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| Number | Title | Issue Date |
| 8066991 | Enzyme inhibitors of PAI-1 The invention provides a method for the treatment of a subject suffering from a cardiovascular disease using a therapeutically effective amount of at least one enzyme that is capable of inhibiting PAI-1 activity. The invention also provides a method of decreasing th... | 11/29/2011 |
| 7943127 | Defense and counter-defense compositions and methods Contemplated compositions and methods are directed to the use of a proteinase to reduce capsaicin-induced pain sensation in a mammal. Preferably, the proteinase comprises a bromelain preparation in a liquid formulation for topical or enteral administration. In addit... | 05/17/2011 |
| 7871609 | Supplements for pain management Dietary supplements, compositions and methods of administering the supplements to reduce pain, inflammation and stiffness in said mammal within a few hours. The supplements and compositions can include a combination of an amino acid, vitamins, herbs and enzymes. The... | 01/18/2011 |
| 7794709 | Apparatus and methods for enzymatic escharotomy in burn induced compartment syndrome Apparatus suitable for use in the prevention and treatment of burn induced compartment syndrome facilitates the rapid and efficient deployment of enzymatic compositions to the affected limb or limbs of a burn victim suffering from a circumferential burn. The apparat... | 09/14/2010 |
| 7785584 | Ointment wound spray A spray-on topical wound debrider spray is prepared forming a mist, spray or foam which will not drip significantly after application. The preferred wound debrider is papain. The spray contains a surfactant emulsifier admixture having a composition viscosity of from... | 08/31/2010 |
| 7731958 | Use of bromelain for the treatment of inflammatory diseases and for adjuvant therapy during wound healing processes The present application pertains to the use of bromelain preparing a medicament for increasing the IL-(8) level in an individual so as to reduce or prevent inflammation in said individual and as an adjuvant therapy during wound healing processes. ... | 06/08/2010 |
| 7429378 | Transdiscal administration of high affinity anti-MMP inhibitors The present invention relates to injecting a high affinity antagonist of MMPs into a diseased intervertebral disc. ... | 09/30/2008 |
| 7402311 | Composition and method for treating non-bacterial cystitis A composition and a method for treatment of urinary tract dysfunction and, particularly, non-bacterial cystitis and, even more particularly, non-bacterial chronic interstitial cystitis. The composition primarily relies upon the use of a bioflavonoid and, particularl... | 07/22/2008 |
| 7393528 | Biological pesticide Methods for exterminating pests using compositions comprising at least one protease enzyme. A detergent component may also be utilized in such compositions. ... | 07/01/2008 |
| 7371389 | Methods and products for enhancing energy and nutrition in human beings Methods for increasing energy in men and women include ingesting internally, twice a day, products that include, for women, multivitamins, multiminerals, high-calcium bone support products, high-ORAC super food products, and enzymes, and, for men, multivitamins, mul... | 05/13/2008 |
| 7351561 | Thrombin preparations and process for their production The production of a thrombin preparation which is obtained from prothrombin which is, after activation to thrombin without the addition of thromboplastin, purified by a hydrophobic interaction chromatography, it being possible subsequently also to inactivate or remo... | 04/01/2008 |
| 7326686 | Compounds and methods for regulating cell adhesion Methods for using modulating agents to enhance or inhibit cadherin-mediated cell adhesion in a variety of in vivo and in vitro contexts are provided. In particular, the modulating agents may be used in the therapy of multiple sclerosis and other demyelinating diseas... | 02/05/2008 |
| 7304171 | Compounds and methods for cytoprotection Compounds, compositions and methods for treating degenerative diseases and disorders are disclosed, the compounds having the following structure (I): including stereoisomers, prodrugs and pharmaceutically accepta... | 12/04/2007 |
| 7262271 | Synthetic peptide constructs for the diagnosis and treatment of periodontitis associated with The present invention relates to an oral composition and an immunogenic composition for the suppression of the pathogenic effects of the intra-oral bacterium Porphyromonas gingivalis associated with periodontal disease. ... | 08/28/2007 |
| 7258856 | Proteases from having mitogenic activity and their methods of use Proteases having mitogenic activity isolated from the genus Carica are provided. In particular the proteases are cysteine proteases isolated from Carica candamarcensis. In addition, the recombinant forms of the protease, including fragments and mutants... | 08/21/2007 |
| 7211278 | Treating method for suppressing hair growth treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, which comprises (B) an elastase inhibit... | 05/01/2007 |
| 7169405 | Methods and devices for the treatment of intervertebral discs Methods for treating at least one condition of an intervertebral disc (e.g. protrusion, hemiation, discogenic pain, dehydration, or degeneration) in a patient in need thereof are provided. The method comprises placing a device into an intervertebral space of a patie... | 01/30/2007 |
| 7166281 | Pharmaceutical composition and method for relieving itch, pain and swelling resulting from insect bites and stings A pharmaceutical composition for relieving the itch, pain, and swelling resulting from insect bites and stings, and methods for producing and using the composition. The method preferably comprises topically applying to the affected area the composition which contain... | 01/23/2007 |
| 7125544 | Kit for promoting the growth of human hair and its method of use Provided is a kit that composes of two products and its method of use to promote hair growth. The kit has two products that are applied to the scalp of a human sequentially. The first product applied to the scalp of a human is a monoethanolamine salt composition tha... | 10/24/2006 |
| 7115260 | Interleukin-1β converting enzyme like apoptotic protease-6 Human ICE LAP-6 polypeptides and DNA (RNA) encoding such ICE LAP-6 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ICE LAP-6 for the treatment of a susceptibility to viral infectio... | 10/03/2006 |
| 7083964 | Method for purifying enzymes from clostridium histolyticum using multi-stage chromatography The invention relates to a method for purifying at least one enzyme obtained in an excess fermentation of Clostridium histolyticum. It is provided for that the enzymes of the excess fermentation are separated by a multistage chromatography method by e... | 08/01/2006 |
| 7078024 | Compositions and method for promoting the growth of human hair Provided are compositions comprising monoethanolamine salts of thioglycolic, salicylic, lactic and glycolic acids in combination with an organic enzyme, preferably papain, and an oxidizing aged their methods of use to induce hair growth in the scalp of humans and ot... | 07/18/2006 |
| 7060281 | Groups of and that cause lyme disease in humans The present invention is drawn to an immunogenic composition comprising OspC polypeptides from Lyme Disease causing Borrelia. In one embodiment, the immunogenic composition of the present invention comprises at least one OspC polypeptide or immunogenic fragme... | 06/13/2006 |
| 7056499 | Treating method for suppressing hair growth The present invention relates to a treating method for hair growth inhibition, which comprises administering (A) the extract of a plant of the family Juniperus or a malt. In addition, the present invention relates to a dermatologic composition for external use, whic... | 06/06/2006 |
| 7053065 | Vitamin B12 and pemetrexed disodium combination therapies A method of administering an antifolate to a mammal in need thereof, comprising administering an effective amount of said antifolate in combination with a methylmalonic acid lowering agent. ... | 05/30/2006 |
| 7041302 | Therapeutic modulation of the tumor inflammatory response The invention relates to compositions, kits, and methods for alleviating cancer (i.e., a tumor) in a human patient. The therapeutic modality effected by the invention involves inducing a type 1 inflammatory response in the tumor tissue, whereby the tumor tissue is d... | 05/09/2006 |
| 6958150 | Reduction of adipose tissue The amount of adipose tissue, including lipomas, at selected locations in the body is reduced by introducing collagenase or collagenase plus another proteinase into the tissue. ... | 10/25/2005 |
| 6927053 | Dual component dental composition containing enzyme A two component desensitizing dentifrice composition is disclosed which comprises a first dentifrice component containing an enzyme such as papain and a second dentifrice component containing an ionic surfactant such as sodium lauryl sulfate, the first and second de... | 08/09/2005 |
| 6806070 | Use of bacterial extracts of the pseudomonadaceae family as cosmetic agents Use of an extract of bacterium from the family Pseudomonadaceae in the production of cosmetic compositions in particular for combating ageing of the skin. ... | 10/19/2004 |
| 6803038 | Use of bromelaine proteases for inhibiting blood coagulation The present invention relates to the use of bromelaine proteases for inhibiting blood coagulation, especially for stimulating the production of plasmin, for inhibiting the production of fibrin and for inhibiting the adhesion of human thrombocytes on endothelilum cel... | 10/12/2004 |
| 6800473 | Human cathepsin L2 protein, gene encoding said protein and use thereof Novel proteins which belong to the papain family and are cysteine proteinase enzymes (the cysteine proteinase enzymes are expected to be involved in the turnover of intracellular proteins, antigen presentation, prohormone activation, bone remodeling, etc. and to pla... | 10/05/2004 |
| 6783757 | Composition and method for increasing exorphin catabolism to treat autism A composition for use in treating autism spectrum disorders. The composition preferably includes a genomeceutical type compound that increases the user's expression of DPPIV or like substances. The genomeceutical compound may include a sugar (such as a milk sugar), ... | 08/31/2004 |
| 6773704 | Methods of treating vascular disease associated with cystatin C deficiency The invention provides methods of treating and preventing vascular diseases, by inhibiting cysteine proteases active at sites of vascular injury, particularly cathepsins K and S, by administering cystatin C or TGF-β1. Cystatin C is severely reduced in bo... | 08/10/2004 |
| 6713096 | Dietary supplements and methods for treating pain and inflammation The invention provides compositions such as dietary supplements. Such compositions can be used to reduce pain, inflammation, stiffness, and/or discomfort associated with inflammatory conditions such as arthritis. The invention also provides methods for reducing pain... | 03/30/2004 |
| 6709651 | Treatment of substance P-related disorders The present invention is directed to methods of treating a wide variety of diseases, disorders and conditions characterized by excessive activity of substance P. The treatment involves administering peptidases that recognize and selectively cleave polypeptides at Xa... | 03/23/2004 |
| 6663860 | Biological pesticide Methods for exterminating pests using compositions comprising at least one protease enzyme. A detergent component may also be utilized in such compositions.... | 12/16/2003 |
| 6645509 | Polypeptide expressed in the horny layer of epidermis and use thereof The present invention relates to a cosmetic or pharmaceutical composition comprising, in a physiologically acceptable medium, a purified natural or synthetic epidermis-specific polypeptide which is involved in horny layer cell cohesion. The invention also... | 11/11/2003 |
| 6627193 | Methods and compositions for control of blood coagulation Methods for controlling blood coagulation, and suitable pharmaceutical compositions that include a polypeptide that enhances the anticoagulation process (or inhibitors thereof for reversing the anticoagulation process) are provided.... | 09/30/2003 |
| 6623735 | Vaccine containing a thiol protease Thiol proteases having Cathepsin 1 type activity are used in the formulation of vaccines for combating helminth parasites. Preferably the protease is derived from a fluke such as Fasciola hepatica.... | 09/23/2003 |
| 6605306 | Food supplement formulation A food supplement formulation comprises quercetin, bromelain, papain, passiflora incarnata, valeriana officinalis, gotu kola, usnea barbata, althea officinalis, and L-arginine.... | 08/12/2003 |
