furthe... | 10/22/2002 |
| 6461874 | Stabilization of particles and reduction of sample discordance in immunoassays using casein coating of particles It has been found that casein and salts of casein are useful as replacements for, or in addition to, BSA as materials for coating solid phases, particularly magnetic particles, used in immunoassays and other binding assays for separation of the desired an... | 10/08/2002 |
| 6417009 | Reservoir components A linker lipid for use in attaching a membrane including a plurality of ionophores to an electrode and providing a space between the membrane and the electrode in which the membrane is either in part or totally made up of the linker lipid. The linker lipi... | 07/09/2002 |
| 6358753 | Method of coupling ligands to a solid phase in acidic solution and anionic surfactant The present invention relates to a method for binding antibody or antigen molecules to solid phase. The reactive compound comprising an antibody or antigen molecule and a solide phase are formed by coupling a specific antibody or antigen molecule to a sol... | 03/19/2002 |
| 6342346 | Method of producing an electrode membrane combination Electrode membrane combinations for use in biosensors to detect analytes in a sample and methods for making and storing same are disclosed. In one aspect, a method is provided for producing a first layer electrode membrane comprising: (1) Forming a soluti... | 01/29/2002 |
| 6261809 | Method for marking solid, liquid or gaseous substances The invention relates to a method for marking solid, liquid or gaseous substances, whereby the substance to be marked is provided with at least one synthetically produced nucleic acid sequence. Said nucleic acid sequence contains a first sequence section ... | 07/17/2001 |
| 6150181 | Magnetic nanoparticles coupled to annexine, and utilization thereof The invention relates to a process for producing ferrofluid-forming magnetic particles substituted by DMSA (FFSH) that can be covalently coupled, directly or through a difunctional reactant, to an effector, which process comprises combining DMSA with ferr... | 11/21/2000 |
| 6149977 | Method of catalytic crosslinking of polymer and two-pack composition used therein A method of crosslinking an oxidative polymer having oxidatively crosslinkable functional groups and a two-pack composition used therein is provided. The oxidatively crosslinkable functional groups on the oxidative polymer are crosslinked by contacting th... | 11/21/2000 |
| 6133047 | Superparamagnetic monodisperse particles The superparamagnetic monodispersed particles comprise a core of a first polymer, an internal layer of a second polymer coating the core and in which a magnetic material is distributed, and an external layer of a third polymer coating the magnetic layer a... | 10/17/2000 |
| 6074884 | Stable protein-nickel particles and methods of production and use thereof A stable protein-coated nickel particle useful in biological assays contains a nickel particle having removed from the surface thereof nickel oxide; a linker attached to said nickel particle, the linker having a free amino group; and a protein attached to... | 06/13/2000 |
| 6042875 | Drug-releasing coatings for medical devices The invention is directed to medical devices having a drug-releasing coating and methods for making such coated devices. The coating permits timed or prolonged pharmacological activity on the surface of medical devices through a reservoir concept. Specifi... | 03/28/2000 |
| 6033719 | Method for covalent attachment of biomolecules to surfaces of medical devices A method for making a medical device having at least one biomolecule immobilized on a substrate surface is provided. The method may include combining a biomolecule comprising a 1,2 dicarbonyl moiety with a material comprising a guanidino moiety to form an... | 03/07/2000 |
| 5985353 | Biomolecular synthesis of quantum dot composites A biomimetic approach utilizing biomolecular self-assembly is described to form nanometer particle size composites for uses, such as, nonlinear optical media. Yeast tRNA was utilized as an ion-exchange/nucleation site within a polymeric matrix (polyacryla... | 11/16/1999 |
| 5958512 | Method and apparatus for selectively removing or displacing a fluid on a web An apparatus for forming bands of reduced coat weight of a coating on a coated web that is moving through a laminating machine includes a supply of fluid and a nozzle for directing a stream of fluid from the supply toward the web, said nozzle having a rel... | 09/28/1999 |
| 5919712 | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays Methods and apparatus for evanescent light fluoroimmunoassays are disclosed. The apparatus employs a planar waveguide with an integral semi-cylindrical lens, and has multi-analyte features and calibration features, along with improved evanescent field int... | 07/06/1999 |
| 5891506 | Oxidative method for attachment of glycoproteins or glycopeptides to surfaces of medical devices A method for making a medical device having at least one glycoprotein and/or glycopeptide immobilized on a substrate surface is provided. The method may include oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; com... | 04/06/1999 |
| 5885647 | Coating process A process for coating of an intraocular lens to impart tissue compatibility thereto, comprising the steps: a) priming said lens using a solution of a polyamine; b) coating the lens treated in step a) above with a solution of a periodate-oxidized polysacch... | 03/23/1999 |
| 5876454 | Modified implant with bioactive conjugates on its surface for improved integration The present invention relates to a bioactive conjugate adapted to coat a metal implant outer surface, which has the following structural formula I: --R--X--P I wherein, R is O or S, adapted to be covalently attached ... | 03/02/1999 |
| 5858503 | Method of applying chemical charge modifiers to a substrate and article thereof A method of applying chemical charge-modifiers to a permeable sheet including the steps of: providing a permeable sheet having a plurality of individual exposed surfaces, at least a portion of which having relatively low surface energies; providing an aqu... | 01/12/1999 |
| 5854083 | Post synthesis chemical modification of particle reagents A method is provided for enhancing the stability and increasing the activity of polymer particle reagents by incubating a polymer particle which has been covalently bound to a compound of biological interest, such as a drug, with a modifying agent that wi... | 12/29/1998 |
| 5824651 | Process for modification of implant surface with bioactive conjugates for improved integration The present invention relates to a process for the covalent coating of implants with a bioactive conjugate, which comprises the steps of: a) cleaning a metal implant surface from contaminants by deoxidation with potentiostatic electrochemical polishing in... | 10/20/1998 |
| 5820998 | Coated paper and process for making the same A process of making a coated paper comprises the following steps: 1) providing a paper layer composed of a blend of pulp fibers and particulate material containing polyvalent metal cations, 2) applying a acidified alginate solution of a material selected ... | 10/13/1998 |
| 5807668 | Hardening of hydrophilic colloids An improved method for increaseing the hardening in a photographic element is described. The hardener is an imidazolium compound of formula: ##STR1## and the imidazolium is used in conjunction with a hardening accelerator defined by: ##STR2## ... | 09/15/1998 |
| 5736099 | Test plates for agglutination test and production process thereof A test plate for an agglutination test which comprises a plate with a plurality of wells formed thereon, each of the wells having adhered to a surface thereof a protein A and/or a protein G. The agglutination test plate, according to the present invention... | 04/07/1998 |
| 5728461 | Functional fiber products and process for producing the same Functional fiber products are provided. The functional fiber products are those adhered thereto a protein containing 20% to 40% by weight of serine as an amino acid component and those adhered thereto sericin and deacetylated chitin.... | 03/17/1998 |
| 5716660 | Tubular polytetrafluoroethylene implantable prostheses An implantable prosthesis comprising an expanded polytetraethylene member having pores present in its wall structure wherein said pores contain a solid insoluble biocompatible, biodegradable material of natural origin. A process of preparing said prosthes... | 02/10/1998 |
| 5660873 | Coating intraluminal stents A method is provided for forming fibrin coatings on a substrate, such as device for implantation in a body. The fibrin coatings are dried to provide a fibrin coating having the ability to be stored for extended periods before use. To provide coatings havi... | 08/26/1997 |
| 5639671 | Methods for optimizing of an optical assay device Method for optimizing an optical assay device for an analyte, including the steps of: providing a substrate having a chosen thickness of an optically active layer thereon; providing an attachment layer of a chosen thickness on the optical coating; providi... | 06/17/1997 |
