Class 424/94.5 - Transferases (2. ), Lyase (4.), Isomerase (5.), Ligase (6.)

Subclass of Class 424 - Drug, bio-affecting and body treating compositions
Definition: Subject matter wherein (a) the enzyme catalyzes the transfer
No. of patents: 304
Last issue date: 05/01/2012

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Number	Title	Issue Date
8168176	CBLB for treating endotoxin-mediated disorders Methods of treating endotoxin-mediated disorders are provided. ...	05/01/2012
8142775	Crystallized oxalate decarboxylase and methods of use Oxalate decarboxylase crystals, including stabilized crystals, such as cross-linked crystals of oxalate decarboxylase, are disclosed. Methods to treat a disorder associated with elevated oxalate concentration using oxalate decarboxylase crystals are also disclosed. ...	03/27/2012
8007787	Human cystathionine β-synthase variants and methods of production thereof Human cystathionine β-synthase variants are disclosed, as well as a method to produce recombinant human cystathionine β-synthase and variants thereof. More particularly, the role of both the N-terminal and C-terminal regions of human CBS has been studied, and a va...	08/30/2011
8003095	Method of using lipid acyltransferase A method for the in situ production of an emulsifier in a foodstuff, wherein a lipid acyltransferase is added to the foodstuff. Preferably the emulsifier is produced without an increase or without a substantial increase in the free fatty acid content of the foodstuf...	08/23/2011
7968089	Proteoglycan degrading mutants for the treatment of CNS The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous sy...	06/28/2011
7939065	Chondroitin sulfate synthesis promoter The invention provides a chondroitin sulfate synthesis promoter useful for the treatment of diseases such as articular disease and discopathy. The chondroitin sulfate synthesis promoter contains, as an active ingredient, chondroitin sulfate glucuronyltransferase pro...	05/10/2011
7910554	Treatment of macular degeneration with ADP-ribosyl transferase fusion protein therapeutic compositions The Rho family of GTPases regulates axon growth and regeneration. Inactivation of Rho with C3, a toxin from Clostridium botulinum, can stimulate regeneration and sprouting of injured axons. The present invention provides novel chimeric C3-like Rho antagonists...	03/22/2011
7776326	Methods and compositions for treating neuropathies Methods of treating or preventing axonal degradation in neuropathic diseases in mammals are disclosed. The methods can comprise administering to the mammal an effective amount of an agent that acts by increasing sirtuin activity in diseased and/or injured neurons. T...	08/17/2010
7767204	Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels A method of reducing extracellular brain glutamate levels. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent capable of reducing blood glutamate levels thereby reducing extracellular brain glutamate levels...	08/03/2010
7731956	Compositions and methods of using chondroitinase ABCI mutants One aspect of the present invention relates to mutants of chondroitinase ABCI. Such chondroitinase ABCI mutants exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including exposure to UV light or heat. Methods of using...	06/08/2010
7722864	Compositions and methods of using chondroitinase ABCI mutants The present invention relates to protein and nucleic acid mutants of chondroitinase ABCI. Such chondroitinase ABCI mutant enzymes exhibit altered chondroitin lyase activity or increased resistance to inactivation from stressors including UV light or heat. Methods of...	05/25/2010
7560106	Rationally designed heparinases derived from heparinase I and II and methods of sequencing therewith Modified heparinases having altered binding specificity and activity are provided. Isolated nucleic acids encoding the same as well as vectors and host cells are provided. Methods for using the modified heparinases are also provided. ...	07/14/2009
7498025	Targeted bifunctional molecules and therapies based thereon Targeted bifunctional molecules and methods for their use are provided. The subject targeted bifunctional molecules are conjugates of a drug moiety and a targeting moiety, where these two moieties are optionally joined by a linking group. The bifunctional molecules ...	03/03/2009
7498026	Acyltransferase The invention relates to at least one nucleotide sequence, derived from a nucleotide sequence encoding an acyltransferase polypeptide comprising at least one membrane-spanning region, encoding an improved active membrane independent acyltransferase polypeptide in wh...	03/03/2009
7429375	Proteoglycan degrading mutants for the treatment of CNS The present disclosure relates to the preparation and deletion mutants of chondroitinase proteins and their use in methods for promoting the diffusion of therapeutic composition into tissues and their use for neurological functional recovery after central nervous sy...	09/30/2008
7425435	genes encoding phosphoenolpyruvate: sugar phosphotransferase system proteins Isolated nucleic acid molecules, designated PTS nucleic acid molecules, which encode novel PTS proteins from Corynebacterium glutamicum are described. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PTS ...	09/16/2008
7413735	Pharmaceutical composition comprising arginine deiminase for inhibiting angiogenesis The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained from Mycoplasma arginini or prepared by a genetic recombination techni...	08/19/2008
7407986	Prevention and treatment of oxidative stress disorders by glutathione and phase II detoxification enzymes The present invention generally relates to the field of treating oxidative stress disorders by administering a pharmaceutically effective amount of a compound that elevates the intracellular levels of glutathone or intracellular levels of at least one Phase II detox...	08/05/2008
7407775	Method for identifying and culture medium A substrate which can be used for the direct identification of pathogenic bacteria belonging to the genus Listeria by detecting an esterase activity other than Phosphatidyl Inositol-specific Phospholipase C (PI-PLC), an esterase which is specific to the speci...	08/05/2008
7404952	Protein disulfide isomerase and ABC transporter homologous proteins involved in the regulation of energy homeostasis The present invention discloses three novel proteins regulating the energy homeostasis and the metabolism of triglycerides, and polynucleotides, which identify and encode the proteins disclosed in this invention. The invention also relates to vectors, host cells, an...	07/29/2008
7404951	Method and composition for protecting neuronal tissue from damage induced by elevated glutamate levels A method of reducing extracellular brain glutamate levels. The method comprises administering to a subject in need thereof a therapeutically effective amount of an agent capable of reducing blood glutamate levels thereby reducing extracellular brain glutamate levels...	07/29/2008
7390784	Administering bifunctional molecules containing a drug moiety and presenter protein ligand for therapy Bifunctional molecules and methods for their use in the production of binary complexes in a host are provided. The bifunctional molecule is a conjugate of a drug moiety and a presenter protein ligand. In the subject methods, an effective amount of the bifunctional m...	06/24/2008
7378090	Alleviation of the memory deficits and memory components of psychiatric dysfunctions by altering atypical PKM activity Methods have been developed for alleviating memory problems or psychiatric dysfunctions that have a memory formation component. These methods are based on the finding that a truncated form of an aPKCζ protein is intimately involved in memory formation in animals. T...	05/27/2008
7368108	Glycopeptide remodeling using amidases This invention provides methods for modifying glycosylation patterns of glycopeptides, including recombinantly produced glycopeptides. Also provided are glycopeptide compositions in which the glycopeptides have a homogeneous glycosylation pattern. ...	05/06/2008
7361502	Nucleic acid molecule encoding a neuronal serine-threonine protein kinase The present invention relates to a gene and the coded protein thereof that is involved in the development of sequelae of local ischaemia. The new protein is a serine threonine protein kinase and provides a new therapeutic approach to the prophylaxis and therapy of a...	04/22/2008
7348301	Lysozyme-based method and composition to control the growth of microorganisms in aqueous systems A method for killing, preventing, or inhibiting the growth of microorganisms in an aqueous system or on a substrate capable of supporting a growth of microorganisms is provided by providing lysozyme, alone or in combination with a quaternary ammonium compound to the...	03/25/2008
7348034	Plant based formulations for improving skin moisture, texture, and appearance The present invention relates to formulations of ingredients that are useful for improving the appearance, texture and/or moisture of skin. In particular, the formulations of the present invention stimulate collagen, elastin, and lipid synthesis and/or inhibit or mi...	03/25/2008
7344870	3-phosphoinositide-dependent protein kinase The present invention provides for a substantially pure human or rabbit 3-phosphoinositide-dependent protein kinase. ...	03/18/2008
7338936	Use of antimicrobial proteins and peptides for the treatment of otitis media and paranasal sinusitis The pharmaceutical composition and a method of treatment of infectious diseases, such as otitis media, paranasal sinusitis, labyrinthitis and meningitis are described. The composition comprises EP2E or homologues thereof. ...	03/04/2008
7332304	Process and materials for production of glucosamine and N-acetylglucosamine A biosynthetic method for producing glucosamine and N-acetylglucosamine is disclosed. Such a method includes the fermentation of a genetically modified microorganism to produce glucosamine and/or N-acetylglucosamine. Also disclosed are genetically modified microorga...	02/19/2008
7309484	Compositions and methods for screening antibacterial compounds The present invention pertains to compositions and methods used to ascertain if putative antibiotics trigger a cell envelope stress response in bacterial organisms. In one aspect of the invention, three two-component systems are described: LiaR & LiaS (formerly YvqC...	12/18/2007
7309482	Long lasting waterproof sunscreen comprising metal oxide and peptide conditioner The disclosure provides a sunscreen formulation comprising a peptide-based metal oxide sunscreen agent, such as titanium dioxide nanoparticles, and a fluid vehicle. ...	12/18/2007
7273844	Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis An isolated, water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase is useful for the inhibition of angiogenesis. The polypeptide has the amino acid residue sequence shown in SEQ ID NO: 7, SEQ ID NO: 12, or an angiogenesis inhibiting fragment there...	09/25/2007
7271249	Biosensors, method for obtaining the same and uses thereof The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of...	09/18/2007
7270978	Method for identifying and culture medium A substrate which can be used for the direct identification of pathogenic bacteria belonging to the genus Listeria by detecting an esterase activity other than Phosphatidyl Inositol-specific Phospholipase C (PI-PLC), an esterase which is specific to the speci...	09/18/2007
7265092	Pharmaceutical formulation A pharmaceutical formulation for a PKC modulatory peptide and a transport moiety comprising the aforementioned components and an anti-aggregant. ...	09/04/2007
7264799	Use of heparinases to decrease inflammatory response Heparinase enzymes can be used as a medical treatment to reduce localized inflammatory responses. Treatment of activated endothelium with heparinase inhibits leukocyte rolling, adhesion and extravasation. Most of the heparin and heparan sulfate on endothelial cell s...	09/04/2007
7264819	Lyase treatment for Infection by P. carinii can be treated by administering methioninase optionally in combination with additional therapeutic agents, such as antibiotics. ...	09/04/2007
7262174	Treatment for wounds It has been discovered that increasing telomerase activity in cells surrounding a wound has a variety of effects that enhance wound healing. Replication capacity is enhanced, and the mobility of the epithelial cells can be increased by 3-fold or more. Some aspects o...	08/28/2007
7251525	Treatment of arrhythmias via inhibition of a multifunctional calcium/calmodulin-dependent protein kinase This invention provides a method for treating or preventing arrhythmias in a human subject comprising the administration of an effective amount of a calcium/calmodulin-dependent protein kinase inhibitor. Also provided are pharmaceutical compositions comprising a cal...	07/31/2007

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Class 424/94.5 - Transferases (2. ), Lyase (4.), Isomerase (5.), Ligase (6.)