Did You Know...
...that it was melting ice cream that inspired the invention of the outboard motor? It was a lovely August day and Ole Evinrude was rowing his boat to his favorite island picnic spot. As he rowed, he watched his ice cream melt and wished he had a faster way to get to the island. At that moment the idea for the outboard motor was born!
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| Number | Title | Issue Date |
| 8168175 | Pretreatment or post exposure treatment for exposure to a toxic substance by pulmonary delivery (inhaler) of a bioscavenger The present invention relates to a treatment by pulmonary delivery of bioscavengers to animals as an effective antidote to prevent toxicity produced by exposure of an animal to nerve agents and other toxic substances. ... | 05/01/2012 |
| 8147826 | Method of making a soft gel capsule comprising CoQ-10 solubilized in a monoterpene The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft ge... | 04/03/2012 |
| 8147825 | Topical co-enzyme Q10 formulations and methods of use Topical formulations of CoQ10 reduce the rate of tumor growth in an animal subject. In the experiments described herein, CoQ10 was shown to increase the rate of apoptosis in a culture of skin cancer cells but not normal cells. Moreover, treatment of tumor-bearing an... | 04/03/2012 |
| 8133482 | Activatable photodynamic therapy agents The present invention relates to the field of conjugates comprising a substrate which is attached to at least one photoactivatable killing agent and at least one first quencher, and methods for their use. More particularly, the present invention relates to photodyna... | 03/13/2012 |
| 8124072 | Solubilized CoQ-10 The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft ge... | 02/28/2012 |
| 8105583 | Solubilized CoQ-10 The present invention is directed to compositions and methods of delivery of CoQ-10 solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 in formulations, such as soft ge... | 01/31/2012 |
| 8101174 | Pharmaceutical compositions for treating arthritis and inflammatory disease The biological effects of the cytokine TNF are mediated by binding to receptors on the surface of cells. This disclosure describes new proteins and polynucleotides that promote enzymatic cleavage and release of TNF receptors. Also provided are methods for identifyin... | 01/24/2012 |
| 8029781 | Methods of treating a deficiency of functional tripeptidyl peptidase I (CLN2) protein The present invention relates to a method for treating a patient having disorder characterized by a deficient amount of functional CLN2 protein in the affected cells, which comprises administering to the patient an amount of CLN2 protein effective to reduce or elimi... | 10/04/2011 |
| 8021659 | Coenzyme Q10, lactoferrin and angiogenin compositions and uses thereof Methods of enhancing the bio-availability of coenzyme Q10, and methods of supporting the cardiovascular system to accommodate the increase in cellular energy synthesis as a result of the bio-availability of coenzyme Q10 are described. Compositions which include coen... | 09/20/2011 |
| 8012471 | Screening and treatment methods using IGS5 enzymes of the metalloprotease family Polypeptides which are related to the neprilysin enzyme family and have zinc metalloprotease activities and are referred to as IGS5, polynucleotides encoding such polypeptides, vectors containing such polynucleotides, host cells containing such vectors, processes fo... | 09/06/2011 |
| 8003094 | Chemical combination and method for increasing delivery of Coenzyme Q10 The present invention relates to a chemical combination and method for increasing delivery of Coenzyme Q10. The chemical combination comprises Coenzyme Q10 mixed with at least one chemical. The at least one chemical includes cyclic monoterpene containing essential o... | 08/23/2011 |
| 7964189 | Nutritional supplements for women desiring to become pregnant, and pregnant and nursing women The present invention relates to nutritional supplements to be administered to, or to be taken by, women desiring to become pregnant, and pregnant and nursing women. The nutritional supplements of this invention have a unique blend of vitamins, minerals, lycopene, c... | 06/21/2011 |
| 7964188 | Use of placental alkaline phosphatase to promote skin cell proliferation Methods for promoting survival and stimulating proliferation of cells in the epidermis and dermis of undamaged mammalian skin are disclosed. The methods comprise the step of administering to an area of the skin a composition comprising a therapeutically effective am... | 06/21/2011 |
| 7959913 | Skin conditioning compositions containing compounds for mimicking the effect on skin of retinoic acid A skin care product comprising from about 0.001% to about 10% of a retinoid, in combination with 0.0001% to about 50% of a combination of retinoid boosters. ... | 06/14/2011 |
| 7956031 | Metallo-lactoferrin-coenzyme compositions for trigger and release of bioenergy Formulations are provided for the trigger and release of bioenergy. The formulations generally include a trigger complex, an elemental complex and a coenzyme-vitamin B complex. The trigger complex is high in fiber and includes at least one metal-binding protein in a... | 06/07/2011 |
| 7943126 | Compositions and methods for treating hypophosphatasia The present invention provides compositions and methods for use in enzyme replacement therapy. The inventors disclose a method of producing membrane bound enzymes in an active soluble form by eliminating the glycosylphosphatidylinositol (GPI) membrane anchor. In par... | 05/17/2011 |
| 7939064 | Phospholipase(s) and use(s) thereof The invention relates to phospholipase(s), isoforms, derivatives, mutants and/or fragments thereof, for the preparation of a medicament for the treatment and/or prevention of ischemia. Preferred is the use of secretory phospholipase, particularly phospholipase A | 05/10/2011 |
| 7906114 | Compositions for promoting wound healing and treating psoriasis The present invention relates to compositions and methods for promoting healing of cutaneous, mucosal and/or mucocutaneous lesions associated with the presence of a mycoplasma and one or more non-mycoplasma microorganisms. The compositions and methods of the inventi... | 03/15/2011 |
| 7901675 | Method of using coenzyme Qto treat Huntington's disease A method of ameliorating or abrogating the effects of a neurodegenerative disorder, such as Huntington's disease, includes administering a formulation including mitochondrial coenzyme Q10 in a subject in need thereof. The formulation includes Hydro-Q Sorb... | 03/08/2011 |
| 7862811 | Protease inhibition for prevention or treatment of heart failure Methods, and compositions to prevent and/or treat acute or chronic right ventricular failure from pressure over load (RVPO). In one embodiment, the method includes the inhibition of at least one cysteine protease. In other embodiments, the method includes the inhibi... | 01/04/2011 |
| 7829080 | Stabilization method of reduced coenzyme Q The present invention provides a method for stabilizing reduced coenzyme Q10, which is useful as a food, nutritional product, nutritional supplement, animal drug, drink, feed, cosmetic, pharmaceutical product, therapeutic drug, prophylactic drug and the l... | 11/09/2010 |
| 7811559 | Methods of reducing storage products using tripeptidyl peptidase I (CLN2) protein The present invention relates to a method for treating a patient having disorder characterized by a deficient amount of functional CLN2 protein in the affected cells, which comprises administering to the patient an amount of CLN2 protein effective to reduce or elimi... | 10/12/2010 |
| 7803366 | Methods and compositions that enhance bioavailability of coenzyme-Q10 Bioavailability of Coenzyme-Q 10 (“Co-Q10”), an oil-soluble substance, can be enhanced in a subject by modifying, e.g. nanonizing or charging, the form of Co-Q10. Co-Q10 bioavailability also can be enhanced by administering Co-Q10 to the subject as an oil (lipid... | 09/28/2010 |
| 7794708 | Pharmaceutical composition for preventing and treating restenosis comprising peroxiredoxin 2 protein as an active ingredient and composition for screening therapeutics of restenosis comprising peroxiredoxin 2 gene or its protein product, and method for screening therapeutics of restinosis using said composition Disclosed herein is a pharmaceutical composition for the prophylaxis and treatment of restenosis, comprising a peroxiredoxin 2 (Prx II) protein as an active ingredient. Optionally, the composition may contain other active ingredients suppressive of restenosis at the... | 09/14/2010 |
| 7794707 | ACE2 activation for treatment of heart, lung and kidney disease and hypertension The invention relates to ACE2 activating compounds for prevention and treatment of cardiovascular disease, kidney disease, lung disease and hypertension. The invention also includes methods of diagnosing cardiovascular disease, kidney disease, lung disease and hyper... | 09/14/2010 |
| 7776325 | Bactericide against and The present invention provides an enzyme with lytic activity against cariogenic bacteria and a means for treating and preventing tooth decay using the enzyme. The enzyme provided by the present invention is a lytic enzyme produced by Streptococcus mutans and ... | 08/17/2010 |
| 7754205 | Composition for transmucosal administration containing conenzyme Q as the active ingredient The present invention relates to the supply of coenzyme Q which is highly useful in maintaining human health, and provides a method and preparations whereby coenzyme Q can be efficiently supplied to patients having difficulties in oral administration, aged having sw... | 07/13/2010 |
| 7749496 | Neuronal regeneration A method of promoting neuronal regeneration includes administering an agent to at least one neural cell in contact with at least one neural cell growth inhibiting component in an amount effective to promote neuronal regeneration. The agent is selected from the group... | 07/06/2010 |
| 7722863 | Use of granzyme b as an hsp70/hsp70 peptide dependent inducer of apoptosis in tumor cells The present invention relates to a method of inducing or enhancing the expression of granzyme B in natural killer (NK) cells. The present invention relates also to a use of said NK cells for the preparation of a pharmaceutical composition for the treatment of tumors... | 05/25/2010 |
| 7718168 | Medical implant materials containing immobilized transglutaminase The present invention provides a medical implant material comprising mammalian transglutaminase and a polymer, wherein the transglutaminase is provided in the absence of free divalent metal ions and wherein the polymer is associated with the transglutaminase binding... | 05/18/2010 |
| 7713523 | Solubilized CoQ-10 and carnitine The present invention is directed to compositions and methods of delivery of CoQ-10 and an amino acid solubilized in monoterpenes. Use of monoterpenes as dissolving agents, greatly effects the ability to incorporate greater amounts of bioactive CoQ-10 and the amino ... | 05/11/2010 |
| 7708990 | Coenzyme Q compositions persisting in blood The object of the present invention is to provide a composition maintaining a blood coenzyme Q concentration at a high level in blood for a prolonged period of time, in order to surely attain an effect of coenzyme Q, which can be expected to manifest a superior effe... | 05/04/2010 |
| 7708989 | Methods of treating vascular diseases characterized by nitric oxide insufficiency The invention provides methods of treating and/or preventing vascular diseases characterized by nitric oxide insufficiency by administering a therapeutically effective amount of at least one nitrosated angiotensin-converting enzyme inhibitor, nitrosated beta-adrener... | 05/04/2010 |
| 7658916 | Methods of enhancing lysosomal storage disease therapy by modulation of cell surface receptor density Methods of modulating uptake of extracellular lysosomal enzymes by administering a pharmaceutical agent and methods of treating a lysosomal storage disease (such as Gaucher disease, Pompe disease, Fabry disease or Niemann-Pick disease) or enhancing enzyme replacemen... | 02/09/2010 |
| 7635469 | Micronutrient formulations for hearing health A hearing health micronutrient formulation is provided and the formulation comprises dietary antioxidants and endogenous antioxidants, and the dietary antioxidants are selected from a group consisting essentially of Vitamin A (Palmitate), Vitamin E, Vitamin C (Calci... | 12/22/2009 |
| 7628983 | Kallikrein-binding “Kunitz domain” proteins and analogues thereof This invention provides: novel protein homologous of a Kunitz domain, which are capable of binding kallikrein; polynucleotides that encode such novel proteins; and vectors and transformed host cells containing these polynucleotides. ... | 12/08/2009 |
| 7628984 | Micronutrient formulations for pulmonary and heart health A heart and pulmonry health micronutrient formulation is provided and the formulation comprises dietary antioxidants and endogenous antioxidants, and the formulation comprising dietary micronutrients and endogenous antioxidants, the dietary antioxidants are selected... | 12/08/2009 |
| 7566447 | Biocides The present invention relates to the use of biocide (e.g., bactericidal enzyme) to target pathogens. In particular, the present invention provides biocides for use in health care (e.g., human and veterinary), agriculture (e.g., animal and plant production), and food... | 07/28/2009 |
| 7527785 | Glutamic acid decarboxylase (GAD) chimera and methods of use The invention relates to a novel Glutamic Acid Decarboxylase (GAD). More specifically, novel DNA and protein sequences relating to GAD. Additionally, the invention discloses a novel composition and related methods for treating neurodegenerative diseases such as Park... | 05/05/2009 |
| 7521044 | Human histone deacetylase, HDAC9c The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vec... | 04/21/2009 |
