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Class 427/2.16 - Retarded or controlled-release layer produced (e.g., enteric)


Subclass of Class 427 - Coating processes
Definition: Processes in which the product is intended to provide retarded
No. of patents: 44
Last issue date: 10/31/2006


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NumberTitleIssue Date
7129248Process for preparing oxycodone hydrochloride having less than 25 ppm 14-hydroxycodeinone
In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone. ...
10/31/2006
7070806Controlled release formulations coated with aqueous dispersions of acrylic polymers
A stable solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic acrylic polymer includes a substrate including an active agent selected from the group consisting of a systemically active therapeutic agent, a locally...
07/04/2006
7022663Oral, nasal and pulmonary dosage formulations of copolymer 1
Pharmaceutical compositions useful for treating autoimmune diseases in a mammal comprising as an active ingredient a therapeutically effective amount of Copolymer 1, and microcrystalline cellulose are disclosed. Processes for the manufacture of such compositions are...
04/04/2006
6872336Process for producing a pharmaceutical solid preparation containing a poorly soluble drug
Among the conventional processes for producing solid dispersion, the solid dispersion obtained by a solvent method is excellent in terms of solubility and bioavailability of a poorly soluble drug. However, due to frequent uses of organic solvents in the solvent meth...
03/29/2005
6723372Method for producing encased spherical granular grains
A process for the production of encased, spherical granular grains comprising spraying grains which consist of a prostane derivative and a cyclodextrin vehicle, forming together a prostane-cyclodextrine-clathrate, with an aqueous polymer dispersion of ethyl cellulos...
04/20/2004
5958460Preparation process for a multiparticulate pharmaceutical form with plurality of sequences of controlled release
Preparation process for a multiparticulate pharmaceutical form with a plurality of sequences of controlled release of the type which allows the body of the patient to be provided with a sufficient concentration of one or more active ingredients by one or ...
09/28/1999
5888545Carbamazepine medicament with retarded active substance release
An oral administration carbamazepine medicament with a retarded active substance release is disclosed. An aqueous plasticised polymer dispersion is applied on carbamazepine crystals without causing formation of carbamazepine dihydrate. The carbamazepine c...
03/30/1999
5882715Method of preparing an oral preparation provided on the outer side with an enteric coating, as well as an oral preparation obtained by the method
A method of preparing an oral preparation, especially in the form of hard gelatin capsules, tablets or pellets, for use by the administration of drugs or supplementary nutrients for human beings or animals, said preparation on its outer side being provide...
03/16/1999
5851579Aqueous enteric coating compositions
The present invention sets forth an enteric coating composition comprising a blend of a) an alkali-soluble acrylic latex polymer and b) an aqueous solution of ammonium or alkaline salts of cellulose polymers. The invention also sets forth a method for preparing an ...
12/22/1998
5780028Method of obtaining immunoglobulins from colostrum and their use in pharmaceutical composition
A pharmaceutical composition consisting, of nontoxic components wherein the nontoxic components comprise a core element comprising an antibody which binds to an antigen wherein the core element is a compressed tablet wherein compression forces used to pre...
07/14/1998
5547683Method for producing microgranulated particle
The present invention relates to a method for producing a microgranulated particle having particle size of not more than 0.2 mm, wherein a fine powder with the average particle size of not more than 10 .mu.m, which is being agitated, tumbled or fluidized,...
08/20/1996
5505983Spherical seed cores, spherical granules and process for production thereof
Pharmacologically inactive spherical seed cores comprising at least 50% by weight of microcrystalline cellulose having an average degree of polymerization of 60 to 375, wherein the spherical seed cores have an average particle size of 100 to 1000 μm, a t...
04/09/1996
5472712Controlled-release formulations coated with aqueous dispersions of ethylcellulose
A stabilized solid controlled release formulation having a coating derived from an aqueous dispersion of a hydrophobic polymer is obtained by overcoating a substrate including an active agent selected from the group consisting of a systemically active the...
12/05/1995
5310572Process for forming a coated active agent-containing article
Aqueous coating compositions for forming elastomeric films around active cores (e.g., drugs) comprising a dispersion of pre-crosslinked polyorganosiloxane latex particles, colloidal silica particles, and a water-dispersible organic material (e.g., polyeth...
05/10/1994
5256440Process for producing a tablet core aperture
Process for preparing and film coating a dosage form. An intagliated dosage form core is produced by inscribing one or more areas on the surface of the dosage form core prior to coating. An aqueous dispersion of a polymeric coating is then applied to the ...
10/26/1993
5225238Method for coating active principles with a pH-sensitive polymer
A new method of coating an active principle which comprises the step of coating an active principle with an aqueous emulsion or dispersion containing one or more pH-sensitive polymers....
07/06/1993
5194464Enteric film and preparatoin thereof
An enteric film is produced by spraying on a material a mixed solution of (a) hydroxypropylmethylcellulose phthalate exhibiting a viscosity of about 136 to 204 centistokes as 10% methanol/dichloromethane (1:1 by weight) solution at 20° C., (b) polyethyle...
03/16/1993
5158804Particle coating apparatus for small-scale processing
Apparatus and methods are provided for coating relatively small quantities of particles including tablets, pellets, or granules. The device effectively fluidizes the particles to be coated by controlled vibration of a perforated platform through which dry...
10/27/1992
5112621Sustained release pharmaceutical composition of diltiazem
A sustained-release pharmaceutical composition which comprises microparticles comprising an active principle, said microparticles being coated with a coating mixture comprising ethyl cellulose and an acrylic resin which is a polymerizate of acrylic and me...
05/12/1992
5085866Method of producing zero-order controlled-released devices
An improved method of producing a reservoir device having a rate-controlling membrane and zero-order (constant) release of an agent is provided. A core is sprayed with a solution having a polymer and a solvent, the solvent having a first component which i...
02/04/1992
5023108Aqueous dispersions of waxes and lipids for pharmaceutical coating
This invention relates to the coating of pharmaceutically useful solids with an emulsion comprising a wax/lipid, an emulsifying agent and water, which emulsion can be spray dried to form a powder which can subsequently be dispersed in water and coated ont...
06/11/1991
5017383Method of producing fine coated pharmaceutical preparation
A method of producing a fine coated pharmaceutical preparation, which includes cooling fine liquid droplets composed of a liquid medium, a drug dissolved or suspended in the liquid medium, and as required, a binder to a temperature of not higher than the ...
05/21/1991
4948622Method for the preparation of coated solid medicament form
Solid medicament forms, such as granules, beads, tablets, are first coated with a hot aqueous dispersion of a cellulose ether, which is soluble in cold water but insoluble in hot water, and then subjected to a wax treatment with heating to form a masking ...
08/14/1990
4933186Dihydropyridine depot formulation
A pharmaceutical formulation tablet with a long-lasting action for 1 to 2 daily doses having a diameter between about 0.5 and 15 mm and comprising (a) a rapid-release core of a dihydropyridine, (b) a coat containing no active compound and formed of a free-flowing ...
06/12/1990
4800056Process for making dispenser with cooperating elements
A method of forming a dispenser for delivering a beneficial agent to a biological environment. A beneficial agent and an expandable composition are placed in a capsule made of fluid dissolvable material. The capsule is closed and surrounded by a semiperme...
01/24/1989
4713245Granule containing physiologically-active substance, method for preparing same and use thereof
Disclosed herein is a granule containing physiologically-active substance which comprises at least (A): a physiologically-active substance; (B): a substance which is stable under neutral condition but disintegrates or dissolves at a pH of 3 or less; and (C): a...
12/15/1987
4684534Quick-liquifying, chewable tablet
This application discloses tablets having a harder outer shell which inhibits penetration of liquid into the interior of the tablet, and a softer interior which quickly liquifies when the tablet and shell are broken into pieces and contacted by the liquid...
08/04/1987
4644031Coating for pharmaceutical dosage forms
Coated pharmaceutical dosage forms which are resistant to gastric juice and release their active ingredient rapidly at a predetermined pH value in the range from pH 5 to pH 8 are obtained in accordance with the invention by coating pharmaceutical dosage f...
02/17/1987
4632843Process for the preparation of solid pharmaceutical products
A process for the preparation of solid pharmaceutical products, wherein, in a first step, spherical single crystals of a pharmaceutical active compound or assistant are prepared by agitating a saturated aqueous, organic or organic-aqueous solution in high...
12/30/1986
4623588Controlled release composite core coated microparticles
A process for preparing coated microparticles, which process comprises preparing a solvent solution of an active ingredient to be encapsulated and a film-forming polymer, removing the solvent to provide a dry, composite, uniform admixture of the active in...
11/18/1986
4600645Process for treating dosage forms
The problems of tackiness and long curing times usually associated with the treatment of dosage forms are overcome via the use of a new curing process. That process involves: (1) coating a drug with a sustained release formulation, (2) immediately coating...
07/15/1986
4574080Combination formulation
A pharmaceutical oral controlled release multiple-units formulation is prepared by mixing units containing an active substance and coated with a substantially water-insoluble, but water diffusable controlled release coating with particles of an active sub...
03/04/1986
4572833Method for preparing a pharmaceutical controlled release composition
A pharmaceutical oral multiple-units composition with controlled release, in which the individual units are coated units of an active substance, e.g. potassium chloride, which is subject to controlled release in consequence of the units being coated with ...
02/25/1986
4553973Process for preparing osmotic device
An osmotic delivery system is disclosed for dispensing a useful agent. The system comprises a semipermeable wall surrounding a compartment housing the agent. The wall comprises a cellulose ether, an organic solvent soluble polymer, and optionally an aqueo...
11/19/1985
4540602Process for the preparation of activated pharmaceutical compositions
Disclosed is a process for the preparation of an activated pharmaceutical composition containing a solid drug that is scarcely soluble in water, the pharmaceutical composition being characterized in that, when it is administered orally, the drug is readil...
09/10/1985
4497847Process for coating solid pharmaceutical preparations and coated preparations thus obtained
A plasticizer for film-forming enteric polymers to be used in coating solid pharmaceutical preparations comprises a monoester or diester or both of glycerol with a saturated aliphatic carboxylic acid having from 6 to 10 carbon atoms. This is particularly ...
02/05/1985
4285987Process for manufacturing device with dispersion zone
An osmotic system is disclosed for dispensing a beneficial agent. The system comprises (1) a first wall of a semipermeable material that surrounds a compartment containing a drug formulation, and has a passageway through the wall for releasing agent from ...
08/25/1981
4267138Coating ensuring a controlled release of active ingredients of biologically active compositions, particularly pharmaceutical compositions and a process for preparation of biologically active compositions ensuring controlled release of active ingredients
A coating ensuring the controlled release of a biological active ingredient, which can be incorporated in the coating or is surrounded thereby, consists of a varnish-forming polymer selected from the group which consists of cellulose triacetate containing...
05/12/1981
4220552Method of producing delayed release of sodium fluoride
A process of pretreating a lower alkyl cellulose, such as ethyl cellulose, which is to be used in microencapsulation of sodium fluoride for dental purposes. This process comprises dispersing a predetermined quantity of lower alkyl cellulose in an aqueous ...
09/02/1980
4166800Processes for preparation of microspheres
Microspheres, prepared by the low-temperature e.g., -40° to -100° C., phase separation of a polymer and a core material....
09/04/1979
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