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| Number | Title | Issue Date |
| 8168177 | Method of regulating mammalian target-of-rapamycin activity by interaction between phospholipase D and Rheb The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to... | 05/01/2012 |
| 8128925 | Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or ... | 03/06/2012 |
| 8114398 | EGLN2 variants and use thereof in preventing or treating thromboembolic disorders and coronary heart disease The present invention refers to human EGLN2 variants having at position 58 of the amino acid sequence a serine or a leucine and their use in the prevention or treatment of thromboembolic or coronary heart diseases, in particular stroke, prolonged reversible ischemic... | 02/14/2012 |
| 8105585 | Ply-GBS mutant lysins Methods, compositions and articles of manufacture useful for the treatment of various Group B streptococci (GBS) bacteria using various lysins, including certain PlyGBS mutant lysins, are provided. ... | 01/31/2012 |
| 8084025 | Method for the treatment of the symptoms of drug and alcohol addiction A therapeutic agent for the treatment of the symptoms of addiction and the method for preparing the therapeutic agent is disclosed. The therapeutic agent is a stable pharmaceutical preparation containing, but not limited to, digestive/pancreatic enzymes. The therape... | 12/27/2011 |
| 8071089 | Composition with a fungal (yeast) lipase and method for treating lipid malabsorption in cystic fibrosis as well as people suffering from pancreatic lipase insufficiency The invention provides compositions and methods for treating pancreatic enzyme insufficiency, such as the pancreatic enzyme insufficiency associated with cystic fibrosis. The invention also provides compositions comprising lipase from Candida cylindracea, alo... | 12/06/2011 |
| 8066990 | Lysin protein having broad antibacterial activity specific to bacteria The present invention relates to a lysin protein originated from bacteriophage, more precisely a lysin protein comprising the amino acid sequence represented by SEQ. ID. NO: 2 which has no harm to human and animals comprising eukaryotic cells owing to its specificit... | 11/29/2011 |
| 8052970 | Lysosomal phospholipase A2 (LPLA2) activity as a diagnostic and therapeutic target for identifying and treating systemic lupus erythematosis The present invention is directed to methods for diagnosis and treatment of systemic lupus erythematosus and drug-induced systemic lupus erythematosus. More specifically, the specification describes methods using a lysosomal phospholipase A2 in methods for the diagn... | 11/08/2011 |
| 8048412 | Enzyme with microbial lysis activity from The invention provides fungal polypeptides from Trichoderma reesei that possess anti-microbial activity, polynucleotides encoding the polypeptides, compositions comprising the polypeptides and polynucleotides, and methods of use, thereof. ... | 11/01/2011 |
| 8029782 | Therapeutic ribonucleases The present invention relates to the use of ribonucleases (RNases) in the treatment or prevention of disease. ... | 10/04/2011 |
| 7951366 | Pharmaceutical preparation and method of treatment of human malignancies with arginine deprivation The present invention provides an isolated and substantially purified recombinant human arginase having sufficiently high enzymatic activity and stability to maintain Adequate Arginine Depletion in a patient. The present invention also provides a pharmaceutical comp... | 05/31/2011 |
| 7919082 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 04/05/2011 |
| 7892537 | High activity mutants of butyrylcholinesterase for cocaine hydrolysis Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE poly... | 02/22/2011 |
| 7858085 | Alkaline phosphatase to control diabetes The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention may be used to control Type 1 and Type 2 forms of diabetes in humans... | 12/28/2010 |
| 7833523 | Compositions and methods for enzymatic detachment of bacterial and fungal biofilms Isolated nucleic acid sequences and amino acid sequences for soluble, β-N-acetylglucosaminidase or active fragments or variants thereof which promote detachment of bacterial cells from a biofilm are provided. An isolated mutant bacteria which forms biofilm colonies... | 11/16/2010 |
| 7803368 | Pharmacological vitreolysis Methods of treating or preventing a disorder, or a complication of a disorder, of an eye of a subject, comprising contacting a vitreous and/or aqueous humor with a composition comprising a truncated form of plasmin comprising a catalytic domain of plasmin (TPCD) are... | 09/28/2010 |
| 7740840 | High activity mutants of butyrylcholinesterase for cocaine hydrolysis Butyrylcholinesterase (BChE) polypeptide variants of the presently-disclosed subject matter have enhanced catalytic efficiency for (−)-cocaine, as compared to wild-type BChE. Pharmaceutical compositions of the presently-disclosed subject matter include a BChE poly... | 06/22/2010 |
| 7736643 | Method for screening of a lipase having improved enzymatic activity using yeast surface display vector and the lipase The present invention relates to a method for screening of the lipase having improved enzymatic activity using yeast surface display vector and the mutant lipase prepared by the same, more particularly to the method comprising; 1) cloning lipase gene into surface di... | 06/15/2010 |
| 7731957 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 06/08/2010 |
| 7722865 | Manufacture of active highly phosphorylated human lysosomal sulfatase enzymes and uses thereof This invention provides compositions of active highly phosphorylated lysosomal sulfatase enzymes, their pharmaceutical compositions, methods of producing and purifying such lysosomal sulfatase enzymes and compositions and their use in the diagnosis, prophylaxis, or ... | 05/25/2010 |
| 7718170 | Alkaline phosphatase compositions to reduce skin cancer Compositions of human proteins, methods and regimens for reducing the occurrence and growth of skin cancer, including melanoma, are provided. The methods include steps of administering topically on the skin tumor or a skin cancer-free area of compositions containing... | 05/18/2010 |
| 7695714 | Use of alkaline phosphatase to maintain healthy tissue mass in mammals Embodiments of the present invention relate to the use of placental alkaline phosphatase, and other members of the alkaline phosphatase family, to enhance protein synthesis in the muscle as well as the survival of non-cancerous differentiated cells in the muscle, ad... | 04/13/2010 |
| 7662372 | Insect inhibitory lipid acyl hydrolases The present invention discloses DNA sequences encoding plant and novel lipid acyl hydrolase proteins having coleopteran specific insect inhibitory activity, as well as variants and permuteins having enhanced levels of activity directed to controlling coleopteran ins... | 02/16/2010 |
| 7658918 | Stable digestive enzyme compositions Compositions of the present invention, comprising at least one digestive enzyme (e.g., pancrelipase) are useful for treating or preventing disorders associated with digestive enzyme deficiencies. The compositions of the present invention can comprise a plurality of ... | 02/09/2010 |
| 7645448 | Class of therapeutic protein based molecules The present invention provides new compositions and methods for preventing and treating pathogen infection. In particular, the present invention provides compounds having an anchoring domain that anchors the compound to the surface of a target cell, and a therapeuti... | 01/12/2010 |
| 7635470 | Fungal cell wall degrading enzyme A novel fungal enzyme having lysozyme activity has been isolated. The invention further relates to a fungal polypeptide having lysozyme activity and belonging to the GH25 family, wherein the enzyme is selected from the group consisting of (a) a polypeptide comprisin... | 12/22/2009 |
| 7622109 | Plant gene and uses thereof A novel gene isolated from Deschampsia antarctica coding for a lipase like protein is disclosed. A system for production of recombinant enzyme is also disclosed as well as use for the enzyme in sunscreen. ... | 11/24/2009 |
| 7611701 | Preparation of phytase-containing granulates for use in animal feed A process for the preparation of an enzyme-containing granulate is disclosed where an aqueous enzyme-containing liquid is mixed with an edible carbohydrate-based solid carrier, such as starch, mechanically processed into granules, and subsequently dried. This enzyme... | 11/03/2009 |
| 7572439 | Enzyme disruption of bacterial biofilms Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to... | 08/11/2009 |
| 7541026 | Alpha-amylase variants with altered properties Disclosed are compositions comprising variants of a parent G. stearothermophilus alpha-amylase that have alpha-amylase activity and which exhibit altered properties relative to a parent AmyS-like alpha-amylase from which they are derived. The compositions com... | 06/02/2009 |
| 7524494 | Degradation of hydrophobic ester pesticides and toxins The present invention relates to methods and enzymes for degrading hydrophobic ester pesticides and toxins. In particular, the present invention relates to the use of insect esterases, and mutants thereof, in the bioremediation of hydrophobic ester pesticides and to... | 04/28/2009 |
| 7501116 | Placental alkaline phosphatase to control diabetes The present invention provides methods for using human placental alkaline phosphatase or an active derivative to reduce blood glucose level in a mammal. Treatment regimens provided by the invention may be used to control Type 1 and Type 2 forms of diabetes in humans... | 03/10/2009 |
| 7494645 | Lipid phosphate phosphatases and uses thereof for treating neuronal diseases Lipid phosphate phosphatase proteins, genes coding for them, vectors and cells comprising them, antibodies directed against them, methods of identifying compounds binding to them and functional interactors as well as to the use of proteins, genes, vectors, cells, in... | 02/24/2009 |
| 7438904 | High-activity mutants of butyrylcholinesterase for cocaine hydrolysis and method of generating the same A novel computational method and generation of mutant butyrylcholinesterase for cocaine hydrolysis is provided. The method includes molecular modeling a possible BChE mutant and conducting molecular dynamics simulations and hybrid quantum mechanical/molecular mechan... | 10/21/2008 |
| 7432097 | Phytases, nucleic acids encoding them and methods of making and using them In one aspect, the invention provides a purified and modified phytase enzyme from Escherichia coli K12 appA phytase. The enzyme has phytase activity and improved thermal tolerance as compared with the wild-type enzyme. In addition, the enzyme has improved pro... | 10/07/2008 |
| 7432098 | Phytases and methods for making and using them The invention provides isolated and recombinant phytase enzymes. In one aspect, the phytases are produced by modification of the wild type appA of E. coli. The enzyme can be produced from recombinant host cells. The phytases of the invention can be used to ai... | 10/07/2008 |
| 7417021 | Biologically active conjugate of a biopolymer and therapeutic agent A biologically active conjugate is disclosed comprising a biopolymer and a therapeutic agent joined by a disulfide bond. The conjugate, when formulated in a pharmaceutical composition with a suitable carrier, has improved in vivo stability and activity, and can be t... | 08/26/2008 |
| 7407785 | Human DNase I hyperactive variants The present invention relates to amino acid sequence variants of human DNase I that have increased DNA-hydrolytic activity. The invention provides nucleic acid sequences encoding such hyperactive variants, thereby enabling the production of these variants in quantit... | 08/05/2008 |
| 7407775 | Method for identifying and culture medium A substrate which can be used for the direct identification of pathogenic bacteria belonging to the genus Listeria by detecting an esterase activity other than Phosphatidyl Inositol-specific Phospholipase C (PI-PLC), an esterase which is specific to the speci... | 08/05/2008 |
| 7402309 | Phage-associated lytic enzymes for treatment of and related conditions The present disclosure relates to methods, compositions and articles of manufacture useful for the treatment of Bacillus anthracis and B. cereus bacteria and spores, and related conditions. The disclosure further relates to methods and compositions for... | 07/22/2008 |
