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| Number | Title | Issue Date |
| 8105586 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 01/31/2012 |
| 7871607 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 01/18/2011 |
| 7846431 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 12/07/2010 |
| 7829081 | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases The invention relates to the discovery of novel soluble neutral active Hyaluronidase Glycoproteins (sHASEGPs), methods of manufacture, and their use to facilitate administration of other molecules or to alleviate glycosaminoglycan associated pathologies. Minimally a... | 11/09/2010 |
| 7354416 | Methods and devices for draining fluids and lowering intraocular pressure Methods, devices and systems for draining fluid from the eye and/or for reducing intraocular pressure. A passageway (e.g., an opening, puncture or incision) is formed in the lamina cribosa or elsewhere to facilitate flow of fluid from the posterior chamber of the ey... | 04/08/2008 |
| 7348009 | Recombinant allergen with reduced enzymatic activity The present invention provides a novel treatment for allergy comprising a recombinant allergen with reduced enzymatic activity, thereby reducing the potential for an allergic response upon contact with a wild-type allergen. ... | 03/25/2008 |
| 7261889 | Local anesthetic methods and kits Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. A... | 08/28/2007 |
| 7229630 | Stabilized formulations of alpha adrenergic receptor antagonists and the uses thereof The present invention provides compositions and stable liquid formulations comprising alpha adrenergic receptor antagonists and use thereof for increasing blood flow. In one embodiment, the stable liquid formulations of this invention are useful for reversing the ef... | 06/12/2007 |
| 7179461 | Plasminogen activator to prevent corneal and subepithelial haze after laser vision correction surgery The present invention is directed to a method to prevent or reduce postoperative corneal subepithelial haze after excimer laser photorefractive keratectomy (PRK), laser in situ keratomileusis (LASIK) surgery. According to the method, a therapeutically effective amou... | 02/20/2007 |
| 7141610 | Compositions and methods for the induction of retinal detachments A method comprising administering by ocular route a dose of a glycol ether effective to induce retinal detachment. ... | 11/28/2006 |
| 7115408 | Method of stabilizing hyaluronidase with annexin II This invention relates generally to the use of annexin II for the purpose of stabilizing a hyaluronidase enzyme for administration to the eyes of humans or other mammals. ... | 10/03/2006 |
| 7105330 | Human plasma hyaluronidase The invention is based on the discovery of methods for purification of an acid active hyaluronidase found in human plasma (hpHAse), including both biochemical and immunoaffinity purification methods. The method of immunoaffinity purification of the invention is base... | 09/12/2006 |
| 7097858 | Polyoxometalate materials, metal-containing materials, and methods of use thereof Polyoxometalate topical compositions for removing contaminants from an environment and methods of use thereof are disclosed. An embodiment of the polyoxometalate topical composition includes a topical carrier and at least one polyoxometalate, with the proviso that t... | 08/29/2006 |
| 7049124 | Hyaluronidase from the isolation, purification and recombinant method of production The present invention relates to the isolation, purification and characterization of a hyaluronidase which derives from the tropical leech Hirudinaria manillensis. Therefore, according to this invention, the enzyme was called “manillase”. The invention is... | 05/23/2006 |
| 6998389 | Pharmaceutical composition comprised of spider venoms, the production thereof, and its use for treating tumor diseases The present invention describes pharmaceutically effective substances from the poison of spiders of the family of Sicariidae as well as their preparation and their use in medicine. ... | 02/14/2006 |
| 6984406 | . WL-1 strain producing mannanase The present invention relates to a Bacillus sp. strain producing a mannanase which is highly active in the neutral and the acidic media. The Bacillus sp. WL-1 strain (KCTC 0800BP), which is isolated from the soil, produces in large scale the mannanase ... | 01/10/2006 |
| 6969514 | Method for treating elevated intraocular pressure, including glaucoma Hyaluronic acid, a polymer found in the trabecular meshwork of the eye, has a polymeric structure that is broken down by the enzyme hyaluronidase. A method is provided for reducing elevated intraocular pressure in an eye of a patient, such as a patient suffering fro... | 11/29/2005 |
| 6962699 | Rationally designed polysaccharide lyases derived from chondroitinase B The invention relates to rationally designed polysaccharide lyases and uses thereof. In particular, the invention relates to modified chondroitinase B. The modified chondroitinase B enzymes of the invention are useful for a variety of purposes, including cleaving an... | 11/08/2005 |
| 6939542 | Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vitreous body of the eye A thimerosal-free hyaluronidase preparation wherein the preferred hyaluronidase enzyme is devoid of molecular weight fractions below 40,000 MW, between 60-70,000 MW and above 100,000 MW. Also disclosed is a method for accelerating the clearance of hemorrhagic blood ... | 09/06/2005 |
| 6913744 | Method and composition for treating prostate cancer A method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase. In one embodiment, a method of treating prostate cancer in a living mammal includes local a... | 07/05/2005 |
| 6905517 | Tissue grafting material The present invention relates to a tissue grafting material that includes a first tissue element harvested from an individual, a carrier, and a therapeutic substance contained in the carrier. The carrier and therapeutic substance are incorporated into the first tiss... | 06/14/2005 |
| 6902548 | Use of enzyme in ophthalmic treatments A highly specific and easily purified form of hyaluronidase is described for use in ophthalmic treatments. The enzyme, from Streptomyces hyalurolyticus is specific for hyaluronidase and carries out an elimination reaction that results in the production of dou... | 06/07/2005 |
| 6872390 | Local anesthetic methods and kits Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. A... | 03/29/2005 |
| 6863886 | Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to retina is accomplished by administering an amount of hyaluronidase ef... | 03/08/2005 |
| 6806070 | Use of bacterial extracts of the pseudomonadaceae family as cosmetic agents Use of an extract of bacterium from the family Pseudomonadaceae in the production of cosmetic compositions in particular for combating ageing of the skin. ... | 10/19/2004 |
| 6787135 | Modification of vitreal matrix metalloproteinase activity Methods of modifying total MMP activity levels in the vitreous of an eye are provided. In a preferred embodiment, the method results in reduced MMP activity and comprises introducing plasmin into the vitreous of the eye. Enzyme assisted vitrectomy procedures are als... | 09/07/2004 |
| 6764678 | Local anesthetic methods and kits Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor antagonist. A... | 07/20/2004 |
| 6737075 | Biochemical methods that eliminate corneal scars, opacification and haze The invention disclosed herein relates to biochemical methods for the elimination of corneal collagen fiber disorganization to improve vision. Disorganization of corneal collagen fibers is seen in corneal scars, corneal opacification and corneal haze. In addition, t... | 05/18/2004 |
| 6719986 | Hyaluronate lyase used for promoting penetration in topical agents The invention relates to an agent for treating skin diseases and/or functional disorders of the skin on the basis of different medicaments and/or auxiliary substances through promotion of penetration from topical formulations into the skin. According to the inventio... | 04/13/2004 |
| 6652851 | Cloning and recombinant production of polistinae venom enzymes, such as phospholipase and hyaluronidase, and immunological therapies based thereon A unique clone of a Polistinae venom enzyme, recombinantly produced Polistinae venom enzymes, and methods of using the recombinant enzymes are provided. In a specific example, both phospholipase and hyaluronidase cDNA from Polistes annulares contain appar... | 11/25/2003 |
| 6610292 | Use of hyaluronidase in the manufacture of an ophthalmic preparation for liquefying vitreous humor in the treatment of eye disorders An enzymatic method is provided for treating ophthalmic disorders of the mammalian eye. Prevention of neovascularization and the increased rate of clearance from the vitreous of materials toxic to the retina is accomplished by administering an amount of h... | 08/26/2003 |
| 6599513 | Products for topical applications comprising oil bodies The present invention provides novel emulsion formulations which comprise oil bodies. The invention also provides a method for preparing the emulsions and the use of the emulsions in products for topical application to the skin. The products are very mild... | 07/29/2003 |
| 6572855 | Use of hyaluronidase in the manufacturing of a drug for the treatment of inflammation Hyaluronidase is used in the treatment of inflammation associated with an increased local synthesis of hyaluronan in a mammal, e.g. in connection with organ grafting, hyaluronidase being administered locally or systemically. The effect is to reduce inflam... | 06/03/2003 |
| 6551590 | Hyaluronidase preparation for ophthalmic administration and enzymatic methods for accelerating clearance of hemorrhagic blood from the vireous body of the eye The invention provide a method for accelerating the clearance of hemorrhagic blood from the vitreous humor of a mammalian eye without producing toxicity to the eye, the method comprising contacting with the vitreous humor an amount of a solution which con... | 04/22/2003 |
| 6537545 | Use of corneal hardening agents in enzymeorthokeratology An Enzyme Orthokeratology method is provided for correcting refractive errors in the eye of a subject mammal. Accelerating reshaping of the cornea is accomplished by administering a corneal hardening amount of a corneal hardening agent to the eye of the s... | 03/25/2003 |
| 6432401 | Local anesthetic methods and kits Methods of reversing local anesthesia are disclosed. The methods comprise administering a local anesthetic and alpha adrenergic receptor agonist to induce local anesthesia followed by reversing anesthesia with a low dose of an alpha adrenergic receptor an... | 08/13/2002 |
| 6428785 | Method and composition for treating prostate cancer A method of treating prostate cancer in a living mammal includes local administration of a composition that includes a therapeutically effective concentration of collagenase. In one embodiment, a method of treating prostate cancer in a living mammal inclu... | 08/06/2002 |
| 6423312 | Compositions including glycosaminoglycans degrading enzymes and use of same against surface protected bacteria A method of rendering a surface protected bacteria more susceptible to an anti-bacterial agent effected by subjecting the bacteria to a glycosaminoglycans degrading enzyme.... | 07/23/2002 |
| 6399059 | Thermally stable enzyme composition and method of preparing the same A thermally stable enzyme composition contains an enzyme, and a heat stabilizer including a phospholipid and an oil-soluble vitamin. The enzyme composition can be prepared in the form of a powder by drying an enzyme solution containing a phospholipid and ... | 06/04/2002 |
| 6338847 | Compositions and methods to disinfect contact lenses Compositions and methods to disinfect contact lenses are disclosed. In one embodiment, the present composition comprises a cellulose decomposing enzyme component, e.g., lysozyme, and a hydrogen peroxide destroying component. The composition is structured ... | 01/15/2002 |
