Class 424/94.63 - Acting on peptide bonds (3.4) (e.g., urokinease, etc.)

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein the enzyme catalyzes hydrolysis of
No. of patents: 478
Last issue date: 03/13/2012

«First «Previous1 2 3 4 5 6 7 8 9 10 11 Next»Last»

Number	Title	Issue Date
8133484	Hemostatic materials and dressing An adhesive material comprising gelatin and a non-toxic cross-linking material such as transglutaminase. The adhesive material is useful for medical purposes as hemostatic products. The hemostatic products are useful for the treatment of wounded tissue. ...	03/13/2012
8133483	Method of treating or preventing a disease or condition mediated by pathogenic IgG antibodies The invention provides use of an IdeS polypeptide, or a polynucleotide encoding an IdeS polypeptide, in the manufacture of a medicament for the treatment or prevention of a disease or condition mediated by IgG antibodies. ...	03/13/2012
8124074	Fusion proteins The invention provides a single chain, polypeptide fusion protein, comprising: a non-cytotoxic protease, or a fragment thereof, which protease or protease fragment is capable of cleaving a protein of the exocytic fusion apparatus of a target cell; a Targeting Moiety...	02/28/2012
8119125	Compositions and methods for enhanced gastrointestinal stability of oligopeptides and polypeptides Methods and compositions are provided for stabilizing polypeptides for oral administration, particularly where enteric delivery is desirable. By administering the polypeptides with a bile sequestering agent, the stability of the polypeptide can be increased. Pharmac...	02/21/2012
RE42954	Method for repairing a defect in an intervertebral disc Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra...	11/22/2011
8003096	Means and methods for the recruitment and identification of stem cells Described are methods of modulating stem/progenitor cell recruitment involving molecules that agonize the formation of plasmin stimulating the recruitment of stem/progenitor cells, including hematopoietic and endothelial precursor cells. Conversely, antagonists of p...	08/23/2011
7998476	Method of treatment using protease A method for treating various diseases, conditions and injuries with a protease preparation derived from Aspergillus orzyze and made using potato dextrin as the carbohydrate source is described. The method comprises orally administering the Aspergillus ory...	08/16/2011
7951367	Methods and compositions for reducing amyloid beta levels The present invention provides a method of increasing cathepsin B-induced cleavage of amyloid-β (Aβ) peptide in a cell or tissue, the method generally involving contacting the cell or tissue with an agent that increases the level of cathepsin B in the cell or tiss...	05/31/2011
7829082	Catheter composition and uses thereof A composition useful for removal of fibrin-bound blood clots from a catheter comprises water, a fibrinolytically effective amount of a plasminogen activator, and a preservatively effective amount of a bacteriostatic organic alcohol. The composition does not comprise...	11/09/2010
7803369	Devices and method for repair of larynx, trachea, and other fibrocartilaginous tissues Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra...	09/28/2010
7799326	Methods and compositions for cathespin k complex-mediated disorders Methods and compositions for the amelioration of symptoms mediated by the collagenolytic activity of cathepsin K complex are provided. Methods of specifically modulating the collagenolytic activity of cathepsin K without substantial interference in other biologicall...	09/21/2010
7628985	Therapeutic enzyme formulations and uses thereof in celiac sprue and/or dermatitis herpetoformis Pharmaceutical formulations of glutenase enzymes are provided. The enzymes find particular use in the treatment of a Celiac or dermatitis herpetiformis patient. ...	12/08/2009
7572440	Method for repairing a defect in an intervertebral disc Provided herein are methods and devices for inducing the formation of functional replacement nonarticular cartilage tissues and ligament tissues. These methods and devices involve the use of osteogenic proteins, and are useful in repairing defects in the larynx, tra...	08/11/2009
7569223	Phage-associated lytic enzymes for treatment of and related conditions The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Streptococcus pneumonia bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for the identificat...	08/04/2009
7566448	Reduced aerosol generating formulations The present invention relates to compositions comprising high molecular weight polymers, particularly polyethylene oxide polymers, wherein the high molecular weight polymer serves as an anti-misting agent to reduce the potential of aerosol generation from a composit...	07/28/2009
7534426	Glutenase enzyme assays Administering an effective dose of glutenase to a Celiac or dermatitis herpetiformis patient reduces levels of toxic gluten oligopeptides, thereby attenuating or eliminating the damaging effects of gluten. ...	05/19/2009
7452533	Antimicrobial polymer conjugate containing lysostaphin and polyethylene glycol Water-soluble polymer conjugates of antimicrobial agents retaining at least a portion of the antimicrobial activity of the agent, pharmaceutical compositions containing the polymer conjugates, and methods for treating microbial infections with the pharmaceutical com...	11/18/2008
7432355	Apolipoprotein E stable folding intermediate and methods of use thereof The present invention provides isolated apolipoprotein E (apoE) stable folding intermediates. The invention further provides methods for identifying compounds that alter the structure or level or activity of an apoE stable folding intermediate, as well as methods of...	10/07/2008
7429476	Acid fungal proteases The present invention is directed to novel acid proteases and more specifically to NSP24 family proteases and NSP25 family proteases including biologically active fragments thereof and to nucleic acid molecules encoding said proteases. Also provided are vectors and ...	09/30/2008
7425534	Compositions and methods for modulating muscle cell and tissue contractility The present invention relates to compositions and methods comprising one or more domains of urokinase-type plasminogen activator (uPA) in an amount effective to modulate one or more of the contractility and angiogenic activity of a mammalian muscle or endothelial ce...	09/16/2008
7407933	Drug containing angiotensin convertase The medicine containing angiotensin-converting enzyme or its peptidase-inactivated mutants that specifically releasing GPI-anchored proteins from the cell surface, for preventing or curing diseases, such as prion-related diseases, inflammatory diseases, bacterial in...	08/05/2008
7393528	Biological pesticide Methods for exterminating pests using compositions comprising at least one protease enzyme. A detergent component may also be utilized in such compositions. ...	07/01/2008
7378078	Compositions and methods for detecting proteolytic activity The invention provides compositions and methods for non-invasive imaging of enzyme (e.g., protease) activity in cells, tissues and organs and entire bodies in vitro, in vivo and in situ. The invention provides a chimeric polypeptide having a bioluminescent or chemil...	05/27/2008
7371539	Targeted polypeptide degradation This invention pertains to compositions, methods, cells and organisms useful for selectively localizing polypeptides to the proteasome for degradation. Therapeutic methods and pharmaceutical compositions for treating disorders associated with the expression and/or a...	05/13/2008
7361344	Co-administration of a thrombolytic and an-anti-CD18 antibody in stroke A method for improving clinical outcome in focal ischemic stroke in a mammal by increasing cerebral blood flow and/or reducing infarct size is described which involves administering an effective amount of an anti-CD18 antibody to the mammal, in the absence of remova...	04/22/2008
7361644	Specific antagonist for both E- and P-selectins Compounds and methods are provided for modulating in vitro and in vivo processes mediated by selectin binding. More specifically, selectin modulators and their use are described, wherein the selectin modulators that modulate (e.g., inhibit or enhance) a selectin-med...	04/22/2008
7347163	Microbial feedstock for filter feeding aquatic organisms The present invention provides a method of cultivating filter feeders such as Artemia by substituting special microorganisms for naturally occurring microscopic algae, and providing conditions optimal for the growth of these organisms. These subsituted special micro...	03/25/2008
7335645	Effectors of dipeptidyl peptidase IV for topical use The invention relates to compounds for topically influencing the activity of dipeptidyl peptidase of the general formula wherein A is an amino acid having at least one f...	02/26/2008
7332224	Cleaning article containing hydrophilic polymers The invention relates to a cloth that can function as a moisturizing cleanser. When the cloth is moistened with water, it works up into a warm, sudsy cleansing lotion that feels great and works well as a facial cleansing cloth. The cloth contains water, at least one...	02/19/2008
7332320	Protease producing an altered immunogenic response and methods of making and using the same The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants...	02/19/2008
7332160	Medical device and method for tissue removal and repair The present invention relates to medical devices that are to be implanted or inserted into the body of a patient for the purpose of removing undesired body tissues. In one embodiment of the invention the medical device comprises a body tissue removal agent for remov...	02/19/2008
RE39941	Amelioration of Dupuytren's disease The cords of Dupuytren's disease are injected with collagenase, the hand is immediately immobilized and maintained immobile for several hours. The cord becomes relaxed or ruptured, relieving the hand contracture of the disease. ...	12/18/2007
7303768	Preparation of aqueous clear solution dosage forms with bile acids Compositions for pharmaceutical and other uses comprising clear aqueous solutions of bile acids which do not form any detectable precipitates over selected ranges of pH values of the aqueous solution and methods of making such solutions. The compositions of the inve...	12/04/2007
7291597	Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA and VEGF165; (ii) isolating the peripheral bl...	11/06/2007
7291587	Pharmaceutical composition comprising factor VII polypeptides and TAFI polypeptides The present invention relates to a composition comprising factor VII or a factor VII-related polypeptide, and TAFI or a TAFI-related polypeptide, and the use thereof for treating bleeding episodes. ...	11/06/2007
7288521	Growth factor therapy mobilization of stem cells into the peripheral blood Stem cells are mobilized into the peripheral blood by a method comprising the steps of: (i) administering to an individual at least one of the following: FGF1 and FGF2, and also at least one of the following: VEGF, VEGFA, VEGFB, PLGF, VEGF121, VEGF145, VEGF165, VEGF...	10/30/2007
7285635	Modified proteins, designer toxins, and methods of making thereof The present invention concerns methods of reducing the antigenicity of a proteinaceous compound while maintaining the compounds biological activity, as well as proteinaceous compositions with biological activity but reduced antigenicity. These methods and compositio...	10/23/2007
7276235	Tissue glue with improved antiadhesive properties The use of a tissue glue comprising a stabilized fibrinogen preparation, which can be stored in the liquid or frozen state and comprises a chaotropic substance, and a thrombin preparation, for reducing or preventing tissue adhesions, is described. ...	10/02/2007
7276535	Intratesticular injection of chemical sterilant A low effective dose of a biologically acceptable chemical sterilant is injected into the dorsal cranial portion of a scrotal testis of a male animal for the purpose effecting sterilization of the animal. The injection of the chemical sterilant into the dorsal crani...	10/02/2007
7265098	Polyacid/polyalkylene oxide gels and methods for their delivery The present invention relates to improved methods for delivering bioadhesive, bioresorbable, anti-adhesion compositions. Antiadhesion compositions can be made of intermacromolecular complexes of carboxyl-containing polysaccharides, polyethers, polyacids, polyalkylen...	09/04/2007

«First «Previous1 2 3 4 5 6 7 8 9 10 11 Next»Last»

PatentStorm

Quotables

PatentStorm News

Class 424/94.63 - Acting on peptide bonds (3.4) (e.g., urokinease, etc.)